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Q9UJ96

- KCNG2_HUMAN

UniProt

Q9UJ96 - KCNG2_HUMAN

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Protein

Potassium voltage-gated channel subfamily G member 2

Gene
KCNG2, KCNF2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: ProtInc

GO - Biological processi

  1. energy reserve metabolic process Source: Reactome
  2. potassium ion transport Source: ProtInc
  3. protein homooligomerization Source: InterPro
  4. regulation of heart contraction Source: ProtInc
  5. regulation of insulin secretion Source: Reactome
  6. small molecule metabolic process Source: Reactome
  7. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 2
Alternative name(s):
Cardiac potassium channel subunit
Voltage-gated potassium channel subunit Kv6.2
Gene namesi
Name:KCNG2
Synonyms:KCNF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:6249. KCNG2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 177177Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei178 – 19821Helical; Name=Segment S1; Reviewed predictionAdd
BLAST
Transmembranei218 – 23821Helical; Name=Segment S2; Reviewed predictionAdd
BLAST
Transmembranei253 – 27321Helical; Name=Segment S3; Reviewed predictionAdd
BLAST
Transmembranei288 – 30821Helical; Voltage-sensor; Name=Segment S4; Reviewed predictionAdd
BLAST
Topological domaini309 – 32113Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei322 – 34221Helical; Name=Segment S5; Reviewed predictionAdd
BLAST
Intramembranei357 – 37721Pore-forming; Name=Segment H5; Reviewed predictionAdd
BLAST
Transmembranei385 – 40521Helical; Name=Segment S6; Reviewed predictionAdd
BLAST
Topological domaini406 – 46661Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. plasma membrane Source: Reactome
  3. voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Potassium voltage-gated channel subfamily G member 2PRO_0000054074Add
BLAST

Proteomic databases

PaxDbiQ9UJ96.
PRIDEiQ9UJ96.

Expressioni

Tissue specificityi

Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.

Gene expression databases

BgeeiQ9UJ96.
CleanExiHS_KCNG2.
GenevestigatoriQ9UJ96.

Organism-specific databases

HPAiHPA048628.

Interactioni

Subunit structurei

Heterodimer with KCNB1. Does not form homomultimers.

Protein-protein interaction databases

BioGridi117638. 1 interaction.
STRINGi9606.ENSP00000315654.

Structurei

3D structure databases

ProteinModelPortaliQ9UJ96.
SMRiQ9UJ96. Positions 19-412.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi369 – 3746Selectivity filter By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 135Poly-Gly

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG286772.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ9UJ96.
KOiK04901.
OMAiCEVQTKK.
OrthoDBiEOG712TWK.
PhylomeDBiQ9UJ96.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UJ96-1 [UniParc]FASTAAdd to Basket

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MEPWPCSPGG GGGTRARHVI INVGGCRVRL AWAALARCPL ARLERLRACR    50
GHDDLLRVCD DYDVSRDEFF FDRSPCAFRA IVALLRAGKL RLLRGPCALA 100
FRDELAYWGI DEARLERCCL RRLRRREEEA AEARAGPTER GAQGSPARAL 150
GPRGRLQRGR RRLRDVVDNP HSGLAGKLFA CVSVSFVAVT AVGLCLSTMP 200
DIRAEEERGE CSPKCRSLFV LETVCVAWFS FEFLLRSLQA ESKCAFLRAP 250
LNIIDILALL PFYVSLLLGL AAGPGGTKLL ERAGLVLRLL RALRVLYVMR 300
LARHSLGLRS LGLTMRRCAR EFGLLLLFLC VAMALFAPLV HLAERELGAR 350
RDFSSVPASY WWAVISMTTV GYGDMVPRSL PGQVVALSSI LSGILLMAFP 400
VTSIFHTFSR SYSELKEQQQ RAASPEPALQ EDSTHSATAT EDSSQGPDSA 450
GLADDSADAL WVRAGR 466
Length:466
Mass (Da):51,240
Last modified:May 1, 2000 - v1
Checksum:i0D978934F5E71469
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011021 mRNA. Translation: CAB56834.1.
CCDSiCCDS12019.1.
RefSeqiNP_036415.1. NM_012283.1.
UniGeneiHs.247905.

Genome annotation databases

EnsembliENST00000316249; ENSP00000315654; ENSG00000178342.
GeneIDi26251.
KEGGihsa:26251.
UCSCiuc010xfl.2. human.

Polymorphism databases

DMDMi24418480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011021 mRNA. Translation: CAB56834.1 .
CCDSi CCDS12019.1.
RefSeqi NP_036415.1. NM_012283.1.
UniGenei Hs.247905.

3D structure databases

ProteinModelPortali Q9UJ96.
SMRi Q9UJ96. Positions 19-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117638. 1 interaction.
STRINGi 9606.ENSP00000315654.

Chemistry

ChEMBLi CHEMBL2362996.

Polymorphism databases

DMDMi 24418480.

Proteomic databases

PaxDbi Q9UJ96.
PRIDEi Q9UJ96.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316249 ; ENSP00000315654 ; ENSG00000178342 .
GeneIDi 26251.
KEGGi hsa:26251.
UCSCi uc010xfl.2. human.

Organism-specific databases

CTDi 26251.
GeneCardsi GC18P077677.
HGNCi HGNC:6249. KCNG2.
HPAi HPA048628.
MIMi 605696. gene.
neXtProti NX_Q9UJ96.
PharmGKBi PA30035.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG286772.
HOGENOMi HOG000231014.
HOVERGENi HBG100172.
InParanoidi Q9UJ96.
KOi K04901.
OMAi CEVQTKK.
OrthoDBi EOG712TWK.
PhylomeDBi Q9UJ96.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCNG2.
GenomeRNAii 26251.
NextBioi 48464.
PROi Q9UJ96.
SOURCEi Search...

Gene expression databases

Bgeei Q9UJ96.
CleanExi HS_KCNG2.
Genevestigatori Q9UJ96.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Structural and functional characterization of Kv6.2, a new gamma-subunit of voltage-gated potassium channel."
    Zhu X.-R., Netzer R., Boehlke K., Liu Q., Pongs O.
    Recept. Channels 6:337-350(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

Entry informationi

Entry nameiKCNG2_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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