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Protein

Serpin B13

Gene

SERPINB13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the proliferation or differentiation of keratinocytes.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei356 – 3572Reactive bondBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: GO_Central
  2. regulation of proteolysis Source: UniProtKB
  3. response to UV Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B13
Alternative name(s):
HaCaT UV-repressible serpin
Short name:
Hurpin
Headpin
Peptidase inhibitor 13
Short name:
PI-13
Proteinase inhibitor 13
Gene namesi
Name:SERPINB13
Synonyms:PI13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:8944. SERPINB13.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular space Source: GO_Central
  3. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Serpin B13PRO_0000094121Add
BLAST

Proteomic databases

MaxQBiQ9UIV8.
PaxDbiQ9UIV8.
PRIDEiQ9UIV8.

PTM databases

PhosphoSiteiQ9UIV8.

Expressioni

Tissue specificityi

Skin specific.

Gene expression databases

BgeeiQ9UIV8.
CleanExiHS_SERPINB13.
ExpressionAtlasiQ9UIV8. baseline and differential.
GenevestigatoriQ9UIV8.

Organism-specific databases

HPAiHPA057129.

Interactioni

Protein-protein interaction databases

BioGridi111293. 3 interactions.
IntActiQ9UIV8. 1 interaction.
STRINGi9606.ENSP00000341584.

Structurei

3D structure databases

ProteinModelPortaliQ9UIV8.
SMRiQ9UIV8. Positions 2-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOVERGENiHBG005957.
InParanoidiQ9UIV8.
KOiK13963.
OMAiKFLHRSF.
PhylomeDBiQ9UIV8.
TreeFamiTF352619.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UIV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA
60 70 80 90 100
SQLEEVFHSE KETKSSRIKA EEKEVIENTE AVHQQFQKFL TEISKLTNDY
110 120 130 140 150
ELNITNRLFG EKTYLFLQKY LDYVEKYYHA SLEPVDFVNA ADESRKKINS
160 170 180 190 200
WVESKTNEKI KDLFPDGSIS SSTKLVLVNM VYFKGQWDRE FKKENTKEEK
210 220 230 240 250
FWMNKSTSKS VQMMTQSHSF SFTFLEDLQA KILGIPYKNN DLSMFVLLPN
260 270 280 290 300
DIDGLEKIID KISPEKLVEW TSPGHMEERK VNLHLPRFEV EDGYDLEAVL
310 320 330 340 350
AAMGMGDAFS EHKADYSGMS SGSGLYAQKF LHSSFVAVTE EGTEAAAATG
360 370 380 390
IGFTVTSAPG HENVHCNHPF LFFIRHNESN SILFFGRFSS P
Length:391
Mass (Da):44,276
Last modified:December 1, 2000 - v2
Checksum:i2CA88558D4BC2B09
GO
Isoform 2 (identifier: Q9UIV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-257: Missing.

Show »
Length:339
Mass (Da):38,413
Checksum:iEDF2E376FB246068
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81S → N in CAC03569 (PubMed:11313015).Curated
Sequence conflicti75 – 751Missing in CAA04937 (PubMed:10512713).Curated
Sequence conflicti297 – 2971E → Q in CAA04937 (PubMed:10512713).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti293 – 2931G → S.3 Publications
Corresponds to variant rs1020694 [ dbSNP | Ensembl ].
VAR_024356

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei206 – 25752Missing in isoform 2. CuratedVSP_006058Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001696 mRNA. Translation: CAA04935.2.
AJ001697 mRNA. Translation: CAA04936.2.
AJ001698 mRNA. Translation: CAA04937.1.
AF169949 mRNA. Translation: AAD55765.1.
AF216854 Genomic DNA. Translation: AAF72879.1.
AJ278717 Genomic DNA. Translation: CAC03569.1.
AK290323 mRNA. Translation: BAF83012.1.
AK313486 mRNA. Translation: BAG36269.1.
CH471096 Genomic DNA. Translation: EAW63153.1.
BC101821 mRNA. Translation: AAI01822.1.
CCDSiCCDS11985.1. [Q9UIV8-1]
PIRiJC7118.
RefSeqiNP_036529.1. NM_012397.3. [Q9UIV8-1]
UniGeneiHs.241407.

