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Protein

RNA pseudouridylate synthase domain-containing protein 1

Gene

RPUSD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pseudouridylate synthase domain-containing protein 1
Alternative name(s):
Ribosomal large subunit pseudouridine synthase C-like protein
Gene namesi
Name:RPUSD1
Synonyms:C16orf40, RLUCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14173. RPUSD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25556.

Polymorphism and mutation databases

BioMutaiRPUSD1.
DMDMi74753357.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312RNA pseudouridylate synthase domain-containing protein 1PRO_0000300816Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9UJJ7.
PRIDEiQ9UJJ7.

PTM databases

PhosphoSiteiQ9UJJ7.

Expressioni

Gene expression databases

BgeeiQ9UJJ7.
CleanExiHS_RPUSD1.
ExpressionAtlasiQ9UJJ7. baseline.
GenevisibleiQ9UJJ7. HS.

Organism-specific databases

HPAiHPA041144.
HPA041938.

Interactioni

Protein-protein interaction databases

BioGridi125221. 2 interactions.
IntActiQ9UJJ7. 1 interaction.
STRINGi9606.ENSP00000007264.

Structurei

3D structure databases

ProteinModelPortaliQ9UJJ7.
SMRiQ9UJJ7. Positions 9-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi258 – 29033Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated

Phylogenomic databases

eggNOGiCOG0564.
GeneTreeiENSGT00510000048339.
HOGENOMiHOG000047212.
HOVERGENiHBG096261.
InParanoidiQ9UJJ7.
OMAiAYRCFKD.
OrthoDBiEOG74FF19.
PhylomeDBiQ9UJJ7.
TreeFamiTF324755.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UJJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGSVENLS IVYRSRDFLV VNKHWDVRID SKAWRETLTL QKQLRYRFPE
60 70 80 90 100
LADPDTCYGF RFCHQLDFST SGALCVALNK AAAGSAYRCF KERRVTKAYL
110 120 130 140 150
ALLRGHIQES RVTISHAIGR NSTEGRAHTM CIEGSQGCEN PKPSLTDLVV
160 170 180 190 200
LEHGLYAGDP VSKVLLKPLT GRTHQLRVHC SALGHPVVGD LTYGEVSGRE
210 220 230 240 250
DRPFRMMLHA FYLRIPTDTE CVEVCTPDPF LPSLDACWSP HTLLQSLDQL
260 270 280 290 300
VQALRATPDP DPEDRGPRPG SPSALLPGPG RPPPPPTKPP ETEAQRGPCL
310
QWLSEWTLEP DS
Length:312
Mass (Da):34,756
Last modified:May 1, 2000 - v1
Checksum:i0D4A31752A0D6AED
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241E → Q.
Corresponds to variant rs2272898 [ dbSNP | Ensembl ].
VAR_034883
Natural varianti247 – 2471L → P.
Corresponds to variant rs3751672 [ dbSNP | Ensembl ].
VAR_034884

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006465 Genomic DNA. Translation: AAK61255.1.
AL031033 Genomic DNA. Translation: CAB53055.1.
CH471112 Genomic DNA. Translation: EAW85712.1.
CH471112 Genomic DNA. Translation: EAW85713.1.
CH471112 Genomic DNA. Translation: EAW85715.1.
BC011783 mRNA. Translation: AAH11783.1.
CCDSiCCDS10426.1.
RefSeqiNP_478072.1. NM_058192.2.
UniGeneiHs.101742.

Genome annotation databases

EnsembliENST00000007264; ENSP00000007264; ENSG00000007376.
ENST00000561734; ENSP00000455026; ENSG00000007376.
GeneIDi113000.
KEGGihsa:113000.
UCSCiuc002cka.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006465 Genomic DNA. Translation: AAK61255.1.
AL031033 Genomic DNA. Translation: CAB53055.1.
CH471112 Genomic DNA. Translation: EAW85712.1.
CH471112 Genomic DNA. Translation: EAW85713.1.
CH471112 Genomic DNA. Translation: EAW85715.1.
BC011783 mRNA. Translation: AAH11783.1.
CCDSiCCDS10426.1.
RefSeqiNP_478072.1. NM_058192.2.
UniGeneiHs.101742.

3D structure databases

ProteinModelPortaliQ9UJJ7.
SMRiQ9UJJ7. Positions 9-227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125221. 2 interactions.
IntActiQ9UJJ7. 1 interaction.
STRINGi9606.ENSP00000007264.

PTM databases

PhosphoSiteiQ9UJJ7.

Polymorphism and mutation databases

BioMutaiRPUSD1.
DMDMi74753357.

Proteomic databases

MaxQBiQ9UJJ7.
PRIDEiQ9UJJ7.

Protocols and materials databases

DNASUi113000.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000007264; ENSP00000007264; ENSG00000007376.
ENST00000561734; ENSP00000455026; ENSG00000007376.
GeneIDi113000.
KEGGihsa:113000.
UCSCiuc002cka.3. human.

Organism-specific databases

CTDi113000.
GeneCardsiGC16M000834.
HGNCiHGNC:14173. RPUSD1.
HPAiHPA041144.
HPA041938.
neXtProtiNX_Q9UJJ7.
PharmGKBiPA25556.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0564.
GeneTreeiENSGT00510000048339.
HOGENOMiHOG000047212.
HOVERGENiHBG096261.
InParanoidiQ9UJJ7.
OMAiAYRCFKD.
OrthoDBiEOG74FF19.
PhylomeDBiQ9UJJ7.
TreeFamiTF324755.

Miscellaneous databases

ChiTaRSiRPUSD1. human.
GenomeRNAii113000.
NextBioi78731.
PROiQ9UJJ7.

Gene expression databases

BgeeiQ9UJJ7.
CleanExiHS_RPUSD1.
ExpressionAtlasiQ9UJJ7. baseline.
GenevisibleiQ9UJJ7. HS.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRUSD1_HUMAN
AccessioniPrimary (citable) accession number: Q9UJJ7
Secondary accession number(s): D3DU66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.