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Q9UJ71

- CLC4K_HUMAN

UniProt

Q9UJ71 - CLC4K_HUMAN

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Protein

C-type lectin domain family 4 member K

Gene

CD207

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.4 Publications

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB
  2. mannose binding Source: ProtInc

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  4. defense response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiREACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member K
Alternative name(s):
Langerin
CD_antigen: CD207
Gene namesi
Name:CD207
Synonyms:CLEC4K
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:17935. CD207.

Subcellular locationi

Membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Note: Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei44 – 6421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini65 – 328264ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. clathrin-coated endocytic vesicle membrane Source: Reactome
  2. early endosome membrane Source: Reactome
  3. endocytic vesicle Source: ProtInc
  4. integral component of membrane Source: UniProtKB-KW
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Birbeck granule deficiency (BIRGD) [MIM:613393]: A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti264 – 2641W → R in BIRGD; abolishes mannose-binding ability. 1 Publication
VAR_063828

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi285 – 2851E → A: Loss of binding to 6'-sulfo-LacNAc and invertase. 1 Publication
Mutagenesisi287 – 2871N → A: Loss of binding to 6'-sulfo-LacNAc and invertase. 1 Publication
Mutagenesisi299 – 2991K → A: Loss of binding to 6'-sulfo-LacNAc. 1 Publication
Mutagenesisi313 – 3131K → A: Loss of binding to 6'-sulfo-LacNAc and 6-sulfo-GlcNAc. 1 Publication

Organism-specific databases

MIMi613393. phenotype.
PharmGKBiPA134986203.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328C-type lectin domain family 4 member KPRO_0000223693Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi223 ↔ 3191 PublicationPROSITE-ProRule annotation
Modified residuei237 – 2371Phosphoserine1 Publication
Modified residuei243 – 2431Phosphotyrosine1 Publication
Disulfide bondi295 ↔ 3111 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UJ71.
PRIDEiQ9UJ71.

PTM databases

PhosphoSiteiQ9UJ71.

Expressioni

Tissue specificityi

Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.2 Publications

Gene expression databases

BgeeiQ9UJ71.
CleanExiHS_CD207.
GenevestigatoriQ9UJ71.

Organism-specific databases

HPAiCAB002222.
HPA011216.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridi119076. 2 interactions.
IntActiQ9UJ71. 1 interaction.
MINTiMINT-6631688.
STRINGi9606.ENSP00000386378.

Structurei

Secondary structure

1
328
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi160 – 19536Combined sources
Turni196 – 1983Combined sources
Beta strandi200 – 2023Combined sources
Beta strandi205 – 2095Combined sources
Helixi216 – 22510Combined sources
Helixi236 – 24611Combined sources
Beta strandi251 – 2588Combined sources
Turni259 – 2624Combined sources
Beta strandi263 – 2664Combined sources
Helixi274 – 2774Combined sources
Helixi278 – 2803Combined sources
Helixi289 – 2913Combined sources
Beta strandi295 – 2984Combined sources
Beta strandi300 – 3045Combined sources
Beta strandi306 – 3094Combined sources
Beta strandi315 – 3228Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3C22X-ray1.50A/B/C/D188-328[»]
3KQGX-ray2.30A/B/C/D/E/F147-328[»]
3P5DX-ray1.80A/B/C/D193-328[»]
3P5EX-ray1.70A/B/C/D193-328[»]
3P5FX-ray1.75A/B/C/D193-328[»]
3P5GX-ray1.60A/B/C/D193-328[»]
3P5HX-ray1.61A/B/C/D193-328[»]
3P5IX-ray1.80A/B/C/D193-328[»]
3P7FX-ray2.50A/B/C/D193-328[»]
3P7GX-ray1.60A/B/C/D193-328[»]
3P7HX-ray2.30A/B/C/D193-328[»]
4AK8X-ray1.40A/B/C/D188-328[»]
4N32X-ray1.75A/B/C/D193-328[»]
4N33X-ray1.85A/B/C/D193-328[»]
4N34X-ray1.75A/B/C/D193-328[»]
4N35X-ray1.85A/B/C/D193-328[»]
4N36X-ray1.85A/B/C/D193-328[»]
4N37X-ray2.00A/B/C/D193-328[»]
4N38X-ray2.00A/B/C/D193-328[»]
ProteinModelPortaliQ9UJ71.
SMRiQ9UJ71. Positions 159-328.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UJ71.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini202 – 320119C-type lectinPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili145 – 19046Sequence AnalysisAdd
BLAST

