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Protein
Submitted name:

Dihydropyridine receptor alpha 2 subunit

Gene

CACNA2D1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiR-HSA-112308. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
R-HSA-5576892. Phase 0 - rapid depolarisation.
R-HSA-5576893. Phase 2 - plateau phase.
R-HSA-5576894. Phase 1 - inactivation of fast Na+ channels.

Names & Taxonomyi

Protein namesi
Submitted name:
Dihydropyridine receptor alpha 2 subunitImported
Gene namesi
Name:CACNA2D1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 11101086Sequence analysisPRO_5004335235Add
BLAST

Proteomic databases

PaxDbiQ9UIU0.
PeptideAtlasiQ9UIU0.
PRIDEiQ9UIU0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349320.

Structurei

3D structure databases

ProteinModelPortaliQ9UIU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini253 – 430178VWFAInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2353. Eukaryota.
ENOG410XPDX. LUCA.
HOGENOMiHOG000004860.
HOVERGENiHBG057779.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013680. VDCC_a2/dsu.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view]
PfamiPF08473. VGCC_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UIU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGCLLALT LTLFQSLLIG PSSEEPFPSA VTIKSWVDKM QEDLVTLAKT
60 70 80 90 100
ASGVNQLVDI YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL
110 120 130 140 150
ALEAEKVQAA HQWREDFASN EVVYYNAKDD LDPEKNDSEP GSQRIKPVFI
160 170 180 190 200
EDANFGRQIS YQHAAVHIPT DIYEGSTIVL NELNWTSALD EVFKKNREED
210 220 230 240 250
PSLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR RPWYIQGAAS
260 270 280 290 300
PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASFNSNAQD
310 320 330 340 350
VSCFQHLVQA NVRNKKVLKD AVNNITAKGI TDYKKGFSFA FEQLLNYNVS
360 370 380 390 400
RANCNKIIML FTDGGEERAQ EIFNKYNKDK KVRVFTFSVG QHNYDRGPIQ
410 420 430 440 450
WMACENKGYY YEIPSIGAIR INTQEYLDVL GRPMVLAGDK AKQVQWTNVY
460 470 480 490 500
LDALELGLVI TGTLPVFNIT GQFENKTNLK NQLILGVMGV DVSLEDIKRL
510 520 530 540 550
TPRFTLCPNG YYFAIDPNGY VLLHPNLQPK PIGVGIPTIN LRKRRPNIQN
560 570 580 590 600
PKSQEPVTLD FLDAELENDI KVEIRNKMID GESGEKTFRT LVKSQDERYI
610 620 630 640 650
DKGNRTYTWT PVNGTDYSLA LVLPTYSFYY IKAKLEETIT QARSKKGKMK
660 670 680 690 700
DSETLKPDNF EESGYTFIAP RDYCNDLKIS DNNTEFLLNF NEFIDRKTPN
710 720 730 740 750
NPSCNADLIN RVLLDAGFTN ELVQNYWSKQ KNIKGVKARF VVTDGGITRV
760 770 780 790 800
YPKEAGENWQ ENPETYEDSF YKRSLDNDNY VFTAPYFNKS GPGAYESGIM
810 820 830 840 850
VSKAVEIYIQ GKLLKPAVVG IKIDVNSWIE NFTKTSIRDP CAGPVCDCKR
860 870 880 890 900
NSDVMDCVIL DDGGFLLMAN HDDYTNQIGR FFGEIDPSLM RHLVNISVYA
910 920 930 940 950
FNKSYDYQSV CEPGAAPKQG AGHRSAYVPS VADILQIGWW ATAAAWSILQ
960 970 980 990 1000
QFLLSLTFPR LLEAVEMEDD DFTASLSKQS CITEQTQYFF DNDSKSFSGV
1010 1020 1030 1040 1050
LDCGNCSRIF HGEKLMNTNL IFIMVESKGT CPCDTRLLIQ AEQTSDGPNP
1060 1070 1080 1090 1100
CDMVKQPRYR KGPDVCFDNN VLEDYTDCGG VSGLNPSLWY IIGIQFLLLW
1110
LVSGSTHRLL
Length:1,110
Mass (Da):125,308
Last modified:May 1, 2000 - v1
Checksum:i8358DC6AD489C074
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083854
, AF083817, AF083818, AF083819, AF083820, AF083821, AF083822, AF083823, AF083824, AF083825, AF083826, AF083827, AF083828, AF083829, AF083830, AF083831, AF083832, AF083833, AF083834, AF083835, AF083836, AF083837, AF083838, AF083839, AF083840, AF083841, AF083842, AF083843, AF083844, AF083845, AF083846, AF083847, AF083848, AF083849, AF083850, AF083851, AF083852, AF083853 Genomic DNA. Translation: AAF03259.1.
RefSeqiXP_006716181.1. XM_006716118.2.
UniGeneiHs.282151.
Hs.592625.
Hs.743228.

Genome annotation databases

GeneIDi781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083854
, AF083817, AF083818, AF083819, AF083820, AF083821, AF083822, AF083823, AF083824, AF083825, AF083826, AF083827, AF083828, AF083829, AF083830, AF083831, AF083832, AF083833, AF083834, AF083835, AF083836, AF083837, AF083838, AF083839, AF083840, AF083841, AF083842, AF083843, AF083844, AF083845, AF083846, AF083847, AF083848, AF083849, AF083850, AF083851, AF083852, AF083853 Genomic DNA. Translation: AAF03259.1.
RefSeqiXP_006716181.1. XM_006716118.2.
UniGeneiHs.282151.
Hs.592625.
Hs.743228.

3D structure databases

ProteinModelPortaliQ9UIU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349320.

Proteomic databases

PaxDbiQ9UIU0.
PeptideAtlasiQ9UIU0.
PRIDEiQ9UIU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi781.

Organism-specific databases

CTDi781.

Phylogenomic databases

eggNOGiKOG2353. Eukaryota.
ENOG410XPDX. LUCA.
HOGENOMiHOG000004860.
HOVERGENiHBG057779.

Enzyme and pathway databases

ReactomeiR-HSA-112308. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
R-HSA-5576892. Phase 0 - rapid depolarisation.
R-HSA-5576893. Phase 2 - plateau phase.
R-HSA-5576894. Phase 1 - inactivation of fast Na+ channels.

Miscellaneous databases

ChiTaRSiCACNA2D1. human.
GenomeRNAii781.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013680. VDCC_a2/dsu.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view]
PfamiPF08473. VGCC_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9UIU0_HUMAN
AccessioniPrimary (citable) accession number: Q9UIU0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.