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Protein

RWD domain-containing protein 2A

Gene

RWDD2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000013392-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RWD domain-containing protein 2A
Gene namesi
Name:RWDD2A
Synonyms:RWDD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21385. RWDD2A.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000013392.
PharmGKBiPA162402307.

Polymorphism and mutation databases

BioMutaiRWDD2A.
DMDMi9979483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975431 – 292RWD domain-containing protein 2AAdd BLAST292

Proteomic databases

EPDiQ9UIY3.
PaxDbiQ9UIY3.
PeptideAtlasiQ9UIY3.
PRIDEiQ9UIY3.

PTM databases

iPTMnetiQ9UIY3.
PhosphoSitePlusiQ9UIY3.

Expressioni

Gene expression databases

BgeeiENSG00000013392.
CleanExiHS_RWDD2A.
GenevisibleiQ9UIY3. HS.

Organism-specific databases

HPAiHPA030105.
HPA030106.
HPA030107.

Interactioni

Protein-protein interaction databases

BioGridi125196. 2 interactors.

Structurei

Secondary structure

1292
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 22Combined sources18
Beta strandi28 – 32Combined sources5
Helixi34 – 36Combined sources3
Helixi38 – 45Combined sources8
Beta strandi55 – 63Combined sources9
Turni64 – 67Combined sources4
Beta strandi68 – 76Combined sources9
Beta strandi86 – 90Combined sources5
Beta strandi92 – 94Combined sources3
Helixi96 – 110Combined sources15
Helixi120 – 129Combined sources10
Helixi132 – 135Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DAWNMR-A1-141[»]
ProteinModelPortaliQ9UIY3.
SMRiQ9UIY3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UIY3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 134RWDPROSITE-ProRule annotationAdd BLAST121

Sequence similaritiesi

Contains 1 RWD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKH2. Eukaryota.
ENOG410Y76V. LUCA.
GeneTreeiENSGT00390000007224.
HOGENOMiHOG000007195.
HOVERGENiHBG051223.
InParanoidiQ9UIY3.
OMAiKECLQLQ.
OrthoDBiEOG091G0E9W.
PhylomeDBiQ9UIY3.
TreeFamiTF324344.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR010541. DUF1115.
IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR017359. UCP038021_RWD.
[Graphical view]
PANTHERiPTHR15955. PTHR15955. 1 hit.
PfamiPF06544. DUF1115. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
PIRSFiPIRSF038021. UCP038021_RWDD2. 1 hit.
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UIY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASVKESLQ LQLLEMEMLF SMFPNQGEVK LEDVNALTNI KRYLEGTREA
60 70 80 90 100
LPPKIEFVIT LQIEEPKVKI DLQVTMPHSY PYVALQLFGR SSELDRHQQL
110 120 130 140 150
LLNKGLTSYI GTFDPGELCV CAAIQWLQDN SASYFLNRKL VYEPSTQAKP
160 170 180 190 200
VKNTFLRMWI YSHHIYQQDL RKKILDVGKR LDVTGFCMTG KPGIICVEGF
210 220 230 240 250
KEHCEEFWHT IRYPNWKHIS CKHAESVETE GNGEDLRLFH SFEELLLEAH
260 270 280 290
GDYGLRNDYH MNLGQFLEFL KKHKSEHVFQ ILFGIESKSS DS
Length:292
Mass (Da):33,893
Last modified:May 1, 2000 - v1
Checksum:i00669FA229F0D487
GO
Isoform 2 (identifier: Q9UIY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MSASVKESLQ...FVITLQIEEP → MLWYLNLFDFHF