Domaini

The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.1 Publication

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311341.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000064516.
HOVERGENiHBG073250.
InParanoidiQ9UJ71.
KOiK06561.
OMAiFKGNFYY.
OrthoDBiEOG7QZGBX.
PhylomeDBiQ9UJ71.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UJ71-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVEKEAPDA HFTVDKQNIS LWPREPPPKS GPSLVPGKTP TVRAALICLT
60 70 80 90 100
LVLVASVLLQ AVLYPRFMGT ISDVKTNVQL LKGRVDNIST LDSEIKKNSD
110 120 130 140 150
GMEAAGVQIQ MVNESLGYVR SQFLKLKTSV EKANAQIQIL TRSWEEVSTL
160 170 180 190 200
NAQIPELKSD LEKASALNTK IRALQGSLEN MSKLLKRQND ILQVVSQGWK
210 220 230 240 250
YFKGNFYYFS LIPKTWYSAE QFCVSRNSHL TSVTSESEQE FLYKTAGGLI
260 270 280 290 300
YWIGLTKAGM EGDWSWVDDT PFNKVQSVRF WIPGEPNNAG NNEHCGNIKA
310 320
PSLQAWNDAP CDKTFLFICK RPYVPSEP
Length:328
Mass (Da):36,725
Last modified:March 24, 2009 - v2
Checksum:i83DF432682BF4B62
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551A → V.
Corresponds to variant rs10489990 [ dbSNP | Ensembl ].
VAR_054781
Natural varianti136 – 1361Q → E.
Corresponds to variant rs17718987 [ dbSNP | Ensembl ].
VAR_056151
Natural varianti213 – 2131P → S.
Corresponds to variant rs17006436 [ dbSNP | Ensembl ].
VAR_054782
Natural varianti264 – 2641W → R in BIRGD; abolishes mannose-binding ability. 1 Publication
VAR_063828
Natural varianti278 – 2781V → A No effect on mannose-binding ability. 2 Publications
Corresponds to variant rs741326 [ dbSNP | Ensembl ].
VAR_054783
Natural varianti288 – 2881N → D Significant reduction in mannose-binding ability. 1 Publication
Corresponds to variant rs13383830 [ dbSNP | Ensembl ].
VAR_054784
Natural varianti300 – 3001A → P Significant reduction in mannose-binding ability; significant decrease in thermal stability; increased sensitivity of sugar binding to pH change. 1 Publication
Corresponds to variant rs2080391 [ dbSNP | Ensembl ].
VAR_059448

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242859 mRNA. Translation: CAB62403.1.
AC007395 Genomic DNA. No translation available.
BC022278 mRNA. Translation: AAH22278.1.
CCDSiCCDS74520.1.
RefSeqiNP_056532.4. NM_015717.4.
UniGeneiHs.199731.

Genome annotation databases

EnsembliENST00000410009; ENSP00000386378; ENSG00000116031.
GeneIDi50489.
KEGGihsa:50489.
UCSCiuc002shg.3. human.

Polymorphism databases

DMDMi229784129.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Langerin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242859 mRNA. Translation: CAB62403.1 .
AC007395 Genomic DNA. No translation available.
BC022278 mRNA. Translation: AAH22278.1 .
CCDSi CCDS74520.1.
RefSeqi NP_056532.4. NM_015717.4.
UniGenei Hs.199731.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3C22 X-ray 1.50 A/B/C/D 188-328 [» ]
3KQG X-ray 2.30 A/B/C/D/E/F 147-328 [» ]
3P5D X-ray 1.80 A/B/C/D 193-328 [» ]
3P5E X-ray 1.70 A/B/C/D 193-328 [» ]
3P5F X-ray 1.75 A/B/C/D 193-328 [» ]
3P5G X-ray 1.60 A/B/C/D 193-328 [» ]
3P5H X-ray 1.61 A/B/C/D 193-328 [» ]
3P5I X-ray 1.80 A/B/C/D 193-328 [» ]
3P7F X-ray 2.50 A/B/C/D 193-328 [» ]
3P7G X-ray 1.60 A/B/C/D 193-328 [» ]
3P7H X-ray 2.30 A/B/C/D 193-328 [» ]
4AK8 X-ray 1.40 A/B/C/D 188-328 [» ]
4N32 X-ray 1.75 A/B/C/D 193-328 [» ]
4N33 X-ray 1.85 A/B/C/D 193-328 [» ]
4N34 X-ray 1.75 A/B/C/D 193-328 [» ]
4N35 X-ray 1.85 A/B/C/D 193-328 [» ]
4N36 X-ray 1.85 A/B/C/D 193-328 [» ]
4N37 X-ray 2.00 A/B/C/D 193-328 [» ]
4N38 X-ray 2.00 A/B/C/D 193-328 [» ]
ProteinModelPortali Q9UJ71.
SMRi Q9UJ71. Positions 159-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119076. 2 interactions.
IntActi Q9UJ71. 1 interaction.
MINTi MINT-6631688.
STRINGi 9606.ENSP00000386378.

