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Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

Gene

ST6GALNAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

CMP-N-acetylneuraminate + glycano-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP + glycano-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:HS01005-MONOMER.
BRENDAi2.4.99.3. 2681.
ReactomeiR-HSA-4085001. Sialic acid metabolism.
R-HSA-977068. Termination of O-glycan biosynthesis.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (EC:2.4.99.-)
Alternative name(s):
GalNAc alpha-2,6-sialyltransferase II
ST6GalNAc II
Short name:
ST6GalNAcII
SThM
Sialyltransferase 7B
Short name:
SIAT7-B
Gene namesi
Name:ST6GALNAC2
Synonyms:SIAT7B, SIATL1, STHM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10867. ST6GALNAC2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini29 – 374LumenalSequence analysisAdd BLAST346

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10610.
OpenTargetsiENSG00000070731.
PharmGKBiPA35769.

Polymorphism and mutation databases

BioMutaiST6GALNAC2.
DMDMi21759448.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492721 – 374Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi151 ↔ 317By similarity
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9UJ37.
PaxDbiQ9UJ37.
PeptideAtlasiQ9UJ37.
PRIDEiQ9UJ37.

PTM databases

iPTMnetiQ9UJ37.
PhosphoSitePlusiQ9UJ37.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.

Gene expression databases

BgeeiENSG00000070731.
CleanExiHS_ST6GALNAC2.
ExpressionAtlasiQ9UJ37. baseline and differential.
GenevisibleiQ9UJ37. HS.

Organism-specific databases

HPAiHPA048849.

Interactioni

Protein-protein interaction databases

BioGridi115856. 1 interactor.
IntActiQ9UJ37. 1 interactor.
MINTiMINT-1189715.
STRINGi9606.ENSP00000225276.

Structurei

3D structure databases

ProteinModelPortaliQ9UJ37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000231097.
HOVERGENiHBG056467.
InParanoidiQ9UJ37.
KOiK06616.
OMAiDKGDRPH.
OrthoDBiEOG091G09FL.
PhylomeDBiQ9UJ37.
TreeFamiTF354325.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UJ37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPRGSFFW LLLLLTAACS GLLFALYFSA VQRYPGPAAG ARDTTSFEAF
60 70 80 90 100
FQSKASNSWT GKGQACRHLL HLAIQRHPHF RGLFNLSIPV LLWGDLFTPA
110 120 130 140 150
LWDRLSQHKA PYGWRGLSHQ VIASTLSLLN GSESAKLFAP PRDTPPKCIR
160 170 180 190 200
CAVVGNGGIL NGSRQGPNID AHDYVFRLNG AVIKGFERDV GTKTSFYGFT
210 220 230 240 250
VNTMKNSLVS YWNLGFTSVP QGQDLQYIFI PSDIRDYVML RSAILGVPVP
260 270 280 290 300
EGLDKGDRPH AYFGPEASAS KFKLLHPDFI SYLTERFLKS KLINTHFGDL
310 320 330 340 350
YMPSTGALML LTALHTCDQV SAYGFITSNY WKFSDHYFER KMKPLIFYAN
360 370
HDLSLEAALW RDLHKAGILQ LYQR
Length:374
Mass (Da):41,939
Last modified:May 1, 2000 - v1
Checksum:iE0BD439E4C6BB427
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11L → V in AAA52228 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251053 mRNA. Translation: CAB61434.1.
U14550 mRNA. Translation: AAA52228.1.
BT019972 mRNA. Translation: AAV38775.1.
BC040455 mRNA. Translation: AAH40455.1.
CCDSiCCDS11747.1.
RefSeqiNP_006447.2. NM_006456.2.
UniGeneiHs.592105.

Genome annotation databases

EnsembliENST00000225276; ENSP00000225276; ENSG00000070731.
GeneIDi10610.
KEGGihsa:10610.
UCSCiuc002jsg.5. human.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

ST6GalNAc II

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251053 mRNA. Translation: CAB61434.1.
U14550 mRNA. Translation: AAA52228.1.
BT019972 mRNA. Translation: AAV38775.1.
BC040455 mRNA. Translation: AAH40455.1.
CCDSiCCDS11747.1.
RefSeqiNP_006447.2. NM_006456.2.
UniGeneiHs.592105.

3D structure databases

ProteinModelPortaliQ9UJ37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115856. 1 interactor.
IntActiQ9UJ37. 1 interactor.
MINTiMINT-1189715.
STRINGi9606.ENSP00000225276.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

PTM databases

iPTMnetiQ9UJ37.
PhosphoSitePlusiQ9UJ37.

Polymorphism and mutation databases

BioMutaiST6GALNAC2.
DMDMi21759448.

Proteomic databases

MaxQBiQ9UJ37.
PaxDbiQ9UJ37.
PeptideAtlasiQ9UJ37.
PRIDEiQ9UJ37.

Protocols and materials databases

DNASUi10610.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225276; ENSP00000225276; ENSG00000070731.
GeneIDi10610.
KEGGihsa:10610.
UCSCiuc002jsg.5. human.

Organism-specific databases

CTDi10610.
DisGeNETi10610.
GeneCardsiST6GALNAC2.
H-InvDBHIX0135622.
HGNCiHGNC:10867. ST6GALNAC2.
HPAiHPA048849.
MIMi610137. gene.
neXtProtiNX_Q9UJ37.
OpenTargetsiENSG00000070731.
PharmGKBiPA35769.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000231097.
HOVERGENiHBG056467.
InParanoidiQ9UJ37.
KOiK06616.
OMAiDKGDRPH.
OrthoDBiEOG091G09FL.
PhylomeDBiQ9UJ37.
TreeFamiTF354325.

Enzyme and pathway databases

UniPathwayiUPA00378.
BioCyciZFISH:HS01005-MONOMER.
BRENDAi2.4.99.3. 2681.
ReactomeiR-HSA-4085001. Sialic acid metabolism.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSiST6GALNAC2. human.
GeneWikiiST6GALNAC2.
GenomeRNAii10610.
PROiQ9UJ37.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070731.
CleanExiHS_ST6GALNAC2.
ExpressionAtlasiQ9UJ37. baseline and differential.
GenevisibleiQ9UJ37. HS.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSIA7B_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ37
Secondary accession number(s): Q12971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.