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Q9UJ71

- CLC4K_HUMAN

UniProt

Q9UJ71 - CLC4K_HUMAN

Protein

C-type lectin domain family 4 member K

Gene

CD207

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.4 Publications

    GO - Molecular functioni

    1. carbohydrate binding Source: UniProtKB
    2. mannose binding Source: ProtInc

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    4. defense response to virus Source: UniProtKB

    Keywords - Ligandi

    Lectin

    Enzyme and pathway databases

    ReactomeiREACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-type lectin domain family 4 member K
    Alternative name(s):
    Langerin
    CD_antigen: CD207
    Gene namesi
    Name:CD207
    Synonyms:CLEC4K
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:17935. CD207.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type II membrane protein 1 Publication
    Note: Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.

    GO - Cellular componenti

    1. clathrin-coated endocytic vesicle membrane Source: Reactome
    2. early endosome membrane Source: Reactome
    3. endocytic vesicle Source: ProtInc
    4. integral component of membrane Source: UniProtKB-KW
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Birbeck granule deficiency (BIRGD) [MIM:613393]: A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti264 – 2641W → R in BIRGD; abolishes mannose-binding ability. 1 Publication
    VAR_063828

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi285 – 2851E → A: Loss of binding to 6'-sulfo-LacNAc and invertase. 1 Publication
    Mutagenesisi287 – 2871N → A: Loss of binding to 6'-sulfo-LacNAc and invertase. 1 Publication
    Mutagenesisi299 – 2991K → A: Loss of binding to 6'-sulfo-LacNAc. 1 Publication
    Mutagenesisi313 – 3131K → A: Loss of binding to 6'-sulfo-LacNAc and 6-sulfo-GlcNAc. 1 Publication

    Organism-specific databases

    MIMi613393. phenotype.
    PharmGKBiPA134986203.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328C-type lectin domain family 4 member KPRO_0000223693Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi223 ↔ 3191 PublicationPROSITE-ProRule annotation
    Modified residuei237 – 2371Phosphoserine1 Publication
    Modified residuei243 – 2431Phosphotyrosine1 Publication
    Disulfide bondi295 ↔ 3111 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9UJ71.
    PRIDEiQ9UJ71.

    PTM databases

    PhosphoSiteiQ9UJ71.

    Expressioni

    Tissue specificityi

    Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.2 Publications

    Gene expression databases

    BgeeiQ9UJ71.
    CleanExiHS_CD207.
    GenevestigatoriQ9UJ71.

    Organism-specific databases

    HPAiCAB002222.
    HPA011216.

    Interactioni

    Subunit structurei

    Homotrimer.1 Publication

    Protein-protein interaction databases

    IntActiQ9UJ71. 1 interaction.
    MINTiMINT-6631688.
    STRINGi9606.ENSP00000386378.

    Structurei

    Secondary structure

    1
    328
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi160 – 19536
    Turni196 – 1983
    Beta strandi200 – 2023
    Beta strandi205 – 2095
    Helixi216 – 22510
    Helixi236 – 24611
    Beta strandi251 – 2588
    Turni259 – 2624
    Beta strandi263 – 2664
    Helixi274 – 2774
    Helixi278 – 2803
    Helixi289 – 2913
    Beta strandi295 – 2984
    Beta strandi300 – 3045
    Beta strandi306 – 3094
    Beta strandi315 – 3228

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3C22X-ray1.50A/B/C/D188-328[»]
    3KQGX-ray2.30A/B/C/D/E/F147-328[»]
    3P5DX-ray1.80A/B/C/D193-328[»]
    3P5EX-ray1.70A/B/C/D193-328[»]
    3P5FX-ray1.75A/B/C/D193-328[»]
    3P5GX-ray1.60A/B/C/D193-328[»]
    3P5HX-ray1.61A/B/C/D193-328[»]
    3P5IX-ray1.80A/B/C/D193-328[»]
    3P7FX-ray2.50A/B/C/D193-328[»]
    3P7GX-ray1.60A/B/C/D193-328[»]
    3P7HX-ray2.30A/B/C/D193-328[»]
    4AK8X-ray1.40A/B/C/D188-328[»]
    4N32X-ray1.75A/B/C/D193-328[»]
    4N33X-ray1.85A/B/C/D193-328[»]
    4N34X-ray1.75A/B/C/D193-328[»]
    4N35X-ray1.85A/B/C/D193-328[»]
    4N36X-ray1.85A/B/C/D193-328[»]
    4N37X-ray2.00A/B/C/D193-328[»]
    4N38X-ray2.00A/B/C/D193-328[»]
    ProteinModelPortaliQ9UJ71.
    SMRiQ9UJ71. Positions 159-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UJ71.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini65 – 328264ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini202 – 320119C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili145 – 19046Sequence AnalysisAdd
    BLAST

