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Protein

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

Gene

TRMT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089195-MONOMER.
ZFISH:ENSG00000121236-MONOMER.
BRENDAi2.1.1.220. 2681.
ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
Alternative name(s):
tRNA(m1A58)-methyltransferase subunit TRM6
Short name:
tRNA(m1A58)MTase subunit TRM6
Gene namesi
Name:TRMT6
Synonyms:KIAA1153, TRM6
ORF Names:CGI-09
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:20900. TRMT6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000089195.
PharmGKBiPA162407063.

Polymorphism and mutation databases

DMDMi74753354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002330981 – 497tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6Add BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107PhosphothreonineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei305PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UJA5.
PaxDbiQ9UJA5.
PeptideAtlasiQ9UJA5.
PRIDEiQ9UJA5.

PTM databases

iPTMnetiQ9UJA5.
PhosphoSitePlusiQ9UJA5.

Expressioni

Tissue specificityi

Expressed in brain, liver, testis and ovary.1 Publication

Gene expression databases

BgeeiENSG00000089195.
CleanExiHS_TRMT6.
GenevisibleiQ9UJA5. HS.

Organism-specific databases

HPAiHPA047032.
HPA050408.

Interactioni

Subunit structurei

tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61.1 Publication

Protein-protein interaction databases

BioGridi119634. 49 interactors.
IntActiQ9UJA5. 14 interactors.
MINTiMINT-5005724.
STRINGi9606.ENSP00000203001.

Structurei

Secondary structure

1497
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 30Combined sources6
Beta strandi33 – 38Combined sources6
Beta strandi44 – 46Combined sources3
Beta strandi51 – 53Combined sources3
Helixi54 – 56Combined sources3
Beta strandi59 – 61Combined sources3
Beta strandi64 – 74Combined sources11
Helixi108 – 116Combined sources9
Helixi122 – 130Combined sources9
Beta strandi132 – 134Combined sources3
Helixi135 – 137Combined sources3
Helixi140 – 154Combined sources15
Beta strandi159 – 161Combined sources3
Helixi165 – 175Combined sources11
Helixi177 – 180Combined sources4
Helixi185 – 194Combined sources10
Beta strandi202 – 207Combined sources6
Helixi212 – 221Combined sources10
Beta strandi225 – 232Combined sources8
Helixi239 – 243Combined sources5
Helixi248 – 251Combined sources4
Beta strandi254 – 258Combined sources5
Helixi259 – 261Combined sources3
Helixi262 – 267Combined sources6
Helixi342 – 365Combined sources24
Beta strandi369 – 375Combined sources7
Helixi380 – 387Combined sources8
Helixi388 – 390Combined sources3
Beta strandi396 – 404Combined sources9
Helixi405 – 417Combined sources13
Beta strandi420 – 434Combined sources15
Beta strandi441 – 446Combined sources6
Beta strandi448 – 450Combined sources3
Beta strandi452 – 458Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CCBX-ray2.00B1-497[»]
5CCXX-ray2.10B1-497[»]
5CD1X-ray3.60B/E1-497[»]
ProteinModelPortaliQ9UJA5.
SMRiQ9UJA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRM6/GCD10 family.Curated

Phylogenomic databases

eggNOGiKOG1416. Eukaryota.
ENOG410XSXD. LUCA.
GeneTreeiENSGT00390000008327.
HOGENOMiHOG000232007.
HOVERGENiHBG061231.
InParanoidiQ9UJA5.
KOiK03256.
OMAiTESWLRR.
OrthoDBiEOG091G095O.
PhylomeDBiQ9UJA5.
TreeFamiTF314835.

Family and domain databases

InterProiIPR017423. TRM6.
[Graphical view]
PANTHERiPTHR12945. PTHR12945. 1 hit.
PfamiPF04189. Gcd10p. 1 hit.
[Graphical view]
PIRSFiPIRSF038170. tRNA_m1A_mtfrase. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGSGEQPGP QPQHPGDHRI RDGDFVVLKR EDVFKAVQVQ RRKKVTFEKQ
60 70 80 90 100
WFYLDNVIGH SYGTAFEVTS GGSLQPKKKR EEPTAETKEA GTDNRNIVDD
110 120 130 140 150
GKSQKLTQDD IKALKDKGIK GEEIVQQLIE NSTTFRDKTE FAQDKYIKKK
160 170 180 190 200
KKKYEAIITV VKPSTRILSI MYYAREPGKI NHMRYDTLAQ MLTLGNIRAG
210 220 230 240 250
NKMIVMETCA GLVLGAMMER MGGFGSIIQL YPGGGPVRAA TACFGFPKSF
260 270 280 290 300
LSGLYEFPLN KVDSLLHGTF SAKMLSSEPK DSALVEESNG TLEEKQASEQ
310 320 330 340 350
ENEDSMAEAP ESNHPEDQET METISQDPEH KGPKERGSKK DYIQEKQRRQ
360 370 380 390 400
EEQRKRHLEA AALLSERNAD GLIVASRFHP TPLLLSLLDF VAPSRPFVVY
410 420 430 440 450
CQYKEPLLEC YTKLRERGGV INLRLSETWL RNYQVLPDRS HPKLLMSGGG
460 470 480 490
GYLLSGFTVA MDNLKADTSL KSNASTLESH ETEEPAAKKR KCPESDS
Length:497
Mass (Da):55,799
Last modified:May 1, 2000 - v1
Checksum:i920800D0722A6CBB
GO
Isoform 2 (identifier: Q9UJA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     372-497: LIVASRFHPT...KKRKCPESDS → CVDGRRQETPQCMWALLQTDWHSLSPCL

Show »
Length:399
Mass (Da):44,963
Checksum:i28C0FB314555F56C
GO
Isoform 3 (identifier: Q9UJA5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-365: QEKQRRQEEQRKRHLEAAALLS → SGKNRGRQGRSSGKDFWGCRFA
     366-497: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):40,816
Checksum:i15B0559642D8D087
GO
Isoform 4 (identifier: Q9UJA5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.

