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Q9UJ41

- RABX5_HUMAN

UniProt

Q9UJ41 - RABX5_HUMAN

Protein

Rab5 GDP/GTP exchange factor

Gene

RABGEF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri151 – 18535A20-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. protein binding Source: UniProtKB
    3. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW
    2. positive regulation of Rab GTPase activity Source: GOC
    3. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Endocytosis, Protein transport, Transport, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rab5 GDP/GTP exchange factor
    Alternative name(s):
    RAP1
    Rabaptin-5-associated exchange factor for Rab5
    Rabex-5
    Gene namesi
    Name:RABGEF1
    Synonyms:RABEX5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:17676. RABGEF1.

    Subcellular locationi

    Cytoplasm 1 Publication. Early endosome 1 Publication. Recycling endosome 1 Publication

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell
    2. recycling endosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endosome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi196 – 1961A → G: Reduces affinity for ubiquitin 3-fold. 1 Publication
    Mutagenesisi530 – 5301D → A: Strongly reduced activity. 1 Publication
    Mutagenesisi534 – 5341P → A: Strongly reduced activity. 1 Publication
    Mutagenesisi571 – 5711Y → A: Strongly reduced activity. 1 Publication
    Mutagenesisi574 – 5741T → A: Strongly reduced activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA134946532.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 708708Rab5 GDP/GTP exchange factorPRO_0000191315Add
    BLAST

    Post-translational modificationi

    Monoubiquitinated.

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ9UJ41.
    PaxDbiQ9UJ41.
    PRIDEiQ9UJ41.

    PTM databases

    PhosphoSiteiQ9UJ41.

    Expressioni

    Gene expression databases

    CleanExiHS_RABGEF1.
    GenevestigatoriQ9UJ41.

    Organism-specific databases

    HPAiHPA001407.

    Interactioni

    Subunit structurei

    Interacts with RGS14; the interaction is GTP-dependent By similarity. Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR.By similarity6 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EGFRP005334EBI-913954,EBI-297353
    KXD1Q9BQD32EBI-913954,EBI-739657
    UBBP0CG476EBI-913954,EBI-413034
    UBCP629902EBI-913954,EBI-413053From a different organism.

    Protein-protein interaction databases

    BioGridi118154. 25 interactions.
    DIPiDIP-29348N.
    IntActiQ9UJ41. 11 interactions.
    MINTiMINT-1189235.
    STRINGi9606.ENSP00000284957.

    Structurei

    Secondary structure

    1
    708
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi161 – 1633
    Helixi167 – 1693
    Helixi174 – 19825
    Helixi239 – 24810
    Helixi318 – 3258
    Helixi328 – 34619
    Turni347 – 3504
    Helixi353 – 37220
    Helixi418 – 44023
    Helixi448 – 46114
    Turni462 – 4643
    Turni467 – 4715
    Helixi479 – 49416
    Helixi495 – 4973
    Helixi501 – 52323
    Helixi529 – 54315
    Helixi548 – 55811
    Turni561 – 5655
    Helixi568 – 58518
    Helixi589 – 5913
    Helixi595 – 6028

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1TXUX-ray2.35A311-611[»]
    2C7MX-ray2.40A139-252[»]
    2C7NX-ray2.10A/C/E/G/I/K139-252[»]
    2OT3X-ray2.10A310-614[»]
    ProteinModelPortaliQ9UJ41.
    SMRiQ9UJ41. Positions 155-252, 312-604.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UJ41.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini449 – 592144VPS9PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni139 – 252114Interaction with ubiquitinated proteinsAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili624 – 66542Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 A20-type zinc finger.PROSITE-ProRule annotation
    Contains 1 VPS9 domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri151 – 18535A20-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG301606.
    HOGENOMiHOG000070180.
    HOVERGENiHBG062584.
    PhylomeDBiQ9UJ41.
    TreeFamiTF321331.