    Domaini

    The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.1 Publication

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311341.
    HOGENOMiHOG000064516.
    HOVERGENiHBG073250.
    InParanoidiQ9UJ71.
    KOiK06561.
    OMAiFKGNFYY.
    OrthoDBiEOG7QZGBX.
    PhylomeDBiQ9UJ71.
    TreeFamiTF333341.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UJ71-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVEKEAPDA HFTVDKQNIS LWPREPPPKS GPSLVPGKTP TVRAALICLT    50
    LVLVASVLLQ AVLYPRFMGT ISDVKTNVQL LKGRVDNIST LDSEIKKNSD 100
    GMEAAGVQIQ MVNESLGYVR SQFLKLKTSV EKANAQIQIL TRSWEEVSTL 150
    NAQIPELKSD LEKASALNTK IRALQGSLEN MSKLLKRQND ILQVVSQGWK 200
    YFKGNFYYFS LIPKTWYSAE QFCVSRNSHL TSVTSESEQE FLYKTAGGLI 250
    YWIGLTKAGM EGDWSWVDDT PFNKVQSVRF WIPGEPNNAG NNEHCGNIKA 300
    PSLQAWNDAP CDKTFLFICK RPYVPSEP 328
    Length:328
    Mass (Da):36,725
    Last modified:March 24, 2009 - v2
    Checksum:i83DF432682BF4B62
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551A → V.
    Corresponds to variant rs10489990 [ dbSNP | Ensembl ].
    VAR_054781
    Natural varianti136 – 1361Q → E.
    Corresponds to variant rs17718987 [ dbSNP | Ensembl ].
    VAR_056151
    Natural varianti213 – 2131P → S.
    Corresponds to variant rs17006436 [ dbSNP | Ensembl ].
    VAR_054782
    Natural varianti264 – 2641W → R in BIRGD; abolishes mannose-binding ability. 1 Publication
    VAR_063828
    Natural varianti278 – 2781V → A No effect on mannose-binding ability. 2 Publications
    Corresponds to variant rs741326 [ dbSNP | Ensembl ].
    VAR_054783
    Natural varianti288 – 2881N → D Significant reduction in mannose-binding ability. 1 Publication
    Corresponds to variant rs13383830 [ dbSNP | Ensembl ].
    VAR_054784
    Natural varianti300 – 3001A → P Significant reduction in mannose-binding ability; significant decrease in thermal stability; increased sensitivity of sugar binding to pH change. 1 Publication
    Corresponds to variant rs2080391 [ dbSNP | Ensembl ].
    VAR_059448

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ242859 mRNA. Translation: CAB62403.1.
    AC007395 Genomic DNA. No translation available.
    BC022278 mRNA. Translation: AAH22278.1.
    RefSeqiNP_056532.4. NM_015717.4.
    UniGeneiHs.199731.

    Genome annotation databases

    EnsembliENST00000410009; ENSP00000386378; ENSG00000116031.
    GeneIDi50489.
    KEGGihsa:50489.
    UCSCiuc002shg.3. human.

    Polymorphism databases

    DMDMi229784129.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Langerin

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ242859 mRNA. Translation: CAB62403.1 .
    AC007395 Genomic DNA. No translation available.
    BC022278 mRNA. Translation: AAH22278.1 .
    RefSeqi NP_056532.4. NM_015717.4.
    UniGenei Hs.199731.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3C22 X-ray 1.50 A/B/C/D 188-328 [» ]
    3KQG X-ray 2.30 A/B/C/D/E/F 147-328 [» ]
    3P5D X-ray 1.80 A/B/C/D 193-328 [» ]
    3P5E X-ray 1.70 A/B/C/D 193-328 [» ]
    3P5F X-ray 1.75 A/B/C/D 193-328 [» ]
    3P5G X-ray 1.60 A/B/C/D 193-328 [» ]
    3P5H X-ray 1.61 A/B/C/D 193-328 [» ]
    3P5I X-ray 1.80 A/B/C/D 193-328 [» ]
    3P7F X-ray 2.50 A/B/C/D 193-328 [» ]
    3P7G X-ray 1.60 A/B/C/D 193-328 [» ]
    3P7H X-ray 2.30 A/B/C/D 193-328 [» ]
    4AK8 X-ray 1.40 A/B/C/D 188-328 [» ]
    4N32 X-ray 1.75 A/B/C/D 193-328 [» ]
    4N33 X-ray 1.85 A/B/C/D 193-328 [» ]
    4N34 X-ray 1.75 A/B/C/D 193-328 [» ]
    4N35 X-ray 1.85 A/B/C/D 193-328 [» ]
    4N36 X-ray 1.85 A/B/C/D 193-328 [» ]
    4N37 X-ray 2.00 A/B/C/D 193-328 [» ]
    4N38 X-ray 2.00 A/B/C/D 193-328 [» ]
    ProteinModelPortali Q9UJ71.
    SMRi Q9UJ71. Positions 159-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9UJ71. 1 interaction.
    MINTi MINT-6631688.
    STRINGi 9606.ENSP00000386378.

