Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SH3 domain-binding glutamic acid-rich-like protein 2

Gene

SH3BGRL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich-like protein 2
Alternative name(s):
Fovea-associated SH3 domain-binding protein
Gene namesi
Name:SH3BGRL2
Synonyms:FASH3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000198478.7.
HGNCiHGNC:15567. SH3BGRL2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83699.
OpenTargetsiENSG00000198478.
PharmGKBiPA37978.

Polymorphism and mutation databases

BioMutaiSH3BGRL2.
DMDMi24638476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002207471 – 107SH3 domain-binding glutamic acid-rich-like protein 2Add BLAST107

Proteomic databases

EPDiQ9UJC5.
MaxQBiQ9UJC5.
PaxDbiQ9UJC5.
PeptideAtlasiQ9UJC5.
PRIDEiQ9UJC5.
TopDownProteomicsiQ9UJC5.

2D gel databases

UCD-2DPAGEiQ9UJC5.

PTM databases

iPTMnetiQ9UJC5.
PhosphoSitePlusiQ9UJC5.

Expressioni

Tissue specificityi

Highly expressed in brain, placenta, liver and kidney. Expressed in retina.1 Publication

Gene expression databases

BgeeiENSG00000198478.
CleanExiHS_SH3BGRL2.
GenevisibleiQ9UJC5. HS.

Organism-specific databases

HPAiHPA047486.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123733. 5 interactors.
IntActiQ9UJC5. 2 interactors.
STRINGi9606.ENSP00000358853.

Structurei

Secondary structure

1107
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi14 – 29Combined sources16
Beta strandi34 – 38Combined sources5
Turni39 – 41Combined sources3
Helixi43 – 51Combined sources9
Turni55 – 57Combined sources3
Beta strandi60 – 63Combined sources4
Beta strandi68 – 71Combined sources4
Beta strandi74 – 78Combined sources5
Helixi79 – 86Combined sources8
Turni87 – 89Combined sources3
Helixi91 – 95Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CT6NMR-A1-98[»]
ProteinModelPortaliQ9UJC5.
SMRiQ9UJC5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UJC5.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi61 – 67SH3-bindingSequence analysis7

Sequence similaritiesi

Belongs to the SH3BGR family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG4023. Eukaryota.
ENOG4111N7M. LUCA.
GeneTreeiENSGT00440000039098.
HOVERGENiHBG054781.
InParanoidiQ9UJC5.
OMAiVDITMLE.
OrthoDBiEOG091G10PC.
PhylomeDBiQ9UJC5.
TreeFamiTF105574.

Family and domain databases

CDDicd03030. GRX_SH3BGR. 1 hit.
InterProiView protein in InterPro
IPR006993. Glut_rich_SH3-bd.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF04908. SH3BGR. 1 hit.
PIRSFiPIRSF008142. SH3-bind_E-rich_L. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UJC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIRVFIASS SGFVAIKKKQ QDVVRFLEAN KIEFEEVDIT MSEEQRQWMY
60 70 80 90 100
KNVPPEKKPT QGNPLPPQIF NGDRYCGDYD SFFESKESNT VFSFLGLKPR

LASKAEP
Length:107
Mass (Da):12,326
Last modified:November 1, 2002 - v2
Checksum:iD160736103FA8635
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7I → V in AAH70059 (PubMed:15489334).Curated1
Sequence conflicti39I → T in AAH40489 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297972 mRNA. Translation: CAC35771.1.
AF340151 mRNA. Translation: AAK37526.1.
AK311757 mRNA. Translation: BAG34700.1.
AL035700, AL451064 Genomic DNA. Translation: CAB55867.2.
AL451064, AL035700 Genomic DNA. Translation: CAH70932.1.
CH471051 Genomic DNA. Translation: EAW48703.1.
BC040489 mRNA. Translation: AAH40489.2.
BC052987 mRNA. Translation: AAH52987.2.
BC060799 mRNA. Translation: AAH60799.2.
BC070059 mRNA. Translation: AAH70059.2.
BC109043 mRNA. Translation: AAI09044.2.
BC109044 mRNA. Translation: AAI09045.2.
CCDSiCCDS4991.1.
RefSeqiNP_113657.1. NM_031469.3.
XP_016866833.1. XM_017011344.1.
UniGeneiHs.302772.

Genome annotation databases

EnsembliENST00000369838; ENSP00000358853; ENSG00000198478.
GeneIDi83699.
KEGGihsa:83699.
UCSCiuc003piz.2. human.

Similar proteinsi

Entry informationi

Entry nameiSH3L2_HUMAN
AccessioniPrimary (citable) accession number: Q9UJC5
Secondary accession number(s): A8MQU2
, Q2VPC2, Q5VV96, Q6NSK8, Q6P9E8, Q7Z734, Q8IWD3, Q9BPY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 2002
Last modified: September 27, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families