Q9UJ96 (KCNG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily G member 2

Alternative name(s):
Cardiac potassium channel subunit
Voltage-gated potassium channel subunit Kv6.2

Gene names

Name:	KCNG2
Synonyms:	KCNF2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.
Subunit structure	Heterodimer with KCNB1. Does not form homomultimers.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Miscellaneous	Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone.
Sequence similarities	Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	energy reserve metabolic process Traceable author statement. Source: Reactome protein homooligomerization Inferred from electronic annotation. Source: InterPro regulation of heart contraction Traceable author statement Ref.1. Source: ProtInc regulation of insulin secretion Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	voltage-gated potassium channel complex Traceable author statement Ref.1. Source: ProtInc
Molecular_function	delayed rectifier potassium channel activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Potassium voltage-gated channel subfamily G member 2		PRO_0000054074
Regions
	Topological domain	1 – 177	177	Cytoplasmic Potential
	Transmembrane	178 – 198	21	Helical; Name=Segment S1; Potential
	Transmembrane	218 – 238	21	Helical; Name=Segment S2; Potential
	Transmembrane	253 – 273	21	Helical; Name=Segment S3; Potential
	Transmembrane	288 – 308	21	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	309 – 321	13	Cytoplasmic Potential
	Transmembrane	322 – 342	21	Helical; Name=Segment S5; Potential
	Intramembrane	357 – 377	21	Pore-forming; Name=Segment H5; Potential
	Transmembrane	385 – 405	21	Helical; Name=Segment S6; Potential
	Topological domain	406 – 466	61	Cytoplasmic Potential
	Motif	369 – 374	6	Selectivity filter By similarity
	Compositional bias	9 – 13	5	Poly-Gly

Sequences

	Sequence		Length	Mass (Da)
	Q9UJ96 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 0D978934F5E71469	FASTA	466	51,240
	10 20 30 40 50 60 MEPWPCSPGG GGGTRARHVI INVGGCRVRL AWAALARCPL ARLERLRACR GHDDLLRVCD 70 80 90 100 110 120 DYDVSRDEFF FDRSPCAFRA IVALLRAGKL RLLRGPCALA FRDELAYWGI DEARLERCCL 130 140 150 160 170 180 RRLRRREEEA AEARAGPTER GAQGSPARAL GPRGRLQRGR RRLRDVVDNP HSGLAGKLFA 190 200 210 220 230 240 CVSVSFVAVT AVGLCLSTMP DIRAEEERGE CSPKCRSLFV LETVCVAWFS FEFLLRSLQA 250 260 270 280 290 300 ESKCAFLRAP LNIIDILALL PFYVSLLLGL AAGPGGTKLL ERAGLVLRLL RALRVLYVMR 310 320 330 340 350 360 LARHSLGLRS LGLTMRRCAR EFGLLLLFLC VAMALFAPLV HLAERELGAR RDFSSVPASY 370 380 390 400 410 420 WWAVISMTTV GYGDMVPRSL PGQVVALSSI LSGILLMAFP VTSIFHTFSR SYSELKEQQQ 430 440 450 460 RAASPEPALQ EDSTHSATAT EDSSQGPDSA GLADDSADAL WVRAGR

References

[1]	"Structural and functional characterization of Kv6.2, a new gamma-subunit of voltage-gated potassium channel." Zhu X.-R., Netzer R., Boehlke K., Liu Q., Pongs O. Recept. Channels 6:337-350(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ011021 mRNA. Translation: CAB56834.1.
IPI	IPI00017521.
RefSeq	NP_036415.1. NM_012283.1.
UniGene	Hs.247905.
3D structure databases
ProteinModelPortal	Q9UJ96.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000315654.
Polymorphism databases
DMDM	24418480.
Proteomic databases
PaxDb	Q9UJ96.
PRIDE	Q9UJ96.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316249; ENSP00000315654; ENSG00000178342.
GeneID	26251.
KEGG	hsa:26251.
UCSC	uc010xfl.2. human.
Organism-specific databases
CTD	26251.
GeneCards	GC18P077677.
HGNC	HGNC:6249. KCNG2.
HPA	HPA048628.
MIM	605696. gene.
neXtProt	NX_Q9UJ96.
PharmGKB	PA30035.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG286772.
HOGENOM	HOG000231014.
HOVERGEN	HBG100172.
InParanoid	Q9UJ96.
KO	K04901.
OMA	IINVGGC.
OrthoDB	EOG4XD3RH.
PhylomeDB	Q9UJ96.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_13685. Neuronal System.
Gene expression databases
Bgee	Q9UJ96.
CleanEx	HS_KCNG2.
Genevestigator	Q9UJ96.
GermOnline	ENSG00000178342. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003969. K_chnl_volt-dep_Kv6. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01492. KV6CHANNEL. PR01491. KVCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	26251.
NextBio	48464.
SOURCE	Search...

Entry information

Entry name

KCNG2_HUMAN

Accession

Primary (citable) accession number: Q9UJ96

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.