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Q9UIV8

- SPB13_HUMAN

UniProt

Q9UIV8 - SPB13_HUMAN

Protein

Serpin B13

Gene

SERPINB13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    May play a role in the proliferation or differentiation of keratinocytes.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei356 – 3572Reactive bondBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of proteolysis Source: UniProtKB
    3. response to UV Source: ProtInc

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.017.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin B13
    Alternative name(s):
    HaCaT UV-repressible serpin
    Short name:
    Hurpin
    Headpin
    Peptidase inhibitor 13
    Short name:
    PI-13
    Proteinase inhibitor 13
    Gene namesi
    Name:SERPINB13
    Synonyms:PI13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:8944. SERPINB13.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular region Source: RefGenome
    3. extracellular space Source: InterPro
    4. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35512.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Serpin B13PRO_0000094121Add
    BLAST

    Proteomic databases

    MaxQBiQ9UIV8.
    PaxDbiQ9UIV8.
    PRIDEiQ9UIV8.

    PTM databases

    PhosphoSiteiQ9UIV8.

    Expressioni

    Tissue specificityi

    Skin specific.

    Gene expression databases

    ArrayExpressiQ9UIV8.
    BgeeiQ9UIV8.
    CleanExiHS_SERPINB13.
    GenevestigatoriQ9UIV8.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9UIV8. 1 interaction.
    STRINGi9606.ENSP00000341584.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UIV8.
    SMRiQ9UIV8. Positions 2-391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    HOVERGENiHBG005957.
    InParanoidiQ9UIV8.
    KOiK13963.
    OMAiPGHMEER.
    PhylomeDBiQ9UIV8.
    TreeFamiTF352619.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UIV8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA    50
    SQLEEVFHSE KETKSSRIKA EEKEVIENTE AVHQQFQKFL TEISKLTNDY 100
    ELNITNRLFG EKTYLFLQKY LDYVEKYYHA SLEPVDFVNA ADESRKKINS 150
    WVESKTNEKI KDLFPDGSIS SSTKLVLVNM VYFKGQWDRE FKKENTKEEK 200
    FWMNKSTSKS VQMMTQSHSF SFTFLEDLQA KILGIPYKNN DLSMFVLLPN 250
    DIDGLEKIID KISPEKLVEW TSPGHMEERK VNLHLPRFEV EDGYDLEAVL 300
    AAMGMGDAFS EHKADYSGMS SGSGLYAQKF LHSSFVAVTE EGTEAAAATG 350
    IGFTVTSAPG HENVHCNHPF LFFIRHNESN SILFFGRFSS P 391
    Length:391
    Mass (Da):44,276
    Last modified:December 1, 2000 - v2
    Checksum:i2CA88558D4BC2B09
    GO
    Isoform 2 (identifier: Q9UIV8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         206-257: Missing.

    Show »
    Length:339
    Mass (Da):38,413
    Checksum:iEDF2E376FB246068
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81S → N in CAC03569. (PubMed:11313015)Curated
    Sequence conflicti75 – 751Missing in CAA04937. (PubMed:10512713)Curated
    Sequence conflicti297 – 2971E → Q in CAA04937. (PubMed:10512713)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti293 – 2931G → S.3 Publications
    Corresponds to variant rs1020694 [ dbSNP | Ensembl ].
    VAR_024356

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei206 – 25752Missing in isoform 2. CuratedVSP_006058Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001696 mRNA. Translation: CAA04935.2.
    AJ001697 mRNA. Translation: CAA04936.2.
    AJ001698 mRNA. Translation: CAA04937.1.
    AF169949 mRNA. Translation: AAD55765.1.
    AF216854 Genomic DNA. Translation: AAF72879.1.
    AJ278717 Genomic DNA. Translation: CAC03569.1.
    AK290323 mRNA. Translation: BAF83012.1.
    AK313486 mRNA. Translation: BAG36269.1.
    CH471096 Genomic DNA. Translation: EAW63153.1.
    BC101821 mRNA. Translation: AAI01822.1.
    CCDSiCCDS11985.1. [Q9UIV8-1]
    PIRiJC7118.
    RefSeqiNP_036529.1. NM_012397.3. [Q9UIV8-1]
    UniGeneiHs.241407.

