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Protein

Ribosome biogenesis protein TSR3 homolog

Gene

TSR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable pre-rRNA processing protein involved in ribosome biogenesis.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein TSR3 homologUniRule annotation
Gene namesi
Name:TSR3UniRule annotation
Synonyms:C16orf42, UND313L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14175. TSR3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25558.

Polymorphism and mutation databases

BioMutaiTSR3.
DMDMi74753359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Ribosome biogenesis protein TSR3 homologPRO_0000278669Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241PhosphoserineBy similarity
Modified residuei259 – 2591PhosphoserineCombined sources
Modified residuei261 – 2611PhosphothreonineCombined sources
Modified residuei264 – 2641PhosphoserineCombined sources
Modified residuei282 – 2821PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UJK0.
MaxQBiQ9UJK0.
PaxDbiQ9UJK0.
PeptideAtlasiQ9UJK0.
PRIDEiQ9UJK0.

PTM databases

iPTMnetiQ9UJK0.
PhosphoSiteiQ9UJK0.

Expressioni

Gene expression databases

BgeeiENSG00000007520.
CleanExiHS_C16orf42.
ExpressionAtlasiQ9UJK0. baseline and differential.
GenevisibleiQ9UJK0. HS.

Organism-specific databases

HPAiHPA040760.
HPA046265.

Interactioni

Protein-protein interaction databases

BioGridi125462. 23 interactions.
IntActiQ9UJK0. 3 interactions.
STRINGi9606.ENSP00000007390.

Structurei

3D structure databases

ProteinModelPortaliQ9UJK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TSR3 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3154. Eukaryota.
COG2042. LUCA.
GeneTreeiENSGT00390000014665.
HOVERGENiHBG063013.
InParanoidiQ9UJK0.
KOiK09140.
OMAiPAEVWKG.
OrthoDBiEOG091G0KRB.
PhylomeDBiQ9UJK0.
TreeFamiTF105862.

Family and domain databases

HAMAPiMF_01116. TSR3. 1 hit.
InterProiIPR022968. Rbsm_biogenesis.
IPR007209. RNaseL-inhib_metal-bd_dom.
IPR007177. TDD_dom.
[Graphical view]
PANTHERiPTHR20426. PTHR20426. 1 hit.
PfamiPF04034. DUF367. 1 hit.
PF04068. RLI. 1 hit.
[Graphical view]
ProDomiPD016638. DUF367. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9UJK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRRAARGP GAEGGRPRHL PTRSLEAFAE EVGAALQASV EPGAADGEGG
60 70 80 90 100
PGPAALPCTL AMWELGHCDP RRCTGRKLAR LGLVRCLRLG HRFGGLVLSP
110 120 130 140 150
VGKQYASPAD RQLVAQSGVA VIDCSWARLD ETPFGKMRGS HLRLLPYLVA
160 170 180 190 200
ANPVNYGRPY RLSCVEAFAA TFCIVGFPDL AVILLRKFKW GKGFLDLNRQ
210 220 230 240 250
LLDKYAACGS PEEVLQAEQE FLANAKESPQ EEEIDPFDVD SGREFGNPNR
260 270 280 290 300
PVASTRLPSD TDDSDASEDP GPGAERGGAS SSCCEEEQTQ GRGAEARAPA
310
EVWKGIKKRQ RD
Length:312
Mass (Da):33,596
Last modified:May 1, 2000 - v1
Checksum:i47D33346832145BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006467 Genomic DNA. Translation: AAK61276.1.
AL031709 Genomic DNA. Translation: CAB56183.1.
BC013943 mRNA. Translation: AAH13943.1.
BC016699 mRNA. Translation: AAH16699.1.
BC017325 mRNA. Translation: AAH17325.1.
CCDSiCCDS10435.1.
PIRiT45061.
RefSeqiNP_001001410.1. NM_001001410.2.
UniGeneiHs.134846.

Genome annotation databases

EnsembliENST00000007390; ENSP00000007390; ENSG00000007520.
GeneIDi115939.
KEGGihsa:115939.
UCSCiuc002cll.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006467 Genomic DNA. Translation: AAK61276.1.
AL031709 Genomic DNA. Translation: CAB56183.1.
BC013943 mRNA. Translation: AAH13943.1.
BC016699 mRNA. Translation: AAH16699.1.
BC017325 mRNA. Translation: AAH17325.1.
CCDSiCCDS10435.1.
PIRiT45061.
RefSeqiNP_001001410.1. NM_001001410.2.
UniGeneiHs.134846.

3D structure databases

ProteinModelPortaliQ9UJK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125462. 23 interactions.
IntActiQ9UJK0. 3 interactions.
STRINGi9606.ENSP00000007390.

PTM databases

iPTMnetiQ9UJK0.
PhosphoSiteiQ9UJK0.

Polymorphism and mutation databases

BioMutaiTSR3.
DMDMi74753359.

Proteomic databases

EPDiQ9UJK0.
MaxQBiQ9UJK0.
PaxDbiQ9UJK0.
PeptideAtlasiQ9UJK0.
PRIDEiQ9UJK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000007390; ENSP00000007390; ENSG00000007520.
GeneIDi115939.
KEGGihsa:115939.
UCSCiuc002cll.4. human.

Organism-specific databases

CTDi115939.
GeneCardsiTSR3.
HGNCiHGNC:14175. TSR3.
HPAiHPA040760.
HPA046265.
neXtProtiNX_Q9UJK0.
PharmGKBiPA25558.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3154. Eukaryota.
COG2042. LUCA.
GeneTreeiENSGT00390000014665.
HOVERGENiHBG063013.
InParanoidiQ9UJK0.
KOiK09140.
OMAiPAEVWKG.
OrthoDBiEOG091G0KRB.
PhylomeDBiQ9UJK0.
TreeFamiTF105862.

Miscellaneous databases

GeneWikiiC16orf42.
GenomeRNAii115939.
PROiQ9UJK0.

Gene expression databases

BgeeiENSG00000007520.
CleanExiHS_C16orf42.
ExpressionAtlasiQ9UJK0. baseline and differential.
GenevisibleiQ9UJK0. HS.

Family and domain databases

HAMAPiMF_01116. TSR3. 1 hit.
InterProiIPR022968. Rbsm_biogenesis.
IPR007209. RNaseL-inhib_metal-bd_dom.
IPR007177. TDD_dom.
[Graphical view]
PANTHERiPTHR20426. PTHR20426. 1 hit.
PfamiPF04034. DUF367. 1 hit.
PF04068. RLI. 1 hit.
[Graphical view]
ProDomiPD016638. DUF367. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiTSR3_HUMAN
AccessioniPrimary (citable) accession number: Q9UJK0
Secondary accession number(s): Q6PJT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.