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Protein

Testis-specific Y-encoded-like protein 4

Gene

TSPYL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific Y-encoded-like protein 4
Short name:
TSPY-like protein 4
Gene namesi
Name:TSPYL4
Synonyms:KIAA0721
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000187189.10
HGNCiHGNC:21559 TSPYL4
neXtProtiNX_Q9UJ04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi23270
OpenTargetsiENSG00000187189
PharmGKBiPA134942080

Polymorphism and mutation databases

BioMutaiTSPYL4
DMDMi34098754

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001856731 – 414Testis-specific Y-encoded-like protein 4Add BLAST414

Proteomic databases

EPDiQ9UJ04
MaxQBiQ9UJ04
PaxDbiQ9UJ04
PeptideAtlasiQ9UJ04
PRIDEiQ9UJ04
ProteomicsDBi84577

PTM databases

iPTMnetiQ9UJ04
PhosphoSitePlusiQ9UJ04

Expressioni

Gene expression databases

BgeeiENSG00000187189
CleanExiHS_TSPYL4
GenevisibleiQ9UJ04 HS

Organism-specific databases

HPAiHPA044863

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116871, 17 interactors
IntActiQ9UJ04, 15 interactors
MINTiQ9UJ04
STRINGi9606.ENSP00000410943

Structurei

3D structure databases

ProteinModelPortaliQ9UJ04
SMRiQ9UJ04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1508 Eukaryota
ENOG410XQRX LUCA
GeneTreeiENSGT00530000062882
HOVERGENiHBG014779
InParanoidiQ9UJ04
KOiK11287
OMAiRWHRGQD
OrthoDBiEOG091G00YT
PhylomeDBiQ9UJ04
TreeFamiTF313386

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UJ04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLDGGNKL PLAQTGGLAA PDHASGDPDR DQCQGLREET EATQVMANTG
60 70 80 90 100
GGSLETVAEG GASQDPVDCG PALRVPVAGS RGGAATKAGQ EDAPPSTKGL
110 120 130 140 150
EAASAAEAAD SSQKNGCQLG EPRGPAGQKA LEACGAGGLG SQMIPGKKAK
160 170 180 190 200
EVTTKKRAIS AAVEKEGEAG AAMEEKKVVQ KEKKVAGGVK EETRPRAPKI
210 220 230 240 250
NNCMDSLEAI DQELSNVNAQ ADRAFLQLER KFGRMRRLHM QRRSFIIQNI
260 270 280 290 300
PGFWVTAFRN HPQLSPMISG QDEDMLRYMI NLEVEELKHP RAGCKFKFIF
310 320 330 340 350
QGNPYFRNEG LVKEYERRSS GRVVSLSTPI RWHRGQDPQA HIHRNREGNT
360 370 380 390 400
IPSFFNWFSD HSLLEFDRIA EIIKGELWPN PLQYYLMGEG PRRGIRGPPR
410
QPVESARSFR FQSG
Length:414
Mass (Da):45,126
Last modified:August 15, 2003 - v2
Checksum:iCD841DA3FEFC445E
GO

Sequence cautioni

The sequence BAA34441 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05022830R → L. Corresponds to variant dbSNP:rs2232470Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018264 mRNA Translation: BAA34441.1 Different initiation.
AK302542 mRNA Translation: BAG63814.1
AL050331 Genomic DNA No translation available.
BC009116 mRNA Translation: AAH09116.2
CCDSiCCDS5106.1
RefSeqiNP_067680.3, NM_021648.4
UniGeneiHs.284141

Genome annotation databases

EnsembliENST00000420283; ENSP00000410943; ENSG00000187189
GeneIDi23270
KEGGihsa:23270
UCSCiuc003pwn.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTSYL4_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ04
Secondary accession number(s): B4DYQ2, O94828, Q96GW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: June 20, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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