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Q9UJJ7 (RUSD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA pseudouridylate synthase domain-containing protein 1
Alternative name(s):
Ribosomal large subunit pseudouridine synthase C-like protein
Gene names
Name:RPUSD1
Synonyms:C16orf40, RLUCL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the pseudouridine synthase RluA family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpseudouridine synthesis

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

pseudouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312RNA pseudouridylate synthase domain-containing protein 1
PRO_0000300816

Regions

Compositional bias258 – 29033Pro-rich

Sites

Active site671 By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.5

Natural variations

Natural variant1241E → Q.
Corresponds to variant rs2272898 [ dbSNP | Ensembl ].
VAR_034883
Natural variant2471L → P.
Corresponds to variant rs3751672 [ dbSNP | Ensembl ].
VAR_034884

Sequences

Sequence LengthMass (Da)Tools
Q9UJJ7 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 0D4A31752A0D6AED

FASTA31234,756
        10         20         30         40         50         60 
MEPGSVENLS IVYRSRDFLV VNKHWDVRID SKAWRETLTL QKQLRYRFPE LADPDTCYGF 

        70         80         90        100        110        120 
RFCHQLDFST SGALCVALNK AAAGSAYRCF KERRVTKAYL ALLRGHIQES RVTISHAIGR 

       130        140        150        160        170        180 
NSTEGRAHTM CIEGSQGCEN PKPSLTDLVV LEHGLYAGDP VSKVLLKPLT GRTHQLRVHC 

       190        200        210        220        230        240 
SALGHPVVGD LTYGEVSGRE DRPFRMMLHA FYLRIPTDTE CVEVCTPDPF LPSLDACWSP 

       250        260        270        280        290        300 
HTLLQSLDQL VQALRATPDP DPEDRGPRPG SPSALLPGPG RPPPPPTKPP ETEAQRGPCL 

       310 
QWLSEWTLEP DS 

« Hide

References

[1]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006465 Genomic DNA. Translation: AAK61255.1.
AL031033 Genomic DNA. Translation: CAB53055.1.
CH471112 Genomic DNA. Translation: EAW85712.1.
CH471112 Genomic DNA. Translation: EAW85713.1.
CH471112 Genomic DNA. Translation: EAW85715.1.
BC011783 mRNA. Translation: AAH11783.1.
CCDSCCDS10426.1.
RefSeqNP_478072.1. NM_058192.2.
UniGeneHs.101742.

3D structure databases

ProteinModelPortalQ9UJJ7.
SMRQ9UJJ7. Positions 9-227.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125221. 3 interactions.
IntActQ9UJJ7. 1 interaction.
STRING9606.ENSP00000007264.

PTM databases

PhosphoSiteQ9UJJ7.

Polymorphism databases

DMDM74753357.

Proteomic databases

MaxQBQ9UJJ7.
PRIDEQ9UJJ7.

Protocols and materials databases

DNASU113000.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000007264; ENSP00000007264; ENSG00000007376.
ENST00000561734; ENSP00000455026; ENSG00000007376.
GeneID113000.
KEGGhsa:113000.
UCSCuc002cka.3. human.

Organism-specific databases

CTD113000.
GeneCardsGC16M000834.
HGNCHGNC:14173. RPUSD1.
HPAHPA041144.
HPA041938.
neXtProtNX_Q9UJJ7.
PharmGKBPA25556.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0564.
HOGENOMHOG000047212.
HOVERGENHBG096261.
InParanoidQ9UJJ7.
OMAEGKTHMM.
OrthoDBEOG74FF19.
PhylomeDBQ9UJJ7.
TreeFamTF324755.

Gene expression databases

ArrayExpressQ9UJJ7.
BgeeQ9UJJ7.
CleanExHS_RPUSD1.
GenevestigatorQ9UJJ7.

Family and domain databases

InterProIPR020103. PsdUridine_synth_cat_dom.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view]
PfamPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi113000.
NextBio78731.
PROQ9UJJ7.

Entry information

Entry nameRUSD1_HUMAN
AccessionPrimary (citable) accession number: Q9UJJ7
Secondary accession number(s): D3DU66
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM