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Protein

Regulating synaptic membrane exocytosis protein 3

Gene

RIMS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates synaptic membrane exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 3
Short name:
Nim3
Alternative name(s):
RIM3 gamma
Rab-3-interacting molecule 3
Short name:
RIM 3
Gene namesi
Name:RIMS3
Synonyms:KIAA0237
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21292. RIMS3.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • presynaptic active zone Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134980870.

Polymorphism and mutation databases

BioMutaiRIMS3.
DMDMi41017811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Regulating synaptic membrane exocytosis protein 3PRO_0000190204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei295 – 2951PhosphoserineBy similarity
Modified residuei298 – 2981PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UJD0.
PaxDbiQ9UJD0.
PeptideAtlasiQ9UJD0.
PRIDEiQ9UJD0.

PTM databases

iPTMnetiQ9UJD0.
PhosphoSiteiQ9UJD0.

Expressioni

Gene expression databases

BgeeiQ9UJD0.
CleanExiHS_RIMS3.
GenevisibleiQ9UJD0. HS.

Interactioni

Subunit structurei

Binds PPFIA3 (By similarity). Does not bind RAB3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115127. 3 interactions.
IntActiQ9UJD0. 3 interactions.
STRINGi9606.ENSP00000361768.

Structurei

3D structure databases

ProteinModelPortaliQ9UJD0.
SMRiQ9UJD0. Positions 142-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini156 – 258103C2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2060. Eukaryota.
ENOG410ZNB1. LUCA.
GeneTreeiENSGT00550000074588.
HOGENOMiHOG000231017.
HOVERGENiHBG056381.
InParanoidiQ9UJD0.
KOiK15298.
OMAiGPESQFS.
OrthoDBiEOG7BGHJV.
PhylomeDBiQ9UJD0.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFNGEPGPAS SGASRNVVRS SSISGEICGS QQAGGGAGTT TAKKRRSSLG
60 70 80 90 100
AKMVAIVGLT QWSKSTLQLP QPEGATKKLR SNIRRSTETG IAVEMRSRVT
110 120 130 140 150
RQGSRESTDG STNSNSSDGT FIFPTTRLGA ESQFSDFLDG LGPAQIVGRQ
160 170 180 190 200
TLATPPMGDV HIAIMDRSGQ LEVEVIEARG LTPKPGSKSL PATYIKVYLL
210 220 230 240 250
ENGACLAKKK TKMTKKTCDP LYQQALLFDE GPQGKVLQVI VWGDYGRMDH
260 270 280 290 300
KCFMGMAQIM LDELDLSAAV TGWYKLFPTS SVADSTLGSL TRRLSQSSLE

SATSPSCS
Length:308
Mass (Da):32,796
Last modified:May 1, 2000 - v1
Checksum:iEDB57162FC75DF5F
GO
Isoform 2 (identifier: Q9UJD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-153: FIFPTTRLGAESQFSDFLDGLGPAQIVGRQTLA → CVQPRAVVPSLLLGPPVTEPLGRVHLPHYPARG
     154-308: Missing.

Show »
Length:153
Mass (Da):15,898
Checksum:i0CFBD7643256F100
GO

Sequence cautioni

The sequence BAA13243.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241S → G in BAA13243 (PubMed:9039502).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei121 – 15333FIFPT…RQTLA → CVQPRAVVPSLLLGPPVTEP LGRVHLPHYPARG in isoform 2. 1 PublicationVSP_055836Add
BLAST
Alternative sequencei154 – 308155Missing in isoform 2. 1 PublicationVSP_055837Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326956 mRNA. Translation: AAQ01683.1.
KJ535026 mRNA. Translation: AHW56665.1.
D87074 mRNA. Translation: BAA13243.2. Different initiation.
AL031289 Genomic DNA. Translation: CAA20357.1.
CH471059 Genomic DNA. Translation: EAX07206.1.
CH471059 Genomic DNA. Translation: EAX07207.1.
BC003103 mRNA. Translation: AAH03103.1.
CCDSiCCDS30687.1. [Q9UJD0-1]
RefSeqiNP_055562.2. NM_014747.2. [Q9UJD0-1]
XP_011540782.1. XM_011542480.1. [Q9UJD0-1]
UniGeneiHs.654808.

Genome annotation databases

EnsembliENST00000372683; ENSP00000361768; ENSG00000117016. [Q9UJD0-1]
ENST00000372684; ENSP00000361769; ENSG00000117016. [Q9UJD0-1]
GeneIDi9783.
KEGGihsa:9783.
UCSCiuc001cfu.2. human. [Q9UJD0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326956 mRNA. Translation: AAQ01683.1.
KJ535026 mRNA. Translation: AHW56665.1.
D87074 mRNA. Translation: BAA13243.2. Different initiation.
AL031289 Genomic DNA. Translation: CAA20357.1.
CH471059 Genomic DNA. Translation: EAX07206.1.
CH471059 Genomic DNA. Translation: EAX07207.1.
BC003103 mRNA. Translation: AAH03103.1.
CCDSiCCDS30687.1. [Q9UJD0-1]
RefSeqiNP_055562.2. NM_014747.2. [Q9UJD0-1]
XP_011540782.1. XM_011542480.1. [Q9UJD0-1]
UniGeneiHs.654808.

3D structure databases

ProteinModelPortaliQ9UJD0.
SMRiQ9UJD0. Positions 142-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115127. 3 interactions.
IntActiQ9UJD0. 3 interactions.
STRINGi9606.ENSP00000361768.

PTM databases

iPTMnetiQ9UJD0.
PhosphoSiteiQ9UJD0.

Polymorphism and mutation databases

BioMutaiRIMS3.
DMDMi41017811.

Proteomic databases

MaxQBiQ9UJD0.
PaxDbiQ9UJD0.
PeptideAtlasiQ9UJD0.
PRIDEiQ9UJD0.

Protocols and materials databases

DNASUi9783.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372683; ENSP00000361768; ENSG00000117016. [Q9UJD0-1]
ENST00000372684; ENSP00000361769; ENSG00000117016. [Q9UJD0-1]
GeneIDi9783.
KEGGihsa:9783.
UCSCiuc001cfu.2. human. [Q9UJD0-1]

Organism-specific databases

CTDi9783.
GeneCardsiRIMS3.
HGNCiHGNC:21292. RIMS3.
MIMi611600. gene.
neXtProtiNX_Q9UJD0.
PharmGKBiPA134980870.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2060. Eukaryota.
ENOG410ZNB1. LUCA.
GeneTreeiENSGT00550000074588.
HOGENOMiHOG000231017.
HOVERGENiHBG056381.
InParanoidiQ9UJD0.
KOiK15298.
OMAiGPESQFS.
OrthoDBiEOG7BGHJV.
PhylomeDBiQ9UJD0.
TreeFamiTF315600.

Miscellaneous databases

ChiTaRSiRIMS3. human.
GenomeRNAii9783.
NextBioi36838.
PROiQ9UJD0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UJD0.
CleanExiHS_RIMS3.
GenevisibleiQ9UJD0. HS.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins."
    Wang Y., Suedhof T.C.
    Genomics 81:126-137(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    Tissue: Fetal brain.
  3. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.

Entry informationi

Entry nameiRIMS3_HUMAN
AccessioniPrimary (citable) accession number: Q9UJD0
Secondary accession number(s): D3DPV8, Q92511, X5D7U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: April 13, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.