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Protein

Annexin A10

Gene

ANXA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: InterPro
  • calcium ion binding Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A10
Alternative name(s):
Annexin-10
Annexin-14
Gene namesi
Name:ANXA10
Synonyms:ANX14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:534. ANXA10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24824.

Polymorphism and mutation databases

BioMutaiANXA10.
DMDMi126302518.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Annexin A10PRO_0000067507Add
BLAST

Proteomic databases

EPDiQ9UJ72.
PaxDbiQ9UJ72.
PRIDEiQ9UJ72.

PTM databases

iPTMnetiQ9UJ72.
PhosphoSiteiQ9UJ72.

Expressioni

Gene expression databases

BgeeiQ9UJ72.
CleanExiHS_ANXA10.
ExpressionAtlasiQ9UJ72. baseline and differential.
GenevisibleiQ9UJ72. HS.

Organism-specific databases

HPAiCAB025171.
HPA005469.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EDC3Q96F864EBI-8648654,EBI-997311

Protein-protein interaction databases

BioGridi116368. 2 interactions.
IntActiQ9UJ72. 1 interaction.
STRINGi9606.ENSP00000352248.

Structurei

3D structure databases

ProteinModelPortaliQ9UJ72.
SMRiQ9UJ72. Positions 9-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati19 – 8668Annexin 1Add
BLAST
Repeati91 – 15868Annexin 2Add
BLAST
Repeati174 – 24168Annexin 3Add
BLAST
Repeati249 – 31668Annexin 4Add
BLAST

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiQ9UJ72.
KOiK17097.
OMAiMYPPPLY.
OrthoDBiEOG74XS72.
PhylomeDBiQ9UJ72.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR008156. AnnexinX.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01809. ANNEXINX.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UJ72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFCGDYVQGT IFPAPNFNPI MDAQMLGGAL QGFDCDKDML INILTQRCNA
60 70 80 90 100
QRMMIAEAYQ SMYGRDLIGD MREQLSDHFK DVMAGLMYPP PLYDAHELWH
110 120 130 140 150
AMKGVGTDEN CLIEILASRT NGEIFQMREA YCLQYSNNLQ EDIYSETSGH
160 170 180 190 200
FRDTLMNLVQ GTREEGYTDP AMAAQDAMVL WEACQQKTGE HKTMLQMILC
210 220 230 240 250
NKSYQQLRLV FQEFQNISGQ DMVDAINECY DGYFQELLVA IVLCVRDKPA
260 270 280 290 300
YFAYRLYSAI HDFGFHNKTV IRILIARSEI DLLTIRKRYK ERYGKSLFHD
310 320
IRNFASGHYK KALLAICAGD AEDY
Length:324
Mass (Da):37,278
Last modified:February 20, 2007 - v3
Checksum:iDE17DF81B5D8D047
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti72 – 8514REQLS…DVMAG → KGAAFGSLPRCDGW (Ref. 2) CuratedAdd
BLAST
Sequence conflicti168 – 1681T → S in CAB51917 (PubMed:10458909).Curated
Sequence conflicti190 – 1901E → G in CAB51917 (PubMed:10458909).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711M → L.1 Publication
Corresponds to variant rs6836994 [ dbSNP | Ensembl ].
VAR_030786

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238979 mRNA. Translation: CAB51917.1.
AF196478 mRNA. Translation: AAF06672.1.
BC007320 mRNA. Translation: AAH07320.1.
CCDSiCCDS34096.1.
RefSeqiNP_009124.2. NM_007193.4.
UniGeneiHs.188401.

Genome annotation databases

EnsembliENST00000359299; ENSP00000352248; ENSG00000109511.
GeneIDi11199.
KEGGihsa:11199.
UCSCiuc003irm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238979 mRNA. Translation: CAB51917.1.
AF196478 mRNA. Translation: AAF06672.1.
BC007320 mRNA. Translation: AAH07320.1.
CCDSiCCDS34096.1.
RefSeqiNP_009124.2. NM_007193.4.
UniGeneiHs.188401.

3D structure databases

ProteinModelPortaliQ9UJ72.
SMRiQ9UJ72. Positions 9-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116368. 2 interactions.
IntActiQ9UJ72. 1 interaction.
STRINGi9606.ENSP00000352248.

PTM databases

iPTMnetiQ9UJ72.
PhosphoSiteiQ9UJ72.

Polymorphism and mutation databases

BioMutaiANXA10.
DMDMi126302518.

Proteomic databases

EPDiQ9UJ72.
PaxDbiQ9UJ72.
PRIDEiQ9UJ72.

Protocols and materials databases

DNASUi11199.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359299; ENSP00000352248; ENSG00000109511.
GeneIDi11199.
KEGGihsa:11199.
UCSCiuc003irm.4. human.

Organism-specific databases

CTDi11199.
GeneCardsiANXA10.
HGNCiHGNC:534. ANXA10.
HPAiCAB025171.
HPA005469.
MIMi608008. gene.
neXtProtiNX_Q9UJ72.
PharmGKBiPA24824.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiQ9UJ72.
KOiK17097.
OMAiMYPPPLY.
OrthoDBiEOG74XS72.
PhylomeDBiQ9UJ72.
TreeFamiTF105452.

Miscellaneous databases

GenomeRNAii11199.
NextBioi42625.
PROiQ9UJ72.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UJ72.
CleanExiHS_ANXA10.
ExpressionAtlasiQ9UJ72. baseline and differential.
GenevisibleiQ9UJ72. HS.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR008156. AnnexinX.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01809. ANNEXINX.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution."
    Morgan R.O., Jenkins N.A., Gilbert D.J., Copeland N.G., Balsara B.R., Testa J.R., Fernandez M.-P.
    Genomics 60:40-49(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-71.
    Tissue: Lung.
  2. "Annexin 14 highly expressed in metastatic pancreatic cancer cell line."
    Paul H., Gress T.M.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiANX10_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ72
Secondary accession number(s): Q96IQ5, Q9UJV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 20, 2007
Last modified: March 16, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.