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Protein

Meteorin

Gene

METRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Meteorin
Gene namesi
Name:METRN
Synonyms:C16orf23
ORF Names:RJD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14151. METRN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25537.

Polymorphism and mutation databases

BioMutaiMETRN.
DMDMi50401202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 293270MeteorinPRO_0000021680Add
BLAST

Post-translational modificationi

Contains five disulfide bridges.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9UJH8.
PRIDEiQ9UJH8.

PTM databases

iPTMnetiQ9UJH8.
PhosphoSiteiQ9UJH8.

Expressioni

Gene expression databases

BgeeiQ9UJH8.
CleanExiHS_METRN.
ExpressionAtlasiQ9UJH8. baseline and differential.
GenevisibleiQ9UJH8. HS.

Organism-specific databases

HPAiHPA051164.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi122477. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9UJH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the meteorin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKV7. Eukaryota.
ENOG4111FCI. LUCA.
GeneTreeiENSGT00390000001390.
HOGENOMiHOG000236301.
HOVERGENiHBG052461.
InParanoidiQ9UJH8.
OMAiIEWLYPA.
OrthoDBiEOG77DJ6J.
PhylomeDBiQ9UJH8.
TreeFamiTF330918.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UJH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFPAAALLC ALCCGLLAPA ARAGYSEERC SWRGSGLTQE PGSVGQLALA
60 70 80 90 100
CAEGAVEWLY PAGALRLTLG GPDPRARPGI ACLRPVRPFA GAQVFAERAG
110 120 130 140 150
GALELLLAEG PGPAGGRCVR WGPRERRALF LQATPHQDIS RRVAAFRFEL
160 170 180 190 200
REDGRPELPP QAHGLGVDGA CRPCSDAELL LAACTSDFVI HGIIHGVTHD
210 220 230 240 250
VELQESVITV VAARVLRQTP PLFQAGRSGD QGLTSIRTPL RCGVHPGPGT
260 270 280 290
FLFMGWSRFG EARLGCAPRF QEFRRAYEAA RAAHLHPCEV ALH
Length:293
Mass (Da):31,207
Last modified:July 19, 2004 - v2
Checksum:i45B9136BF9153F28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006464 Genomic DNA. Translation: AAK61247.1.
Z97653 Genomic DNA. Translation: CAB56188.1.
BC000662 mRNA. Translation: AAH00662.1.
CCDSiCCDS10422.1.
RefSeqiNP_076947.1. NM_024042.2.
UniGeneiHs.533772.
Hs.732288.

Genome annotation databases

EnsembliENST00000568223; ENSP00000455068; ENSG00000103260.
GeneIDi79006.
KEGGihsa:79006.
UCSCiuc010bra.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006464 Genomic DNA. Translation: AAK61247.1.
Z97653 Genomic DNA. Translation: CAB56188.1.
BC000662 mRNA. Translation: AAH00662.1.
CCDSiCCDS10422.1.
RefSeqiNP_076947.1. NM_024042.2.
UniGeneiHs.533772.
Hs.732288.

3D structure databases

ProteinModelPortaliQ9UJH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122477. 3 interactions.

PTM databases

iPTMnetiQ9UJH8.
PhosphoSiteiQ9UJH8.

Polymorphism and mutation databases

BioMutaiMETRN.
DMDMi50401202.

Proteomic databases

PaxDbiQ9UJH8.
PRIDEiQ9UJH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000568223; ENSP00000455068; ENSG00000103260.
GeneIDi79006.
KEGGihsa:79006.
UCSCiuc010bra.4. human.

Organism-specific databases

CTDi79006.
GeneCardsiMETRN.
HGNCiHGNC:14151. METRN.
HPAiHPA051164.
MIMi610998. gene.
neXtProtiNX_Q9UJH8.
PharmGKBiPA25537.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKV7. Eukaryota.
ENOG4111FCI. LUCA.
GeneTreeiENSGT00390000001390.
HOGENOMiHOG000236301.
HOVERGENiHBG052461.
InParanoidiQ9UJH8.
OMAiIEWLYPA.
OrthoDBiEOG77DJ6J.
PhylomeDBiQ9UJH8.
TreeFamiTF330918.

Miscellaneous databases

ChiTaRSiMETRN. human.
GenomeRNAii79006.
NextBioi67637.
PROiQ9UJH8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UJH8.
CleanExiHS_METRN.
ExpressionAtlasiQ9UJH8. baseline and differential.
GenevisibleiQ9UJH8. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension."
    Nishino J., Yamashita K., Hashiguchi H., Fujii H., Shimazaki T., Hamada H.
    EMBO J. 23:1998-2008(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiMETRN_HUMAN
AccessioniPrimary (citable) accession number: Q9UJH8
Secondary accession number(s): Q9UJH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: March 16, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.