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Protein

Ectonucleotide pyrophosphatase/phosphodiesterase family member 5

Gene

ENPP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Zinc 1; catalyticBy similarity
Active sitei72 – 721NucleophileSequence analysis
Metal bindingi72 – 721Zinc 1; catalyticBy similarity
Metal bindingi191 – 1911Zinc 2; catalyticBy similarity
Metal bindingi195 – 1951Zinc 2; via tele nitrogen; catalyticBy similarity
Metal bindingi238 – 2381Zinc 1; catalyticBy similarity
Metal bindingi239 – 2391Zinc 1; via tele nitrogen; catalyticBy similarity
Metal bindingi339 – 3391Zinc 2; via tele nitrogen; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (EC:3.1.-.-)
Short name:
E-NPP 5
Short name:
NPP-5
Gene namesi
Name:ENPP5Imported
ORF Names:UNQ550/PRO1107
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13717. ENPP5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei432 – 45221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27795.

Polymorphism and mutation databases

BioMutaiENPP5.
DMDMi50401201.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 477453Ectonucleotide pyrophosphatase/phosphodiesterase family member 5PRO_0000036401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence analysis
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence analysis
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence analysis
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence analysis
Glycosylationi369 – 3691N-linked (GlcNAc...)Sequence analysis
Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence analysis
Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UJA9.
MaxQBiQ9UJA9.
PaxDbiQ9UJA9.
PeptideAtlasiQ9UJA9.
PRIDEiQ9UJA9.

PTM databases

iPTMnetiQ9UJA9.
PhosphoSiteiQ9UJA9.

Expressioni

Gene expression databases

BgeeiENSG00000112796.
CleanExiHS_ENPP5.
GenevisibleiQ9UJA9. HS.

Organism-specific databases

HPAiHPA016902.

Interactioni

Protein-protein interaction databases

BioGridi121860. 1 interaction.
STRINGi9606.ENSP00000230565.

Structurei

3D structure databases

ProteinModelPortaliQ9UJA9.
SMRiQ9UJA9. Positions 31-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2645. Eukaryota.
COG1524. LUCA.
GeneTreeiENSGT00760000119157.
HOGENOMiHOG000231018.
HOVERGENiHBG051485.
InParanoidiQ9UJA9.
KOiK18398.
OMAiKHLIHSQ.
OrthoDBiEOG091G06NA.
PhylomeDBiQ9UJA9.
TreeFamiTF330032.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024873. E-NPP.
IPR029896. ENPP5.
IPR002591. Phosphodiest/P_Trfase.
[Graphical view]
PANTHERiPTHR10151. PTHR10151. 1 hit.
PTHR10151:SF80. PTHR10151:SF80. 1 hit.
PfamiPF01663. Phosphodiest. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UJA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKFLLVSF ILAALSLSTT FSLQPDQQKV LLVSFDGFRW DYLYKVPTPH
60 70 80 90 100
FHYIMKYGVH VKQVTNVFIT KTYPNHYTLV TGLFAENHGI VANDMFDPIR
110 120 130 140 150
NKSFSLDHMN IYDSKFWEEA TPIWITNQRA GHTSGAAMWP GTDVKIHKRF
160 170 180 190 200
PTHYMPYNES VSFEDRVAKI IEWFTSKEPI NLGLLYWEDP DDMGHHLGPD
210 220 230 240 250
SPLMGPVISD IDKKLGYLIQ MLKKAKLWNT LNLIITSDHG MTQCSEERLI
260 270 280 290 300
ELDQYLDKDH YTLIDQSPVA AILPKEGKFD EVYEALTHAH PNLTVYKKED
310 320 330 340 350
VPERWHYKYN SRIQPIIAVA DEGWHILQNK SDDFLLGNHG YDNALADMHP
360 370 380 390 400
IFLAHGPAFR KNFSKEAMNS TDLYPLLCHL LNITAMPHNG SFWNVQDLLN
410 420 430 440 450
SAMPRVVPYT QSTILLPGSV KPAEYDQEGS YPYFIGVSLG SIIVIVFFVI
460 470
FIKHLIHSQI PALQDMHAEI AQPLLQA
Length:477
Mass (Da):54,666
Last modified:May 1, 2000 - v1
Checksum:i6F776FD68E6536C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251P → L in AAQ88878 (PubMed:12975309).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61L → I.1 Publication
Corresponds to variant rs3806995 [ dbSNP | Ensembl ].
VAR_020248
Natural varianti39 – 391R → P.
Corresponds to variant rs34109856 [ dbSNP | Ensembl ].
VAR_033918
Natural varianti69 – 691I → V.
Corresponds to variant rs34432940 [ dbSNP | Ensembl ].
VAR_052940
Natural varianti171 – 1711I → V.1 Publication
Corresponds to variant rs6926570 [ dbSNP | Ensembl ].
VAR_024693
Natural varianti283 – 2831Y → C.
Corresponds to variant rs16874326 [ dbSNP | Ensembl ].
VAR_052941

