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Q9UJ14

- GGT7_HUMAN

UniProt

Q9UJ14 - GGT7_HUMAN

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Protein

Gamma-glutamyltransferase 7

Gene
GGT7, GGTL3, GGTL5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cleaves glutathione conjugates By similarity.

Catalytic activityi

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathwayi

GO - Molecular functioni

  1. gamma-glutamyltransferase activity Source: UniProtKB
  2. glutathione hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutathione biosynthetic process Source: UniProtKB-KW
  2. glutathione metabolic process Source: UniProtKB
  3. leukotriene biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Hydrolase, Transferase

Keywords - Biological processi

Glutathione biosynthesis

Enzyme and pathway databases

ReactomeiREACT_6960. Glutathione synthesis and recycling.
UniPathwayiUPA00204.

Protein family/group databases

MEROPSiT03.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyltransferase 7 (EC:2.3.2.2)
Short name:
GGT 7
Alternative name(s):
Gamma-glutamyltransferase-like 3
Gamma-glutamyltransferase-like 5
Gamma-glutamyltranspeptidase 7
Glutathione hydrolase 7 (EC:3.4.19.13)
Cleaved into the following 2 chains:
Gene namesi
Name:GGT7
Synonyms:GGTL3, GGTL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:4259. GGT7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 106106Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei107 – 12721Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini128 – 662535Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. anchored component of external side of plasma membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28669.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Gamma-glutamyltransferase 7 heavy chain By similarityPRO_0000011066Add
BLAST
Chaini473 – 662190Gamma-glutamyltransferase 7 light chain By similarityPRO_0000011067Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi198 – 1981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi267 – 2671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi283 – 2831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi330 – 3301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi353 – 3531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi394 – 3941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi452 – 4521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi519 – 5191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi523 – 5231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi586 – 5861N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ9UJ14.
PaxDbiQ9UJ14.
PRIDEiQ9UJ14.

PTM databases

PhosphoSiteiQ9UJ14.

Expressioni

Tissue specificityi

Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.

Gene expression databases

ArrayExpressiQ9UJ14.
BgeeiQ9UJ14.
CleanExiHS_GGT7.
GenevestigatoriQ9UJ14.

Organism-specific databases

HPAiHPA013204.

Interactioni

Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain By similarity. Isoform 3 interacts with FAM57A.1 Publication

Protein-protein interaction databases

BioGridi108953. 2 interactions.
IntActiQ9UJ14. 1 interaction.
STRINGi9606.ENSP00000338964.

Structurei

3D structure databases

ProteinModelPortaliQ9UJ14.
SMRiQ9UJ14. Positions 133-655.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0405.
HOGENOMiHOG000231793.
HOVERGENiHBG039468.
InParanoidiQ9UJ14.
KOiK00681.
OMAiMLVHDIR.
OrthoDBiEOG7DNNTR.
PhylomeDBiQ9UJ14.
TreeFamiTF333329.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UJ14-1) [UniParc]FASTAAdd to Basket

Also known as: a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF    50
LGDPDTDPDS FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC 100
SCRQDGLTVI VTACLTFATG VTVALVMQIY FGDPQIFQQG AVVTDAARCT 150
SLGIEVLSKQ GSSVDAAVAA ALCLGIVAPH SSGLGGGGVM LVHDIRRNES 200
HLIDFRESAP GALREETLQR SWETKPGLLV GVPGMVKGLH EAHQLYGRLP 250
WSQVLAFAAA VAQDGFNVTH DLARALAEQL PPNMSERFRE TFLPSGRPPL 300
PGSLLHRPDL AEVLDVLGTS GPAAFYAGGN LTLEMVAEAQ HAGGVITEED 350
FSNYSALVEK PVCGVYRGHL VLSPPPPHTG PALISALNIL EGFNLTSLVS 400
REQALHWVAE TLKIALALAS RLGDPVYDST ITESMDDMLS KVEAAYLRGH 450
INDSQAAPAP LLPVYELDGA PTAAQVLIMG PDDFIVAMVS SLNQPFGSGL 500
ITPSGILLNS QMLDFSWPNR TANHSAPSLE NSVQPGKRPL SFLLPTVVRP 550
AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LARGRLHPDL 600
QSNLLQVDSE FTEEEIEFLE ARGHHVEKVD VLSWVHGSRR TNNFIIAVKD 650
PRSPDAAGAT IL 662

Note: Gene prediction confirmed by EST data.

Length:662
Mass (Da):70,467
Last modified:July 10, 2007 - v2
Checksum:i29DDBC719CADD195
GO
Isoform 2 (identifier: Q9UJ14-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.
     273-289: ARALAEQLPPNMSERFR → GQWGLGIWERHEVDGEG
     290-662: Missing.

Note: No experimental confirmation available.

Show »
Length:213
Mass (Da):22,494
Checksum:i830752C08248C1DA
GO
Isoform 3 (identifier: Q9UJ14-5) [UniParc]FASTAAdd to Basket

Also known as: GGTL3B, B

The sequence of this isoform differs from the canonical sequence as follows:
     226-251: PGLLVGVPGMVKGLHEAHQLYGRLPW → VGTLVRRESSGESLFIALLLTQALIC
     252-662: Missing.