    Genome annotation databases

    EnsembliENST00000269489; ENSP00000269489; ENSG00000197641. [Q9UIV8-2]
    ENST00000344731; ENSP00000341584; ENSG00000197641. [Q9UIV8-1]
    GeneIDi5275.
    KEGGihsa:5275.
    UCSCiuc002ljc.3. human. [Q9UIV8-1]

    Polymorphism databases

    DMDMi12643252.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001696 mRNA. Translation: CAA04935.2 .
    AJ001697 mRNA. Translation: CAA04936.2 .
    AJ001698 mRNA. Translation: CAA04937.1 .
    AF169949 mRNA. Translation: AAD55765.1 .
    AF216854 Genomic DNA. Translation: AAF72879.1 .
    AJ278717 Genomic DNA. Translation: CAC03569.1 .
    AK290323 mRNA. Translation: BAF83012.1 .
    AK313486 mRNA. Translation: BAG36269.1 .
    CH471096 Genomic DNA. Translation: EAW63153.1 .
    BC101821 mRNA. Translation: AAI01822.1 .
    CCDSi CCDS11985.1. [Q9UIV8-1 ]
    PIRi JC7118.
    RefSeqi NP_036529.1. NM_012397.3. [Q9UIV8-1 ]
    UniGenei Hs.241407.

    3D structure databases

    ProteinModelPortali Q9UIV8.
    SMRi Q9UIV8. Positions 2-391.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9UIV8. 1 interaction.
    STRINGi 9606.ENSP00000341584.

    Protein family/group databases

    MEROPSi I04.017.

    PTM databases

    PhosphoSitei Q9UIV8.

    Polymorphism databases

    DMDMi 12643252.

    Proteomic databases

    MaxQBi Q9UIV8.
    PaxDbi Q9UIV8.
    PRIDEi Q9UIV8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269489 ; ENSP00000269489 ; ENSG00000197641 . [Q9UIV8-2 ]
    ENST00000344731 ; ENSP00000341584 ; ENSG00000197641 . [Q9UIV8-1 ]
    GeneIDi 5275.
    KEGGi hsa:5275.
    UCSCi uc002ljc.3. human. [Q9UIV8-1 ]

    Organism-specific databases

    CTDi 5275.
    GeneCardsi GC18P061227.
    HGNCi HGNC:8944. SERPINB13.
    MIMi 604445. gene.
    neXtProti NX_Q9UIV8.
    PharmGKBi PA35512.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOVERGENi HBG005957.
    InParanoidi Q9UIV8.
    KOi K13963.
    OMAi PGHMEER.
    PhylomeDBi Q9UIV8.
    TreeFami TF352619.

    Miscellaneous databases

    GeneWikii SERPINB13.
    GenomeRNAii 5275.
    NextBioi 20384.
    PROi Q9UIV8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UIV8.
    Bgeei Q9UIV8.
    CleanExi HS_SERPINB13.
    Genevestigatori Q9UIV8.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of hurpin (Protease Inhibitor 13): a new skin specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family."
      Abts H.F., Welss T., Mirmohammadsadegh A., Koehrer K., Michel G., Ruzicka T.
      J. Mol. Biol. 293:29-39(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Skin.
    2. "Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q."
      Spring P., Nakashima T., Frederick M., Henderson Y., Clayman G.
      Biochem. Biophys. Res. Commun. 264:299-304(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-293.
    3. "Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells."
      Nakashima T., Pak S.C., Silverman G.A., Spring P.M., Frederick M.J., Clayman G.L.
      Biochim. Biophys. Acta 1492:441-446(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    4. "Sequence, organization, chromosomal localization and alternative splicing of the human serine protease inhibitor gene hurpin (PI13), which is up-regulated in psoriasis."
      Abts H.F., Welss T., Scheuring S., Scott F.L., Irving J.A., Michel G., Bird P.I., Ruzicka T.
      DNA Cell Biol. 20:123-131(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
      Tissue: Placenta.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-293.
      Tissue: Tongue.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-293.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSPB13_HUMAN
    AccessioniPrimary (citable) accession number: Q9UIV8
    Secondary accession number(s): A8K2Q8
    , Q3MII2, Q9HCX1, Q9UBW1, Q9UKG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3