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Q9UIR0

- BTNL2_HUMAN

UniProt

Q9UIR0 - BTNL2_HUMAN

Protein

Butyrophilin-like protein 2

Gene

BTNL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Negative regulator of T-cell proliferation.By similarity

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Butyrophilin-like protein 2
    Short name:
    BTL-II
    Gene namesi
    Name:BTNL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1142. BTNL2.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type II membrane protein 1 Publication
    Note: Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Sarcoidosis 2 (SS2) [MIM:612387]: An idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved.
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis.

    Organism-specific databases

    MIMi612387. phenotype.
    Orphaneti797. Sarcoidosis.
    PharmGKBiPA25463.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Butyrophilin-like protein 2PRO_0000014537Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 124PROSITE-ProRule annotation
    Disulfide bondi164 ↔ 218PROSITE-ProRule annotation
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi267 ↔ 341PROSITE-ProRule annotation
    Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UIR0.
    PRIDEiQ9UIR0.

    PTM databases

    PhosphoSiteiQ9UIR0.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis and thymus.1 Publication

    Inductioni

    By proinflammatory cytokines such as TNF and IL1B/interleukin-1 beta.1 Publication

    Gene expression databases

    ArrayExpressiQ9UIR0.
    BgeeiQ9UIR0.
    GenevestigatoriQ9UIR0.

    Organism-specific databases

    HPAiHPA039844.

    Interactioni

    Protein-protein interaction databases

    BioGridi121112. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UIR0.
    SMRiQ9UIR0. Positions 29-236, 244-452.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicSequence Analysis
    Topological domaini24 – 455432ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2317Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 140112Ig-like V-type 1Add
    BLAST
    Domaini142 – 23493Ig-like V-type 2Add
    BLAST
    Domaini236 – 355120Ig-like V-type 3Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG131805.
    HOVERGENiHBG054868.
    InParanoidiQ9UIR0.
    OMAiHIRMERP.
    PhylomeDBiQ9UIR0.
    TreeFamiTF331083.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF08205. C2-set_2. 2 hits.
    PF07686. V-set. 2 hits.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UIR0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVDFPGYNLS GAVASFLFIL LTMKQSEDFR VIGPAHPILA GVGEDALLTC    50
    QLLPKRTTMH VEVRWYRSEP STPVFVHRDG VEVTEMQMEE YRGWVEWIEN 100
    GIAKGNVALK IHNIQPSDNG QYWCHFQDGN YCGETSLLLK VAGLGSAPSI 150
    HMEGPGESGV QLVCTARGWF PEPQVYWEDI RGEKLLAVSE HRIQDKDGLF 200
    YAEATLVVRN ASAESVSCLV HNPVLTEEKG SVISLPEKLQ TELASLKVNG 250
    PSQPILVRVG EDIQLTCYLS PKANAQSMEV RWDRSHRYPA VHVYMDGDHV 300
    AGEQMAEYRG RTVLVSDAID EGRLTLQILS ARPSDDGQYR CLFEKDDVYQ 350
    EASLDLKVVS LGSSPLITVE GQEDGEMQPM CSSDGWFPQP HVPWRDMEGK 400
    TIPSSSQALT QGSHGLFHVQ TLLRVTNISA VDVTCSISIP FLGEEKIATF 450
    SLSGW 455
    Length:455
    Mass (Da):50,436
    Last modified:May 1, 2000 - v1
    Checksum:i4194025C7416F839
    GO
    Isoform 2 (identifier: Q9UIR0-2) [UniParc]FASTAAdd to Basket

    Also known as: Long

    The sequence of this isoform differs from the canonical sequence as follows:
         143-236: Missing.
         454-455: GW → ESRMTFLWKTLLVWGLLLAVAVGLPRKRS

    Show »
    Length:388
    Mass (Da):43,373
    Checksum:iC7398D15BAF5492D
    GO
    Isoform 3 (identifier: Q9UIR0-3) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         143-236: Missing.
         360-364: SLGSS → WVLPH
         365-455: Missing.

    Show »
    Length:270
    Mass (Da):30,568
    Checksum:i284B8285EA865323
    GO
    Isoform 4 (identifier: Q9UIR0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         28-237: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:245
    Mass (Da):27,086
    Checksum:i0141DB697EF1DDD4
    GO
    Isoform 5 (identifier: Q9UIR0-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-277: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:178
    Mass (Da):19,831
    Checksum:iBE380AD9588A90C6
    GO
    Isoform 6 (identifier: Q9UIR0-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         244-259: ASLKVNGPSQPILVRV → GKYEVLAHTCGGSLCP
         260-455: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:259
    Mass (Da):28,660
    Checksum:iBF7BA587B9FC4526
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271Missing in AAV91023. (PubMed:15516930)Curated
    Isoform 5 (identifier: Q9UIR0-5)
    Sequence conflicti83 – 831S → G in AAI19669. (PubMed:15489334)Curated
    Isoform 4 (identifier: Q9UIR0-4)
    Sequence conflicti150 – 1501S → G in AAI27643. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti94 – 941W → R.
    Corresponds to variant rs28362682 [ dbSNP | Ensembl ].
    VAR_033602
    Natural varianti181 – 1811R → Q.
    Corresponds to variant rs28362681 [ dbSNP | Ensembl ].
    VAR_061307
    Natural varianti188 – 1881V → M.
    Corresponds to variant rs9461742 [ dbSNP | Ensembl ].
    VAR_049837
    Natural varianti196 – 1961K → E.1 Publication
    Corresponds to variant rs2076523 [ dbSNP | Ensembl ].
    VAR_021171
    Natural varianti202 – 2021A → V.
    Corresponds to variant rs28362680 [ dbSNP | Ensembl ].
    VAR_061308
    Natural varianti283 – 2831D → V.
    Corresponds to variant rs34423804 [ dbSNP | Ensembl ].
    VAR_033603
    Natural varianti334 – 3341S → L.1 Publication
    Corresponds to variant rs28362679 [ dbSNP | Ensembl ].
    VAR_029128
    Natural varianti352 – 3521A → T.
    Corresponds to variant rs35037492 [ dbSNP | Ensembl ].
    VAR_033604
    Natural varianti360 – 3601S → G.
    Corresponds to variant rs2076530 [ dbSNP | Ensembl ].
    VAR_049838
    Natural varianti379 – 3791P → L.
    Corresponds to variant rs28362678 [ dbSNP | Ensembl ].
    VAR_033605
    Natural varianti380 – 3801M → I.
    Corresponds to variant rs28362677 [ dbSNP | Ensembl ].
    VAR_033606
    Natural varianti393 – 3931P → Q.
    Corresponds to variant rs41521946 [ dbSNP | Ensembl ].
    VAR_033607

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 277277Missing in isoform 5. 1 PublicationVSP_027184Add
    BLAST
    Alternative sequencei28 – 237210Missing in isoform 4. 1 PublicationVSP_027185Add
    BLAST
    Alternative sequencei143 – 23694Missing in isoform 2 and isoform 3. CuratedVSP_027186Add
    BLAST
    Alternative sequencei244 – 25916ASLKV…ILVRV → GKYEVLAHTCGGSLCP in isoform 6. CuratedVSP_027187Add
    BLAST
    Alternative sequencei260 – 455196Missing in isoform 6. CuratedVSP_027188Add
    BLAST
    Alternative sequencei360 – 3645SLGSS → WVLPH in isoform 3. CuratedVSP_027189
    Alternative sequencei365 – 45591Missing in isoform 3. CuratedVSP_027190Add
    BLAST
    Alternative sequencei454 – 4552GW → ESRMTFLWKTLLVWGLLLAV AVGLPRKRS in isoform 2. CuratedVSP_027191

