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Protein

RNA pseudouridylate synthase domain-containing protein 1

Gene

RPUSD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67By similarity1

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pseudouridylate synthase domain-containing protein 1
Alternative name(s):
Ribosomal large subunit pseudouridine synthase C-like protein
Gene namesi
Name:RPUSD1
Synonyms:C16orf40, RLUCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14173. RPUSD1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000007376.
PharmGKBiPA25556.

Polymorphism and mutation databases

BioMutaiRPUSD1.
DMDMi74753357.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003008161 – 312RNA pseudouridylate synthase domain-containing protein 1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UJJ7.
MaxQBiQ9UJJ7.
PaxDbiQ9UJJ7.
PeptideAtlasiQ9UJJ7.
PRIDEiQ9UJJ7.

PTM databases

iPTMnetiQ9UJJ7.
PhosphoSitePlusiQ9UJJ7.

Expressioni

Gene expression databases

BgeeiENSG00000007376.
CleanExiHS_RPUSD1.
ExpressionAtlasiQ9UJJ7. baseline and differential.
GenevisibleiQ9UJJ7. HS.

Organism-specific databases

HPAiHPA041144.
HPA041938.

Interactioni

Protein-protein interaction databases

BioGridi125221. 4 interactors.
IntActiQ9UJJ7. 4 interactors.
STRINGi9606.ENSP00000007264.

Structurei

Secondary structure

1312
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 14Combined sources5
Beta strandi16 – 23Combined sources8
Helixi40 – 47Combined sources8
Beta strandi61 – 64Combined sources4
Beta strandi71 – 79Combined sources9
Helixi80 – 91Combined sources12
Beta strandi96 – 105Combined sources10
Beta strandi109 – 114Combined sources6
Beta strandi118 – 124Combined sources7
Turni125 – 127Combined sources3
Beta strandi130 – 132Combined sources3
Beta strandi138 – 142Combined sources5
Beta strandi146 – 156Combined sources11
Beta strandi159 – 170Combined sources12
Helixi175 – 182Combined sources8
Turni191 – 193Combined sources3
Beta strandi202 – 205Combined sources4
Beta strandi208 – 216Combined sources9
Beta strandi221 – 225Combined sources5
Turni232 – 234Combined sources3
Beta strandi238 – 243Combined sources6
Helixi247 – 256Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VBBX-ray1.94A1-261[»]
ProteinModelPortaliQ9UJJ7.
SMRiQ9UJJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 290Pro-richAdd BLAST33

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated

Phylogenomic databases

eggNOGiKOG1919. Eukaryota.
COG0564. LUCA.
GeneTreeiENSGT00510000048339.
HOGENOMiHOG000047212.
HOVERGENiHBG096261.
InParanoidiQ9UJJ7.
OMAiHWDLRID.
OrthoDBiEOG091G0NIM.
PhylomeDBiQ9UJJ7.
TreeFamiTF324755.

Family and domain databases

InterProiView protein in InterPro
IPR020103. PsdUridine_synth_cat_dom.
IPR006145. PsdUridine_synth_RsuA/RluD.
PfamiView protein in Pfam
PF00849. PseudoU_synth_2. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UJJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGSVENLS IVYRSRDFLV VNKHWDVRID SKAWRETLTL QKQLRYRFPE
60 70 80 90 100
LADPDTCYGF RFCHQLDFST SGALCVALNK AAAGSAYRCF KERRVTKAYL
110 120 130 140 150
ALLRGHIQES RVTISHAIGR NSTEGRAHTM CIEGSQGCEN PKPSLTDLVV
160 170 180 190 200
LEHGLYAGDP VSKVLLKPLT GRTHQLRVHC SALGHPVVGD LTYGEVSGRE
210 220 230 240 250
DRPFRMMLHA FYLRIPTDTE CVEVCTPDPF LPSLDACWSP HTLLQSLDQL
260 270 280 290 300
VQALRATPDP DPEDRGPRPG SPSALLPGPG RPPPPPTKPP ETEAQRGPCL
310
QWLSEWTLEP DS
Length:312
Mass (Da):34,756
Last modified:May 1, 2000 - v1
Checksum:i0D4A31752A0D6AED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034883124E → Q. Corresponds to variant dbSNP:rs2272898Ensembl.1
Natural variantiVAR_034884247L → P. Corresponds to variant dbSNP:rs3751672Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006465 Genomic DNA. Translation: AAK61255.1.
AL031033 Genomic DNA. Translation: CAB53055.1.
CH471112 Genomic DNA. Translation: EAW85712.1.
CH471112 Genomic DNA. Translation: EAW85713.1.
CH471112 Genomic DNA. Translation: EAW85715.1.
BC011783 mRNA. Translation: AAH11783.1.
CCDSiCCDS10426.1.
RefSeqiNP_478072.1. NM_058192.2.
UniGeneiHs.101742.

Genome annotation databases

EnsembliENST00000007264; ENSP00000007264; ENSG00000007376.
ENST00000561734; ENSP00000455026; ENSG00000007376.
GeneIDi113000.
KEGGihsa:113000.
UCSCiuc002cka.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRUSD1_HUMAN
AccessioniPrimary (citable) accession number: Q9UJJ7
Secondary accession number(s): D3DU66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: July 5, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families