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Protein

Ribosome biogenesis protein TSR3 homolog

Gene

TSR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable pre-rRNA processing protein involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein TSR3 homologUniRule annotation
Gene namesi
Name:TSR3UniRule annotation
Synonyms:C16orf42, UND313L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000007520.3
HGNCiHGNC:14175 TSR3
neXtProtiNX_Q9UJK0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000007520
PharmGKBiPA25558

Polymorphism and mutation databases

BioMutaiTSR3
DMDMi74753359

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002786691 – 312Ribosome biogenesis protein TSR3 homologAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1
Modified residuei259PhosphoserineCombined sources1
Modified residuei261PhosphothreonineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei282PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UJK0
MaxQBiQ9UJK0
PaxDbiQ9UJK0
PeptideAtlasiQ9UJK0
PRIDEiQ9UJK0

PTM databases

iPTMnetiQ9UJK0
PhosphoSitePlusiQ9UJK0

Expressioni

Gene expression databases

BgeeiENSG00000007520
CleanExiHS_C16orf42
ExpressionAtlasiQ9UJK0 baseline and differential
GenevisibleiQ9UJK0 HS

Organism-specific databases

HPAiHPA040760
HPA046265

Interactioni

Protein-protein interaction databases

BioGridi125462, 28 interactors
IntActiQ9UJK0, 3 interactors
STRINGi9606.ENSP00000007390

Structurei

3D structure databases

ProteinModelPortaliQ9UJK0
SMRiQ9UJK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TSR3 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3154 Eukaryota
COG2042 LUCA
GeneTreeiENSGT00390000014665
HOVERGENiHBG063013
InParanoidiQ9UJK0
KOiK09140
OMAiPAEVWKG
OrthoDBiEOG091G0KRB
PhylomeDBiQ9UJK0
TreeFamiTF105862

Family and domain databases

HAMAPiMF_01116 TSR3, 1 hit
InterProiView protein in InterPro
IPR022968 Rbsm_biogenesis
IPR007209 RNaseL-inhib_metal-bd_dom
IPR007177 TDD_dom
PANTHERiPTHR20426 PTHR20426, 1 hit
PfamiView protein in Pfam
PF04034 Ribo_biogen_C, 1 hit
PF04068 RLI, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016638 DUF367, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UJK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRRAARGP GAEGGRPRHL PTRSLEAFAE EVGAALQASV EPGAADGEGG
60 70 80 90 100
PGPAALPCTL AMWELGHCDP RRCTGRKLAR LGLVRCLRLG HRFGGLVLSP
110 120 130 140 150
VGKQYASPAD RQLVAQSGVA VIDCSWARLD ETPFGKMRGS HLRLLPYLVA
160 170 180 190 200
ANPVNYGRPY RLSCVEAFAA TFCIVGFPDL AVILLRKFKW GKGFLDLNRQ
210 220 230 240 250
LLDKYAACGS PEEVLQAEQE FLANAKESPQ EEEIDPFDVD SGREFGNPNR
260 270 280 290 300
PVASTRLPSD TDDSDASEDP GPGAERGGAS SSCCEEEQTQ GRGAEARAPA
310
EVWKGIKKRQ RD
Length:312
Mass (Da):33,596
Last modified:May 1, 2000 - v1
Checksum:i47D33346832145BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006467 Genomic DNA Translation: AAK61276.1
AL031709 Genomic DNA No translation available.
BC013943 mRNA Translation: AAH13943.1
BC016699 mRNA Translation: AAH16699.1
BC017325 mRNA Translation: AAH17325.1
CCDSiCCDS10435.1
PIRiT45061
RefSeqiNP_001001410.1, NM_001001410.2
UniGeneiHs.134846

Genome annotation databases

EnsembliENST00000007390; ENSP00000007390; ENSG00000007520
GeneIDi115939
KEGGihsa:115939
UCSCiuc002cll.4 human

Similar proteinsi

Entry informationi

Entry nameiTSR3_HUMAN
AccessioniPrimary (citable) accession number: Q9UJK0
Secondary accession number(s): Q6PJT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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