Show »
Length:327
Mass (Da):36,439
Checksum:iF01F65B739562EE6
GO

Sequence cautioni

The sequence BAA86467 differs from that shown. Reason: Frameshift at position 319.Curated
The sequence BAA86467 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053789293E → K.Corresponds to variant rs6139876dbSNPEnsembl.1
Natural variantiVAR_053790299E → G.2 PublicationsCorresponds to variant rs451571dbSNPEnsembl.1
Natural variantiVAR_053791333P → L.Corresponds to variant rs35203742dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547401 – 170Missing in isoform 4. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_031100344 – 365QEKQR…AALLS → SGKNRGRQGRSSGKDFWGCR FA in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_031101366 – 497Missing in isoform 3. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_018025372 – 497LIVAS…PESDS → CVDGRRQETPQCMWALLQTD WHSLSPCL in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032979 mRNA. Translation: BAA86467.1. Different initiation.
AF132943 mRNA. Translation: AAD27718.1. Frameshift.
AK000613 mRNA. No translation available.
AK300812 mRNA. Translation: BAG62468.1.
AL035461 Genomic DNA. Translation: CAB55274.1.
BC001262 mRNA. Translation: AAH01262.1.
CCDSiCCDS13093.1. [Q9UJA5-1]
CCDS63225.1. [Q9UJA5-4]
RefSeqiNP_001268396.1. NM_001281467.1. [Q9UJA5-4]
NP_057023.2. NM_015939.4. [Q9UJA5-1]
UniGeneiHs.128791.

Genome annotation databases

EnsembliENST00000203001; ENSP00000203001; ENSG00000089195. [Q9UJA5-1]
ENST00000453074; ENSP00000392070; ENSG00000089195. [Q9UJA5-4]
GeneIDi51605.
KEGGihsa:51605.
UCSCiuc002wmh.3. human. [Q9UJA5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032979 mRNA. Translation: BAA86467.1. Different initiation.
AF132943 mRNA. Translation: AAD27718.1. Frameshift.
AK000613 mRNA. No translation available.
AK300812 mRNA. Translation: BAG62468.1.
AL035461 Genomic DNA. Translation: CAB55274.1.
BC001262 mRNA. Translation: AAH01262.1.
CCDSiCCDS13093.1. [Q9UJA5-1]
CCDS63225.1. [Q9UJA5-4]
RefSeqiNP_001268396.1. NM_001281467.1. [Q9UJA5-4]
NP_057023.2. NM_015939.4. [Q9UJA5-1]
UniGeneiHs.128791.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CCBX-ray2.00B1-497[»]
5CCXX-ray2.10B1-497[»]
5CD1X-ray3.60B/E1-497[»]
ProteinModelPortaliQ9UJA5.
SMRiQ9UJA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119634. 49 interactors.
IntActiQ9UJA5. 14 interactors.
MINTiMINT-5005724.
STRINGi9606.ENSP00000203001.

PTM databases

iPTMnetiQ9UJA5.
PhosphoSitePlusiQ9UJA5.

Polymorphism and mutation databases

DMDMi74753354.

Proteomic databases

EPDiQ9UJA5.
PaxDbiQ9UJA5.
PeptideAtlasiQ9UJA5.
PRIDEiQ9UJA5.

Protocols and materials databases

DNASUi51605.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000203001; ENSP00000203001; ENSG00000089195. [Q9UJA5-1]
ENST00000453074; ENSP00000392070; ENSG00000089195. [Q9UJA5-4]
GeneIDi51605.
KEGGihsa:51605.
UCSCiuc002wmh.3. human. [Q9UJA5-1]

Organism-specific databases

CTDi51605.
GeneCardsiTRMT6.
HGNCiHGNC:20900. TRMT6.
HPAiHPA047032.
HPA050408.
neXtProtiNX_Q9UJA5.
OpenTargetsiENSG00000089195.
PharmGKBiPA162407063.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1416. Eukaryota.
ENOG410XSXD. LUCA.
GeneTreeiENSGT00390000008327.
HOGENOMiHOG000232007.
HOVERGENiHBG061231.
InParanoidiQ9UJA5.
KOiK03256.
OMAiTESWLRR.
OrthoDBiEOG091G095O.
PhylomeDBiQ9UJA5.
TreeFamiTF314835.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089195-MONOMER.
ZFISH:ENSG00000121236-MONOMER.
BRENDAi2.1.1.220. 2681.
ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Miscellaneous databases

GenomeRNAii51605.
PROiQ9UJA5.

Gene expression databases

BgeeiENSG00000089195.
CleanExiHS_TRMT6.
GenevisibleiQ9UJA5. HS.

Family and domain databases

InterProiIPR017423. TRM6.
[Graphical view]
PANTHERiPTHR12945. PTHR12945. 1 hit.
PfamiPF04189. Gcd10p. 1 hit.
[Graphical view]
PIRSFiPIRSF038170. tRNA_m1A_mtfrase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRM6_HUMAN
AccessioniPrimary (citable) accession number: Q9UJA5
Secondary accession number(s): B4DUV6
, Q76P92, Q9BQV5, Q9ULR7, Q9Y2Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.