Reviewed, UniProtKB/Swiss-Prot Q9UJ14 (GGT7_HUMAN)

Names and origin

Protein names

Recommended name:
    Gamma-glutamyltransferase 7
    EC=2.3.2.2
Alternative name(s):
    Gamma-glutamyltranspeptidase 7
      Short name=GGT 7
    Gamma-glutamyltransferase-like 3
    Gamma-glutamyltransferase-like 5
Cleaved into the following 2 chains:
    1- Recommended name:
            Gamma-glutamyltransferase 7 heavy chain
    2- Recommended name:
            Gamma-glutamyltransferase 7 light chain

Gene names

Name:	GGT7
Synonyms:	GGTL3, GGTL5

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	662 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cleaves glutathione conjugates By similarity.
Catalytic activity	(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.
Pathway	Sulfur metabolism; glutathione metabolism.
Subunit structure	Heterodimer composed of the light and heavy chains. The active site is located in the light chain By similarity. Isoform 3 interacts with FAM57A.
Subcellular location	Membrane; Single-pass type II membrane protein By similarity.
Tissue specificity	Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.
Sequence similarities	Belongs to the gamma-glutamyltransferase family.

Ontologies

Keywords
Biological process	Glutathione biosynthesis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal-anchor Transmembrane
Molecular function	Acyltransferase Transferase
PTM	Glycoprotein Phosphoprotein Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glutathione biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW gamma-glutamyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UJ14-1)

Also known as: a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Gene prediction confirmed by EST data.

Isoform 2 (identifier: Q9UJ14-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.
     273-289: ARALAEQLPPNMSERFR → GQWGLGIWERHEVDGEG
     290-662: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9UJ14-5)

Also known as: GGTL3B; B;

The sequence of this isoform differs from the canonical sequence as follows:
     226-251: PGLLVGVPGMVKGLHEAHQLYGRLPW → VGTLVRRESSGESLFIALLLTQALIC
     252-662: Missing.