Chemistry

BindingDBi Q9UJ71.
ChEMBLi CHEMBL2176853.

PTM databases

PhosphoSitei Q9UJ71.

Polymorphism databases

DMDMi 229784129.

Proteomic databases

PaxDbi Q9UJ71.
PRIDEi Q9UJ71.

Protocols and materials databases

DNASUi 50489.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000410009 ; ENSP00000386378 ; ENSG00000116031 .
GeneIDi 50489.
KEGGi hsa:50489.
UCSCi uc002shg.3. human.

Organism-specific databases

CTDi 50489.
GeneCardsi GC02M071057.
HGNCi HGNC:17935. CD207.
HPAi CAB002222.
HPA011216.
MIMi 604862. gene.
613393. phenotype.
neXtProti NX_Q9UJ71.
PharmGKBi PA134986203.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG311341.
GeneTreei ENSGT00760000118924.
HOGENOMi HOG000064516.
HOVERGENi HBG073250.
InParanoidi Q9UJ71.
KOi K06561.
OMAi FKGNFYY.
OrthoDBi EOG7QZGBX.
PhylomeDBi Q9UJ71.
TreeFami TF333341.

Enzyme and pathway databases

Reactomei REACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).

Miscellaneous databases

EvolutionaryTracei Q9UJ71.
GeneWikii Langerin.
GenomeRNAii 50489.
NextBioi 53062.
PROi Q9UJ71.
SOURCEi Search...

Gene expression databases

Bgeei Q9UJ71.
CleanExi HS_CD207.
Genevestigatori Q9UJ71.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules."
    Valladeau J., Ravel O., Dezutter-Dambuyant C., Moore K., Kleijmeer M., Liu Y., Duvert-Frances V., Vincent C., Schmitt D., Davoust J., Caux C., Lebecque S., Saeland S.
    Immunity 12:71-81(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ALA-278.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. "Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells."
    Stambach N.S., Taylor M.E.
    Glycobiology 13:401-410(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  5. "Langerin/CD207 sheds light on formation of Birbeck granules and their possible function in Langerhans cells."
    Valladeau J., Dezutter-Dambuyant C., Saeland S.
    Immunol. Res. 28:93-107(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  6. Cited for: FUNCTION.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237 AND TYR-243, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Dual specificity of langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain."
    Tateno H., Ohnishi K., Yabe R., Hayatsu N., Sato T., Takeya M., Narimatsu H., Hirabayashi J.
    J. Biol. Chem. 285:6390-6400(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DOMAIN C-TYPE LECTIN, MUTAGENESIS OF GLU-285; ASN-287; LYS-299 AND LYS-313.
  9. "C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi."
    de Jong M.A., Vriend L.E., Theelen B., Taylor M.E., Fluitsma D., Boekhout T., Geijtenbeek T.B.
    Mol. Immunol. 47:1216-1225(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Structural studies of langerin and Birbeck granule: a macromolecular organization model."
    Thepaut M., Valladeau J., Nurisso A., Kahn R., Arnou B., Vives C., Saeland S., Ebel C., Monnier C., Dezutter-Dambuyant C., Imberty A., Fieschi F.
    Biochemistry 48:2684-2698(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 188-328, DISULFIDE BONDS.
  11. "A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene."
    Verdijk P., Dijkman R., Plasmeijer E.I., Mulder A.A., Zoutman W.H., Mieke Mommaas A., Tensen C.P.
    J. Invest. Dermatol. 124:714-717(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT BIRGD ARG-264.
  12. "Polymorphisms in human langerin affect stability and sugar binding activity."
    Ward E.M., Stambach N.S., Drickamer K., Taylor M.E.
    J. Biol. Chem. 281:15450-15456(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ALA-278; ASP-288 AND PRO-300, CHARACTERIZATION OF VARIANT BIRGD ARG-264, CHARACTERIZATION OF VARIANTS ALA-278; ASP-288 AND PRO-300.

Entry informationi

Entry nameiCLC4K_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 24, 2009
Last modified: November 26, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3