    Chemistry

    ChEMBLi CHEMBL2176853.

    PTM databases

    PhosphoSitei Q9UJ71.

    Polymorphism databases

    DMDMi 229784129.

    Proteomic databases

    PaxDbi Q9UJ71.
    PRIDEi Q9UJ71.

    Protocols and materials databases

    DNASUi 50489.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000410009 ; ENSP00000386378 ; ENSG00000116031 .
    GeneIDi 50489.
    KEGGi hsa:50489.
    UCSCi uc002shg.3. human.

    Organism-specific databases

    CTDi 50489.
    GeneCardsi GC02M071057.
    HGNCi HGNC:17935. CD207.
    HPAi CAB002222.
    HPA011216.
    MIMi 604862. gene.
    613393. phenotype.
    neXtProti NX_Q9UJ71.
    PharmGKBi PA134986203.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311341.
    HOGENOMi HOG000064516.
    HOVERGENi HBG073250.
    InParanoidi Q9UJ71.
    KOi K06561.
    OMAi FKGNFYY.
    OrthoDBi EOG7QZGBX.
    PhylomeDBi Q9UJ71.
    TreeFami TF333341.

    Enzyme and pathway databases

    Reactomei REACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).

    Miscellaneous databases

    EvolutionaryTracei Q9UJ71.
    GeneWikii Langerin.
    GenomeRNAii 50489.
    NextBioi 53062.
    PROi Q9UJ71.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UJ71.
    CleanExi HS_CD207.
    Genevestigatori Q9UJ71.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules."
      Valladeau J., Ravel O., Dezutter-Dambuyant C., Moore K., Kleijmeer M., Liu Y., Duvert-Frances V., Vincent C., Schmitt D., Davoust J., Caux C., Lebecque S., Saeland S.
      Immunity 12:71-81(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ALA-278.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    4. "Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells."
      Stambach N.S., Taylor M.E.
      Glycobiology 13:401-410(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    5. "Langerin/CD207 sheds light on formation of Birbeck granules and their possible function in Langerhans cells."
      Valladeau J., Dezutter-Dambuyant C., Saeland S.
      Immunol. Res. 28:93-107(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    6. Cited for: FUNCTION.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237 AND TYR-243, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Dual specificity of langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain."
      Tateno H., Ohnishi K., Yabe R., Hayatsu N., Sato T., Takeya M., Narimatsu H., Hirabayashi J.
      J. Biol. Chem. 285:6390-6400(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DOMAIN C-TYPE LECTIN, MUTAGENESIS OF GLU-285; ASN-287; LYS-299 AND LYS-313.
    9. "C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi."
      de Jong M.A., Vriend L.E., Theelen B., Taylor M.E., Fluitsma D., Boekhout T., Geijtenbeek T.B.
      Mol. Immunol. 47:1216-1225(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Structural studies of langerin and Birbeck granule: a macromolecular organization model."
      Thepaut M., Valladeau J., Nurisso A., Kahn R., Arnou B., Vives C., Saeland S., Ebel C., Monnier C., Dezutter-Dambuyant C., Imberty A., Fieschi F.
      Biochemistry 48:2684-2698(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 188-328, DISULFIDE BONDS.
    11. "A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene."
      Verdijk P., Dijkman R., Plasmeijer E.I., Mulder A.A., Zoutman W.H., Mieke Mommaas A., Tensen C.P.
      J. Invest. Dermatol. 124:714-717(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT BIRGD ARG-264.
    12. "Polymorphisms in human langerin affect stability and sugar binding activity."
      Ward E.M., Stambach N.S., Drickamer K., Taylor M.E.
      J. Biol. Chem. 281:15450-15456(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ALA-278; ASP-288 AND PRO-300, CHARACTERIZATION OF VARIANT BIRGD ARG-264, CHARACTERIZATION OF VARIANTS ALA-278; ASP-288 AND PRO-300.

    Entry informationi

    Entry nameiCLC4K_HUMAN
    AccessioniPrimary (citable) accession number: Q9UJ71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3