Isoform 4 (identifier: Q9UJ14-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-283: Missing.
     369-425: HLVLSPPPPH...LALASRLGDP → DLSPGSQGPP...QTRVSPPSEK
     426-662: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 472	472	Gamma-glutamyltransferase 7 heavy chain By similarity		PRO_0000011066
	Chain	473 – 662	190	Gamma-glutamyltransferase 7 light chain By similarity		PRO_0000011067
Regions
	Topological domain	1 – 106	106	Cytoplasmic Potential
	Transmembrane	107 – 127	21	Signal-anchor for type II membrane protein Potential
	Topological domain	128 – 662	535	Extracellular Potential
Amino acid modifications
	Modified residue	83	1	Phosphoserine By similarity
	Glycosylation	198	1	N-linked (GlcNAc...) Potential
	Glycosylation	267	1	N-linked (GlcNAc...) Potential
	Glycosylation	283	1	N-linked (GlcNAc...) Potential
	Glycosylation	330	1	N-linked (GlcNAc...) Potential
	Glycosylation	353	1	N-linked (GlcNAc...) Potential
	Glycosylation	394	1	N-linked (GlcNAc...) Potential
	Glycosylation	452	1	N-linked (GlcNAc...) Potential
	Glycosylation	519	1	N-linked (GlcNAc...) Potential
	Glycosylation	523	1	N-linked (GlcNAc...) Potential
	Glycosylation	586	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 283	283	Missing in isoform 4.		VSP_008133
	Alternative sequence	1 – 76	76	Missing in isoform 2.		VSP_008134
	Alternative sequence	226 – 251	26	PGLLV…GRLPW → VGTLVRRESSGESLFIALLL TQALIC in isoform 3.		VSP_008136
	Alternative sequence	252 – 662	411	Missing in isoform 3.		VSP_008137
	Alternative sequence	273 – 289	17	ARALA…SERFR → GQWGLGIWERHEVDGEG in isoform 2.		VSP_008138
	Alternative sequence	290 – 662	373	Missing in isoform 2.		VSP_008139
	Alternative sequence	369 – 425	57	HLVLS…RLGDP → DLSPGSQGPPSGEASQSMAT SFWPRDSSPFHRRETKAVSY LGSQLLKQTRVSPPSEK in isoform 4.		VSP_008140
	Alternative sequence	426 – 662	237	Missing in isoform 4.		VSP_008141
Experimental info
	Sequence conflict	5	1	N → K in AAN15928. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (a) [UniParc]. Last modified July 10, 2007. Version 2. Checksum: 29DDBC719CADD195	FASTA	662	70,467
	10 20 30 40 50 60 MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF LGDPDTDPDS 70 80 90 100 110 120 FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC SCRQDGLTVI VTACLTFATG 130 140 150 160 170 180 VTVALVMQIY FGDPQIFQQG AVVTDAARCT SLGIEVLSKQ GSSVDAAVAA ALCLGIVAPH 190 200 210 220 230 240 SSGLGGGGVM LVHDIRRNES HLIDFRESAP GALREETLQR SWETKPGLLV GVPGMVKGLH 250 260 270 280 290 300 EAHQLYGRLP WSQVLAFAAA VAQDGFNVTH DLARALAEQL PPNMSERFRE TFLPSGRPPL 310 320 330 340 350 360 PGSLLHRPDL AEVLDVLGTS GPAAFYAGGN LTLEMVAEAQ HAGGVITEED FSNYSALVEK 370 380 390 400 410 420 PVCGVYRGHL VLSPPPPHTG PALISALNIL EGFNLTSLVS REQALHWVAE TLKIALALAS 430 440 450 460 470 480 RLGDPVYDST ITESMDDMLS KVEAAYLRGH INDSQAAPAP LLPVYELDGA PTAAQVLIMG 490 500 510 520 530 540 PDDFIVAMVS SLNQPFGSGL ITPSGILLNS QMLDFSWPNR TANHSAPSLE NSVQPGKRPL 550 560 570 580 590 600 SFLLPTVVRP AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LARGRLHPDL 610 620 630 640 650 660 QSNLLQVDSE FTEEEIEFLE ARGHHVEKVD VLSWVHGSRR TNNFIIAVKD PRSPDAAGAT IL
	Isoform 2. Checksum: 830752C08248C1DA	FASTA	213	22,494
	10 20 30 40 50 60 MGSQDGSPLR ETRKDPFSAA AAECSCRQDG LTVIVTACLT FATGVTVALV MQIYFGDPQI 70 80 90 100 110 120 FQQGAVVTDA ARCTSLGIEV LSKQGSSVDA AVAAALCLGI VAPHSSGLGG GGVMLVHDIR 130 140 150 160 170 180 RNESHLIDFR ESAPGALREE TLQRSWETKP GLLVGVPGMV KGLHEAHQLY GRLPWSQVLA 190 200 210 FAAAVAQDGF NVTHDLGQWG LGIWERHEVD GEG
	Isoform 3 (GGTL3B) (B). Checksum: 3A8BBC5A2B81311C	FASTA	251	26,578
	10 20 30 40 50 60 MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF LGDPDTDPDS 70 80 90 100 110 120 FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC SCRQDGLTVI VTACLTFATG 130 140 150 160 170 180 VTVALVMQIY FGDPQIFQQG AVVTDAARCT SLGIEVLSKQ GSSVDAAVAA ALCLGIVAPH 190 200 210 220 230 240 SSGLGGGGVM LVHDIRRNES HLIDFRESAP GALREETLQR SWETKVGTLV RRESSGESLF 250 IALLLTQALI C
	Isoform 4. Checksum: 15B48378E9DCA3A5	FASTA	142	15,236
	10 20 30 40 50 60 MSERFRETFL PSGRPPLPGS LLHRPDLAEV LDVLGTSGPA AFYAGGNLTL EMVAEAQHAG 70 80 90 100 110 120 GVITEEDFSN YSALVEKPVC GVYRGDLSPG SQGPPSGEAS QSMATSFWPR DSSPFHRRET 130 140 KAVSYLGSQL LKQTRVSPPS EK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism." He X.H., Di Y., Li J., Xie Y., Tang Y., Zhang F., Wei L., Zhang Y., Qin W.X., Huo K., Li Y., Wan D.F., Gu J.R. Biochem. Biophys. Res. Commun. 297:528-536(2002) [PubMed: 12270127] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH FAM57A.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Spleen.
[3]	"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones." Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O. DNA Res. 10:49-57(2003) [PubMed: 12693554] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Spleen.
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The human gamma-glutamyltransferase gene family." Heisterkamp N., Groffen J., Warburton D., Sneddon T.P. Hum. Genet. 123:321-332(2008) [PubMed: 18357469] [Abstract] Cited for: NOMENCLATURE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY138815 mRNA. Translation: AAN15928.1. AK097100 mRNA. Translation: BAC04950.1. AK090413 mRNA. Translation: BAC03394.1. Different initiation. AL049709 Genomic DNA. Translation: CAB61787.2.
IPI	IPI00030634. IPI00167415. IPI00339302. IPI00339303.
RefSeq	NP_821158.2.
UniGene	Hs.433738
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UJ14.
Protein family/group databases
MEROPS	T03.017.
PTM databases
PhosphoSite	Q9UJ14.
Genome annotation databases
Ensembl	ENST00000253380; ENSP00000253380; ENSG00000131067; Homo sapiens. [Genome view] ENST00000336431; ENSP00000338964; ENSG00000131067; Homo sapiens. [Genome view] ENST00000356042; ENSP00000348326; ENSG00000131067; Homo sapiens. [Genome view] ENST00000427420; ENSP00000394993; ENSG00000131067; Homo sapiens. [Genome view] ENST00000429091; ENSP00000398600; ENSG00000131067; Homo sapiens. [Genome view] ENST00000439668; ENSP00000394448; ENSG00000131067; Homo sapiens. [Genome view] ENST00000457617; ENSP00000405466; ENSG00000131067; Homo sapiens. [Genome view]
GeneID	2686.
KEGG	hsa:2686.
UCSC	uc002xay.1. human. uc002xba.1. human.
Organism-specific databases
CTD	2686.
GeneCards	GC20M032897.
H-InvDB	HIX0015753.
HGNC	HGNC:4259. GGT7.
HPA	HPA013204.
MIM	612342. gene.
PharmGKB	PA28669.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9UJ14.
HOVERGEN	Q9UJ14.
OMA	CRQDGLT.
Enzyme and pathway databases
BRENDA	2.3.2.2. 247.
Gene expression databases
ArrayExpress	Q9UJ14.
Bgee	Q9UJ14.
CleanEx	HS_GGT7.
Genevestigator	Q9UJ14.
GermOnline	ENSG00000131067. Homo sapiens.
Family and domain databases
InterPro	IPR000101. GGT_peptidase. [Graphical view]
Pfam	PF01019. G_glu_transpept. 1 hit. [Graphical view]
PRINTS	PR01210. GGTRANSPTASE.
PROSITE	PS00462. G_GLU_TRANSPEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	10602.
SOURCE	Search...

Entry information

Entry name

GGT7_HUMAN

Accession

Primary (citable) accession number: Q9UJ14
Secondary accession number(s): Q8N899 , Q8NF66, Q9BYP5, Q9BYP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	July 10, 2007
Last modified:	November 3, 2009
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.