    Family and domain databases

    InterProiIPR003123. VPS9.
    IPR013995. VPS9_subgr.
    IPR002653. Znf_A20.
    [Graphical view]
    PfamiPF02204. VPS9. 1 hit.
    PF01754. zf-A20. 1 hit.
    [Graphical view]
    SMARTiSM00167. VPS9. 1 hit.
    SM00259. ZnF_A20. 1 hit.
    [Graphical view]
    PROSITEiPS51205. VPS9. 1 hit.
    PS51036. ZF_A20. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UJ41-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVVVTGREPD SRRQDGAMSS SDAEDDFLEP ATPTATQAGH ALPLLPQERC    50
    AEFPALRGPP TQGACSSCVQ RGPVLCHRAP PGAAGEHAAT EGREGAPSVS 100
    GTHALLQRPL GADCGDRPAA CGPAEGPLCQ AQVVSRKKMS LKSERRGIHV 150
    DQSDLLCKKG CGYYGNPAWQ GFCSKCWREE YHKARQKQIQ EDWELAERVL 200
    LCCPGWSAMV QFQLTATSAS WAQVILLLQP PKWLGLQKLQ REEEEAFASS 250
    QSSQGAQSLT FSKFEEKKTN EKTRKVTTVK KFFSASSRVG SKKEIQEAKA 300
    PSPSINRQTS IETDRVSKEF IEFLKTFHKT GQEIYKQTKL FLEGMHYKRD 350
    LSIEEQSECA QDFYHNVAER MQTRGKERRF HHVGQAGLEL LTSGDPPASA 400
    SQSAGNTGVE PPHPAVPPER VEKIMDQIEK YIMTRLYKYV FCPETTDDEK 450
    KDLAIQKRIR ALRWVTPQML CVPVNEDIPE VSDMVVKAIT DIIEMDSKRV 500
    PRDKLACITK CSKHIFNAIK ITKNEPASAD DFLPTLIYIV LKGNPPRLQS 550
    NIQYITRFCN PSRLMTGEDG YYFTNLCCAV AFIEKLDAQS LNLSQEDFDR 600
    YMSGQTSPRK QEAESWSPDA CLGVKQMYKN LDLLSQLNER QERIMNEAKK 650
    LEKDLIDWTD GIAREVQDIV EKYPLEIKPP NQPLAAIDSE NVENDKLPPP 700
    LQPQVYAG 708

    Note: No experimental confirmation available.

    Length:708
    Mass (Da):79,371
    Last modified:July 5, 2004 - v2
    Checksum:i007E404F13AC91D8
    GO
    Isoform 2 (identifier: Q9UJ41-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-138: Missing.
         199-238: Missing.
         377-415: Missing.

    Show »
    Length:491
    Mass (Da):56,891
    Checksum:i49ACABA276E65E91
    GO
    Isoform 3 (identifier: Q9UJ41-3) [UniParc]FASTAAdd to Basket

    Also known as: Long

    The sequence of this isoform differs from the canonical sequence as follows:
         1-138: Missing.
         377-415: Missing.

    Show »
    Length:531
    Mass (Da):61,300
    Checksum:i3C21934AA5ABBF9A
    GO
    Isoform 4 (identifier: Q9UJ41-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-8: MVVVTGRE → MMASSYHE
         9-132: Missing.
         199-238: Missing.
         377-415: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:505
    Mass (Da):58,526
    Checksum:i655A49886ADE2891
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti199 – 1991V → A in ABA64474. 1 PublicationCurated
    Sequence conflicti203 – 2031C → Y in ABA64474. 1 PublicationCurated
    Sequence conflicti476 – 4761E → D in BAC87138. (PubMed:14702039)Curated
    Sequence conflicti487 – 4871K → R in BAD97049. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 138138Missing in isoform 2 and isoform 3. 5 PublicationsVSP_010690Add
    BLAST
    Alternative sequencei1 – 88MVVVTGRE → MMASSYHE in isoform 4. 1 PublicationVSP_054643
    Alternative sequencei9 – 132124Missing in isoform 4. 1 PublicationVSP_054644Add
    BLAST
    Alternative sequencei199 – 23840Missing in isoform 2 and isoform 4. 6 PublicationsVSP_010691Add
    BLAST
    Alternative sequencei377 – 41539Missing in isoform 2, isoform 3 and isoform 4. 6 PublicationsVSP_010692Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250042 mRNA. Translation: CAB57359.1.
    DQ230533 mRNA. Translation: ABA64473.1.
    DQ230534 mRNA. Translation: ABA64474.1.
    BT007107 mRNA. Translation: AAP35771.1.
    AK127790 mRNA. Translation: BAC87138.1.
    AK303006 mRNA. Translation: BAG64139.1.
    AK223329 mRNA. Translation: BAD97049.1.
    AC027644 Genomic DNA. Translation: AAQ93362.1.
    AC079588 Genomic DNA. No translation available.
    BC015330 mRNA. Translation: AAH15330.1.
    CCDSiCCDS5535.1. [Q9UJ41-2]
    CCDS69308.1. [Q9UJ41-4]
    RefSeqiNP_001273989.1. NM_001287060.1.
    NP_001273990.1. NM_001287061.1. [Q9UJ41-4]
    NP_001273991.1. NM_001287062.1. [Q9UJ41-2]
    NP_055319.1. NM_014504.2. [Q9UJ41-2]
    UniGeneiHs.530053.
    Hs.662268.
    Hs.733181.

