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Protein

Cohesin subunit SA-3

Gene

STAG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.By similarity

GO - Biological processi

  • synaptonemal complex assembly Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Chromosome partition, Meiosis

Enzyme and pathway databases

ReactomeiR-HSA-1221632. Meiotic synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cohesin subunit SA-3
Alternative name(s):
SCC3 homolog 3
Stromal antigen 3
Stromalin-3
Gene namesi
Name:STAG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11356. STAG3.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric region Source: UniProtKB-SubCell
  • extracellular space Source: UniProtKB
  • meiotic cohesin complex Source: UniProtKB
  • nucleus Source: ProtInc
  • synaptonemal complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Involvement in diseasei

Premature ovarian failure 8 (POF8)1 Publication1 Publication
The disease is caused by mutations affecting the gene represented in this entry. A homozygous deletion in STAG3 predicted to result in frameshift and premature truncation, has been shown to be the cause of premature ovarian failure in a large consanguineous family.1 Publication
Disease descriptionAn ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
See also OMIM:615723

Keywords - Diseasei

Premature ovarian failure

Organism-specific databases

MalaCardsiSTAG3.
MIMi615723. phenotype.
Orphaneti619. Primary ovarian failure.
PharmGKBiPA36178.

Polymorphism and mutation databases

BioMutaiSTAG3.
DMDMi68847235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12251225Cohesin subunit SA-3PRO_0000120188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1203 – 12031PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UJ98.
MaxQBiQ9UJ98.
PaxDbiQ9UJ98.
PRIDEiQ9UJ98.

PTM databases

iPTMnetiQ9UJ98.
PhosphoSiteiQ9UJ98.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiQ9UJ98.
CleanExiHS_STAG3.
ExpressionAtlasiQ9UJ98. baseline and differential.
GenevisibleiQ9UJ98. HS.

Organism-specific databases

HPAiHPA047030.
HPA049106.
HPA058330.

Interactioni

Subunit structurei

Component of the meiosis-specific cohesin complex, which also contains the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer. Such complex likely contains RAD21, or the meiosis-specific related protein REC8. Interacts with CCDC79/TERB1; recruiting cohesin to telomeres to develop structural rigidity (By similarity).By similarity

Protein-protein interaction databases

BioGridi115957. 2 interactions.
IntActiQ9UJ98. 1 interaction.
STRINGi9606.ENSP00000319318.

Structurei

3D structure databases

ProteinModelPortaliQ9UJ98.
SMRiQ9UJ98. Positions 100-1056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini309 – 39486SCDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 259Poly-Ser
Compositional biasi1177 – 11859Poly-Glu

