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Protein

Annexin A10

Gene

ANXA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: InterPro
  • calcium ion binding Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A10
Alternative name(s):
Annexin-10
Annexin-14
Gene namesi
Name:ANXA10
Synonyms:ANX14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109511.10
HGNCiHGNC:534 ANXA10
MIMi608008 gene
neXtProtiNX_Q9UJ72

Pathology & Biotechi

Organism-specific databases

DisGeNETi11199
OpenTargetsiENSG00000109511
PharmGKBiPA24824

Polymorphism and mutation databases

BioMutaiANXA10
DMDMi126302518

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675071 – 324Annexin A10Add BLAST324

Proteomic databases

PaxDbiQ9UJ72
PeptideAtlasiQ9UJ72
PRIDEiQ9UJ72

PTM databases

iPTMnetiQ9UJ72
PhosphoSitePlusiQ9UJ72

Expressioni

Gene expression databases

BgeeiENSG00000109511
CleanExiHS_ANXA10
GenevisibleiQ9UJ72 HS

Organism-specific databases

HPAiHPA005469

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EDC3Q96F866EBI-8648654,EBI-997311

Protein-protein interaction databases

BioGridi116368, 2 interactors
IntActiQ9UJ72, 2 interactors
MINTiQ9UJ72
STRINGi9606.ENSP00000352248

Structurei

3D structure databases

ProteinModelPortaliQ9UJ72
SMRiQ9UJ72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 86Annexin 1Add BLAST68
Repeati91 – 158Annexin 2Add BLAST68
Repeati174 – 241Annexin 3Add BLAST68
Repeati249 – 316Annexin 4Add BLAST68

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00900000140975
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiQ9UJ72
KOiK17097
OMAiHELWHAM
OrthoDBiEOG091G0AL5
PhylomeDBiQ9UJ72
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR008156 ANX10
PANTHERiPTHR10502:SF100 PTHR10502:SF100, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR01809 ANNEXINX
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UJ72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFCGDYVQGT IFPAPNFNPI MDAQMLGGAL QGFDCDKDML INILTQRCNA
60 70 80 90 100
QRMMIAEAYQ SMYGRDLIGD MREQLSDHFK DVMAGLMYPP PLYDAHELWH
110 120 130 140 150
AMKGVGTDEN CLIEILASRT NGEIFQMREA YCLQYSNNLQ EDIYSETSGH
160 170 180 190 200
FRDTLMNLVQ GTREEGYTDP AMAAQDAMVL WEACQQKTGE HKTMLQMILC
210 220 230 240 250
NKSYQQLRLV FQEFQNISGQ DMVDAINECY DGYFQELLVA IVLCVRDKPA
260 270 280 290 300
YFAYRLYSAI HDFGFHNKTV IRILIARSEI DLLTIRKRYK ERYGKSLFHD
310 320
IRNFASGHYK KALLAICAGD AEDY
Length:324
Mass (Da):37,278
Last modified:February 20, 2007 - v3
Checksum:iDE17DF81B5D8D047
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72 – 85REQLS…DVMAG → KGAAFGSLPRCDGW (Ref. 2) CuratedAdd BLAST14
Sequence conflicti168T → S in CAB51917 (PubMed:10458909).Curated1
Sequence conflicti190E → G in CAB51917 (PubMed:10458909).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03078671M → L1 PublicationCorresponds to variant dbSNP:rs6836994Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238979 mRNA Translation: CAB51917.1
AF196478 mRNA Translation: AAF06672.1
BC007320 mRNA Translation: AAH07320.1
CCDSiCCDS34096.1
RefSeqiNP_009124.2, NM_007193.4
UniGeneiHs.188401

Genome annotation databases

EnsembliENST00000359299; ENSP00000352248; ENSG00000109511
GeneIDi11199
KEGGihsa:11199
UCSCiuc003irm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANX10_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ72
Secondary accession number(s): Q96IQ5, Q9UJV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health