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Q9UIV8 (SPB13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serpin B13
Alternative name(s):
HaCaT UV-repressible serpin
Short name=Hurpin
Headpin
Peptidase inhibitor 13
Short name=PI-13
Proteinase inhibitor 13
Gene names
Name:SERPINB13
Synonyms:PI13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the proliferation or differentiation of keratinocytes.

Subcellular location

Cytoplasm.

Tissue specificity

Skin specific.

Sequence similarities

Belongs to the serpin family. Ov-serpin subfamily.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UIV8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UIV8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     206-257: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Serpin B13
PRO_0000094121

Sites

Site356 – 3572Reactive bond By similarity

Natural variations

Alternative sequence206 – 25752Missing in isoform 2.
VSP_006058
Natural variant2931G → S. Ref.2 Ref.5 Ref.6
Corresponds to variant rs1020694 [ dbSNP | Ensembl ].
VAR_024356

Experimental info

Sequence conflict81S → N in CAC03569. Ref.4
Sequence conflict751Missing in CAA04937. Ref.1
Sequence conflict2971E → Q in CAA04937. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 2CA88558D4BC2B09

FASTA39144,276
        10         20         30         40         50         60 
MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA SQLEEVFHSE 

        70         80         90        100        110        120 
KETKSSRIKA EEKEVIENTE AVHQQFQKFL TEISKLTNDY ELNITNRLFG EKTYLFLQKY 

       130        140        150        160        170        180 
LDYVEKYYHA SLEPVDFVNA ADESRKKINS WVESKTNEKI KDLFPDGSIS SSTKLVLVNM 

       190        200        210        220        230        240 
VYFKGQWDRE FKKENTKEEK FWMNKSTSKS VQMMTQSHSF SFTFLEDLQA KILGIPYKNN 

       250        260        270        280        290        300 
DLSMFVLLPN DIDGLEKIID KISPEKLVEW TSPGHMEERK VNLHLPRFEV EDGYDLEAVL 

       310        320        330        340        350        360 
AAMGMGDAFS EHKADYSGMS SGSGLYAQKF LHSSFVAVTE EGTEAAAATG IGFTVTSAPG 

       370        380        390 
HENVHCNHPF LFFIRHNESN SILFFGRFSS P 

« Hide

Isoform 2 [UniParc].

Checksum: EDF2E376FB246068
Show »

FASTA33938,413

References

« Hide 'large scale' references
[1]"Cloning and characterization of hurpin (Protease Inhibitor 13): a new skin specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family."
Abts H.F., Welss T., Mirmohammadsadegh A., Koehrer K., Michel G., Ruzicka T.
J. Mol. Biol. 293:29-39(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Skin.
[2]"Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q."
Spring P., Nakashima T., Frederick M., Henderson Y., Clayman G.
Biochem. Biophys. Res. Commun. 264:299-304(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-293.
[3]"Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells."
Nakashima T., Pak S.C., Silverman G.A., Spring P.M., Frederick M.J., Clayman G.L.
Biochim. Biophys. Acta 1492:441-446(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[4]"Sequence, organization, chromosomal localization and alternative splicing of the human serine protease inhibitor gene hurpin (PI13), which is up-regulated in psoriasis."
Abts H.F., Welss T., Scheuring S., Scott F.L., Irving J.A., Michel G., Bird P.I., Ruzicka T.
DNA Cell Biol. 20:123-131(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
Tissue: Placenta.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-293.
Tissue: Tongue.
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-293.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ001696 mRNA. Translation: CAA04935.2.
AJ001697 mRNA. Translation: CAA04936.2.
AJ001698 mRNA. Translation: CAA04937.1.
AF169949 mRNA. Translation: AAD55765.1.
AF216854 Genomic DNA. Translation: AAF72879.1.
AJ278717 Genomic DNA. Translation: CAC03569.1.
AK290323 mRNA. Translation: BAF83012.1.
AK313486 mRNA. Translation: BAG36269.1.
CH471096 Genomic DNA. Translation: EAW63153.1.
BC101821 mRNA. Translation: AAI01822.1.
CCDSCCDS11985.1. [Q9UIV8-1]
PIRJC7118.
RefSeqNP_036529.1. NM_012397.3. [Q9UIV8-1]
UniGeneHs.241407.

3D structure databases

ProteinModelPortalQ9UIV8.
SMRQ9UIV8. Positions 2-391.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9UIV8. 1 interaction.
STRING9606.ENSP00000341584.

Protein family/group databases

MEROPSI04.017.

PTM databases

PhosphoSiteQ9UIV8.

Polymorphism databases

DMDM12643252.

Proteomic databases

MaxQBQ9UIV8.
PaxDbQ9UIV8.
PRIDEQ9UIV8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000269489; ENSP00000269489; ENSG00000197641. [Q9UIV8-2]
ENST00000344731; ENSP00000341584; ENSG00000197641. [Q9UIV8-1]
GeneID5275.
KEGGhsa:5275.
UCSCuc002ljc.3. human. [Q9UIV8-1]

Organism-specific databases

CTD5275.
GeneCardsGC18P061227.
HGNCHGNC:8944. SERPINB13.
MIM604445. gene.
neXtProtNX_Q9UIV8.
PharmGKBPA35512.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4826.
HOVERGENHBG005957.
InParanoidQ9UIV8.
KOK13963.
OMAPGHMEER.
PhylomeDBQ9UIV8.
TreeFamTF352619.

Gene expression databases

ArrayExpressQ9UIV8.
BgeeQ9UIV8.
CleanExHS_SERPINB13.
GenevestigatorQ9UIV8.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSERPINB13.
GenomeRNAi5275.
NextBio20384.
PROQ9UIV8.
SOURCESearch...

Entry information

Entry nameSPB13_HUMAN
AccessionPrimary (citable) accession number: Q9UIV8
Secondary accession number(s): A8K2Q8 expand/collapse secondary AC list , Q3MII2, Q9HCX1, Q9UBW1, Q9UKG0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM