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Protein

RWD domain-containing protein 2A

Gene

RWDD2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RWD domain-containing protein 2A
Gene namesi
Name:RWDD2A
Synonyms:RWDD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000013392.7
HGNCiHGNC:21385 RWDD2A
neXtProtiNX_Q9UIY3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000013392
PharmGKBiPA162402307

Polymorphism and mutation databases

BioMutaiRWDD2A
DMDMi9979483

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975431 – 292RWD domain-containing protein 2AAdd BLAST292

Proteomic databases

EPDiQ9UIY3
PaxDbiQ9UIY3
PeptideAtlasiQ9UIY3
PRIDEiQ9UIY3

PTM databases

iPTMnetiQ9UIY3
PhosphoSitePlusiQ9UIY3

Expressioni

Gene expression databases

BgeeiENSG00000013392
CleanExiHS_RWDD2A
GenevisibleiQ9UIY3 HS

Organism-specific databases

HPAiHPA030105
HPA030106
HPA030107

Interactioni

Protein-protein interaction databases

BioGridi125196, 2 interactors
STRINGi9606.ENSP00000358739

Structurei

Secondary structure

1292
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 22Combined sources18
Beta strandi28 – 32Combined sources5
Helixi34 – 36Combined sources3
Helixi38 – 45Combined sources8
Beta strandi55 – 63Combined sources9
Turni64 – 67Combined sources4
Beta strandi68 – 76Combined sources9
Beta strandi86 – 90Combined sources5
Beta strandi92 – 94Combined sources3
Helixi96 – 110Combined sources15
Helixi120 – 129Combined sources10
Helixi132 – 135Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DAWNMR-A1-141[»]
ProteinModelPortaliQ9UIY3
SMRiQ9UIY3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UIY3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 134RWDPROSITE-ProRule annotationAdd BLAST121

Phylogenomic databases

eggNOGiENOG410IKH2 Eukaryota
ENOG410Y76V LUCA
GeneTreeiENSGT00390000007224
HOGENOMiHOG000007195
HOVERGENiHBG051223
InParanoidiQ9UIY3
OMAiYSHHIYR
OrthoDBiEOG091G0E9W
PhylomeDBiQ9UIY3
TreeFamiTF324344

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR010541 DUF1115
IPR006575 RWD-domain
IPR016135 UBQ-conjugating_enzyme/RWD
IPR017359 UCP038021_RWD
PANTHERiPTHR15955 PTHR15955, 1 hit
PfamiView protein in Pfam
PF06544 DUF1115, 1 hit
PF05773 RWD, 1 hit
PIRSFiPIRSF038021 UCP038021_RWDD2, 1 hit
SMARTiView protein in SMART
SM00591 RWD, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50908 RWD, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UIY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASVKESLQ LQLLEMEMLF SMFPNQGEVK LEDVNALTNI KRYLEGTREA
60 70 80 90 100
LPPKIEFVIT LQIEEPKVKI DLQVTMPHSY PYVALQLFGR SSELDRHQQL
110 120 130 140 150
LLNKGLTSYI GTFDPGELCV CAAIQWLQDN SASYFLNRKL VYEPSTQAKP
160 170 180 190 200
VKNTFLRMWI YSHHIYQQDL RKKILDVGKR LDVTGFCMTG KPGIICVEGF
210 220 230 240 250
KEHCEEFWHT IRYPNWKHIS CKHAESVETE GNGEDLRLFH SFEELLLEAH
260 270 280 290
GDYGLRNDYH MNLGQFLEFL KKHKSEHVFQ ILFGIESKSS DS
Length:292
Mass (Da):33,893
Last modified:May 1, 2000 - v1
Checksum:i00669FA229F0D487
GO
Isoform 2 (identifier: Q9UIY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MSASVKESLQ...FVITLQIEEP → MLWYLNLFDFHF

Note: No experimental confirmation available.
Show »
Length:238
Mass (Da):27,957
Checksum:i92BB04B25813B52A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83V → L in AAH10930 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555041 – 66MSASV…QIEEP → MLWYLNLFDFHF in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295724 mRNA Translation: BAG58565.1
AL049699 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48665.1
CH471051 Genomic DNA Translation: EAW48666.1
BC010930 mRNA Translation: AAH10930.1
BC104816 mRNA Translation: AAI04817.1
BC112003 mRNA Translation: AAI12004.1
CCDSiCCDS4998.1 [Q9UIY3-1]
RefSeqiNP_001309264.1, NM_001322335.1
NP_001309265.1, NM_001322336.1
NP_001309266.1, NM_001322337.1
NP_001309268.1, NM_001322339.1
NP_219479.2, NM_033411.4 [Q9UIY3-1]
UniGeneiHs.423336
Hs.709686

Genome annotation databases

EnsembliENST00000369724; ENSP00000358739; ENSG00000013392 [Q9UIY3-1]
GeneIDi112611
KEGGihsa:112611
UCSCiuc003pjx.5 human [Q9UIY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRWD2A_HUMAN
AccessioniPrimary (citable) accession number: Q9UIY3
Secondary accession number(s): B4DIQ3
, E1P548, Q2M3R3, Q96FH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health