Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Plexin-A1

Gene

PLXNA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).By similarity

GO - Molecular functioni

  • receptor activity Source: UniProtKB
  • semaphorin receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114554-MONOMER.
ReactomeiR-HSA-399954. Sema3A PAK dependent Axon repulsion.
R-HSA-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-HSA-399956. CRMPs in Sema3A signaling.
R-HSA-416700. Other semaphorin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A1
Alternative name(s):
Semaphorin receptor NOV
Gene namesi
Name:PLXNA1
Synonyms:NOV, PLXN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:9099. PLXNA1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 1244ExtracellularSequence analysisAdd BLAST1218
Transmembranei1245 – 1265HelicalSequence analysisAdd BLAST21
Topological domaini1266 – 1896CytoplasmicSequence analysisAdd BLAST631

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • nucleus Source: HPA
  • plasma membrane Source: Reactome
  • semaphorin receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5361.
OpenTargetsiENSG00000114554.

Polymorphism and mutation databases

BioMutaiPLXNA1.
DMDMi313104202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000023274527 – 1896Plexin-A1Add BLAST1870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...)1 Publication1
Disulfide bondi95 ↔ 104PROSITE-ProRule annotation
Disulfide bondi130 ↔ 138PROSITE-ProRule annotation
Disulfide bondi286 ↔ 407PROSITE-ProRule annotation
Disulfide bondi302 ↔ 358PROSITE-ProRule annotation
Disulfide bondi376 ↔ 395PROSITE-ProRule annotation
Disulfide bondi515 ↔ 532PROSITE-ProRule annotation
Disulfide bondi521 ↔ 563PROSITE-ProRule annotation
Disulfide bondi524 ↔ 541PROSITE-ProRule annotation
Disulfide bondi535 ↔ 547PROSITE-ProRule annotation
Disulfide bondi598 ↔ 617PROSITE-ProRule annotation
Glycosylationi660N-linked (GlcNAc...)Sequence analysis1
Glycosylationi672N-linked (GlcNAc...)Sequence analysis1
Glycosylationi701N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1043N-linked (GlcNAc...)1 Publication1
Glycosylationi1187N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1212N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UIW2.
MaxQBiQ9UIW2.
PaxDbiQ9UIW2.
PeptideAtlasiQ9UIW2.
PRIDEiQ9UIW2.

PTM databases

iPTMnetiQ9UIW2.
PhosphoSitePlusiQ9UIW2.
SwissPalmiQ9UIW2.

Expressioni

Tissue specificityi

Detected in fetal brain, lung, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000114554.
CleanExiHS_NOV.
HS_PLXNA1.
GenevisibleiQ9UIW2. HS.

Organism-specific databases

HPAiCAB012483.
HPA007499.

Interactioni

Subunit structurei

Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi111375. 23 interactors.
IntActiQ9UIW2. 1 interactor.
MINTiMINT-4053576.
STRINGi9606.ENSP00000377061.

Structurei

3D structure databases

ProteinModelPortaliQ9UIW2.
SMRiQ9UIW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 512SemaPROSITE-ProRule annotationAdd BLAST486
Domaini864 – 959IPT/TIG 1Add BLAST96
Domaini961 – 1045IPT/TIG 2Add BLAST85
Domaini1048 – 1147IPT/TIG 3Add BLAST100
Domaini1150 – 1236IPT/TIG 4Add BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1264 – 1317Sequence analysisAdd BLAST54