Show »
Length:251
Mass (Da):26,578
Checksum:i3A8BBC5A2B81311C
GO
Isoform 4 (identifier: Q9UJ14-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-283: Missing.
     369-425: HLVLSPPPPH...LALASRLGDP → DLSPGSQGPP...QTRVSPPSEK
     426-662: Missing.

Note: No experimental confirmation available.

Show »
Length:142
Mass (Da):15,236
Checksum:i15B48378E9DCA3A5
GO

Sequence cautioni

The sequence BAC03394.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 283283Missing in isoform 4. VSP_008133Add
BLAST
Alternative sequencei1 – 7676Missing in isoform 2. VSP_008134Add
BLAST
Alternative sequencei226 – 25126PGLLV…GRLPW → VGTLVRRESSGESLFIALLL TQALIC in isoform 3. VSP_008136Add
BLAST
Alternative sequencei252 – 662411Missing in isoform 3. VSP_008137Add
BLAST
Alternative sequencei273 – 28917ARALA…SERFR → GQWGLGIWERHEVDGEG in isoform 2. VSP_008138Add
BLAST
Alternative sequencei290 – 662373Missing in isoform 2. VSP_008139Add
BLAST
Alternative sequencei369 – 42557HLVLS…RLGDP → DLSPGSQGPPSGEASQSMAT SFWPRDSSPFHRRETKAVSY LGSQLLKQTRVSPPSEK in isoform 4. VSP_008140Add
BLAST
Alternative sequencei426 – 662237Missing in isoform 4. VSP_008141Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51N → K in AAN15928. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY138815 mRNA. Translation: AAN15928.1.
AK097100 mRNA. Translation: BAC04950.1.
AK090413 mRNA. Translation: BAC03394.1. Different initiation.
AL049709 Genomic DNA. Translation: CAB61787.2.
CCDSiCCDS13242.2. [Q9UJ14-1]
RefSeqiNP_821158.2. NM_178026.2. [Q9UJ14-1]
UniGeneiHs.433738.

Genome annotation databases

EnsembliENST00000336431; ENSP00000338964; ENSG00000131067. [Q9UJ14-1]
GeneIDi2686.
KEGGihsa:2686.
UCSCiuc002xay.3. human. [Q9UJ14-1]
uc002xba.1. human. [Q9UJ14-5]

Polymorphism databases

DMDMi152031612.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY138815 mRNA. Translation: AAN15928.1 .
AK097100 mRNA. Translation: BAC04950.1 .
AK090413 mRNA. Translation: BAC03394.1 . Different initiation.
AL049709 Genomic DNA. Translation: CAB61787.2 .
CCDSi CCDS13242.2. [Q9UJ14-1 ]
RefSeqi NP_821158.2. NM_178026.2. [Q9UJ14-1 ]
UniGenei Hs.433738.

3D structure databases

ProteinModelPortali Q9UJ14.
SMRi Q9UJ14. Positions 133-655.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108953. 2 interactions.
IntActi Q9UJ14. 1 interaction.
STRINGi 9606.ENSP00000338964.

Protein family/group databases

MEROPSi T03.017.

PTM databases

PhosphoSitei Q9UJ14.

Polymorphism databases

DMDMi 152031612.

Proteomic databases

MaxQBi Q9UJ14.
PaxDbi Q9UJ14.
PRIDEi Q9UJ14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336431 ; ENSP00000338964 ; ENSG00000131067 . [Q9UJ14-1 ]
GeneIDi 2686.
KEGGi hsa:2686.
UCSCi uc002xay.3. human. [Q9UJ14-1 ]
uc002xba.1. human. [Q9UJ14-5 ]

Organism-specific databases

CTDi 2686.
GeneCardsi GC20M033435.
H-InvDB HIX0203047.
HGNCi HGNC:4259. GGT7.
HPAi HPA013204.
MIMi 612342. gene.
neXtProti NX_Q9UJ14.
PharmGKBi PA28669.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0405.
HOGENOMi HOG000231793.
HOVERGENi HBG039468.
InParanoidi Q9UJ14.
KOi K00681.
OMAi MLVHDIR.
OrthoDBi EOG7DNNTR.
PhylomeDBi Q9UJ14.
TreeFami TF333329.

Enzyme and pathway databases

UniPathwayi UPA00204 .
Reactomei REACT_6960. Glutathione synthesis and recycling.

Miscellaneous databases

ChiTaRSi GGT7. human.
GeneWikii GGTL3.
GenomeRNAii 2686.
NextBioi 10602.
PROi Q9UJ14.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UJ14.
Bgeei Q9UJ14.
CleanExi HS_GGT7.
Genevestigatori Q9UJ14.

Family and domain databases

InterProi IPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view ]
PANTHERi PTHR11686. PTHR11686. 1 hit.
Pfami PF01019. G_glu_transpept. 1 hit.
[Graphical view ]
PRINTSi PR01210. GGTRANSPTASE.
SUPFAMi SSF56235. SSF56235. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism."
    He X.H., Di Y., Li J., Xie Y., Tang Y., Zhang F., Wei L., Zhang Y., Qin W.X., Huo K., Li Y., Wan D.F., Gu J.R.
    Biochem. Biophys. Res. Commun. 297:528-536(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH FAM57A.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  3. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Spleen.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NOMENCLATURE.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGGT7_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ14
Secondary accession number(s): Q8N899
, Q8NF66, Q9BYP5, Q9BYP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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