Reviewed, UniProtKB/Swiss-Prot Q9UJ72 (ANX10_HUMAN)

Names and origin

Protein names

Recommended name:
    Annexin A10
Alternative name(s):
    Annexin-10
    Annexin-14

Gene names

Name:	ANXA10
Synonyms:	ANX14

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the annexin family. Contains 4 annexin repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Annexin Repeat
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	calcium ion binding Ref.1 Traceable author statement. Source: ProtInc calcium-dependent phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Annexin A10		PRO_0000067507
Regions
	Repeat	19 – 86	68	Annexin 1
	Repeat	91 – 158	68	Annexin 2
	Repeat	174 – 241	68	Annexin 3
	Repeat	249 – 316	68	Annexin 4
Natural variations
	Natural variant	71	1	M → L: dbSNP rs6836994. Ref.1		VAR_030786
Experimental info
	Sequence conflict	72 – 85	14	REQLS…DVMAG → KGAAFGSLPRCDGW Ref.2
	Sequence conflict	168	1	T → S in CAB51917. Ref.1
	Sequence conflict	190	1	E → G in CAB51917. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UJ72-1 [UniParc]. Last modified February 20, 2007. Version 3. Checksum: DE17DF81B5D8D047	FASTA	324	37,278
	10 20 30 40 50 60 MFCGDYVQGT IFPAPNFNPI MDAQMLGGAL QGFDCDKDML INILTQRCNA QRMMIAEAYQ 70 80 90 100 110 120 SMYGRDLIGD MREQLSDHFK DVMAGLMYPP PLYDAHELWH AMKGVGTDEN CLIEILASRT 130 140 150 160 170 180 NGEIFQMREA YCLQYSNNLQ EDIYSETSGH FRDTLMNLVQ GTREEGYTDP AMAAQDAMVL 190 200 210 220 230 240 WEACQQKTGE HKTMLQMILC NKSYQQLRLV FQEFQNISGQ DMVDAINECY DGYFQELLVA 250 260 270 280 290 300 IVLCVRDKPA YFAYRLYSAI HDFGFHNKTV IRILIARSEI DLLTIRKRYK ERYGKSLFHD 310 320 IRNFASGHYK KALLAICAGD AEDY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution." Morgan R.O., Jenkins N.A., Gilbert D.J., Copeland N.G., Balsara B.R., Testa J.R., Fernandez M.-P. Genomics 60:40-49(1999) [PubMed: 10458909] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-71. Tissue: Lung.
[2]	"Annexin 14 highly expressed in metastatic pancreatic cancer cell line." Paul H., Gress T.M. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ238979 mRNA. Translation: CAB51917.1. AF196478 mRNA. Translation: AAF06672.1. BC007320 mRNA. Translation: AAH07320.1.
IPI	IPI00296528.
RefSeq	NP_009124.2.
UniGene	Hs.188401
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UJ72.
PTM databases
PhosphoSite	Q9UJ72.
Proteomic databases
PRIDE	Q9UJ72.
Genome annotation databases
Ensembl	ENST00000359299; ENSP00000352248; ENSG00000109511; Homo sapiens. [Genome view]
GeneID	11199.
KEGG	hsa:11199.
UCSC	uc003irm.1. human.
Organism-specific databases
CTD	11199.
GeneCards	GC04P169250.
HGNC	HGNC:534. ANXA10.
HPA	CAB025171. HPA005469.
MIM	608008. gene.
PharmGKB	PA24824.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG745057.
HOVERGEN	Q9UJ72.
InParanoid	Q9UJ72.
OMA	FKEVMVG.
OrthoDB	EOG92JRB9.
Gene expression databases
ArrayExpress	Q9UJ72.
Bgee	Q9UJ72.
CleanEx	HS_ANXA10.
Genevestigator	Q9UJ72.
GermOnline	ENSG00000109511. Homo sapiens.
Family and domain databases
InterPro	IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR008156. AnnexinX. [Graphical view]
Gene3D	G3DSA:1.10.220.10. Annexin. 4 hits.
PANTHER	PTHR10502. Annexin. 1 hit. PTHR10502:SF14. AnnexinX. 1 hit.
Pfam	PF00191. Annexin. 4 hits. [Graphical view]
PRINTS	PR00196. ANNEXIN. PR01809. ANNEXINX.
SMART	SM00335. ANX. 4 hits. [Graphical view]
PROSITE	PS00223. ANNEXIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	42625.
SOURCE	Search...

Entry information

Entry name

ANX10_HUMAN

Accession

Primary (citable) accession number: Q9UJ72
Secondary accession number(s): Q96IQ5, Q9UJV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	February 20, 2007
Last modified:	December 15, 2009
This is version 83 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.