Q9UJH8 (METRN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Meteorin

Gene names

Name:	METRN
Synonyms:	C16orf23
ORF Names:	RJD6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the meteorin family.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Secreted
Domain	Signal
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 293	270	Meteorin		PRO_0000021680

Sequences

	Sequence		Length	Mass (Da)
	Q9UJH8 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: 45B9136BF9153F28	FASTA	293	31,207
	10 20 30 40 50 60 MGFPAAALLC ALCCGLLAPA ARAGYSEERC SWRGSGLTQE PGSVGQLALA CAEGAVEWLY 70 80 90 100 110 120 PAGALRLTLG GPDPRARPGI ACLRPVRPFA GAQVFAERAG GALELLLAEG PGPAGGRCVR 130 140 150 160 170 180 WGPRERRALF LQATPHQDIS RRVAAFRFEL REDGRPELPP QAHGLGVDGA CRPCSDAELL 190 200 210 220 230 240 LAACTSDFVI HGIIHGVTHD VELQESVITV VAARVLRQTP PLFQAGRSGD QGLTSIRTPL 250 260 270 280 290 RCGVHPGPGT FLFMGWSRFG EARLGCAPRF QEFRRAYEAA RAAHLHPCEV ALH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension." Nishino J., Yamashita K., Hashiguchi H., Fujii H., Shimazaki T., Hamada H. EMBO J. 23:1998-2008(2004) [PubMed: 15085178] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006464 Genomic DNA. Translation: AAK61247.1. Z97653 Genomic DNA. Translation: CAB56188.1. BC000662 mRNA. Translation: AAH00662.1.
IPI	IPI00384225.
RefSeq	NP_076947.1. NM_024042.2.
UniGene	Hs.533772.
3D structure databases
ProteinModelPortal	Q9UJH8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UJH8.
Polymorphism databases
DMDM	50401202.
Proteomic databases
PRIDE	Q9UJH8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000219542; ENSP00000219542; ENSG00000103260.
GeneID	79006.
KEGG	hsa:79006.
UCSC	uc002cjd.1. human.
Organism-specific databases
CTD	79006.
GeneCards	GC16P000765.
H-InvDB	HIX0012664.
HGNC	HGNC:14151. METRN.
MIM	610998. gene.
neXtProt	NX_Q9UJH8.
PharmGKB	PA25537.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG16467.
GeneTree	ENSGT00390000001390.
HOGENOM	HBG715257.
HOVERGEN	HBG052461.
InParanoid	Q9UJH8.
OMA	RCSWRGS.
OrthoDB	EOG4SN1PD.
PhylomeDB	Q9UJH8.
Gene expression databases
ArrayExpress	Q9UJH8.
Bgee	Q9UJH8.
CleanEx	HS_METRN.
Genevestigator	Q9UJH8.
GermOnline	ENSG00000103260. Homo sapiens.
Family and domain databases
InterPro	IPR024821. Meteorin. [Graphical view]
PANTHER	PTHR14529. PTHR14529. 1 hit.
ProtoNet	Search...
Other
NextBio	67637.
SOURCE	Search...

Entry information

Entry name

METRN_HUMAN

Accession

Primary (citable) accession number: Q9UJH8
Secondary accession number(s): Q9UJH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.