Q9UIV1 (CNOT7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CCR4-NOT transcription complex subunit 7

Alternative name(s):
BTG1-binding factor 1
CCR4-associated factor 1
Short name=CAF-1

Gene names

Name:	CNOT7
Synonyms:	CAF1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression By similarity.
Subunit structure	Interacts with TOB1. Interacts with NANOS2 By similarity.
Subcellular location	Nucleus. Cytoplasm › P-body By similarity. Note: NANOS2 promotes its localization to P-body By similarity.
Sequence similarities	Belongs to the CAF1 family.
Sequence caution	The sequence AAF01500.1 differs from that shown. Reason: Frameshift at position 4.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Molecular function	Repressor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Traceable author statement. Source: ProtInc nuclear-transcribed mRNA poly(A) tail shortening Traceable author statement. Source: Reactome transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	CCR4-NOT complex Non-traceable author statement Ref.1. Source: UniProtKB cytoplasmic mRNA processing body Inferred from sequence or structural similarity. Source: UniProtKB cytosol Traceable author statement. Source: Reactome
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction Ref.1. Source: UniProtKB sequence-specific DNA binding transcription factor activity Traceable author statement. Source: ProtInc signal transducer activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 285

285

CCR4-NOT transcription complex subunit 7

PRO_0000212844

Experimental info

Sequence conflict

4 – 5

2

AT → EL in AAP97145. Ref.2

Secondary structure

1

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285

Helix Strand Turn

Details...

Beta strand

12 – 15

4

Helix

17 – 19

3

Helix

20 – 33

14

Beta strand

36 – 42

7

Helix

57 – 69

13

Beta strand

76 – 82

7

Beta strand

94 – 99

6

Turn

103 – 105

3

Helix

110 – 119

10

Helix

123 – 129

7

Helix

133 – 141

9

Turn

142 – 144

3

Beta strand

145 – 150

6

Beta strand

152 – 157

6

Helix

159 – 170

12

Helix

178 – 188

11

Beta strand

192 – 194

3

Helix

195 – 198

4

Helix

199 – 201

3

Helix

209 – 216

8

Helix

227 – 244

18

Helix

252 – 255

4

Sequences

	Sequence		Length	Mass (Da)
	Q9UIV1 [UniParc]. Last modified February 2, 2004. Version 3. Checksum: 2AF23ED27E06EFDB	FASTA	285	32,745
	10 20 30 40 50 60 MPAATVDHSQ RICEVWACNL DEEMKKIRQV IRKYNYVAMD TEFPGVVARP IGEFRSNADY 70 80 90 100 110 120 QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP GTSTWQFNFK FNLTEDMYAQ DSIELLTTSG 130 140 150 160 170 180 IQFKKHEEEG IETQYFAELL MTSGVVLCEG VKWLSFHSGY DFGYLIKILT NSNLPEEELD 190 200 210 220 230 240 FFEILRLFFP VIYDVKYLMK SCKNLKGGLQ EVAEQLELER IGPQHQAGSD SLLTGMAFFK 250 260 270 280 MREMFFEDHI DDAKYCGHLY GLGSGSSYVQ NGTGNAYEEE ANKQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1." Bogdan J.A., Adams-Burton C., Pedicord D.L., Sukovich D.A., Benfield P.A., Corjay M.H., Stoltenborg J.K., Dicker I.B. Biochem. J. 336:471-481(1998) [PubMed: 9820826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and expression of a new human cDNA homology to mouse mCAF1 protein mRNA." Wan Y.Z., Yu L., Zhang H.L., Liu Q., Chen S.Y., Zhao S.Y. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[4]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate and Testis.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"Structural basis for TOB-HCAF1, a novel mammalian antiproliferative domain-poly(A) specific deadenylase complex." Horiuchi M., Suzuki N.N., Muroya N., Takahasi K., Nishida M., Yoshida Y., Ikematsu N., Nakamura T., Kawamura-Tsuzuku J., Yamamoto T., Inagaki F. Submitted (DEC-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 11-262 IN COMPLEX WITH TOB1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L46722 mRNA. Translation: AAF01500.1. Frameshift.
AF086915 mRNA. Translation: AAP97145.1.
AK021808 mRNA. Translation: BAG51053.1.
CH471080 Genomic DNA. Translation: EAW63820.1.
CH471080 Genomic DNA. Translation: EAW63821.1.
CH471080 Genomic DNA. Translation: EAW63823.1.
BC060852 mRNA. Translation: AAH60852.1.
BC070187 mRNA. Translation: AAH70187.1.

IPI

IPI00006552.

RefSeq

NP_037486.2. NM_013354.5.
NP_473367.2. NM_054026.2.

UniGene

Hs.645009.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2D5R	X-ray	2.50	A	11-262	[»]

ProteinModelPortal

Q9UIV1.

SMR

Q9UIV1. Positions 11-262.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-41902N.

IntAct

Q9UIV1. 2 interactions.

STRING

Q9UIV1.

Polymorphism databases

DMDM

41713629.

Proteomic databases

PRIDE

Q9UIV1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000361272; ENSP00000355279; ENSG00000198791.

GeneID

29883.

KEGG

hsa:29883.

UCSC

uc003wxf.1. human.

Organism-specific databases

CTD

29883.

GeneCards

GC08M017086.

H-InvDB

HIX0007335.

HGNC

HGNC:14101. CNOT7.

MIM

604913. gene.

neXtProt

NX_Q9UIV1.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG14569.

GeneTree

ENSGT00390000000080.

HOGENOM

HBG748413.

HOVERGEN

HBG051044.

InParanoid

Q9UIV1.

OMA

GLTFMDD.

OrthoDB

EOG4MKNGS.

PhylomeDB

Q9UIV1.

Enzyme and pathway databases

Reactome

REACT_111217. Metabolism.

Gene expression databases

ArrayExpress

Q9UIV1.

Bgee

Q9UIV1.

CleanEx

HS_CNOT7.

Genevestigator

Q9UIV1.

GermOnline

ENSG00000198791. Homo sapiens.

Family and domain databases

InterPro

IPR006941. RNase_CAF1.
IPR012337. RNaseH-like_dom.
[Graphical view]

KO

K12581.

Pfam

PF04857. CAF1. 1 hit.
[Graphical view]

SUPFAM

SSF53098. RNaseH_fold. 1 hit.

ProtoNet

Search...

Other

NextBio

52417.

SOURCE

Search...

Entry information

Entry name

CNOT7_HUMAN

Accession

Primary (citable) accession number: Q9UIV1
Secondary accession number(s): A8MZM5 , B3KMP1, D3DSP6, Q7Z530

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	February 2, 2004
Last modified:	January 25, 2012
This is version 98 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.