    Genome annotation databases

    EnsembliENST00000284957; ENSP00000284957; ENSG00000154710. [Q9UJ41-2]
    ENST00000437078; ENSP00000390480; ENSG00000154710. [Q9UJ41-4]
    ENST00000450873; ENSP00000415815; ENSG00000154710. [Q9UJ41-2]
    ENST00000510829; ENSP00000421124; ENSG00000154710. [Q9UJ41-2]
    GeneIDi27342.
    KEGGihsa:27342.
    UCSCiuc003tvf.3. human. [Q9UJ41-1]
    uc003tvh.3. human. [Q9UJ41-2]

    Polymorphism databases

    DMDMi56405102.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250042 mRNA. Translation: CAB57359.1 .
    DQ230533 mRNA. Translation: ABA64473.1 .
    DQ230534 mRNA. Translation: ABA64474.1 .
    BT007107 mRNA. Translation: AAP35771.1 .
    AK127790 mRNA. Translation: BAC87138.1 .
    AK303006 mRNA. Translation: BAG64139.1 .
    AK223329 mRNA. Translation: BAD97049.1 .
    AC027644 Genomic DNA. Translation: AAQ93362.1 .
    AC079588 Genomic DNA. No translation available.
    BC015330 mRNA. Translation: AAH15330.1 .
    CCDSi CCDS5535.1. [Q9UJ41-2 ]
    CCDS69308.1. [Q9UJ41-4 ]
    RefSeqi NP_001273989.1. NM_001287060.1.
    NP_001273990.1. NM_001287061.1. [Q9UJ41-4 ]
    NP_001273991.1. NM_001287062.1. [Q9UJ41-2 ]
    NP_055319.1. NM_014504.2. [Q9UJ41-2 ]
    UniGenei Hs.530053.
    Hs.662268.
    Hs.733181.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1TXU X-ray 2.35 A 311-611 [» ]
    2C7M X-ray 2.40 A 139-252 [» ]
    2C7N X-ray 2.10 A/C/E/G/I/K 139-252 [» ]
    2OT3 X-ray 2.10 A 310-614 [» ]
    ProteinModelPortali Q9UJ41.
    SMRi Q9UJ41. Positions 155-252, 312-604.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118154. 25 interactions.
    DIPi DIP-29348N.
    IntActi Q9UJ41. 11 interactions.
    MINTi MINT-1189235.
    STRINGi 9606.ENSP00000284957.

    PTM databases

    PhosphoSitei Q9UJ41.

    Polymorphism databases

    DMDMi 56405102.

    Proteomic databases

    MaxQBi Q9UJ41.
    PaxDbi Q9UJ41.
    PRIDEi Q9UJ41.

