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Protein

Potassium voltage-gated channel subfamily G member 2

Gene

KCNG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: GO_Central

GO - Biological processi

  1. energy reserve metabolic process Source: Reactome
  2. potassium ion transmembrane transport Source: GO_Central
  3. potassium ion transport Source: ProtInc
  4. protein homooligomerization Source: InterPro
  5. regulation of heart contraction Source: ProtInc
  6. regulation of insulin secretion Source: Reactome
  7. small molecule metabolic process Source: Reactome
  8. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 2
Alternative name(s):
Cardiac potassium channel subunit
Voltage-gated potassium channel subunit Kv6.2
Gene namesi
Name:KCNG2
Synonyms:KCNF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:6249. KCNG2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 177177CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei178 – 19821Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei218 – 23821Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini309 – 32113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei322 – 34221Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Intramembranei357 – 37721Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Transmembranei385 – 40521Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini406 – 46661CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: GO_Central
  3. plasma membrane Source: Reactome
  4. voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Potassium voltage-gated channel subfamily G member 2PRO_0000054074Add
BLAST

Proteomic databases

PaxDbiQ9UJ96.
PRIDEiQ9UJ96.

Expressioni

Tissue specificityi

Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.

Gene expression databases

BgeeiQ9UJ96.
CleanExiHS_KCNG2.
GenevestigatoriQ9UJ96.

Organism-specific databases

HPAiHPA048628.

Interactioni

Subunit structurei

Heterodimer with KCNB1. Does not form homomultimers.

Protein-protein interaction databases

BioGridi117638. 1 interaction.
STRINGi9606.ENSP00000315654.

Structurei

3D structure databases

ProteinModelPortaliQ9UJ96.
SMRiQ9UJ96. Positions 19-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi369 – 3746Selectivity filterBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 135Poly-Gly

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG286772.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ9UJ96.
KOiK04901.
OMAiCEVQTKK.
OrthoDBiEOG712TWK.
PhylomeDBiQ9UJ96.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UJ96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPWPCSPGG GGGTRARHVI INVGGCRVRL AWAALARCPL ARLERLRACR
60 70 80 90 100
GHDDLLRVCD DYDVSRDEFF FDRSPCAFRA IVALLRAGKL RLLRGPCALA
110 120 130 140 150
FRDELAYWGI DEARLERCCL RRLRRREEEA AEARAGPTER GAQGSPARAL
160 170 180 190 200
GPRGRLQRGR RRLRDVVDNP HSGLAGKLFA CVSVSFVAVT AVGLCLSTMP
210 220 230 240 250
DIRAEEERGE CSPKCRSLFV LETVCVAWFS FEFLLRSLQA ESKCAFLRAP
260 270 280 290 300
LNIIDILALL PFYVSLLLGL AAGPGGTKLL ERAGLVLRLL RALRVLYVMR
310 320 330 340 350
LARHSLGLRS LGLTMRRCAR EFGLLLLFLC VAMALFAPLV HLAERELGAR
360 370 380 390 400
RDFSSVPASY WWAVISMTTV GYGDMVPRSL PGQVVALSSI LSGILLMAFP
410 420 430 440 450
VTSIFHTFSR SYSELKEQQQ RAASPEPALQ EDSTHSATAT EDSSQGPDSA
460
GLADDSADAL WVRAGR
Length:466
Mass (Da):51,240
Last modified:May 1, 2000 - v1
Checksum:i0D978934F5E71469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011021 mRNA. Translation: CAB56834.1.
CCDSiCCDS12019.1.
RefSeqiNP_036415.1. NM_012283.1.
UniGeneiHs.247905.

Genome annotation databases

EnsembliENST00000316249; ENSP00000315654; ENSG00000178342.
GeneIDi26251.
KEGGihsa:26251.
UCSCiuc010xfl.2. human.

Polymorphism databases

DMDMi24418480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011021 mRNA. Translation: CAB56834.1.
CCDSiCCDS12019.1.
RefSeqiNP_036415.1. NM_012283.1.
UniGeneiHs.247905.

3D structure databases

ProteinModelPortaliQ9UJ96.
SMRiQ9UJ96. Positions 19-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117638. 1 interaction.
STRINGi9606.ENSP00000315654.

Chemistry

ChEMBLiCHEMBL2362996.

Polymorphism databases

DMDMi24418480.

Proteomic databases

PaxDbiQ9UJ96.
PRIDEiQ9UJ96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316249; ENSP00000315654; ENSG00000178342.
GeneIDi26251.
KEGGihsa:26251.
UCSCiuc010xfl.2. human.

Organism-specific databases

CTDi26251.
GeneCardsiGC18P077677.
HGNCiHGNC:6249. KCNG2.
HPAiHPA048628.
MIMi605696. gene.
neXtProtiNX_Q9UJ96.
PharmGKBiPA30035.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG286772.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ9UJ96.
KOiK04901.
OMAiCEVQTKK.
OrthoDBiEOG712TWK.
PhylomeDBiQ9UJ96.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiREACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikiiKCNG2.
GenomeRNAii26251.
NextBioi48464.
PROiQ9UJ96.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UJ96.
CleanExiHS_KCNG2.
GenevestigatoriQ9UJ96.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Structural and functional characterization of Kv6.2, a new gamma-subunit of voltage-gated potassium channel."
    Zhu X.-R., Netzer R., Boehlke K., Liu Q., Pongs O.
    Recept. Channels 6:337-350(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

Entry informationi

Entry nameiKCNG2_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.