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF186593
    , AF186588, AF186589, AF186591, AF186592, AF186590 Genomic DNA. Translation: AAF05530.1.
    AY881999 Genomic DNA. Translation: AAX35330.1.
    AY881999 Genomic DNA. Translation: AAX35331.1.
    AL034394, Z84814 Genomic DNA. Translation: CAI42180.1.
    Z84814, AL034394 Genomic DNA. Translation: CAC69895.2.
    AL662796 Genomic DNA. Translation: CAI18265.2.
    AL670296 Genomic DNA. Translation: CAI17569.2.
    AL670296 Genomic DNA. Translation: CAI17570.2.
    AL935032 Genomic DNA. Translation: CAI18474.2.
    AL935032 Genomic DNA. Translation: CAI18475.2.
    BX255945 Genomic DNA. Translation: CAI18727.2.
    CR753634 Genomic DNA. Translation: CAQ08809.1.
    CR759917 Genomic DNA. Translation: CAQ07562.1.
    BC119668 mRNA. Translation: AAI19669.1.
    BC127642 mRNA. Translation: AAI27643.1.
    AY684332 mRNA. Translation: AAV91022.1.
    AY684333 mRNA. Translation: AAV91023.1.
    RefSeqiNP_062548.1. NM_019602.1. [Q9UIR0-1]
    UniGeneiHs.534471.

    Genome annotation databases

    EnsembliENST00000374993; ENSP00000364132; ENSG00000204290. [Q9UIR0-1]
    ENST00000416597; ENSP00000415396; ENSG00000224770. [Q9UIR0-6]
    ENST00000422056; ENSP00000416544; ENSG00000229597. [Q9UIR0-6]
    ENST00000445928; ENSP00000399884; ENSG00000226127. [Q9UIR0-6]
    ENST00000447918; ENSP00000414811; ENSG00000229741. [Q9UIR0-6]
    ENST00000544175; ENSP00000443364; ENSG00000204290. [Q9UIR0-5]
    ENST00000548253; ENSP00000447733; ENSG00000224242.
    ENST00000548717; ENSP00000449356; ENSG00000225412.
    ENST00000550327; ENSP00000447985; ENSG00000226127. [Q9UIR0-1]
    ENST00000550531; ENSP00000448023; ENSG00000229597. [Q9UIR0-1]
    ENST00000550698; ENSP00000447616; ENSG00000229597. [Q9UIR0-5]
    ENST00000551095; ENSP00000449546; ENSG00000229741. [Q9UIR0-1]
    ENST00000551669; ENSP00000446794; ENSG00000224242.
    ENST00000551686; ENSP00000450139; ENSG00000225412.
    ENST00000552479; ENSP00000449365; ENSG00000224770. [Q9UIR0-1]
    GeneIDi56244.
    KEGGihsa:56244.
    UCSCiuc003obg.1. human. [Q9UIR0-1]
    uc010jua.1. human. [Q9UIR0-4]

    Polymorphism databases

    DMDMi73921189.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF186593
    , AF186588 , AF186589 , AF186591 , AF186592 , AF186590 Genomic DNA. Translation: AAF05530.1 .
    AY881999 Genomic DNA. Translation: AAX35330.1 .
    AY881999 Genomic DNA. Translation: AAX35331.1 .
    AL034394 , Z84814 Genomic DNA. Translation: CAI42180.1 .
    Z84814 , AL034394 Genomic DNA. Translation: CAC69895.2 .
    AL662796 Genomic DNA. Translation: CAI18265.2 .
    AL670296 Genomic DNA. Translation: CAI17569.2 .
    AL670296 Genomic DNA. Translation: CAI17570.2 .
    AL935032 Genomic DNA. Translation: CAI18474.2 .
    AL935032 Genomic DNA. Translation: CAI18475.2 .
    BX255945 Genomic DNA. Translation: CAI18727.2 .
    CR753634 Genomic DNA. Translation: CAQ08809.1 .
    CR759917 Genomic DNA. Translation: CAQ07562.1 .
    BC119668 mRNA. Translation: AAI19669.1 .
    BC127642 mRNA. Translation: AAI27643.1 .
    AY684332 mRNA. Translation: AAV91022.1 .
    AY684333 mRNA. Translation: AAV91023.1 .
    RefSeqi NP_062548.1. NM_019602.1. [Q9UIR0-1 ]
    UniGenei Hs.534471.

    3D structure databases

    ProteinModelPortali Q9UIR0.
    SMRi Q9UIR0. Positions 29-236, 244-452.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121112. 1 interaction.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q9UIR0.

