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Q9UIV8

- SPB13_HUMAN

UniProt

Q9UIV8 - SPB13_HUMAN

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Protein
Serpin B13
Gene
SERPINB13, PI13
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the proliferation or differentiation of keratinocytes.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei356 – 3572Reactive bond By similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. regulation of proteolysis Source: UniProtKB
  3. response to UV Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B13
Alternative name(s):
HaCaT UV-repressible serpin
Short name:
Hurpin
Headpin
Peptidase inhibitor 13
Short name:
PI-13
Proteinase inhibitor 13
Gene namesi
Synonyms:PI13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:8944. SERPINB13.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular region Source: RefGenome
  3. extracellular space Source: InterPro
  4. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Serpin B13
PRO_0000094121Add
BLAST

Proteomic databases

MaxQBiQ9UIV8.
PaxDbiQ9UIV8.
PRIDEiQ9UIV8.

PTM databases

PhosphoSiteiQ9UIV8.

Expressioni

Tissue specificityi

Skin specific.

Gene expression databases

ArrayExpressiQ9UIV8.
BgeeiQ9UIV8.
CleanExiHS_SERPINB13.
GenevestigatoriQ9UIV8.

Interactioni

Protein-protein interaction databases

IntActiQ9UIV8. 1 interaction.
STRINGi9606.ENSP00000341584.

Structurei

3D structure databases

ProteinModelPortaliQ9UIV8.
SMRiQ9UIV8. Positions 2-391.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4826.
HOVERGENiHBG005957.
InParanoidiQ9UIV8.
KOiK13963.
OMAiPGHMEER.
PhylomeDBiQ9UIV8.
TreeFamiTF352619.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UIV8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA    50
SQLEEVFHSE KETKSSRIKA EEKEVIENTE AVHQQFQKFL TEISKLTNDY 100
ELNITNRLFG EKTYLFLQKY LDYVEKYYHA SLEPVDFVNA ADESRKKINS 150
WVESKTNEKI KDLFPDGSIS SSTKLVLVNM VYFKGQWDRE FKKENTKEEK 200
FWMNKSTSKS VQMMTQSHSF SFTFLEDLQA KILGIPYKNN DLSMFVLLPN 250
DIDGLEKIID KISPEKLVEW TSPGHMEERK VNLHLPRFEV EDGYDLEAVL 300
AAMGMGDAFS EHKADYSGMS SGSGLYAQKF LHSSFVAVTE EGTEAAAATG 350
IGFTVTSAPG HENVHCNHPF LFFIRHNESN SILFFGRFSS P 391
Length:391
Mass (Da):44,276
Last modified:December 1, 2000 - v2
Checksum:i2CA88558D4BC2B09
GO
Isoform 2 (identifier: Q9UIV8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-257: Missing.

Show »
Length:339
Mass (Da):38,413
Checksum:iEDF2E376FB246068
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti293 – 2931G → S.3 Publications
Corresponds to variant rs1020694 [ dbSNP | Ensembl ].
VAR_024356

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei206 – 25752Missing in isoform 2.
VSP_006058Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81S → N in CAC03569. 1 Publication
Sequence conflicti75 – 751Missing in CAA04937. 1 Publication
Sequence conflicti297 – 2971E → Q in CAA04937. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001696 mRNA. Translation: CAA04935.2.
AJ001697 mRNA. Translation: CAA04936.2.
AJ001698 mRNA. Translation: CAA04937.1.
AF169949 mRNA. Translation: AAD55765.1.
AF216854 Genomic DNA. Translation: AAF72879.1.
AJ278717 Genomic DNA. Translation: CAC03569.1.
AK290323 mRNA. Translation: BAF83012.1.
AK313486 mRNA. Translation: BAG36269.1.
CH471096 Genomic DNA. Translation: EAW63153.1.
BC101821 mRNA. Translation: AAI01822.1.
CCDSiCCDS11985.1. [Q9UIV8-1]
PIRiJC7118.
RefSeqiNP_036529.1. NM_012397.3. [Q9UIV8-1]
UniGeneiHs.241407.