    Protocols and materials databases

    DNASUi 27342.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000284957 ; ENSP00000284957 ; ENSG00000154710 . [Q9UJ41-2 ]
    ENST00000437078 ; ENSP00000390480 ; ENSG00000154710 . [Q9UJ41-4 ]
    ENST00000450873 ; ENSP00000415815 ; ENSG00000154710 . [Q9UJ41-2 ]
    ENST00000510829 ; ENSP00000421124 ; ENSG00000154710 . [Q9UJ41-2 ]
    GeneIDi 27342.
    KEGGi hsa:27342.
    UCSCi uc003tvf.3. human. [Q9UJ41-1 ]
    uc003tvh.3. human. [Q9UJ41-2 ]

    Organism-specific databases

    CTDi 27342.
    GeneCardsi GC07P066205.
    HGNCi HGNC:17676. RABGEF1.
    HPAi HPA001407.
    MIMi 609700. gene.
    neXtProti NX_Q9UJ41.
    PharmGKBi PA134946532.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301606.
    HOGENOMi HOG000070180.
    HOVERGENi HBG062584.
    PhylomeDBi Q9UJ41.
    TreeFami TF321331.

    Miscellaneous databases

    ChiTaRSi RABGEF1. human.
    EvolutionaryTracei Q9UJ41.
    GeneWikii RABGEF1.
    GenomeRNAii 27342.
    NextBioi 35476520.
    PROi Q9UJ41.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_RABGEF1.
    Genevestigatori Q9UJ41.

    Family and domain databases

    InterProi IPR003123. VPS9.
    IPR013995. VPS9_subgr.
    IPR002653. Znf_A20.
    [Graphical view ]
    Pfami PF02204. VPS9. 1 hit.
    PF01754. zf-A20. 1 hit.
    [Graphical view ]
    SMARTi SM00167. VPS9. 1 hit.
    SM00259. ZnF_A20. 1 hit.
    [Graphical view ]
    PROSITEi PS51205. VPS9. 1 hit.
    PS51036. ZF_A20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Seven genes that are differentially transcribed in colorectal tumor cell lines."
      Nimmrich I., Erdmann S., Melchers U., Finke U., Hentsch S., Moyer M.P., Hoffmann I., Mueller O.
      Cancer Lett. 160:37-43(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. Barbieri M.A., Hunker C.M.
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
      Tissue: Cervix carcinoma.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Brain and Testis.
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    6. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lymph.
    8. "A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function."
      Horiuchi H., Lippe R., McBride H.M., Rubino M., Woodman P., Stenmark H., Rybin V., Wilm M., Ashman K., Mann M., Zerial M.
      Cell 90:1149-1159(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RABEP1.
    9. "Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex."
      Lippe R., Miaczynska M., Rybin V., Runge A., Zerial M.
      Mol. Biol. Cell 12:2219-2228(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RABEP1.
    10. "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex."
      Mattera R., Arighi C.N., Lodge R., Zerial M., Bonifacino J.S.
      EMBO J. 22:78-88(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GGA1; GGA2; GGA3; AP1G1 AND AP1G2, SUBCELLULAR LOCATION.
    11. "Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5."
      Delprato A., Merithew E., Lambright D.G.
      Cell 118:607-617(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 310-611, FUNCTION, INTERACTION WITH RAB5; RAB21 AND RAB22, MUTAGENESIS OF ASP-530; PRO-534; TYR-571 AND THR-574.
    12. "Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin."
      Penengo L., Mapelli M., Murachelli A.G., Confalonieri S., Magri L., Musacchio A., Di Fiore P.P., Polo S., Schneider T.R.
      Cell 124:1183-1195(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 139-252 IN COMPLEX WITH UBIQUITIN, UBIQUITINATION, MUTAGENESIS OF ALA-196.
    13. "Structural basis for Rab GTPase activation by VPS9 domain exchange factors."
      Delprato A., Lambright D.G.
      Nat. Struct. Mol. Biol. 14:406-412(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 310-614 IN COMPLEX WITH RAB21.

    Entry informationi

    Entry nameiRABX5_HUMAN
    AccessioniPrimary (citable) accession number: Q9UJ41
    Secondary accession number(s): B4DZM7
    , Q3HKR2, Q3HKR3, Q53FG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3