Note: No experimental confirmation available.
Show »
Length:238
Mass (Da):27,957
Checksum:i92BB04B25813B52A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83V → L in AAH10930 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555041 – 66MSASV…QIEEP → MLWYLNLFDFHF in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295724 mRNA. Translation: BAG58565.1.
AL049699 Genomic DNA. Translation: CAB52345.1.
CH471051 Genomic DNA. Translation: EAW48665.1.
CH471051 Genomic DNA. Translation: EAW48666.1.
BC010930 mRNA. Translation: AAH10930.1.
BC104816 mRNA. Translation: AAI04817.1.
BC112003 mRNA. Translation: AAI12004.1.
CCDSiCCDS4998.1. [Q9UIY3-1]
RefSeqiNP_001309264.1. NM_001322335.1.
NP_001309265.1. NM_001322336.1.
NP_001309266.1. NM_001322337.1.
NP_001309268.1. NM_001322339.1.
NP_219479.2. NM_033411.4. [Q9UIY3-1]
UniGeneiHs.423336.
Hs.709686.

Genome annotation databases

EnsembliENST00000369724; ENSP00000358739; ENSG00000013392. [Q9UIY3-1]
GeneIDi112611.
KEGGihsa:112611.
UCSCiuc003pjx.5. human. [Q9UIY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295724 mRNA. Translation: BAG58565.1.
AL049699 Genomic DNA. Translation: CAB52345.1.
CH471051 Genomic DNA. Translation: EAW48665.1.
CH471051 Genomic DNA. Translation: EAW48666.1.
BC010930 mRNA. Translation: AAH10930.1.
BC104816 mRNA. Translation: AAI04817.1.
BC112003 mRNA. Translation: AAI12004.1.
CCDSiCCDS4998.1. [Q9UIY3-1]
RefSeqiNP_001309264.1. NM_001322335.1.
NP_001309265.1. NM_001322336.1.
NP_001309266.1. NM_001322337.1.
NP_001309268.1. NM_001322339.1.
NP_219479.2. NM_033411.4. [Q9UIY3-1]
UniGeneiHs.423336.
Hs.709686.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DAWNMR-A1-141[»]
ProteinModelPortaliQ9UIY3.
SMRiQ9UIY3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125196. 2 interactors.

PTM databases

iPTMnetiQ9UIY3.
PhosphoSitePlusiQ9UIY3.

Polymorphism and mutation databases

BioMutaiRWDD2A.
DMDMi9979483.

Proteomic databases

EPDiQ9UIY3.
PaxDbiQ9UIY3.
PeptideAtlasiQ9UIY3.
PRIDEiQ9UIY3.

Protocols and materials databases

DNASUi112611.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369724; ENSP00000358739; ENSG00000013392. [Q9UIY3-1]
GeneIDi112611.
KEGGihsa:112611.
UCSCiuc003pjx.5. human. [Q9UIY3-1]

Organism-specific databases

CTDi112611.
GeneCardsiRWDD2A.
HGNCiHGNC:21385. RWDD2A.
HPAiHPA030105.
HPA030106.
HPA030107.
neXtProtiNX_Q9UIY3.
OpenTargetsiENSG00000013392.
PharmGKBiPA162402307.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKH2. Eukaryota.
ENOG410Y76V. LUCA.
GeneTreeiENSGT00390000007224.
HOGENOMiHOG000007195.
HOVERGENiHBG051223.
InParanoidiQ9UIY3.
OMAiKECLQLQ.
OrthoDBiEOG091G0E9W.
PhylomeDBiQ9UIY3.
TreeFamiTF324344.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000013392-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9UIY3.
GenomeRNAii112611.
PROiQ9UIY3.

Gene expression databases

BgeeiENSG00000013392.
CleanExiHS_RWDD2A.
GenevisibleiQ9UIY3. HS.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR010541. DUF1115.
IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR017359. UCP038021_RWD.
[Graphical view]
PANTHERiPTHR15955. PTHR15955. 1 hit.
PfamiPF06544. DUF1115. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
PIRSFiPIRSF038021. UCP038021_RWDD2. 1 hit.
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRWD2A_HUMAN
AccessioniPrimary (citable) accession number: Q9UIY3
Secondary accession number(s): B4DIQ3
, E1P548, Q2M3R3, Q96FH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.