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358514 mRNA. Translation: AAQ88878.1.
AL035701 Genomic DNA. Translation: CAB56566.1.
CH471081 Genomic DNA. Translation: EAX04293.1.
BC027615 mRNA. Translation: AAH27615.1.
CCDSiCCDS4915.1.
PIRiA59391.
RefSeqiNP_001277001.1. NM_001290072.1.
NP_001277002.1. NM_001290073.1.
NP_067547.1. NM_021572.5.
XP_005249317.1. XM_005249260.3.
XP_011513088.1. XM_011514786.2.
UniGeneiHs.35198.

Genome annotation databases

EnsembliENST00000230565; ENSP00000230565; ENSG00000112796.
ENST00000371383; ENSP00000360436; ENSG00000112796.
GeneIDi59084.
KEGGihsa:59084.
UCSCiuc003oxz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358514 mRNA. Translation: AAQ88878.1.
AL035701 Genomic DNA. Translation: CAB56566.1.
CH471081 Genomic DNA. Translation: EAX04293.1.
BC027615 mRNA. Translation: AAH27615.1.
CCDSiCCDS4915.1.
PIRiA59391.
RefSeqiNP_001277001.1. NM_001290072.1.
NP_001277002.1. NM_001290073.1.
NP_067547.1. NM_021572.5.
XP_005249317.1. XM_005249260.3.
XP_011513088.1. XM_011514786.2.
UniGeneiHs.35198.

3D structure databases

ProteinModelPortaliQ9UJA9.
SMRiQ9UJA9. Positions 31-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121860. 1 interaction.
STRINGi9606.ENSP00000230565.

PTM databases

iPTMnetiQ9UJA9.
PhosphoSiteiQ9UJA9.

Polymorphism and mutation databases

BioMutaiENPP5.
DMDMi50401201.

Proteomic databases

EPDiQ9UJA9.
MaxQBiQ9UJA9.
PaxDbiQ9UJA9.
PeptideAtlasiQ9UJA9.
PRIDEiQ9UJA9.

Protocols and materials databases

DNASUi59084.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230565; ENSP00000230565; ENSG00000112796.
ENST00000371383; ENSP00000360436; ENSG00000112796.
GeneIDi59084.
KEGGihsa:59084.
UCSCiuc003oxz.2. human.

Organism-specific databases

CTDi59084.
GeneCardsiENPP5.
HGNCiHGNC:13717. ENPP5.
HPAiHPA016902.
neXtProtiNX_Q9UJA9.
PharmGKBiPA27795.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2645. Eukaryota.
COG1524. LUCA.
GeneTreeiENSGT00760000119157.
HOGENOMiHOG000231018.
HOVERGENiHBG051485.
InParanoidiQ9UJA9.
KOiK18398.
OMAiKHLIHSQ.
OrthoDBiEOG091G06NA.
PhylomeDBiQ9UJA9.
TreeFamiTF330032.

Miscellaneous databases

GenomeRNAii59084.
PROiQ9UJA9.

Gene expression databases

BgeeiENSG00000112796.
CleanExiHS_ENPP5.
GenevisibleiQ9UJA9. HS.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024873. E-NPP.
IPR029896. ENPP5.
IPR002591. Phosphodiest/P_Trfase.
[Graphical view]
PANTHERiPTHR10151. PTHR10151. 1 hit.
PTHR10151:SF80. PTHR10151:SF80. 1 hit.
PfamiPF01663. Phosphodiest. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiENPP5_HUMAN
AccessioniPrimary (citable) accession number: Q9UJA9
Secondary accession number(s): Q5TFV2, Q6UX49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.