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Q9UJ19

- Q9UJ19_HUMAN

UniProt

Q9UJ19 - Q9UJ19_HUMAN

Protein
Submitted name:

Cystic fibrosis transmembrane conductance regulator

Gene

CFTR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. bicarbonate transmembrane transporter activity Source: Ensembl
    2. chloride transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. cellular response to cAMP Source: Ensembl
    2. cellular response to hormone stimulus Source: Ensembl
    3. cholesterol biosynthetic process Source: Ensembl
    4. cholesterol transport Source: Ensembl
    5. intracellular pH elevation Source: Ensembl
    6. iodide transport Source: Ensembl
    7. lung development Source: Ensembl
    8. membrane hyperpolarization Source: Ensembl
    9. positive regulation of vasodilation Source: Ensembl
    10. response to cytokine Source: Ensembl
    11. response to drug Source: Ensembl
    12. response to estrogen Source: Ensembl
    13. response to peptide hormone Source: Ensembl
    14. sperm capacitation Source: Ensembl
    15. transepithelial chloride transport Source: Ensembl
    16. vasodilation Source: Ensembl
    17. water transport Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cystic fibrosis transmembrane conductance regulatorImported
    Gene namesi
    Name:CFTRImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. cytoplasmic vesicle membrane Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. microvillus Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UJ19.
    BgeeiQ9UJ19.

    Family & Domainsi

    Keywords - Domaini

    TransmembraneImported

    Sequencei

    Sequence statusi: Fragment.

    Q9UJ19-1 [UniParc]FASTAAdd to Basket

    « Hide

    TVILCEHRIE AMLECQQFLV IEENKVRQYD SIQKLLNE                38
    Length:38
    Mass (Da):4,577
    Last modified:May 1, 2000 - v1
    Checksum:i4B72E3B0884DB42F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei38 – 381Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96936 Genomic DNA. Translation: AAB59382.1.
    UniGeneiHs.489786.
    Hs.621460.
    Hs.661104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96936 Genomic DNA. Translation: AAB59382.1 .
    UniGenei Hs.489786.
    Hs.621460.
    Hs.661104.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q9UJ19.
    Bgeei Q9UJ19.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Alternative splicing of intron 23 of the human cystic fibrosis transmembrane conductance regulator gene resulting in a novel exon and transcript coding for a shortened intracytoplasmic C terminus."
      Yoshimura K., Chu C.S., Crystal R.G.
      J. Biol. Chem. 268:686-690(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9UJ19_HUMAN
    AccessioniPrimary (citable) accession number: Q9UJ19
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.