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 4 IPT/TIG domains.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610. Eukaryota.
ENOG410XR88. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231377.
HOVERGENiHBG105711.
InParanoidiQ9UIW2.
KOiK06820.
OMAiIGCEQAG.
OrthoDBiEOG091G00EK.
PhylomeDBiQ9UIW2.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR031148. Plexin.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 1 hit.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UIW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPPRSLQV LLLLLLLLLL LPGMWAEAGL PRAGGGSQPP FRTFSASDWG
60 70 80 90 100
LTHLVVHEQT GEVYVGAVNR IYKLSGNLTL LRAHVTGPVE DNEKCYPPPS
110 120 130 140 150
VQSCPHGLGS TDNVNKLLLL DYAANRLLAC GSASQGICQF LRLDDLFKLG
160 170 180 190 200
EPHHRKEHYL SSVQEAGSMA GVLIAGPPGQ GQAKLFVGTP IDGKSEYFPT
210 220 230 240 250
LSSRRLMANE EDADMFGFVY QDEFVSSQLK IPSDTLSKFP AFDIYYVYSF
260 270 280 290 300
RSEQFVYYLT LQLDTQLTSP DAAGEHFFTS KIVRLCVDDP KFYSYVEFPI
310 320 330 340 350
GCEQAGVEYR LVQDAYLSRP GRALAHQLGL AEDEDVLFTV FAQGQKNRVK
360 370 380 390 400
PPKESALCLF TLRAIKEKIK ERIQSCYRGE GKLSLPWLLN KELGCINSPL
410 420 430 440 450
QIDDDFCGQD FNQPLGGTVT IEGTPLFVDK DDGLTAVAAY DYRGRTVVFA
460 470 480 490 500
GTRSGRIRKI LVDLSNPGGR PALAYESVVA QEGSPILRDL VLSPNHQYLY
510 520 530 540 550
AMTEKQVTRV PVESCVQYTS CELCLGSRDP HCGWCVLHSI CSRRDACERA
560 570 580 590 600
DEPQRFAADL LQCVQLTVQP RNVSVTMSQV PLVLQAWNVP DLSAGVNCSF
610 620 630 640 650
EDFTESESVL EDGRIHCRSP SAREVAPITR GQGDQRVVKL YLKSKETGKK
660 670 680 690 700
FASVDFVFYN CSVHQSCLSC VNGSFPCHWC KYRHVCTHNV ADCAFLEGRV
710 720 730 740 750
NVSEDCPQIL PSTQIYVPVG VVKPITLAAR NLPQPQSGQR GYECLFHIPG
760 770 780 790 800
SPARVTALRF NSSSLQCQNS SYSYEGNDVS DLPVNLSVVW NGNFVIDNPQ
810 820 830 840 850
NIQAHLYKCP ALRESCGLCL KADPRFECGW CVAERRCSLR HHCAADTPAS
860 870 880 890 900
WMHARHGSSR CTDPKILKLS PETGPRQGGT RLTITGENLG LRFEDVRLGV
910 920 930 940 950
RVGKVLCSPV ESEYISAEQI VCEIGDASSV RAHDALVEVC VRDCSPHYRA
960 970 980 990 1000
LSPKRFTFVT PTFYRVSPSR GPLSGGTWIG IEGSHLNAGS DVAVSVGGRP
1010 1020 1030 1040 1050
CSFSWRNSRE IRCLTPPGQS PGSAPIIINI NRAQLTNPEV KYNYTEDPTI
1060 1070 1080 1090 1100
LRIDPEWSIN SGGTLLTVTG TNLATVREPR IRAKYGGIER ENGCLVYNDT
1110 1120 1130 1140 1150
TMVCRAPSVA NPVRSPPELG ERPDELGFVM DNVRSLLVLN STSFLYYPDP
1160 1170 1180 1190 1200
VLEPLSPTGL LELKPSSPLI LKGRNLLPPA PGNSRLNYTV LIGSTPCTLT
1210 1220 1230 1240 1250
VSETQLLCEA PNLTGQHKVT VRAGGFEFSP GTLQVYSDSL LTLPAIVGIG
1260 1270 1280 1290 1300
GGGGLLLLVI VAVLIAYKRK SRDADRTLKR LQLQMDNLES RVALECKEAF
1310 1320 1330 1340 1350
AELQTDIHEL TNDLDGAGIP FLDYRTYAMR VLFPGIEDHP VLKEMEVQAN
1360 1370 1380 1390 1400
VEKSLTLFGQ LLTKKHFLLT FIRTLEAQRS FSMRDRGNVA SLIMTALQGE
1410 1420 1430 1440 1450
MEYATGVLKQ LLSDLIEKNL ESKNHPKLLL RRTESVAEKM LTNWFTFLLY
1460 1470 1480 1490 1500
KFLKECAGEP LFMLYCAIKQ QMEKGPIDAI TGEARYSLSE DKLIRQQIDY
1510 1520 1530 1540 1550
KTLTLNCVNP ENENAPEVPV KGLDCDTVTQ AKEKLLDAAY KGVPYSQRPK
1560 1570 1580 1590 1600
AADMDLEWRQ GRMARIILQD EDVTTKIDND WKRLNTLAHY QVTDGSSVAL
1610 1620 1630 1640 1650
VPKQTSAYNI SNSSTFTKSL SRYESMLRTA SSPDSLRSRT PMITPDLESG
1660 1670 1680 1690 1700
TKLWHLVKNH DHLDQREGDR GSKMVSEIYL TRLLATKGTL QKFVDDLFET
1710 1720 1730 1740 1750
IFSTAHRGSA LPLAIKYMFD FLDEQADKHQ IHDADVRHTW KSNCLPLRFW
1760 1770 1780 1790 1800
VNVIKNPQFV FDIHKNSITD ACLSVVAQTF MDSCSTSEHK LGKDSPSNKL
1810 1820 1830 1840 1850
LYAKDIPNYK SWVERYYADI AKMPAISDQD MSAYLAEQSR LHLSQFNSMS
1860 1870 1880 1890
ALHEIYSYIT KYKDEILAAL EKDEQARRQR LRSKLEQVVD TMALSS
Length:1,896
Mass (Da):211,067
Last modified:November 30, 2010 - v3
Checksum:i76E5C9C0710C7FC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46A → G in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti55V → L in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti110S → N in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti140F → S in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti407C → R in CAB57274 (PubMed:8570614).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011199 Genomic DNA. No translation available.
X87832 mRNA. Translation: CAB57274.1.
AK128612 mRNA. No translation available.
CCDSiCCDS33847.2.
RefSeqiNP_115618.3. NM_032242.3.
UniGeneiHs.432329.