Sequence similaritiesi

Belongs to the SCC3 family.Curated
Contains 1 SCD (stromalin conservative) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2011. Eukaryota.
COG5537. LUCA.
GeneTreeiENSGT00390000014094.
HOGENOMiHOG000231375.
HOVERGENiHBG057636.
InParanoidiQ9UJ98.
KOiK13055.
OrthoDBiEOG7NGQ9M.
PhylomeDBiQ9UJ98.
TreeFamiTF314604.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR020839. SCD.
IPR013721. STAG.
[Graphical view]
PfamiPF08514. STAG. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS51425. SCD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJ98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPLQRAVG DTKRALSASS SSSASLPFDD RDSNHTSEGN GDSLLADEDT
60 70 80 90 100
DFEDSLNRNV KKRAAKRPPK TTPVAKHPKK GSRVVHRHSR KQSEPPANDL
110 120 130 140 150
FNAVKAAKSD MQSLVDEWLD SYKQDQDAGF LELVNFFIQS CGCKGIVTPE
160 170 180 190 200
MFKKMSNSEI IQHLTEQFNE DSGDYPLIAP GPSWKKFQGS FCEFVRTLVC
210 220 230 240 250
QCQYSLLYDG FPMDDLISLL TGLSDSQVRA FRHTSTLAAM KLMTSLVKVA
260 270 280 290 300
LQLSVHQDNN QRQYEAERNK GPGQRAPERL ESLLEKRKEL QEHQEEIEGM
310 320 330 340 350
MNALFRGVFV HRYRDVLPEI RAICIEEIGC WMQSYSTSFL TDSYLKYIGW
360 370 380 390 400
TLHDKHREVR LKCVKALKGL YGNRDLTTRL ELFTSRFKDR MVSMVMDREY
410 420 430 440 450
DVAVEAVRLL ILILKNMEGV LTDADCESVY PVVYASHRGL ASAAGEFLYW
460 470 480 490 500
KLFYPECEIR MMGGREQRQS PGAQRTFFQL LLSFFVESEL HDHAAYLVDS
510 520 530 540 550
LWDCAGARLK DWEGLTSLLL EKDQNLGDVQ ESTLIEILVS SARQASEGHP
560 570 580 590 600
PVGRVTGRKG LTSKERKTQA DDRVKLTEHL IPLLPQLLAK FSADAEKVTP
610 620 630 640 650
LLQLLSCFDL HIYCTGRLEK HLELFLQQLQ EVVVKHAEPA VLEAGAHALY
660 670 680 690 700
LLCNPEFTFF SRADFARSQL VDLLTDRFQQ ELEELLQSSF LDEDEVYNLA
710 720 730 740 750
ATLKRLSAFY NTHDLTRWEL YEPCCQLLQK AVDTGEVPHQ VILPALTLVY
760 770 780 790 800
FSILWTLTHI SKSDASQKQL SSLRDRMVAF CELCQSCLSD VDTEIQEQAF
810 820 830 840 850
VLLSDLLLIF SPQMIVGGRD FLRPLVFFPE ATLQSELASF LMDHVFIQPG
860 870 880 890 900
DLGSGDSQED HLQIERLHQR RRLLAGFCKL LLYGVLEMDA ASDVFKHYNK
910 920 930 940 950
FYNDYGDIIK ETLTRARQID RSHCSRILLL SLKQLYTELL QEHGPQGLNE
960 970 980 990 1000
LPAFIEMRDL ARRFALSFGP QQLQNRDLVV MLHKEGIQFS LSELPPAGSS
1010 1020 1030 1040 1050
NQPPNLAFLE LLSEFSPRLF HQDKQLLLSY LEKCLQHVSQ APGHPWGPVT
1060 1070 1080 1090 1100
TYCHSLSPVE NTAETSPQVL PSSKRRRVEG PAKPNREDVS SSQEESLQLN
1110 1120 1130 1140 1150
SIPPTPTLTS TAVKSRQPLW GLKEMEEEDG SELDFAQGQP VAGTERSRFL
1160 1170 1180 1190 1200
GPQYFQTPHN PSGPGLGNQL MRLSLMEEDE EEELEIQDES NEERQDTDMQ
1210 1220
ASSYSSTSER GLDLLDSTEL DIEDF
Length:1,225
Mass (Da):139,034
Last modified:July 5, 2005 - v2
Checksum:iA29B2FC0C3CCE83D
GO
Isoform 2 (identifier: Q9UJ98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-212: Missing.
     759-1053: Missing.

Note: No experimental confirmation available.
Show »
Length:888
Mass (Da):100,644
Checksum:i2E4A0BA4CEE32E37
GO
Isoform 3 (identifier: Q9UJ98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-170: Missing.

Show »
Length:1,167
Mass (Da):132,319
Checksum:i6DD6702344B7304B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti309 – 3091F → S in BAG63922 (PubMed:14702039).Curated
Sequence conflicti361 – 3611L → V in CAB59367 (PubMed:10698974).Curated
Sequence conflicti378 – 3781T → A in CAB59367 (PubMed:10698974).Curated
Sequence conflicti395 – 3951V → I in CAB59367 (PubMed:10698974).Curated
Sequence conflicti401 – 4011D → S in CAB59367 (PubMed:10698974).Curated
Sequence conflicti420 – 4201V → L in CAB59367 (PubMed:10698974).Curated
Sequence conflicti435 – 4373ASH → PSN in CAB59367 (PubMed:10698974).Curated
Sequence conflicti457 – 4571C → Y in BAG63922 (PubMed:14702039).Curated
Sequence conflicti461 – 4611M → T in CAB59367 (PubMed:10698974).Curated
Sequence conflicti771 – 7711S → W in BAG63922 (PubMed:14702039).Curated
Sequence conflicti1076 – 10761R → K in CAB59367 (PubMed:10698974).Curated
Sequence conflicti1138 – 11381G → GS in CAD38679 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei113 – 17058Missing in isoform 3. 1 PublicationVSP_054742Add
BLAST
Alternative sequencei171 – 21242Missing in isoform 2. 1 PublicationVSP_006996Add
BLAST
Alternative sequencei759 – 1053295Missing in isoform 2. 1 PublicationVSP_006997Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007798 mRNA. Translation: CAB59367.1.
AL833816 mRNA. Translation: CAD38679.2.
AK302693 mRNA. Translation: BAG63922.1.
AC005071 Genomic DNA. No translation available.
AC073842 Genomic DNA. No translation available.
CH471091 Genomic DNA. Translation: EAW76568.1.
CH471091 Genomic DNA. Translation: EAW76570.1.
BC146806 mRNA. Translation: AAI46807.1.
CCDSiCCDS34703.1. [Q9UJ98-1]
CCDS64730.1. [Q9UJ98-3]
RefSeqiNP_001269645.1. NM_001282716.1. [Q9UJ98-1]
NP_001269646.1. NM_001282717.1.
NP_001269647.1. NM_001282718.1. [Q9UJ98-3]
NP_036579.2. NM_012447.3. [Q9UJ98-1]
UniGeneiHs.592283.