Genome annotation databases

EnsembliENST00000344731; ENSP00000341584; ENSG00000197641. [Q9UIV8-1]
GeneIDi5275.
KEGGihsa:5275.
UCSCiuc002ljc.3. human. [Q9UIV8-1]

Polymorphism databases

DMDMi12643252.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001696 mRNA. Translation: CAA04935.2.
AJ001697 mRNA. Translation: CAA04936.2.
AJ001698 mRNA. Translation: CAA04937.1.
AF169949 mRNA. Translation: AAD55765.1.
AF216854 Genomic DNA. Translation: AAF72879.1.
AJ278717 Genomic DNA. Translation: CAC03569.1.
AK290323 mRNA. Translation: BAF83012.1.
AK313486 mRNA. Translation: BAG36269.1.
CH471096 Genomic DNA. Translation: EAW63153.1.
BC101821 mRNA. Translation: AAI01822.1.
CCDSiCCDS11985.1. [Q9UIV8-1]
PIRiJC7118.
RefSeqiNP_036529.1. NM_012397.3. [Q9UIV8-1]
UniGeneiHs.241407.

3D structure databases

ProteinModelPortaliQ9UIV8.
SMRiQ9UIV8. Positions 2-391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111293. 3 interactions.
IntActiQ9UIV8. 1 interaction.
STRINGi9606.ENSP00000341584.

Protein family/group databases

MEROPSiI04.017.

PTM databases

PhosphoSiteiQ9UIV8.

Polymorphism databases

DMDMi12643252.

Proteomic databases

MaxQBiQ9UIV8.
PaxDbiQ9UIV8.
PRIDEiQ9UIV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344731; ENSP00000341584; ENSG00000197641. [Q9UIV8-1]
GeneIDi5275.
KEGGihsa:5275.
UCSCiuc002ljc.3. human. [Q9UIV8-1]

Organism-specific databases

CTDi5275.
GeneCardsiGC18P061227.
HGNCiHGNC:8944. SERPINB13.
HPAiHPA057129.
MIMi604445. gene.
neXtProtiNX_Q9UIV8.
PharmGKBiPA35512.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOVERGENiHBG005957.
InParanoidiQ9UIV8.
KOiK13963.
OMAiKFLHRSF.
PhylomeDBiQ9UIV8.
TreeFamiTF352619.

Miscellaneous databases

ChiTaRSiSERPINB13. human.
GeneWikiiSERPINB13.
GenomeRNAii5275.
NextBioi20384.
PROiQ9UIV8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UIV8.
CleanExiHS_SERPINB13.
ExpressionAtlasiQ9UIV8. baseline and differential.
GenevestigatoriQ9UIV8.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of hurpin (Protease Inhibitor 13): a new skin specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family."
    Abts H.F., Welss T., Mirmohammadsadegh A., Koehrer K., Michel G., Ruzicka T.
    J. Mol. Biol. 293:29-39(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Skin.
  2. "Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q."
    Spring P., Nakashima T., Frederick M., Henderson Y., Clayman G.
    Biochem. Biophys. Res. Commun. 264:299-304(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-293.
  3. "Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells."
    Nakashima T., Pak S.C., Silverman G.A., Spring P.M., Frederick M.J., Clayman G.L.
    Biochim. Biophys. Acta 1492:441-446(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  4. "Sequence, organization, chromosomal localization and alternative splicing of the human serine protease inhibitor gene hurpin (PI13), which is up-regulated in psoriasis."
    Abts H.F., Welss T., Scheuring S., Scott F.L., Irving J.A., Michel G., Bird P.I., Ruzicka T.
    DNA Cell Biol. 20:123-131(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
    Tissue: Placenta.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-293.
    Tissue: Tongue.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-293.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPB13_HUMAN
AccessioniPrimary (citable) accession number: Q9UIV8
Secondary accession number(s): A8K2Q8
, Q3MII2, Q9HCX1, Q9UBW1, Q9UKG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: March 4, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.