Genome annotation databases

EnsembliENST00000393409; ENSP00000377061; ENSG00000114554.
GeneIDi5361.
KEGGihsa:5361.
UCSCiuc003ejg.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011199 Genomic DNA. No translation available.
X87832 mRNA. Translation: CAB57274.1.
AK128612 mRNA. No translation available.
CCDSiCCDS33847.2.
RefSeqiNP_115618.3. NM_032242.3.
UniGeneiHs.432329.

3D structure databases

ProteinModelPortaliQ9UIW2.
SMRiQ9UIW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111375. 23 interactors.
IntActiQ9UIW2. 1 interactor.
MINTiMINT-4053576.
STRINGi9606.ENSP00000377061.

PTM databases

iPTMnetiQ9UIW2.
PhosphoSitePlusiQ9UIW2.
SwissPalmiQ9UIW2.

Polymorphism and mutation databases

BioMutaiPLXNA1.
DMDMi313104202.

Proteomic databases

EPDiQ9UIW2.
MaxQBiQ9UIW2.
PaxDbiQ9UIW2.
PeptideAtlasiQ9UIW2.
PRIDEiQ9UIW2.

Protocols and materials databases

DNASUi5361.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393409; ENSP00000377061; ENSG00000114554.
GeneIDi5361.
KEGGihsa:5361.
UCSCiuc003ejg.3. human.

Organism-specific databases

CTDi5361.
DisGeNETi5361.
GeneCardsiPLXNA1.
H-InvDBHIX0003640.
HIX0030977.
HGNCiHGNC:9099. PLXNA1.
HPAiCAB012483.
HPA007499.
MIMi601055. gene.
neXtProtiNX_Q9UIW2.
OpenTargetsiENSG00000114554.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3610. Eukaryota.
ENOG410XR88. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231377.
HOVERGENiHBG105711.
InParanoidiQ9UIW2.
KOiK06820.
OMAiIGCEQAG.
OrthoDBiEOG091G00EK.
PhylomeDBiQ9UIW2.
TreeFamiTF312962.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114554-MONOMER.
ReactomeiR-HSA-399954. Sema3A PAK dependent Axon repulsion.
R-HSA-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-HSA-399956. CRMPs in Sema3A signaling.
R-HSA-416700. Other semaphorin interactions.

Miscellaneous databases

ChiTaRSiPLXNA1. human.
GeneWikiiPlexin_A1.
GenomeRNAii5361.
PROiQ9UIW2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114554.
CleanExiHS_NOV.
HS_PLXNA1.
GenevisibleiQ9UIW2. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR031148. Plexin.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 1 hit.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLXA1_HUMAN
AccessioniPrimary (citable) accession number: Q9UIW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.