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Q9UJJ7

- RUSD1_HUMAN

UniProt

Q9UJJ7 - RUSD1_HUMAN

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Protein

RNA pseudouridylate synthase domain-containing protein 1

Gene
RPUSD1, C16orf40, RLUCL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671 By similarity

GO - Molecular functioni

  1. pseudouridine synthase activity Source: InterPro
  2. RNA binding Source: InterPro

GO - Biological processi

  1. pseudouridine synthesis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pseudouridylate synthase domain-containing protein 1
Alternative name(s):
Ribosomal large subunit pseudouridine synthase C-like protein
Gene namesi
Name:RPUSD1
Synonyms:C16orf40, RLUCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:14173. RPUSD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312RNA pseudouridylate synthase domain-containing protein 1PRO_0000300816Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9UJJ7.
PRIDEiQ9UJJ7.

PTM databases

PhosphoSiteiQ9UJJ7.

Expressioni

Gene expression databases

ArrayExpressiQ9UJJ7.
BgeeiQ9UJJ7.
CleanExiHS_RPUSD1.
GenevestigatoriQ9UJJ7.

Organism-specific databases

HPAiHPA041144.
HPA041938.

Interactioni

Protein-protein interaction databases

BioGridi125221. 3 interactions.
IntActiQ9UJJ7. 1 interaction.
STRINGi9606.ENSP00000007264.

Structurei

3D structure databases

ProteinModelPortaliQ9UJJ7.
SMRiQ9UJJ7. Positions 9-227.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi258 – 29033Pro-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0564.
HOGENOMiHOG000047212.
HOVERGENiHBG096261.
InParanoidiQ9UJJ7.
OMAiEGKTHMM.
OrthoDBiEOG74FF19.
PhylomeDBiQ9UJJ7.
TreeFamiTF324755.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UJJ7-1 [UniParc]FASTAAdd to Basket

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MEPGSVENLS IVYRSRDFLV VNKHWDVRID SKAWRETLTL QKQLRYRFPE    50
LADPDTCYGF RFCHQLDFST SGALCVALNK AAAGSAYRCF KERRVTKAYL 100
ALLRGHIQES RVTISHAIGR NSTEGRAHTM CIEGSQGCEN PKPSLTDLVV 150
LEHGLYAGDP VSKVLLKPLT GRTHQLRVHC SALGHPVVGD LTYGEVSGRE 200
DRPFRMMLHA FYLRIPTDTE CVEVCTPDPF LPSLDACWSP HTLLQSLDQL 250
VQALRATPDP DPEDRGPRPG SPSALLPGPG RPPPPPTKPP ETEAQRGPCL 300
QWLSEWTLEP DS 312
Length:312
Mass (Da):34,756
Last modified:May 1, 2000 - v1
Checksum:i0D4A31752A0D6AED
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241E → Q.
Corresponds to variant rs2272898 [ dbSNP | Ensembl ].
VAR_034883
Natural varianti247 – 2471L → P.
Corresponds to variant rs3751672 [ dbSNP | Ensembl ].
VAR_034884

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006465 Genomic DNA. Translation: AAK61255.1.
AL031033 Genomic DNA. Translation: CAB53055.1.
CH471112 Genomic DNA. Translation: EAW85712.1.
CH471112 Genomic DNA. Translation: EAW85713.1.
CH471112 Genomic DNA. Translation: EAW85715.1.
BC011783 mRNA. Translation: AAH11783.1.
CCDSiCCDS10426.1.
RefSeqiNP_478072.1. NM_058192.2.
UniGeneiHs.101742.

Genome annotation databases

EnsembliENST00000007264; ENSP00000007264; ENSG00000007376.
ENST00000561734; ENSP00000455026; ENSG00000007376.
GeneIDi113000.
KEGGihsa:113000.
UCSCiuc002cka.3. human.

Polymorphism databases

DMDMi74753357.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006465 Genomic DNA. Translation: AAK61255.1 .
AL031033 Genomic DNA. Translation: CAB53055.1 .
CH471112 Genomic DNA. Translation: EAW85712.1 .
CH471112 Genomic DNA. Translation: EAW85713.1 .
CH471112 Genomic DNA. Translation: EAW85715.1 .
BC011783 mRNA. Translation: AAH11783.1 .
CCDSi CCDS10426.1.
RefSeqi NP_478072.1. NM_058192.2.
UniGenei Hs.101742.

3D structure databases

ProteinModelPortali Q9UJJ7.
SMRi Q9UJJ7. Positions 9-227.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125221. 3 interactions.
IntActi Q9UJJ7. 1 interaction.
STRINGi 9606.ENSP00000007264.

PTM databases

PhosphoSitei Q9UJJ7.

Polymorphism databases

DMDMi 74753357.

Proteomic databases

MaxQBi Q9UJJ7.
PRIDEi Q9UJJ7.

Protocols and materials databases

DNASUi 113000.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000007264 ; ENSP00000007264 ; ENSG00000007376 .
ENST00000561734 ; ENSP00000455026 ; ENSG00000007376 .
GeneIDi 113000.
KEGGi hsa:113000.
UCSCi uc002cka.3. human.

Organism-specific databases

CTDi 113000.
GeneCardsi GC16M000834.
HGNCi HGNC:14173. RPUSD1.
HPAi HPA041144.
HPA041938.
neXtProti NX_Q9UJJ7.
PharmGKBi PA25556.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0564.
HOGENOMi HOG000047212.
HOVERGENi HBG096261.
InParanoidi Q9UJJ7.
OMAi EGKTHMM.
OrthoDBi EOG74FF19.
PhylomeDBi Q9UJJ7.
TreeFami TF324755.

Miscellaneous databases

GenomeRNAii 113000.
NextBioi 78731.
PROi Q9UJJ7.

Gene expression databases

ArrayExpressi Q9UJJ7.
Bgeei Q9UJJ7.
CleanExi HS_RPUSD1.
Genevestigatori Q9UJJ7.

Family and domain databases

InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view ]
Pfami PF00849. PseudoU_synth_2. 1 hit.
[Graphical view ]
SUPFAMi SSF55120. SSF55120. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRUSD1_HUMAN
AccessioniPrimary (citable) accession number: Q9UJJ7
Secondary accession number(s): D3DU66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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