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Protein

Probable G-protein coupled receptor 160

Gene

GPR160

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 160
Alternative name(s):
G-protein coupled receptor GPCR1
Short name:
hGPCR1
Gene namesi
Name:GPR160
Synonyms:GPCR150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:23693. GPR160.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 5814CytoplasmicSequence analysisAdd
BLAST
Transmembranei59 – 7921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 9314ExtracellularSequence analysisAdd
BLAST
Transmembranei94 – 11421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini115 – 13622CytoplasmicSequence analysisAdd
BLAST
Transmembranei137 – 15721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini158 – 17720ExtracellularSequence analysisAdd
BLAST
Transmembranei178 – 19821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini199 – 24446CytoplasmicSequence analysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini266 – 2683ExtracellularSequence analysis
Transmembranei269 – 28921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 33849CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134936972.

Chemistry

ChEMBLiCHEMBL1777664.

Polymorphism and mutation databases

BioMutaiGPR160.
DMDMi48428180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Probable G-protein coupled receptor 160PRO_0000069643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UJ42.
PRIDEiQ9UJ42.

PTM databases

iPTMnetiQ9UJ42.

Expressioni

Gene expression databases

BgeeiQ9UJ42.
CleanExiHS_GPR160.
ExpressionAtlasiQ9UJ42. baseline and differential.
GenevisibleiQ9UJ42. HS.

Organism-specific databases

HPAiHPA006970.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348161.

Structurei

3D structure databases

ProteinModelPortaliQ9UJ42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK2K. Eukaryota.
ENOG410YX66. LUCA.
GeneTreeiENSGT00390000015520.
HOGENOMiHOG000112776.
HOVERGENiHBG062414.
InParanoidiQ9UJ42.
KOiK08438.
OMAiEMNVPWL.
OrthoDBiEOG72G17T.
PhylomeDBiQ9UJ42.
TreeFamiTF335541.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UJ42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALSSENCS FQYQLRQTNQ PLDVNYLLFL IILGKILLNI LTLGMRRKNT
60 70 80 90 100
CQNFMEYFCI SLAFVDLLLL VNISIILYFR DFVLLSIRFT KYHICLFTQI
110 120 130 140 150
ISFTYGFLHY PVFLTACIDY CLNFSKTTKL SFKCQKLFYF FTVILIWISV
160 170 180 190 200
LAYVLGDPAI YQSLKAQNAY SRHCPFYVSI QSYWLSFFMV MILFVAFITC
210 220 230 240 250
WEEVTTLVQA IRITSYMNET ILYFPFSSHS SYTVRSKKIF LSKLIVCFLS
260 270 280 290 300
TWLPFVLLQV IIVLLKVQIP AYIEMNIPWL YFVNSFLIAT VYWFNCHKLN
310 320 330
LKDIGLPLDP FVNWKCCFIP LTIPNLEQIE KPISIMIC
Length:338
Mass (Da):39,787
Last modified:May 1, 2000 - v1
Checksum:i50B38F90E0311175
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249248 mRNA. Translation: CAB55314.1.
AB083583 Genomic DNA. Translation: BAB89296.1.
CH471052 Genomic DNA. Translation: EAW78524.1.
CH471052 Genomic DNA. Translation: EAW78525.1.
CH471052 Genomic DNA. Translation: EAW78526.1.
BC000181 mRNA. Translation: AAH00181.1.
CCDSiCCDS3211.1.
RefSeqiNP_055188.1. NM_014373.2.
XP_005247403.1. XM_005247346.2.
XP_005247404.1. XM_005247347.2.
XP_006713645.1. XM_006713582.2.
XP_006713647.1. XM_006713584.2.
XP_011510979.1. XM_011512677.1.
XP_011510980.1. XM_011512678.1.
UniGeneiHs.231320.

Genome annotation databases

EnsembliENST00000355897; ENSP00000348161; ENSG00000173890.
GeneIDi26996.
KEGGihsa:26996.
UCSCiuc003fgi.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249248 mRNA. Translation: CAB55314.1.
AB083583 Genomic DNA. Translation: BAB89296.1.
CH471052 Genomic DNA. Translation: EAW78524.1.
CH471052 Genomic DNA. Translation: EAW78525.1.
CH471052 Genomic DNA. Translation: EAW78526.1.
BC000181 mRNA. Translation: AAH00181.1.
CCDSiCCDS3211.1.
RefSeqiNP_055188.1. NM_014373.2.
XP_005247403.1. XM_005247346.2.
XP_005247404.1. XM_005247347.2.
XP_006713645.1. XM_006713582.2.
XP_006713647.1. XM_006713584.2.
XP_011510979.1. XM_011512677.1.
XP_011510980.1. XM_011512678.1.
UniGeneiHs.231320.

3D structure databases

ProteinModelPortaliQ9UJ42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348161.

Chemistry

ChEMBLiCHEMBL1777664.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9UJ42.

Polymorphism and mutation databases

BioMutaiGPR160.
DMDMi48428180.

Proteomic databases

PaxDbiQ9UJ42.
PRIDEiQ9UJ42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355897; ENSP00000348161; ENSG00000173890.
GeneIDi26996.
KEGGihsa:26996.
UCSCiuc003fgi.4. human.

Organism-specific databases

CTDi26996.
GeneCardsiGPR160.
HGNCiHGNC:23693. GPR160.
HPAiHPA006970.
neXtProtiNX_Q9UJ42.
PharmGKBiPA134936972.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK2K. Eukaryota.
ENOG410YX66. LUCA.
GeneTreeiENSGT00390000015520.
HOGENOMiHOG000112776.
HOVERGENiHBG062414.
InParanoidiQ9UJ42.
KOiK08438.
OMAiEMNVPWL.
OrthoDBiEOG72G17T.
PhylomeDBiQ9UJ42.
TreeFamiTF335541.

Miscellaneous databases

ChiTaRSiGPR160. human.
GeneWikiiGPR160.
GenomeRNAii26996.
PROiQ9UJ42.

Gene expression databases

BgeeiQ9UJ42.
CleanExiHS_GPR160.
ExpressionAtlasiQ9UJ42. baseline and differential.
GenevisibleiQ9UJ42. HS.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mining of assembled expressed sequence tag (EST) data for protein families: application to the G protein-coupled receptor superfamily."
    Conklin D., Yee D.P., Millar R., Engelbrecht J., Vissing H.
    Brief. Bioinform. 1:93-99(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  2. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.

Entry informationi

Entry nameiGP160_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ42
Secondary accession number(s): D3DNQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.