Genome annotation databases

EnsembliENST00000317296; ENSP00000319318; ENSG00000066923. [Q9UJ98-1]
ENST00000394018; ENSP00000377586; ENSG00000066923. [Q9UJ98-3]
ENST00000426455; ENSP00000400359; ENSG00000066923. [Q9UJ98-1]
ENST00000620100; ENSP00000484098; ENSG00000066923. [Q9UJ98-3]
GeneIDi10734.
KEGGihsa:10734.
UCSCiuc003utx.3. human. [Q9UJ98-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007798 mRNA. Translation: CAB59367.1.
AL833816 mRNA. Translation: CAD38679.2.
AK302693 mRNA. Translation: BAG63922.1.
AC005071 Genomic DNA. No translation available.
AC073842 Genomic DNA. No translation available.
CH471091 Genomic DNA. Translation: EAW76568.1.
CH471091 Genomic DNA. Translation: EAW76570.1.
BC146806 mRNA. Translation: AAI46807.1.
CCDSiCCDS34703.1. [Q9UJ98-1]
CCDS64730.1. [Q9UJ98-3]
RefSeqiNP_001269645.1. NM_001282716.1. [Q9UJ98-1]
NP_001269646.1. NM_001282717.1.
NP_001269647.1. NM_001282718.1. [Q9UJ98-3]
NP_036579.2. NM_012447.3. [Q9UJ98-1]
UniGeneiHs.592283.

3D structure databases

ProteinModelPortaliQ9UJ98.
SMRiQ9UJ98. Positions 100-1056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115957. 2 interactions.
IntActiQ9UJ98. 1 interaction.
STRINGi9606.ENSP00000319318.

PTM databases

iPTMnetiQ9UJ98.
PhosphoSiteiQ9UJ98.

Polymorphism and mutation databases

BioMutaiSTAG3.
DMDMi68847235.

Proteomic databases

EPDiQ9UJ98.
MaxQBiQ9UJ98.
PaxDbiQ9UJ98.
PRIDEiQ9UJ98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317296; ENSP00000319318; ENSG00000066923. [Q9UJ98-1]
ENST00000394018; ENSP00000377586; ENSG00000066923. [Q9UJ98-3]
ENST00000426455; ENSP00000400359; ENSG00000066923. [Q9UJ98-1]
ENST00000620100; ENSP00000484098; ENSG00000066923. [Q9UJ98-3]
GeneIDi10734.
KEGGihsa:10734.
UCSCiuc003utx.3. human. [Q9UJ98-1]

Organism-specific databases

CTDi10734.
GeneCardsiSTAG3.
H-InvDBHIX0017679.
HGNCiHGNC:11356. STAG3.
HPAiHPA047030.
HPA049106.
HPA058330.
MalaCardsiSTAG3.
MIMi608489. gene.
615723. phenotype.
neXtProtiNX_Q9UJ98.
Orphaneti619. Primary ovarian failure.
PharmGKBiPA36178.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2011. Eukaryota.
COG5537. LUCA.
GeneTreeiENSGT00390000014094.
HOGENOMiHOG000231375.
HOVERGENiHBG057636.
InParanoidiQ9UJ98.
KOiK13055.
OrthoDBiEOG7NGQ9M.
PhylomeDBiQ9UJ98.
TreeFamiTF314604.

Enzyme and pathway databases

ReactomeiR-HSA-1221632. Meiotic synapsis.

Miscellaneous databases

ChiTaRSiSTAG3. human.
GenomeRNAii10734.
PROiQ9UJ98.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UJ98.
CleanExiHS_STAG3.
ExpressionAtlasiQ9UJ98. baseline and differential.
GenevisibleiQ9UJ98. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR020839. SCD.
IPR013721. STAG.
[Graphical view]
PfamiPF08514. STAG. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS51425. SCD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion."
    Pezzi N., Prieto I., Kremer L., Perez Jurado L.A., Valero C., Del Mazo J., Martinez-A C., Barbero J.L.
    FASEB J. 14:581-592(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. Cited for: SUBCELLULAR LOCATION DURING MEIOSIS.
  8. "Genome-wide linkage in a highly consanguineous pedigree reveals two novel loci on chromosome 7 for non-syndromic familial Premature Ovarian Failure."
    Caburet S., Zavadakova P., Ben-Neriah Z., Bouhali K., Dipietromaria A., Charon C., Besse C., Laissue P., Chalifa-Caspi V., Christin-Maitre S., Vaiman D., Levi G., Veitia R.A., Fellous M.
    PLoS ONE 7:E33412-E33412(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN POF8.
  9. Cited for: INVOLVEMENT IN POF8.

Entry informationi

Entry nameiSTAG3_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ98
Secondary accession number(s): A6H8Z1
, B4DZ10, D6W5U8, H7BYK9, Q8NDP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: July 5, 2005
Last modified: June 8, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.