Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cadherin-22

Gene

CDH22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-22
Alternative name(s):
Pituitary and brain cadherin
Short name:
PB-cadherin
Gene namesi
Name:CDH22
Synonyms:C20orf25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:13251. CDH22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 624ExtracellularSequence analysisAdd BLAST589
Transmembranei625 – 645HelicalSequence analysisAdd BLAST21
Topological domaini646 – 828CytoplasmicSequence analysisAdd BLAST183

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64405.
OpenTargetsiENSG00000149654.
PharmGKBiPA26295.

Polymorphism and mutation databases

DMDMi24211543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000000382135 – 828Cadherin-22Add BLAST794

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Glycosylationi466N-linked (GlcNAc...)Sequence analysis1
Glycosylationi612N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UJ99.
PeptideAtlasiQ9UJ99.
PRIDEiQ9UJ99.

PTM databases

iPTMnetiQ9UJ99.
PhosphoSitePlusiQ9UJ99.

Expressioni

Gene expression databases

BgeeiENSG00000149654.
CleanExiHS_CDH22.
GenevisibleiQ9UJ99. HS.

Organism-specific databases

HPAiHPA012164.

Interactioni

Protein-protein interaction databases

BioGridi122159. 1 interactor.
STRINGi9606.ENSP00000361336.

Structurei

3D structure databases

ProteinModelPortaliQ9UJ99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 168Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini169 – 277Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini278 – 394Cadherin 3PROSITE-ProRule annotationAdd BLAST117
Domaini395 – 498Cadherin 4PROSITE-ProRule annotationAdd BLAST104
Domaini499 – 616Cadherin 5PROSITE-ProRule annotationAdd BLAST118

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9UJ99.
KOiK06812.
OMAiHHKSHLS.
OrthoDBiEOG091G02GU.
PhylomeDBiQ9UJ99.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UJ99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPRPEGRGL RAGVALSPAL LLLLLLPPPP TLLGRLWAAG TPSPSAPGAR
60 70 80 90 100
QDGALGAGRV KRGWVWNQFF VVEEYTGTEP LYVGKIHSDS DEGDGAIKYT
110 120 130 140 150
ISGEGAGTIF LIDELTGDIH AMERLDREQK TFYTLRAQAR DRATNRLLEP
160 170 180 190 200
ESEFIIKVQD INDSEPRFLH GPYIGSVAEL SPTGTSVMQV MASDADDPTY
210 220 230 240 250
GSSARLVYSV LDGEHHFTVD PKTGVIRTAV PDLDRESQER YEVVIQATDM
260 270 280 290 300
AGQLGGLSGS TTVTIVVTDV NDNPPRFPQK MYQFSIQESA PIGTAVGRVK
310 320 330 340 350
AEDSDVGENT DMTYHLKDES SSGGDVFKVT TDSDTQEAII VVQKRLDFES
360 370 380 390 400
QPVHTVILEA LNKFVDPRFA DLGTFRDQAI VRVAVTDVDE PPEFRPPSGL
410 420 430 440 450
LEVQEDAQVG SLVGVVTARD PDAANRPVRY AIDRESDLDQ IFDIDADTGA
460 470 480 490 500
IVTGKGLDRE TAGWHNITVL AMEADNHAQL SRASLRIRIL DVNDNPPELA
510 520 530 540 550
TPYEAAVCED AKPGQLIQTI SVVDRDEPQG GHRFYFRLVP EAPSNPHFSL
560 570 580 590 600
LDIQDNTAAV HTQHVGFNRQ EQDVFFLPIL VVDSGPPTLS STGTLTIRIC
610 620 630 640 650
GCDSSGTIQS CNTTAFVMAA SLSPGALIAL LVCVLILVVL VLLILTLRRH
660 670 680 690 700
HKSHLSSDED EDMRDNVIKY NDEGGGEQDT EAYDMSALRS LYDFGELKGG
710 720 730 740 750
DGGGSAGGGA GGGSGGGAGS PPQAHLPSER HSLPQGPPSP EPDFSVFRDF
760 770 780 790 800
ISRKVALADG DLSVPPYDAF QTYAFEGADS PAASLSSLHS GSSGSEQDFA
810 820
YLSSWGPRFR PLAALYAGHR GDDEAQAS
Length:828
Mass (Da):89,091
Last modified:March 1, 2001 - v2
Checksum:i520F7B1D1F624DCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031687 Genomic DNA. Translation: CAB51587.2.
CH471077 Genomic DNA. Translation: EAW75755.1.
BC136526 mRNA. Translation: AAI36527.1.
AF035300 mRNA. Translation: AAB88183.1.
CCDSiCCDS13395.1.
RefSeqiNP_067071.1. NM_021248.2.
XP_011527296.1. XM_011528994.2.
UniGeneiHs.472861.

Genome annotation databases

EnsembliENST00000372262; ENSP00000361336; ENSG00000149654.
ENST00000537909; ENSP00000437790; ENSG00000149654.
GeneIDi64405.
KEGGihsa:64405.
UCSCiuc010ghk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031687 Genomic DNA. Translation: CAB51587.2.
CH471077 Genomic DNA. Translation: EAW75755.1.
BC136526 mRNA. Translation: AAI36527.1.
AF035300 mRNA. Translation: AAB88183.1.
CCDSiCCDS13395.1.
RefSeqiNP_067071.1. NM_021248.2.
XP_011527296.1. XM_011528994.2.
UniGeneiHs.472861.

3D structure databases

ProteinModelPortaliQ9UJ99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122159. 1 interactor.
STRINGi9606.ENSP00000361336.

PTM databases

iPTMnetiQ9UJ99.
PhosphoSitePlusiQ9UJ99.

Polymorphism and mutation databases

DMDMi24211543.

Proteomic databases

PaxDbiQ9UJ99.
PeptideAtlasiQ9UJ99.
PRIDEiQ9UJ99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372262; ENSP00000361336; ENSG00000149654.
ENST00000537909; ENSP00000437790; ENSG00000149654.
GeneIDi64405.
KEGGihsa:64405.
UCSCiuc010ghk.3. human.

Organism-specific databases

CTDi64405.
DisGeNETi64405.
GeneCardsiCDH22.
HGNCiHGNC:13251. CDH22.
HPAiHPA012164.
MIMi609920. gene.
neXtProtiNX_Q9UJ99.
OpenTargetsiENSG00000149654.
PharmGKBiPA26295.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9UJ99.
KOiK06812.
OMAiHHKSHLS.
OrthoDBiEOG091G02GU.
PhylomeDBiQ9UJ99.
TreeFamiTF329887.

Miscellaneous databases

ChiTaRSiCDH22. human.
GenomeRNAii64405.
PROiQ9UJ99.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149654.
CleanExiHS_CDH22.
GenevisibleiQ9UJ99. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD22_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ99
Secondary accession number(s): B9EGK7, O43205
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.