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Protein

Testis-specific Y-encoded-like protein 4

Gene

TSPYL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific Y-encoded-like protein 4
Short name:
TSPY-like protein 4
Gene namesi
Name:TSPYL4
Synonyms:KIAA0721
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21559. TSPYL4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134942080.

Polymorphism and mutation databases

BioMutaiTSPYL4.
DMDMi34098754.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Testis-specific Y-encoded-like protein 4PRO_0000185673Add
BLAST

Proteomic databases

MaxQBiQ9UJ04.
PaxDbiQ9UJ04.
PRIDEiQ9UJ04.

PTM databases

PhosphoSiteiQ9UJ04.

Expressioni

Gene expression databases

BgeeiQ9UJ04.
CleanExiHS_TSPYL4.
GenevisibleiQ9UJ04. HS.

Organism-specific databases

HPAiHPA044863.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK5RAP3Q96JB53EBI-308511,EBI-718818
NAP1L3Q8IYV13EBI-308511,EBI-10322170
PNMA1Q8ND903EBI-308511,EBI-302345
TFIP11Q9UBB93EBI-308511,EBI-1105213
TRIM38O006353EBI-308511,EBI-2130415

Protein-protein interaction databases

BioGridi116871. 15 interactions.
IntActiQ9UJ04. 11 interactions.
STRINGi9606.ENSP00000410943.

Structurei

3D structure databases

ProteinModelPortaliQ9UJ04.
SMRiQ9UJ04. Positions 204-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1508. Eukaryota.
ENOG410XQRX. LUCA.
GeneTreeiENSGT00530000062882.
HOVERGENiHBG014779.
InParanoidiQ9UJ04.
KOiK11287.
OMAiRWHRGQD.
OrthoDBiEOG79W957.
PhylomeDBiQ9UJ04.
TreeFamiTF313386.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UJ04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLDGGNKL PLAQTGGLAA PDHASGDPDR DQCQGLREET EATQVMANTG
60 70 80 90 100
GGSLETVAEG GASQDPVDCG PALRVPVAGS RGGAATKAGQ EDAPPSTKGL
110 120 130 140 150
EAASAAEAAD SSQKNGCQLG EPRGPAGQKA LEACGAGGLG SQMIPGKKAK
160 170 180 190 200
EVTTKKRAIS AAVEKEGEAG AAMEEKKVVQ KEKKVAGGVK EETRPRAPKI
210 220 230 240 250
NNCMDSLEAI DQELSNVNAQ ADRAFLQLER KFGRMRRLHM QRRSFIIQNI
260 270 280 290 300
PGFWVTAFRN HPQLSPMISG QDEDMLRYMI NLEVEELKHP RAGCKFKFIF
310 320 330 340 350
QGNPYFRNEG LVKEYERRSS GRVVSLSTPI RWHRGQDPQA HIHRNREGNT
360 370 380 390 400
IPSFFNWFSD HSLLEFDRIA EIIKGELWPN PLQYYLMGEG PRRGIRGPPR
410
QPVESARSFR FQSG
Length:414
Mass (Da):45,126
Last modified:August 15, 2003 - v2
Checksum:iCD841DA3FEFC445E
GO

Sequence cautioni

The sequence BAA34441.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301R → L.
Corresponds to variant rs2232470 [ dbSNP | Ensembl ].
VAR_050228

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018264 mRNA. Translation: BAA34441.1. Different initiation.
AK302542 mRNA. Translation: BAG63814.1.
AL050331 Genomic DNA. No translation available.
BC009116 mRNA. Translation: AAH09116.2.
CCDSiCCDS5106.1.
RefSeqiNP_067680.3. NM_021648.4.
UniGeneiHs.284141.

Genome annotation databases

EnsembliENST00000420283; ENSP00000410943; ENSG00000187189.
GeneIDi23270.
KEGGihsa:23270.
UCSCiuc003pwn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018264 mRNA. Translation: BAA34441.1. Different initiation.
AK302542 mRNA. Translation: BAG63814.1.
AL050331 Genomic DNA. No translation available.
BC009116 mRNA. Translation: AAH09116.2.
CCDSiCCDS5106.1.
RefSeqiNP_067680.3. NM_021648.4.
UniGeneiHs.284141.

3D structure databases

ProteinModelPortaliQ9UJ04.
SMRiQ9UJ04. Positions 204-387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116871. 15 interactions.
IntActiQ9UJ04. 11 interactions.
STRINGi9606.ENSP00000410943.

PTM databases

PhosphoSiteiQ9UJ04.

Polymorphism and mutation databases

BioMutaiTSPYL4.
DMDMi34098754.

Proteomic databases

MaxQBiQ9UJ04.
PaxDbiQ9UJ04.
PRIDEiQ9UJ04.

Protocols and materials databases

DNASUi23270.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420283; ENSP00000410943; ENSG00000187189.
GeneIDi23270.
KEGGihsa:23270.
UCSCiuc003pwn.4. human.

Organism-specific databases

CTDi23270.
GeneCardsiTSPYL4.
HGNCiHGNC:21559. TSPYL4.
HPAiHPA044863.
neXtProtiNX_Q9UJ04.
PharmGKBiPA134942080.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1508. Eukaryota.
ENOG410XQRX. LUCA.
GeneTreeiENSGT00530000062882.
HOVERGENiHBG014779.
InParanoidiQ9UJ04.
KOiK11287.
OMAiRWHRGQD.
OrthoDBiEOG79W957.
PhylomeDBiQ9UJ04.
TreeFamiTF313386.

Miscellaneous databases

GenomeRNAii23270.
NextBioi45038.
PROiQ9UJ04.

Gene expression databases

BgeeiQ9UJ04.
CleanExiHS_TSPYL4.
GenevisibleiQ9UJ04. HS.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-414.
    Tissue: Brain.

Entry informationi

Entry nameiTSYL4_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ04
Secondary accession number(s): B4DYQ2, O94828, Q96GW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: March 16, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.