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Q9UIX4 (KCNG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily G member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv6.1
kH2
Gene names
Name:KCNG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity.

Subunit structure

Heterotetramer of potassium channel proteins By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Detected in brain and placenta, and at much lower levels in kidney and pancreas.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UIX4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UIX4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     259-275: GHCSQMCHNVFIVESVC → VRAHAPRGNAPPRGKGL
     276-513: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Potassium voltage-gated channel subfamily G member 1
PRO_0000054073

Regions

Topological domain1 – 227227Cytoplasmic Potential
Transmembrane228 – 24821Helical; Name=Segment S1; Potential
Transmembrane268 – 28821Helical; Name=Segment S2; Potential
Topological domain289 – 30214Cytoplasmic Potential
Transmembrane303 – 32321Helical; Name=Segment S3; Potential
Transmembrane343 – 36321Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain364 – 37613Cytoplasmic Potential
Transmembrane377 – 39721Helical; Name=Segment S5; Potential
Intramembrane412 – 43221Pore-forming; Name=Segment H5; Potential
Transmembrane440 – 46021Helical; Name=Segment S6; Potential
Topological domain461 – 51353Cytoplasmic Potential
Motif424 – 4296Selectivity filter By similarity
Compositional bias61 – 644Poly-Arg
Compositional bias254 – 2574Poly-Glu

Natural variations

Alternative sequence259 – 27517GHCSQ…VESVC → VRAHAPRGNAPPRGKGL in isoform 2.
VSP_001024
Alternative sequence276 – 513238Missing in isoform 2.
VSP_001025
Natural variant3041I → M.
Corresponds to variant rs17791052 [ dbSNP | Ensembl ].
VAR_053860

Experimental info

Sequence conflict4261G → D in AAC05635. Ref.1
Sequence conflict4651R → P in AAC05635. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: A002F1C0EF2FBDC5

FASTA51357,913
        10         20         30         40         50         60 
MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD EPRQGCQPED 

        70         80         90        100        110        120 
RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD ILNVCDDYDV TCNEFFFDRN 

       130        140        150        160        170        180 
PGAFGTILTF LRAGKLRLLR EMCALSFQEE LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV 

       190        200        210        220        230        240 
EREEEDDALD SEGRDSEGPA EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT 

       250        260        270        280        290        300 
AVNLSVSTLP SLREEEEQGH CSQMCHNVFI VESVCVGWFS LEFLLRLIQA PSKFAFLRSP 

       310        320        330        340        350        360 
LTLIDLVAIL PYYITLLVDG AAAGRRKPGA GNSYLDKVGL VLRVLRALRI LYVMRLARHS 

       370        380        390        400        410        420 
LGLQTLGLTA RRCTREFGLL LLFLCVAIAL FAPLLYVIEN EMADSPEFTS IPACYWWAVI 

       430        440        450        460        470        480 
TMTTVGYGDM VPRSTPGQVV ALSSILSGIL LMAFPVTSIF HTFSRSYLEL KQEQERVMFR 

       490        500        510 
RAQFLIKTKS QLSVSQDSDI LFGSASSDTR DNN 

« Hide

Isoform 2 [UniParc].

Checksum: 7570073D8D1A5B2C
Show »

FASTA27531,229

References

« Hide 'large scale' references
[1]"Isolation, characterization, and mapping of two human potassium channels."
Su K., Kyaw H., Fan P., Zeng Z., Shell B.K., Carter K.C., Li Y.
Biochem. Biophys. Res. Commun. 241:675-681(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF033383 mRNA. Translation: AAC05635.1.
AK290689 mRNA. Translation: BAF83378.1.
AL050404 Genomic DNA. Translation: CAB51753.1.
AL050404 Genomic DNA. Translation: CAI23445.1.
AL121785 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75605.1.
BC006367 mRNA. Translation: AAH06367.1.
CCDSCCDS13436.1. [Q9UIX4-1]
PIRJC5920.
RefSeqNP_002228.2. NM_002237.3. [Q9UIX4-1]
XP_006723848.1. XM_006723785.1. [Q9UIX4-1]
XP_006723849.1. XM_006723786.1. [Q9UIX4-2]
UniGeneHs.118695.
Hs.735151.

3D structure databases

ProteinModelPortalQ9UIX4.
SMRQ9UIX4. Positions 64-467.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109957. 3 interactions.
IntActQ9UIX4. 1 interaction.
STRING9606.ENSP00000360626.

Chemistry

ChEMBLCHEMBL2362996.

PTM databases

PhosphoSiteQ9UIX4.

Polymorphism databases

DMDM24418479.

Proteomic databases

PaxDbQ9UIX4.
PRIDEQ9UIX4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371571; ENSP00000360626; ENSG00000026559. [Q9UIX4-1]
ENST00000396017; ENSP00000379338; ENSG00000026559. [Q9UIX4-2]
GeneID3755.
KEGGhsa:3755.
UCSCuc002xwa.4. human. [Q9UIX4-1]
uc002xwb.3. human. [Q9UIX4-2]

Organism-specific databases

CTD3755.
GeneCardsGC20M049621.
H-InvDBHIX0015916.
HGNCHGNC:6248. KCNG1.
HPAHPA039530.
HPA040024.
MIM603788. gene.
neXtProtNX_Q9UIX4.
PharmGKBPA30034.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231014.
HOVERGENHBG100172.
InParanoidQ9UIX4.
KOK04900.
OMAGQCSQMC.
OrthoDBEOG7K9K2K.
PhylomeDBQ9UIX4.
TreeFamTF313103.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

ArrayExpressQ9UIX4.
BgeeQ9UIX4.
CleanExHS_KCNG1.
GenevestigatorQ9UIX4.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

ChiTaRSKCNG1. human.
GeneWikiKCNG1.
GenomeRNAi3755.
NextBio14705.
PROQ9UIX4.
SOURCESearch...

Entry information

Entry nameKCNG1_HUMAN
AccessionPrimary (citable) accession number: Q9UIX4
Secondary accession number(s): A8K3S4 expand/collapse secondary AC list , O43528, Q5JXL5, Q9BRC1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM