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Protein

Regulating synaptic membrane exocytosis protein 3

Gene

RIMS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates synaptic membrane exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 3
Short name:
Nim3
Alternative name(s):
RIM3 gamma
Rab-3-interacting molecule 3
Short name:
RIM 3
Gene namesi
Name:RIMS3
Synonyms:KIAA0237
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117016.9
HGNCiHGNC:21292 RIMS3
MIMi611600 gene
neXtProtiNX_Q9UJD0

Subcellular locationi

Keywords - Cellular componenti

Cell junction, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi9783
OpenTargetsiENSG00000117016
PharmGKBiPA134980870

Polymorphism and mutation databases

BioMutaiRIMS3
DMDMi41017811

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902041 – 308Regulating synaptic membrane exocytosis protein 3Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei295PhosphoserineBy similarity1
Modified residuei298PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UJD0
PaxDbiQ9UJD0
PeptideAtlasiQ9UJD0
PRIDEiQ9UJD0

PTM databases

iPTMnetiQ9UJD0
PhosphoSitePlusiQ9UJD0

Expressioni

Gene expression databases

BgeeiENSG00000117016
CleanExiHS_RIMS3
GenevisibleiQ9UJD0 HS

Organism-specific databases

HPAiHPA055285

Interactioni

Subunit structurei

Binds PPFIA3 (By similarity). Does not bind RAB3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115127, 3 interactors
IntActiQ9UJD0, 6 interactors
MINTiQ9UJD0

Structurei

3D structure databases

ProteinModelPortaliQ9UJD0
SMRiQ9UJD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 258C2PROSITE-ProRule annotationAdd BLAST103

Phylogenomic databases

eggNOGiKOG2060 Eukaryota
ENOG410ZNB1 LUCA
GeneTreeiENSGT00550000074588
HOGENOMiHOG000231017
HOVERGENiHBG056381
InParanoidiQ9UJD0
KOiK15298
OMAiNRVTRQG
OrthoDBiEOG091G0IYY
PhylomeDBiQ9UJD0
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
PfamiView protein in Pfam
PF00168 C2, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFNGEPGPAS SGASRNVVRS SSISGEICGS QQAGGGAGTT TAKKRRSSLG
60 70 80 90 100
AKMVAIVGLT QWSKSTLQLP QPEGATKKLR SNIRRSTETG IAVEMRSRVT
110 120 130 140 150
RQGSRESTDG STNSNSSDGT FIFPTTRLGA ESQFSDFLDG LGPAQIVGRQ
160 170 180 190 200
TLATPPMGDV HIAIMDRSGQ LEVEVIEARG LTPKPGSKSL PATYIKVYLL
210 220 230 240 250
ENGACLAKKK TKMTKKTCDP LYQQALLFDE GPQGKVLQVI VWGDYGRMDH
260 270 280 290 300
KCFMGMAQIM LDELDLSAAV TGWYKLFPTS SVADSTLGSL TRRLSQSSLE

SATSPSCS
Length:308
Mass (Da):32,796
Last modified:May 1, 2000 - v1
Checksum:iEDB57162FC75DF5F
GO
Isoform 2 (identifier: Q9UJD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-153: FIFPTTRLGAESQFSDFLDGLGPAQIVGRQTLA → CVQPRAVVPSLLLGPPVTEPLGRVHLPHYPARG
     154-308: Missing.

Show »
Length:153
Mass (Da):15,898
Checksum:i0CFBD7643256F100
GO

Sequence cautioni

The sequence BAA13243 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24S → G in BAA13243 (PubMed:9039502).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055836121 – 153FIFPT…RQTLA → CVQPRAVVPSLLLGPPVTEP LGRVHLPHYPARG in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_055837154 – 308Missing in isoform 2. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326956 mRNA Translation: AAQ01683.1
KJ535026 mRNA Translation: AHW56665.1
D87074 mRNA Translation: BAA13243.2 Different initiation.
AL031289 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07206.1
CH471059 Genomic DNA Translation: EAX07207.1
BC003103 mRNA Translation: AAH03103.1
CCDSiCCDS30687.1 [Q9UJD0-1]
RefSeqiNP_055562.2, NM_014747.2 [Q9UJD0-1]
UniGeneiHs.654808

Genome annotation databases

EnsembliENST00000372683; ENSP00000361768; ENSG00000117016 [Q9UJD0-1]
ENST00000372684; ENSP00000361769; ENSG00000117016 [Q9UJD0-1]
GeneIDi9783
KEGGihsa:9783
UCSCiuc001cfu.2 human [Q9UJD0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRIMS3_HUMAN
AccessioniPrimary (citable) accession number: Q9UJD0
Secondary accession number(s): D3DPV8, Q92511, X5D7U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health