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Q9UIX4

- KCNG1_HUMAN

UniProt

Q9UIX4 - KCNG1_HUMAN

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Protein

Potassium voltage-gated channel subfamily G member 1

Gene

KCNG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. potassium channel activity Source: UniProtKB

GO - Biological processi

  1. potassium ion transport Source: UniProtKB
  2. protein homooligomerization Source: InterPro
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv6.1
kH2
Gene namesi
Name:KCNG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:6248. KCNG1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 227227CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei228 – 24821Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei268 – 28821Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini289 – 30214CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei303 – 32321Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei343 – 36321Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini364 – 37613CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei377 – 39721Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Intramembranei412 – 43221Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Transmembranei440 – 46021Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini461 – 51353CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: HPA
  2. plasma membrane Source: Reactome
  3. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Potassium voltage-gated channel subfamily G member 1PRO_0000054073Add
BLAST

Proteomic databases

PaxDbiQ9UIX4.
PRIDEiQ9UIX4.

PTM databases

PhosphoSiteiQ9UIX4.

Expressioni

Tissue specificityi

Detected in brain and placenta, and at much lower levels in kidney and pancreas.

Gene expression databases

BgeeiQ9UIX4.
CleanExiHS_KCNG1.
ExpressionAtlasiQ9UIX4. baseline and differential.
GenevestigatoriQ9UIX4.

Organism-specific databases

HPAiHPA039530.
HPA040024.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins.By similarity

Protein-protein interaction databases

BioGridi109957. 4 interactions.
IntActiQ9UIX4. 1 interaction.
STRINGi9606.ENSP00000360626.

Structurei

3D structure databases

ProteinModelPortaliQ9UIX4.
SMRiQ9UIX4. Positions 64-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi424 – 4296Selectivity filterBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi61 – 644Poly-Arg
Compositional biasi254 – 2574Poly-Glu

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ9UIX4.
KOiK04900.
OMAiGQCSQMC.
OrthoDBiEOG7K9K2K.
PhylomeDBiQ9UIX4.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UIX4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD
60 70 80 90 100
EPRQGCQPED RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD
110 120 130 140 150
ILNVCDDYDV TCNEFFFDRN PGAFGTILTF LRAGKLRLLR EMCALSFQEE
160 170 180 190 200
LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV EREEEDDALD SEGRDSEGPA
210 220 230 240 250
EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT AVNLSVSTLP
260 270 280 290 300
SLREEEEQGH CSQMCHNVFI VESVCVGWFS LEFLLRLIQA PSKFAFLRSP
310 320 330 340 350
LTLIDLVAIL PYYITLLVDG AAAGRRKPGA GNSYLDKVGL VLRVLRALRI
360 370 380 390 400
LYVMRLARHS LGLQTLGLTA RRCTREFGLL LLFLCVAIAL FAPLLYVIEN
410 420 430 440 450
EMADSPEFTS IPACYWWAVI TMTTVGYGDM VPRSTPGQVV ALSSILSGIL
460 470 480 490 500
LMAFPVTSIF HTFSRSYLEL KQEQERVMFR RAQFLIKTKS QLSVSQDSDI
510
LFGSASSDTR DNN
Length:513
Mass (Da):57,913
Last modified:May 1, 2000 - v1
Checksum:iA002F1C0EF2FBDC5
GO
Isoform 2 (identifier: Q9UIX4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-275: GHCSQMCHNVFIVESVC → VRAHAPRGNAPPRGKGL
     276-513: Missing.

Note: No experimental confirmation available.

Show »
Length:275
Mass (Da):31,229
Checksum:i7570073D8D1A5B2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti426 – 4261G → D in AAC05635. (PubMed:9434767)Curated
Sequence conflicti465 – 4651R → P in AAC05635. (PubMed:9434767)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti304 – 3041I → M.
Corresponds to variant rs17791052 [ dbSNP | Ensembl ].
VAR_053860

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei259 – 27517GHCSQ…VESVC → VRAHAPRGNAPPRGKGL in isoform 2. 1 PublicationVSP_001024Add
BLAST
Alternative sequencei276 – 513238Missing in isoform 2. 1 PublicationVSP_001025Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033383 mRNA. Translation: AAC05635.1.
AK290689 mRNA. Translation: BAF83378.1.
AL050404 Genomic DNA. Translation: CAB51753.1.
AL050404 Genomic DNA. Translation: CAI23445.1.
AL121785 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75605.1.
BC006367 mRNA. Translation: AAH06367.1.
CCDSiCCDS13436.1. [Q9UIX4-1]
PIRiJC5920.
RefSeqiNP_002228.2. NM_002237.3. [Q9UIX4-1]
XP_006723848.1. XM_006723785.1. [Q9UIX4-1]
XP_006723849.1. XM_006723786.1. [Q9UIX4-2]
UniGeneiHs.118695.
Hs.735151.

Genome annotation databases

EnsembliENST00000371571; ENSP00000360626; ENSG00000026559. [Q9UIX4-1]
GeneIDi3755.
KEGGihsa:3755.
UCSCiuc002xwa.4. human. [Q9UIX4-1]
uc002xwb.3. human. [Q9UIX4-2]

Polymorphism databases

DMDMi24418479.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033383 mRNA. Translation: AAC05635.1 .
AK290689 mRNA. Translation: BAF83378.1 .
AL050404 Genomic DNA. Translation: CAB51753.1 .
AL050404 Genomic DNA. Translation: CAI23445.1 .
AL121785 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75605.1 .
BC006367 mRNA. Translation: AAH06367.1 .
CCDSi CCDS13436.1. [Q9UIX4-1 ]
PIRi JC5920.
RefSeqi NP_002228.2. NM_002237.3. [Q9UIX4-1 ]
XP_006723848.1. XM_006723785.1. [Q9UIX4-1 ]
XP_006723849.1. XM_006723786.1. [Q9UIX4-2 ]
UniGenei Hs.118695.
Hs.735151.

3D structure databases

ProteinModelPortali Q9UIX4.
SMRi Q9UIX4. Positions 64-467.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109957. 4 interactions.
IntActi Q9UIX4. 1 interaction.
STRINGi 9606.ENSP00000360626.

Chemistry

ChEMBLi CHEMBL2362996.

PTM databases

PhosphoSitei Q9UIX4.

Polymorphism databases

DMDMi 24418479.

Proteomic databases

PaxDbi Q9UIX4.
PRIDEi Q9UIX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371571 ; ENSP00000360626 ; ENSG00000026559 . [Q9UIX4-1 ]
GeneIDi 3755.
KEGGi hsa:3755.
UCSCi uc002xwa.4. human. [Q9UIX4-1 ]
uc002xwb.3. human. [Q9UIX4-2 ]

Organism-specific databases

CTDi 3755.
GeneCardsi GC20M049621.
H-InvDB HIX0015916.
HGNCi HGNC:6248. KCNG1.
HPAi HPA039530.
HPA040024.
MIMi 603788. gene.
neXtProti NX_Q9UIX4.
PharmGKBi PA30034.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118981.
HOGENOMi HOG000231014.
HOVERGENi HBG100172.
InParanoidi Q9UIX4.
KOi K04900.
OMAi GQCSQMC.
OrthoDBi EOG7K9K2K.
PhylomeDBi Q9UIX4.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

ChiTaRSi KCNG1. human.
GeneWikii KCNG1.
GenomeRNAii 3755.
NextBioi 14705.
PROi Q9UIX4.
SOURCEi Search...

Gene expression databases

Bgeei Q9UIX4.
CleanExi HS_KCNG1.
ExpressionAtlasi Q9UIX4. baseline and differential.
Genevestigatori Q9UIX4.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization, and mapping of two human potassium channels."
    Su K., Kyaw H., Fan P., Zeng Z., Shell B.K., Carter K.C., Li Y.
    Biochem. Biophys. Res. Commun. 241:675-681(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Muscle.

Entry informationi

Entry nameiKCNG1_HUMAN
AccessioniPrimary (citable) accession number: Q9UIX4
Secondary accession number(s): A8K3S4
, O43528, Q5JXL5, Q9BRC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3