    Polymorphism databases

    DMDMi 73921189.

    Proteomic databases

    PaxDbi Q9UIR0.
    PRIDEi Q9UIR0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374993 ; ENSP00000364132 ; ENSG00000204290 . [Q9UIR0-1 ]
    ENST00000416597 ; ENSP00000415396 ; ENSG00000224770 . [Q9UIR0-6 ]
    ENST00000422056 ; ENSP00000416544 ; ENSG00000229597 . [Q9UIR0-6 ]
    ENST00000445928 ; ENSP00000399884 ; ENSG00000226127 . [Q9UIR0-6 ]
    ENST00000447918 ; ENSP00000414811 ; ENSG00000229741 . [Q9UIR0-6 ]
    ENST00000544175 ; ENSP00000443364 ; ENSG00000204290 . [Q9UIR0-5 ]
    ENST00000548253 ; ENSP00000447733 ; ENSG00000224242 .
    ENST00000548717 ; ENSP00000449356 ; ENSG00000225412 .
    ENST00000550327 ; ENSP00000447985 ; ENSG00000226127 . [Q9UIR0-1 ]
    ENST00000550531 ; ENSP00000448023 ; ENSG00000229597 . [Q9UIR0-1 ]
    ENST00000550698 ; ENSP00000447616 ; ENSG00000229597 . [Q9UIR0-5 ]
    ENST00000551095 ; ENSP00000449546 ; ENSG00000229741 . [Q9UIR0-1 ]
    ENST00000551669 ; ENSP00000446794 ; ENSG00000224242 .
    ENST00000551686 ; ENSP00000450139 ; ENSG00000225412 .
    ENST00000552479 ; ENSP00000449365 ; ENSG00000224770 . [Q9UIR0-1 ]
    GeneIDi 56244.
    KEGGi hsa:56244.
    UCSCi uc003obg.1. human. [Q9UIR0-1 ]
    uc010jua.1. human. [Q9UIR0-4 ]

    Organism-specific databases

    CTDi 56244.
    GeneCardsi GC06M032359.
    GC06Mi32371.
    GC06Mj32308.
    GC06Mk32336.
    GC06Ml32400.
    GC06Mn32318.
    GC06Mo32367.
    H-InvDB HIX0164795.
    HIX0165959.
    HIX0166164.
    HIX0166450.
    HIX0166717.
    HIX0166977.
    HIX0167211.
    HIX0167458.
    HGNCi HGNC:1142. BTNL2.
    HPAi HPA039844.
    MIMi 606000. gene.
    612387. phenotype.
    neXtProti NX_Q9UIR0.
    Orphaneti 797. Sarcoidosis.
    PharmGKBi PA25463.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG131805.
    HOVERGENi HBG054868.
    InParanoidi Q9UIR0.
    OMAi HIRMERP.
    PhylomeDBi Q9UIR0.
    TreeFami TF331083.

    Miscellaneous databases

    GeneWikii BTNL2.
    GenomeRNAii 56244.
    NextBioi 61864.
    PROi Q9UIR0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UIR0.
    Bgeei Q9UIR0.
    Genevestigatori Q9UIR0.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 2 hits.
    PF07686. V-set. 2 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse."
      Stammers M., Rowen L., Rhodes D., Trowsdale J., Beck S.
      Immunogenetics 51:373-382(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, INDUCTION, INVOLVEMENT IN SUSCEPTIBILITY TO SARCOIDOSIS TYPE 2.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS GLU-196 AND LEU-334.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
    5. "Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity."
      Hiller M., Huse K., Szafranski K., Jahn N., Hampe J., Schreiber S., Backofen R., Platzer M.
      Nat. Genet. 36:1255-1257(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-109 (ISOFORMS 1/2/3/6).

    Entry informationi

    Entry nameiBTNL2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UIR0
    Secondary accession number(s): A0PJV5
    , B0UYW9, B0V0N6, O98261, Q08E96, Q58R22, Q58R23, Q5JYF9, Q5MP42, Q5MP43, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3