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Protein

RWD domain-containing protein 2A

Gene

RWDD2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RWD domain-containing protein 2A
Gene namesi
Name:RWDD2A
Synonyms:RWDD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21385. RWDD2A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402307.

Polymorphism and mutation databases

BioMutaiRWDD2A.
DMDMi9979483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292RWD domain-containing protein 2APRO_0000097543Add
BLAST

Proteomic databases

MaxQBiQ9UIY3.
PaxDbiQ9UIY3.
PRIDEiQ9UIY3.

PTM databases

PhosphoSiteiQ9UIY3.

Expressioni

Gene expression databases

BgeeiQ9UIY3.
CleanExiHS_RWDD2A.
GenevisibleiQ9UIY3. HS.

Organism-specific databases

HPAiHPA030105.
HPA030106.
HPA030107.

Interactioni

Protein-protein interaction databases

BioGridi125196. 2 interactions.

Structurei

Secondary structure

1
292
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 2218Combined sources
Beta strandi28 – 325Combined sources
Helixi34 – 363Combined sources
Helixi38 – 458Combined sources
Beta strandi55 – 639Combined sources
Turni64 – 674Combined sources
Beta strandi68 – 769Combined sources
Beta strandi86 – 905Combined sources
Beta strandi92 – 943Combined sources
Helixi96 – 11015Combined sources
Helixi120 – 12910Combined sources
Helixi132 – 1354Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DAWNMR-A1-141[»]
ProteinModelPortaliQ9UIY3.
SMRiQ9UIY3. Positions 5-146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UIY3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 134121RWDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RWD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKH2. Eukaryota.
ENOG410Y76V. LUCA.
GeneTreeiENSGT00390000007224.
HOGENOMiHOG000007195.
HOVERGENiHBG051223.
InParanoidiQ9UIY3.
OMAiKECLQLQ.
OrthoDBiEOG71G9VN.
PhylomeDBiQ9UIY3.
TreeFamiTF324344.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR010541. DUF1115.
IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR017359. UCP038021_RWD.
[Graphical view]
PANTHERiPTHR15955. PTHR15955. 1 hit.
PfamiPF06544. DUF1115. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
PIRSFiPIRSF038021. UCP038021_RWDD2. 1 hit.
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UIY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASVKESLQ LQLLEMEMLF SMFPNQGEVK LEDVNALTNI KRYLEGTREA
60 70 80 90 100
LPPKIEFVIT LQIEEPKVKI DLQVTMPHSY PYVALQLFGR SSELDRHQQL
110 120 130 140 150
LLNKGLTSYI GTFDPGELCV CAAIQWLQDN SASYFLNRKL VYEPSTQAKP
160 170 180 190 200
VKNTFLRMWI YSHHIYQQDL RKKILDVGKR LDVTGFCMTG KPGIICVEGF
210 220 230 240 250
KEHCEEFWHT IRYPNWKHIS CKHAESVETE GNGEDLRLFH SFEELLLEAH
260 270 280 290
GDYGLRNDYH MNLGQFLEFL KKHKSEHVFQ ILFGIESKSS DS
Length:292
Mass (Da):33,893
Last modified:May 1, 2000 - v1
Checksum:i00669FA229F0D487
GO
Isoform 2 (identifier: Q9UIY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MSASVKESLQ...FVITLQIEEP → MLWYLNLFDFHF

Note: No experimental confirmation available.
Show »
Length:238
Mass (Da):27,957
Checksum:i92BB04B25813B52A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831V → L in AAH10930 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6666MSASV…QIEEP → MLWYLNLFDFHF in isoform 2. 1 PublicationVSP_055504Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295724 mRNA. Translation: BAG58565.1.
AL049699 Genomic DNA. Translation: CAB52345.1.
CH471051 Genomic DNA. Translation: EAW48665.1.
CH471051 Genomic DNA. Translation: EAW48666.1.
BC010930 mRNA. Translation: AAH10930.1.
BC104816 mRNA. Translation: AAI04817.1.
BC112003 mRNA. Translation: AAI12004.1.
CCDSiCCDS4998.1. [Q9UIY3-1]
RefSeqiNP_219479.2. NM_033411.3. [Q9UIY3-1]
XP_011533706.1. XM_011535404.1. [Q9UIY3-1]
UniGeneiHs.423336.
Hs.709686.

Genome annotation databases

EnsembliENST00000369724; ENSP00000358739; ENSG00000013392. [Q9UIY3-1]
GeneIDi112611.
KEGGihsa:112611.
UCSCiuc003pjx.5. human. [Q9UIY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295724 mRNA. Translation: BAG58565.1.
AL049699 Genomic DNA. Translation: CAB52345.1.
CH471051 Genomic DNA. Translation: EAW48665.1.
CH471051 Genomic DNA. Translation: EAW48666.1.
BC010930 mRNA. Translation: AAH10930.1.
BC104816 mRNA. Translation: AAI04817.1.
BC112003 mRNA. Translation: AAI12004.1.
CCDSiCCDS4998.1. [Q9UIY3-1]
RefSeqiNP_219479.2. NM_033411.3. [Q9UIY3-1]
XP_011533706.1. XM_011535404.1. [Q9UIY3-1]
UniGeneiHs.423336.
Hs.709686.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DAWNMR-A1-141[»]
ProteinModelPortaliQ9UIY3.
SMRiQ9UIY3. Positions 5-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125196. 2 interactions.

PTM databases

PhosphoSiteiQ9UIY3.

Polymorphism and mutation databases

BioMutaiRWDD2A.
DMDMi9979483.

Proteomic databases

MaxQBiQ9UIY3.
PaxDbiQ9UIY3.
PRIDEiQ9UIY3.

Protocols and materials databases

DNASUi112611.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369724; ENSP00000358739; ENSG00000013392. [Q9UIY3-1]
GeneIDi112611.
KEGGihsa:112611.
UCSCiuc003pjx.5. human. [Q9UIY3-1]

Organism-specific databases

CTDi112611.
GeneCardsiRWDD2A.
HGNCiHGNC:21385. RWDD2A.
HPAiHPA030105.
HPA030106.
HPA030107.
neXtProtiNX_Q9UIY3.
PharmGKBiPA162402307.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKH2. Eukaryota.
ENOG410Y76V. LUCA.
GeneTreeiENSGT00390000007224.
HOGENOMiHOG000007195.
HOVERGENiHBG051223.
InParanoidiQ9UIY3.
OMAiKECLQLQ.
OrthoDBiEOG71G9VN.
PhylomeDBiQ9UIY3.
TreeFamiTF324344.

Miscellaneous databases

EvolutionaryTraceiQ9UIY3.
GenomeRNAii112611.
NextBioi35472331.
PROiQ9UIY3.

Gene expression databases

BgeeiQ9UIY3.
CleanExiHS_RWDD2A.
GenevisibleiQ9UIY3. HS.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR010541. DUF1115.
IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR017359. UCP038021_RWD.
[Graphical view]
PANTHERiPTHR15955. PTHR15955. 1 hit.
PfamiPF06544. DUF1115. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
PIRSFiPIRSF038021. UCP038021_RWDD2. 1 hit.
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hippocampus.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow and Liver.
  5. "Solution structure of the RWD domain of human RWD domain containing protein 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-141.

Entry informationi

Entry nameiRWD2A_HUMAN
AccessioniPrimary (citable) accession number: Q9UIY3
Secondary accession number(s): B4DIQ3
, E1P548, Q2M3R3, Q96FH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: March 16, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.