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Q9UJ96 (KCNG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily G member 2
Alternative name(s):
Cardiac potassium channel subunit
Voltage-gated potassium channel subunit Kv6.2
Gene names
Name:KCNG2
Synonyms:KCNF2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

Subunit structure

Heterodimer with KCNB1. Does not form homomultimers.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Miscellaneous

Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone.

Sequence similarities

Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 466466Potassium voltage-gated channel subfamily G member 2
PRO_0000054074

Regions

Topological domain1 – 177177Cytoplasmic Potential
Transmembrane178 – 19821Helical; Name=Segment S1; Potential
Transmembrane218 – 23821Helical; Name=Segment S2; Potential
Transmembrane253 – 27321Helical; Name=Segment S3; Potential
Transmembrane288 – 30821Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain309 – 32113Cytoplasmic Potential
Transmembrane322 – 34221Helical; Name=Segment S5; Potential
Intramembrane357 – 37721Pore-forming; Name=Segment H5; Potential
Transmembrane385 – 40521Helical; Name=Segment S6; Potential
Topological domain406 – 46661Cytoplasmic Potential
Motif369 – 3746Selectivity filter By similarity
Compositional bias9 – 135Poly-Gly

Sequences

Sequence LengthMass (Da)Tools
Q9UJ96 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 0D978934F5E71469

FASTA46651,240
        10         20         30         40         50         60 
MEPWPCSPGG GGGTRARHVI INVGGCRVRL AWAALARCPL ARLERLRACR GHDDLLRVCD 

        70         80         90        100        110        120 
DYDVSRDEFF FDRSPCAFRA IVALLRAGKL RLLRGPCALA FRDELAYWGI DEARLERCCL 

       130        140        150        160        170        180 
RRLRRREEEA AEARAGPTER GAQGSPARAL GPRGRLQRGR RRLRDVVDNP HSGLAGKLFA 

       190        200        210        220        230        240 
CVSVSFVAVT AVGLCLSTMP DIRAEEERGE CSPKCRSLFV LETVCVAWFS FEFLLRSLQA 

       250        260        270        280        290        300 
ESKCAFLRAP LNIIDILALL PFYVSLLLGL AAGPGGTKLL ERAGLVLRLL RALRVLYVMR 

       310        320        330        340        350        360 
LARHSLGLRS LGLTMRRCAR EFGLLLLFLC VAMALFAPLV HLAERELGAR RDFSSVPASY 

       370        380        390        400        410        420 
WWAVISMTTV GYGDMVPRSL PGQVVALSSI LSGILLMAFP VTSIFHTFSR SYSELKEQQQ 

       430        440        450        460 
RAASPEPALQ EDSTHSATAT EDSSQGPDSA GLADDSADAL WVRAGR 

« Hide

References

[1]"Structural and functional characterization of Kv6.2, a new gamma-subunit of voltage-gated potassium channel."
Zhu X.-R., Netzer R., Boehlke K., Liu Q., Pongs O.
Recept. Channels 6:337-350(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ011021 mRNA. Translation: CAB56834.1.
CCDSCCDS12019.1.
RefSeqNP_036415.1. NM_012283.1.
UniGeneHs.247905.

3D structure databases

ProteinModelPortalQ9UJ96.
SMRQ9UJ96. Positions 19-412.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117638. 1 interaction.
STRING9606.ENSP00000315654.

Chemistry

ChEMBLCHEMBL2362996.

Polymorphism databases

DMDM24418480.

Proteomic databases

PaxDbQ9UJ96.
PRIDEQ9UJ96.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316249; ENSP00000315654; ENSG00000178342.
GeneID26251.
KEGGhsa:26251.
UCSCuc010xfl.2. human.

Organism-specific databases

CTD26251.
GeneCardsGC18P077677.
HGNCHGNC:6249. KCNG2.
HPAHPA048628.
MIM605696. gene.
neXtProtNX_Q9UJ96.
PharmGKBPA30035.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG286772.
HOGENOMHOG000231014.
HOVERGENHBG100172.
InParanoidQ9UJ96.
KOK04901.
OMACEVQTKK.
OrthoDBEOG712TWK.
PhylomeDBQ9UJ96.
TreeFamTF313103.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_13685. Neuronal System.

Gene expression databases

BgeeQ9UJ96.
CleanExHS_KCNG2.
GenevestigatorQ9UJ96.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNG2.
GenomeRNAi26251.
NextBio48464.
PROQ9UJ96.
SOURCESearch...

Entry information

Entry nameKCNG2_HUMAN
AccessionPrimary (citable) accession number: Q9UJ96
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM