Q9UIX4 (KCNG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily G member 1

Alternative name(s):
Voltage-gated potassium channel subunit Kv6.1
kH2

Gene names

Name:

KCNG1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity.
Subunit structure	Heterotetramer of potassium channel proteins By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Detected in brain and placenta, and at much lower levels in kidney and pancreas.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB intracellular membrane-bounded organelle Inferred from direct assay. Source: HPA plasma membrane Traceable author statement. Source: Reactome voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UIX4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UIX4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     259-275: GHCSQMCHNVFIVESVC → VRAHAPRGNAPPRGKGL
     276-513: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	Potassium voltage-gated channel subfamily G member 1		PRO_0000054073
Regions
	Topological domain	1 – 227	227	Cytoplasmic Potential
	Transmembrane	228 – 248	21	Helical; Name=Segment S1; Potential
	Transmembrane	268 – 288	21	Helical; Name=Segment S2; Potential
	Topological domain	289 – 302	14	Cytoplasmic Potential
	Transmembrane	303 – 323	21	Helical; Name=Segment S3; Potential
	Transmembrane	343 – 363	21	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	364 – 376	13	Cytoplasmic Potential
	Transmembrane	377 – 397	21	Helical; Name=Segment S5; Potential
	Intramembrane	412 – 432	21	Pore-forming; Name=Segment H5; Potential
	Transmembrane	440 – 460	21	Helical; Name=Segment S6; Potential
	Topological domain	461 – 513	53	Cytoplasmic Potential
	Motif	424 – 429	6	Selectivity filter By similarity
	Compositional bias	61 – 64	4	Poly-Arg
	Compositional bias	254 – 257	4	Poly-Glu
Natural variations
	Alternative sequence	259 – 275	17	GHCSQ…VESVC → VRAHAPRGNAPPRGKGL in isoform 2.		VSP_001024
	Alternative sequence	276 – 513	238	Missing in isoform 2.		VSP_001025
	Natural variant	304	1	I → M. Corresponds to variant rs17791052 [ dbSNP | Ensembl ].		VAR_053860
Experimental info
	Sequence conflict	426	1	G → D in AAC05635. Ref.1
	Sequence conflict	465	1	R → P in AAC05635. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: A002F1C0EF2FBDC5	FASTA	513	57,913
	10 20 30 40 50 60 MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD EPRQGCQPED 70 80 90 100 110 120 RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD ILNVCDDYDV TCNEFFFDRN 130 140 150 160 170 180 PGAFGTILTF LRAGKLRLLR EMCALSFQEE LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV 190 200 210 220 230 240 EREEEDDALD SEGRDSEGPA EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT 250 260 270 280 290 300 AVNLSVSTLP SLREEEEQGH CSQMCHNVFI VESVCVGWFS LEFLLRLIQA PSKFAFLRSP 310 320 330 340 350 360 LTLIDLVAIL PYYITLLVDG AAAGRRKPGA GNSYLDKVGL VLRVLRALRI LYVMRLARHS 370 380 390 400 410 420 LGLQTLGLTA RRCTREFGLL LLFLCVAIAL FAPLLYVIEN EMADSPEFTS IPACYWWAVI 430 440 450 460 470 480 TMTTVGYGDM VPRSTPGQVV ALSSILSGIL LMAFPVTSIF HTFSRSYLEL KQEQERVMFR 490 500 510 RAQFLIKTKS QLSVSQDSDI LFGSASSDTR DNN
	Isoform 2 [UniParc]. Checksum: 7570073D8D1A5B2C	FASTA	275	31,229
	10 20 30 40 50 60 MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD EPRQGCQPED 70 80 90 100 110 120 RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD ILNVCDDYDV TCNEFFFDRN 130 140 150 160 170 180 PGAFGTILTF LRAGKLRLLR EMCALSFQEE LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV 190 200 210 220 230 240 EREEEDDALD SEGRDSEGPA EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT 250 260 270 AVNLSVSTLP SLREEEEQVR AHAPRGNAPP RGKGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, characterization, and mapping of two human potassium channels." Su K., Kyaw H., Fan P., Zeng Z., Shell B.K., Carter K.C., Li Y. Biochem. Biophys. Res. Commun. 241:675-681(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF033383 mRNA. Translation: AAC05635.1. AK290689 mRNA. Translation: BAF83378.1. AL050404 Genomic DNA. Translation: CAB51753.1. AL050404 Genomic DNA. Translation: CAI23445.1. AL121785 Genomic DNA. No translation available. CH471077 Genomic DNA. Translation: EAW75605.1. BC006367 mRNA. Translation: AAH06367.1.
IPI	IPI00032434. IPI00220799.
PIR	JC5920.
RefSeq	NP_002228.2. NM_002237.3.
UniGene	Hs.118695. Hs.735151.
3D structure databases
ProteinModelPortal	Q9UIX4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UIX4. 1 interaction.
STRING	9606.ENSP00000360626.
PTM databases
PhosphoSite	Q9UIX4.
Polymorphism databases
DMDM	24418479.
Proteomic databases
PaxDb	Q9UIX4.
PRIDE	Q9UIX4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371571; ENSP00000360626; ENSG00000026559. ENST00000396017; ENSP00000379338; ENSG00000026559. ENST00000439216; ENSP00000394075; ENSG00000026559.
GeneID	3755.
KEGG	hsa:3755.
UCSC	uc002xwa.4. human. uc002xwb.3. human.
Organism-specific databases
CTD	3755.
GeneCards	GC20M049621.
H-InvDB	HIX0015916.
HGNC	HGNC:6248. KCNG1.
HPA	HPA039530. HPA040024.
MIM	603788. gene.
neXtProt	NX_Q9UIX4.
PharmGKB	PA30034.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231014.
HOVERGEN	HBG100172.
InParanoid	Q9UIX4.
KO	K04900.
OMA	GQCSQMC.
OrthoDB	EOG4XPQG0.
PhylomeDB	Q9UIX4.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	Q9UIX4.
Bgee	Q9UIX4.
CleanEx	HS_KCNG1.
Genevestigator	Q9UIX4.
GermOnline	ENSG00000026559. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003969. K_chnl_volt-dep_Kv6. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01492. KV6CHANNEL. PR01491. KVCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	KCNG1. human.
GenomeRNAi	3755.
NextBio	14705.
SOURCE	Search...

Entry information

Entry name

KCNG1_HUMAN

Accession

Primary (citable) accession number: Q9UIX4
Secondary accession number(s): A8K3S4 , O43528, Q5JXL5, Q9BRC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.