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Q9UIX4

- KCNG1_HUMAN

UniProt

Q9UIX4 - KCNG1_HUMAN

Protein

Potassium voltage-gated channel subfamily G member 1

Gene

KCNG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome
    2. potassium channel activity Source: UniProtKB

    GO - Biological processi

    1. potassium ion transport Source: UniProtKB
    2. protein homooligomerization Source: InterPro
    3. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily G member 1
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv6.1
    kH2
    Gene namesi
    Name:KCNG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:6248. KCNG1.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: HPA
    2. plasma membrane Source: Reactome
    3. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30034.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Potassium voltage-gated channel subfamily G member 1PRO_0000054073Add
    BLAST

    Proteomic databases

    PaxDbiQ9UIX4.
    PRIDEiQ9UIX4.

    PTM databases

    PhosphoSiteiQ9UIX4.

    Expressioni

    Tissue specificityi

    Detected in brain and placenta, and at much lower levels in kidney and pancreas.

    Gene expression databases

    ArrayExpressiQ9UIX4.
    BgeeiQ9UIX4.
    CleanExiHS_KCNG1.
    GenevestigatoriQ9UIX4.

    Organism-specific databases

    HPAiHPA039530.
    HPA040024.

    Interactioni

    Subunit structurei

    Heterotetramer of potassium channel proteins.By similarity

    Protein-protein interaction databases

    BioGridi109957. 3 interactions.
    IntActiQ9UIX4. 1 interaction.
    STRINGi9606.ENSP00000360626.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UIX4.
    SMRiQ9UIX4. Positions 64-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 227227CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini289 – 30214CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini364 – 37613CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini461 – 51353CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei412 – 43221Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei228 – 24821Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei343 – 36321Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei377 – 39721Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei440 – 46021Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi424 – 4296Selectivity filterBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi61 – 644Poly-Arg
    Compositional biasi254 – 2574Poly-Glu

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231014.
    HOVERGENiHBG100172.
    InParanoidiQ9UIX4.
    KOiK04900.
    OMAiGQCSQMC.
    OrthoDBiEOG7K9K2K.
    PhylomeDBiQ9UIX4.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003969. K_chnl_volt-dep_Kv6.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01492. KV6CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UIX4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD    50
    EPRQGCQPED RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD 100
    ILNVCDDYDV TCNEFFFDRN PGAFGTILTF LRAGKLRLLR EMCALSFQEE 150
    LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV EREEEDDALD SEGRDSEGPA 200
    EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT AVNLSVSTLP 250
    SLREEEEQGH CSQMCHNVFI VESVCVGWFS LEFLLRLIQA PSKFAFLRSP 300
    LTLIDLVAIL PYYITLLVDG AAAGRRKPGA GNSYLDKVGL VLRVLRALRI 350
    LYVMRLARHS LGLQTLGLTA RRCTREFGLL LLFLCVAIAL FAPLLYVIEN 400
    EMADSPEFTS IPACYWWAVI TMTTVGYGDM VPRSTPGQVV ALSSILSGIL 450
    LMAFPVTSIF HTFSRSYLEL KQEQERVMFR RAQFLIKTKS QLSVSQDSDI 500
    LFGSASSDTR DNN 513
    Length:513
    Mass (Da):57,913
    Last modified:May 1, 2000 - v1
    Checksum:iA002F1C0EF2FBDC5
    GO
    Isoform 2 (identifier: Q9UIX4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         259-275: GHCSQMCHNVFIVESVC → VRAHAPRGNAPPRGKGL
         276-513: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:275
    Mass (Da):31,229
    Checksum:i7570073D8D1A5B2C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti426 – 4261G → D in AAC05635. (PubMed:9434767)Curated
    Sequence conflicti465 – 4651R → P in AAC05635. (PubMed:9434767)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti304 – 3041I → M.
    Corresponds to variant rs17791052 [ dbSNP | Ensembl ].
    VAR_053860

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei259 – 27517GHCSQ…VESVC → VRAHAPRGNAPPRGKGL in isoform 2. 1 PublicationVSP_001024Add
    BLAST
    Alternative sequencei276 – 513238Missing in isoform 2. 1 PublicationVSP_001025Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF033383 mRNA. Translation: AAC05635.1.
    AK290689 mRNA. Translation: BAF83378.1.
    AL050404 Genomic DNA. Translation: CAB51753.1.
    AL050404 Genomic DNA. Translation: CAI23445.1.
    AL121785 Genomic DNA. No translation available.
    CH471077 Genomic DNA. Translation: EAW75605.1.
    BC006367 mRNA. Translation: AAH06367.1.
    CCDSiCCDS13436.1. [Q9UIX4-1]
    PIRiJC5920.
    RefSeqiNP_002228.2. NM_002237.3. [Q9UIX4-1]
    XP_006723848.1. XM_006723785.1. [Q9UIX4-1]
    XP_006723849.1. XM_006723786.1. [Q9UIX4-2]
    UniGeneiHs.118695.
    Hs.735151.

    Genome annotation databases

    EnsembliENST00000371571; ENSP00000360626; ENSG00000026559. [Q9UIX4-1]
    GeneIDi3755.
    KEGGihsa:3755.
    UCSCiuc002xwa.4. human. [Q9UIX4-1]
    uc002xwb.3. human. [Q9UIX4-2]

    Polymorphism databases

    DMDMi24418479.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF033383 mRNA. Translation: AAC05635.1 .
    AK290689 mRNA. Translation: BAF83378.1 .
    AL050404 Genomic DNA. Translation: CAB51753.1 .
    AL050404 Genomic DNA. Translation: CAI23445.1 .
    AL121785 Genomic DNA. No translation available.
    CH471077 Genomic DNA. Translation: EAW75605.1 .
    BC006367 mRNA. Translation: AAH06367.1 .
    CCDSi CCDS13436.1. [Q9UIX4-1 ]
    PIRi JC5920.
    RefSeqi NP_002228.2. NM_002237.3. [Q9UIX4-1 ]
    XP_006723848.1. XM_006723785.1. [Q9UIX4-1 ]
    XP_006723849.1. XM_006723786.1. [Q9UIX4-2 ]
    UniGenei Hs.118695.
    Hs.735151.

    3D structure databases

    ProteinModelPortali Q9UIX4.
    SMRi Q9UIX4. Positions 64-467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109957. 3 interactions.
    IntActi Q9UIX4. 1 interaction.
    STRINGi 9606.ENSP00000360626.

    Chemistry

    ChEMBLi CHEMBL2362996.

    PTM databases

    PhosphoSitei Q9UIX4.

    Polymorphism databases

    DMDMi 24418479.

    Proteomic databases

    PaxDbi Q9UIX4.
    PRIDEi Q9UIX4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371571 ; ENSP00000360626 ; ENSG00000026559 . [Q9UIX4-1 ]
    GeneIDi 3755.
    KEGGi hsa:3755.
    UCSCi uc002xwa.4. human. [Q9UIX4-1 ]
    uc002xwb.3. human. [Q9UIX4-2 ]

    Organism-specific databases

    CTDi 3755.
    GeneCardsi GC20M049621.
    H-InvDB HIX0015916.
    HGNCi HGNC:6248. KCNG1.
    HPAi HPA039530.
    HPA040024.
    MIMi 603788. gene.
    neXtProti NX_Q9UIX4.
    PharmGKBi PA30034.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231014.
    HOVERGENi HBG100172.
    InParanoidi Q9UIX4.
    KOi K04900.
    OMAi GQCSQMC.
    OrthoDBi EOG7K9K2K.
    PhylomeDBi Q9UIX4.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    ChiTaRSi KCNG1. human.
    GeneWikii KCNG1.
    GenomeRNAii 3755.
    NextBioi 14705.
    PROi Q9UIX4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UIX4.
    Bgeei Q9UIX4.
    CleanExi HS_KCNG1.
    Genevestigatori Q9UIX4.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003969. K_chnl_volt-dep_Kv6.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01492. KV6CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, characterization, and mapping of two human potassium channels."
      Su K., Kyaw H., Fan P., Zeng Z., Shell B.K., Carter K.C., Li Y.
      Biochem. Biophys. Res. Commun. 241:675-681(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Muscle.

    Entry informationi

    Entry nameiKCNG1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UIX4
    Secondary accession number(s): A8K3S4
    , O43528, Q5JXL5, Q9BRC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3