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Q9UJ96

- KCNG2_HUMAN

UniProt

Q9UJ96 - KCNG2_HUMAN

Protein

Potassium voltage-gated channel subfamily G member 2

Gene

KCNG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: ProtInc

    GO - Biological processi

    1. energy reserve metabolic process Source: Reactome
    2. potassium ion transport Source: ProtInc
    3. protein homooligomerization Source: InterPro
    4. regulation of heart contraction Source: ProtInc
    5. regulation of insulin secretion Source: Reactome
    6. small molecule metabolic process Source: Reactome
    7. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily G member 2
    Alternative name(s):
    Cardiac potassium channel subunit
    Voltage-gated potassium channel subunit Kv6.2
    Gene namesi
    Name:KCNG2
    Synonyms:KCNF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:6249. KCNG2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. plasma membrane Source: Reactome
    3. voltage-gated potassium channel complex Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30035.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 466466Potassium voltage-gated channel subfamily G member 2PRO_0000054074Add
    BLAST

    Proteomic databases

    PaxDbiQ9UJ96.
    PRIDEiQ9UJ96.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.

    Gene expression databases

    BgeeiQ9UJ96.
    CleanExiHS_KCNG2.
    GenevestigatoriQ9UJ96.

    Organism-specific databases

    HPAiHPA048628.

    Interactioni

    Subunit structurei

    Heterodimer with KCNB1. Does not form homomultimers.

    Protein-protein interaction databases

    BioGridi117638. 1 interaction.
    STRINGi9606.ENSP00000315654.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UJ96.
    SMRiQ9UJ96. Positions 19-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 177177CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini309 – 32113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini406 – 46661CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei357 – 37721Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei178 – 19821Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei322 – 34221Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi369 – 3746Selectivity filterBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi9 – 135Poly-Gly

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG286772.
    HOGENOMiHOG000231014.
    HOVERGENiHBG100172.
    InParanoidiQ9UJ96.
    KOiK04901.
    OMAiCEVQTKK.
    OrthoDBiEOG712TWK.
    PhylomeDBiQ9UJ96.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003969. K_chnl_volt-dep_Kv6.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01492. KV6CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9UJ96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPWPCSPGG GGGTRARHVI INVGGCRVRL AWAALARCPL ARLERLRACR    50
    GHDDLLRVCD DYDVSRDEFF FDRSPCAFRA IVALLRAGKL RLLRGPCALA 100
    FRDELAYWGI DEARLERCCL RRLRRREEEA AEARAGPTER GAQGSPARAL 150
    GPRGRLQRGR RRLRDVVDNP HSGLAGKLFA CVSVSFVAVT AVGLCLSTMP 200
    DIRAEEERGE CSPKCRSLFV LETVCVAWFS FEFLLRSLQA ESKCAFLRAP 250
    LNIIDILALL PFYVSLLLGL AAGPGGTKLL ERAGLVLRLL RALRVLYVMR 300
    LARHSLGLRS LGLTMRRCAR EFGLLLLFLC VAMALFAPLV HLAERELGAR 350
    RDFSSVPASY WWAVISMTTV GYGDMVPRSL PGQVVALSSI LSGILLMAFP 400
    VTSIFHTFSR SYSELKEQQQ RAASPEPALQ EDSTHSATAT EDSSQGPDSA 450
    GLADDSADAL WVRAGR 466
    Length:466
    Mass (Da):51,240
    Last modified:May 1, 2000 - v1
    Checksum:i0D978934F5E71469
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011021 mRNA. Translation: CAB56834.1.
    CCDSiCCDS12019.1.
    RefSeqiNP_036415.1. NM_012283.1.
    UniGeneiHs.247905.

    Genome annotation databases

    EnsembliENST00000316249; ENSP00000315654; ENSG00000178342.
    GeneIDi26251.
    KEGGihsa:26251.
    UCSCiuc010xfl.2. human.

    Polymorphism databases

    DMDMi24418480.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011021 mRNA. Translation: CAB56834.1 .
    CCDSi CCDS12019.1.
    RefSeqi NP_036415.1. NM_012283.1.
    UniGenei Hs.247905.

    3D structure databases

    ProteinModelPortali Q9UJ96.
    SMRi Q9UJ96. Positions 19-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117638. 1 interaction.
    STRINGi 9606.ENSP00000315654.

    Chemistry

    ChEMBLi CHEMBL2362996.

    Polymorphism databases

    DMDMi 24418480.

    Proteomic databases

    PaxDbi Q9UJ96.
    PRIDEi Q9UJ96.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316249 ; ENSP00000315654 ; ENSG00000178342 .
    GeneIDi 26251.
    KEGGi hsa:26251.
    UCSCi uc010xfl.2. human.

    Organism-specific databases

    CTDi 26251.
    GeneCardsi GC18P077677.
    HGNCi HGNC:6249. KCNG2.
    HPAi HPA048628.
    MIMi 605696. gene.
    neXtProti NX_Q9UJ96.
    PharmGKBi PA30035.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286772.
    HOGENOMi HOG000231014.
    HOVERGENi HBG100172.
    InParanoidi Q9UJ96.
    KOi K04901.
    OMAi CEVQTKK.
    OrthoDBi EOG712TWK.
    PhylomeDBi Q9UJ96.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNG2.
    GenomeRNAii 26251.
    NextBioi 48464.
    PROi Q9UJ96.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UJ96.
    CleanExi HS_KCNG2.
    Genevestigatori Q9UJ96.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003969. K_chnl_volt-dep_Kv6.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01492. KV6CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structural and functional characterization of Kv6.2, a new gamma-subunit of voltage-gated potassium channel."
      Zhu X.-R., Netzer R., Boehlke K., Liu Q., Pongs O.
      Recept. Channels 6:337-350(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

    Entry informationi

    Entry nameiKCNG2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UJ96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3