Q9UIV8 (SPB13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serpin B13

Alternative name(s):
HaCaT UV-repressible serpin
Short name=Hurpin
Headpin
Peptidase inhibitor 13
Short name=PI-13
Proteinase inhibitor 13

Gene names

Name:	SERPINB13
Synonyms:	PI13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in the proliferation or differentiation of keratinocytes.
Subcellular location	Cytoplasm.
Tissue specificity	Skin specific.
Sequence similarities	Belongs to the serpin family. Ov-serpin subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Protease inhibitor Serine protease inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of proteolysis Non-traceable author statement Ref.1. Source: UniProtKB response to UV Traceable author statement PubMed 9297979. Source: ProtInc
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	serine-type endopeptidase inhibitor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UIV8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UIV8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     206-257: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 391	391	Serpin B13		PRO_0000094121
Sites
	Site	356 – 357	2	Reactive bond By similarity
Natural variations
	Alternative sequence	206 – 257	52	Missing in isoform 2.		VSP_006058
	Natural variant	293	1	G → S. Ref.2 Ref.5 Ref.6 Corresponds to variant rs1020694 [ dbSNP | Ensembl ].		VAR_024356
Experimental info
	Sequence conflict	8	1	S → N in CAC03569. Ref.4
	Sequence conflict	75	1	Missing in CAA04937. Ref.1
	Sequence conflict	297	1	E → Q in CAA04937. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: 2CA88558D4BC2B09	FASTA	391	44,276
	10 20 30 40 50 60 MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA SQLEEVFHSE 70 80 90 100 110 120 KETKSSRIKA EEKEVIENTE AVHQQFQKFL TEISKLTNDY ELNITNRLFG EKTYLFLQKY 130 140 150 160 170 180 LDYVEKYYHA SLEPVDFVNA ADESRKKINS WVESKTNEKI KDLFPDGSIS SSTKLVLVNM 190 200 210 220 230 240 VYFKGQWDRE FKKENTKEEK FWMNKSTSKS VQMMTQSHSF SFTFLEDLQA KILGIPYKNN 250 260 270 280 290 300 DLSMFVLLPN DIDGLEKIID KISPEKLVEW TSPGHMEERK VNLHLPRFEV EDGYDLEAVL 310 320 330 340 350 360 AAMGMGDAFS EHKADYSGMS SGSGLYAQKF LHSSFVAVTE EGTEAAAATG IGFTVTSAPG 370 380 390 HENVHCNHPF LFFIRHNESN SILFFGRFSS P
	Isoform 2 [UniParc]. Checksum: EDF2E376FB246068	FASTA	339	38,413
	10 20 30 40 50 60 MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA SQLEEVFHSE 70 80 90 100 110 120 KETKSSRIKA EEKEVIENTE AVHQQFQKFL TEISKLTNDY ELNITNRLFG EKTYLFLQKY 130 140 150 160 170 180 LDYVEKYYHA SLEPVDFVNA ADESRKKINS WVESKTNEKI KDLFPDGSIS SSTKLVLVNM 190 200 210 220 230 240 VYFKGQWDRE FKKENTKEEK FWMNKIIDKI SPEKLVEWTS PGHMEERKVN LHLPRFEVED 250 260 270 280 290 300 GYDLEAVLAA MGMGDAFSEH KADYSGMSSG SGLYAQKFLH SSFVAVTEEG TEAAAATGIG 310 320 330 FTVTSAPGHE NVHCNHPFLF FIRHNESNSI LFFGRFSSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of hurpin (Protease Inhibitor 13): a new skin specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family." Abts H.F., Welss T., Mirmohammadsadegh A., Koehrer K., Michel G., Ruzicka T. J. Mol. Biol. 293:29-39(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Skin.
[2]	"Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q." Spring P., Nakashima T., Frederick M., Henderson Y., Clayman G. Biochem. Biophys. Res. Commun. 264:299-304(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-293.
[3]	"Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells." Nakashima T., Pak S.C., Silverman G.A., Spring P.M., Frederick M.J., Clayman G.L. Biochim. Biophys. Acta 1492:441-446(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[4]	"Sequence, organization, chromosomal localization and alternative splicing of the human serine protease inhibitor gene hurpin (PI13), which is up-regulated in psoriasis." Abts H.F., Welss T., Scheuring S., Scott F.L., Irving J.A., Michel G., Bird P.I., Ruzicka T. DNA Cell Biol. 20:123-131(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2). Tissue: Placenta.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-293. Tissue: Tongue.
[6]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-293.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ001696 mRNA. Translation: CAA04935.2. AJ001697 mRNA. Translation: CAA04936.2. AJ001698 mRNA. Translation: CAA04937.1. AF169949 mRNA. Translation: AAD55765.1. AF216854 Genomic DNA. Translation: AAF72879.1. AJ278717 Genomic DNA. Translation: CAC03569.1. AK290323 mRNA. Translation: BAF83012.1. AK313486 mRNA. Translation: BAG36269.1. CH471096 Genomic DNA. Translation: EAW63153.1. BC101821 mRNA. Translation: AAI01822.1.
IPI	IPI00006560. IPI00220494.
PIR	JC7118.
RefSeq	NP_036529.1. NM_012397.3.
UniGene	Hs.241407.
3D structure databases
ProteinModelPortal	Q9UIV8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UIV8. 1 interaction.
STRING	9606.ENSP00000341584.
Protein family/group databases
MEROPS	I04.017.
PTM databases
PhosphoSite	Q9UIV8.
Polymorphism databases
DMDM	12643252.
Proteomic databases
PaxDb	Q9UIV8.
PRIDE	Q9UIV8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000269489; ENSP00000269489; ENSG00000197641. ENST00000344731; ENSP00000341584; ENSG00000197641.
GeneID	5275.
KEGG	hsa:5275.
UCSC	uc002ljc.3. human.
Organism-specific databases
CTD	5275.
GeneCards	GC18P061227.
HGNC	HGNC:8944. SERPINB13.
MIM	604445. gene.
neXtProt	NX_Q9UIV8.
PharmGKB	PA35512.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4826.
HOVERGEN	HBG005957.
InParanoid	Q9UIV8.
KO	K13963.
OMA	PGHMEER.
OrthoDB	EOG4FBHTJ.
PhylomeDB	Q9UIV8.
Gene expression databases
ArrayExpress	Q9UIV8.
Bgee	Q9UIV8.
CleanEx	HS_SERPINB13.
Genevestigator	Q9UIV8.
GermOnline	ENSG00000197641. Homo sapiens.
Family and domain databases
InterPro	IPR023795. Protease_inhib_I4_serpin_CS. IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00284. SERPIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5275.
NextBio	20384.
SOURCE	Search...

Entry information

Entry name

SPB13_HUMAN

Accession

Primary (citable) accession number: Q9UIV8
Secondary accession number(s): A8K2Q8 , Q3MII2, Q9HCX1, Q9UBW1, Q9UKG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.