Genome annotation databases

EnsembliENST00000269489; ENSP00000269489; ENSG00000197641. [Q9UIV8-2]
ENST00000344731; ENSP00000341584; ENSG00000197641. [Q9UIV8-1]
GeneIDi5275.
KEGGihsa:5275.
UCSCiuc002ljc.3. human. [Q9UIV8-1]

Polymorphism databases

DMDMi12643252.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001696 mRNA. Translation: CAA04935.2 .
AJ001697 mRNA. Translation: CAA04936.2 .
AJ001698 mRNA. Translation: CAA04937.1 .
AF169949 mRNA. Translation: AAD55765.1 .
AF216854 Genomic DNA. Translation: AAF72879.1 .
AJ278717 Genomic DNA. Translation: CAC03569.1 .
AK290323 mRNA. Translation: BAF83012.1 .
AK313486 mRNA. Translation: BAG36269.1 .
CH471096 Genomic DNA. Translation: EAW63153.1 .
BC101821 mRNA. Translation: AAI01822.1 .
CCDSi CCDS11985.1. [Q9UIV8-1 ]
PIRi JC7118.
RefSeqi NP_036529.1. NM_012397.3. [Q9UIV8-1 ]
UniGenei Hs.241407.

3D structure databases

ProteinModelPortali Q9UIV8.
SMRi Q9UIV8. Positions 2-391.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9UIV8. 1 interaction.
STRINGi 9606.ENSP00000341584.

Protein family/group databases

MEROPSi I04.017.

PTM databases

PhosphoSitei Q9UIV8.

Polymorphism databases

DMDMi 12643252.

Proteomic databases

MaxQBi Q9UIV8.
PaxDbi Q9UIV8.
PRIDEi Q9UIV8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000269489 ; ENSP00000269489 ; ENSG00000197641 . [Q9UIV8-2 ]
ENST00000344731 ; ENSP00000341584 ; ENSG00000197641 . [Q9UIV8-1 ]
GeneIDi 5275.
KEGGi hsa:5275.
UCSCi uc002ljc.3. human. [Q9UIV8-1 ]

Organism-specific databases

CTDi 5275.
GeneCardsi GC18P061227.
HGNCi HGNC:8944. SERPINB13.
MIMi 604445. gene.
neXtProti NX_Q9UIV8.
PharmGKBi PA35512.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4826.
HOVERGENi HBG005957.
InParanoidi Q9UIV8.
KOi K13963.
OMAi PGHMEER.
PhylomeDBi Q9UIV8.
TreeFami TF352619.

Miscellaneous databases

GeneWikii SERPINB13.
GenomeRNAii 5275.
NextBioi 20384.
PROi Q9UIV8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UIV8.
Bgeei Q9UIV8.
CleanExi HS_SERPINB13.
Genevestigatori Q9UIV8.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of hurpin (Protease Inhibitor 13): a new skin specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family."
    Abts H.F., Welss T., Mirmohammadsadegh A., Koehrer K., Michel G., Ruzicka T.
    J. Mol. Biol. 293:29-39(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Skin.
  2. "Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q."
    Spring P., Nakashima T., Frederick M., Henderson Y., Clayman G.
    Biochem. Biophys. Res. Commun. 264:299-304(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-293.
  3. "Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells."
    Nakashima T., Pak S.C., Silverman G.A., Spring P.M., Frederick M.J., Clayman G.L.
    Biochim. Biophys. Acta 1492:441-446(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  4. "Sequence, organization, chromosomal localization and alternative splicing of the human serine protease inhibitor gene hurpin (PI13), which is up-regulated in psoriasis."
    Abts H.F., Welss T., Scheuring S., Scott F.L., Irving J.A., Michel G., Bird P.I., Ruzicka T.
    DNA Cell Biol. 20:123-131(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
    Tissue: Placenta.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-293.
    Tissue: Tongue.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-293.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPB13_HUMAN
AccessioniPrimary (citable) accession number: Q9UIV8
Secondary accession number(s): A8K2Q8
, Q3MII2, Q9HCX1, Q9UBW1, Q9UKG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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