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Protein

Leucyl-cystinyl aminopeptidase

Gene

LNPEP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.3 Publications

Catalytic activityi

Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.2 Publications

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei295SubstrateBy similarity1
Metal bindingi464Zinc; catalyticPROSITE-ProRule annotation1
Active sitei465Proton acceptorPROSITE-ProRule annotation1
Metal bindingi468Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi487Zinc; catalyticPROSITE-ProRule annotation1
Sitei549Transition state stabilizerBy similarity1

GO - Molecular functioni

  • aminopeptidase activity Source: HGNC
  • metalloaminopeptidase activity Source: GO_Central
  • metallopeptidase activity Source: ProtInc
  • peptide binding Source: GO_Central
  • zinc ion binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS03682-MONOMER.
ReactomeiR-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SABIO-RKQ9UIQ6.

Protein family/group databases

MEROPSiM01.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucyl-cystinyl aminopeptidase (EC:3.4.11.3)
Short name:
Cystinyl aminopeptidase
Alternative name(s):
Insulin-regulated membrane aminopeptidase
Insulin-responsive aminopeptidase
Short name:
IRAP
Oxytocinase
Short name:
OTase
Placental leucine aminopeptidase
Short name:
P-LAP
Cleaved into the following chain:
Gene namesi
Name:LNPEP
Synonyms:OTASE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6656. LNPEP.

Subcellular locationi

Leucyl-cystinyl aminopeptidase, pregnancy serum form :
  • Secreted

  • Note: During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 110CytoplasmicSequence analysisAdd BLAST110
Transmembranei111 – 131Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini132 – 1025ExtracellularSequence analysisAdd BLAST894

GO - Cellular componenti

  • cytoplasmic vesicle membrane Source: Reactome
  • cytosol Source: Reactome
  • early endosome lumen Source: Reactome
  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: HGNC
  • lysosomal membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • perinuclear region of cytoplasm Source: Ensembl
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4012.
OpenTargetsiENSG00000113441.
PharmGKBiPA30418.

Chemistry databases

ChEMBLiCHEMBL2693.
GuidetoPHARMACOLOGYi1570.

Polymorphism and mutation databases

BioMutaiLNPEP.
DMDMi145559489.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000951141 – 1025Leucyl-cystinyl aminopeptidaseAdd BLAST1025
ChainiPRO_0000292264155 – 1025Leucyl-cystinyl aminopeptidase, pregnancy serum formAdd BLAST871

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei70PhosphotyrosineBy similarity1
Modified residuei80PhosphoserineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)1 Publication1
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Glycosylationi374N-linked (GlcNAc...)Sequence analysis1
Glycosylationi448N-linked (GlcNAc...)1 Publication1
Glycosylationi525N-linked (GlcNAc...)Sequence analysis1
Glycosylationi578N-linked (GlcNAc...)Sequence analysis1
Glycosylationi598N-linked (GlcNAc...)Sequence analysis1
Glycosylationi664N-linked (GlcNAc...)Sequence analysis1
Glycosylationi682N-linked (GlcNAc...)1 Publication1
Glycosylationi760N-linked (GlcNAc...)Sequence analysis1
Glycosylationi834N-linked (GlcNAc...)Sequence analysis1
Glycosylationi850N-linked (GlcNAc...)1 Publication1
Glycosylationi989N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.
N-glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei154 – 155Cleavage; to produce pregnancy serum form2

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UIQ6.
PaxDbiQ9UIQ6.
PeptideAtlasiQ9UIQ6.
PRIDEiQ9UIQ6.

PTM databases

iPTMnetiQ9UIQ6.
PhosphoSitePlusiQ9UIQ6.
SwissPalmiQ9UIQ6.

Miscellaneous databases

PMAP-CutDBQ9UIQ6.

Expressioni

Tissue specificityi

Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.3 Publications

Gene expression databases

BgeeiENSG00000113441.
CleanExiHS_LNPEP.
GenevisibleiQ9UIQ6. HS.

Organism-specific databases

HPAiHPA043642.

Interactioni

Subunit structurei

Homodimer. Binds tankyrases 1 and 2.

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-2805360,EBI-743099
RELQ048643EBI-2805360,EBI-307352
TCF4P158843EBI-2805360,EBI-533224

Protein-protein interaction databases

BioGridi110196. 39 interactors.
IntActiQ9UIQ6. 20 interactors.
STRINGi9606.ENSP00000231368.

Chemistry databases

BindingDBiQ9UIQ6.

Structurei

Secondary structure

11025
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi165 – 167Combined sources3
Beta strandi170 – 184Combined sources15
Turni185 – 188Combined sources4
Beta strandi189 – 202Combined sources14
Beta strandi204 – 210Combined sources7
Beta strandi215 – 222Combined sources8
Beta strandi233 – 237Combined sources5
Helixi238 – 240Combined sources3
Beta strandi242 – 251Combined sources10
Beta strandi256 – 266Combined sources11
Beta strandi268 – 280Combined sources13
Beta strandi282 – 284Combined sources3
Beta strandi286 – 293Combined sources8
Turni295 – 298Combined sources4
Helixi299 – 302Combined sources4
Beta strandi308 – 310Combined sources3
Beta strandi312 – 322Combined sources11
Beta strandi325 – 331Combined sources7
Beta strandi335 – 338Combined sources4
Beta strandi342 – 348Combined sources7
Beta strandi353 – 355Combined sources3
Helixi356 – 358Combined sources3
Beta strandi361 – 364Combined sources4
Beta strandi367 – 373Combined sources7
Beta strandi376 – 382Combined sources7
Helixi384 – 389Combined sources6
Helixi391 – 408Combined sources18
Beta strandi414 – 423Combined sources10
Beta strandi433 – 439Combined sources7
Helixi440 – 443Combined sources4
Turni447 – 449Combined sources3
Helixi452 – 470Combined sources19
Turni471 – 474Combined sources4
Beta strandi475 – 479Combined sources5
Helixi480 – 482Combined sources3
Helixi483 – 501Combined sources19
Helixi503 – 505Combined sources3
Helixi508 – 522Combined sources15
Beta strandi523 – 526Combined sources4
Helixi537 – 541Combined sources5
Helixi546 – 562Combined sources17
Helixi565 – 579Combined sources15
Beta strandi582 – 584Combined sources3
Helixi586 – 596Combined sources11
Turni597 – 599Combined sources3
Beta strandi600 – 602Combined sources3
Helixi604 – 611Combined sources8
Beta strandi612 – 615Combined sources4
Beta strandi617 – 624Combined sources8
Beta strandi627 – 631Combined sources5
Beta strandi654 – 661Combined sources8
Beta strandi663 – 665Combined sources3
Beta strandi667 – 674Combined sources8
Beta strandi676 – 682Combined sources7
Beta strandi688 – 693Combined sources6
Helixi694 – 696Combined sources3
Beta strandi701 – 704Combined sources4
Helixi706 – 718Combined sources13
Helixi720 – 722Combined sources3
Helixi725 – 741Combined sources17
Beta strandi742 – 744Combined sources3
Helixi746 – 753Combined sources8
Helixi754 – 758Combined sources5
Helixi762 – 781Combined sources20
Helixi785 – 798Combined sources14
Helixi800 – 804Combined sources5
Beta strandi808 – 810Combined sources3
Helixi814 – 829Combined sources16
Helixi835 – 848Combined sources14
Turni849 – 851Combined sources3
Helixi857 – 859Combined sources3
Helixi860 – 867Combined sources8
Helixi871 – 883Combined sources13
Helixi887 – 897Combined sources11
Helixi903 – 914Combined sources12
Beta strandi917 – 919Combined sources3
Helixi921 – 923Combined sources3
Helixi924 – 933Combined sources10
Helixi935 – 937Combined sources3
Helixi938 – 947Combined sources10
Helixi949 – 955Combined sources7
Helixi961 – 971Combined sources11
Helixi977 – 988Combined sources12
Helixi992 – 995Combined sources4
Helixi998 – 1017Combined sources20
Helixi1019 – 1023Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P8QX-ray3.02A/B155-1025[»]
4PJ6X-ray2.96A/B155-1025[»]
4Z7IX-ray3.31A/B155-1025[»]
5C97X-ray3.37A/B155-1025[»]
5JHQX-ray3.20E/F/G/H/I/J/K/L92-107[»]
ProteinModelPortaliQ9UIQ6.
SMRiQ9UIQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 101Tankyrase binding6
Regioni428 – 432Substrate bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi53 – 54Dileucine internalization motifSequence analysis2
Motifi76 – 77Dileucine internalization motifSequence analysis2

Sequence similaritiesi

Belongs to the peptidase M1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1046. Eukaryota.
COG0308. LUCA.
GeneTreeiENSGT00760000119082.
HOVERGENiHBG108296.
InParanoidiQ9UIQ6.
KOiK01257.
OMAiAKTEKGW.
OrthoDBiEOG091G01GH.
PhylomeDBiQ9UIQ6.
TreeFamiTF300395.

Family and domain databases

InterProiIPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiPF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSiPR00756. ALADIPTASE.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9UIQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPFTNDRLQ LPRNMIENSM FEEEPDVVDL AKEPCLHPLE PDEVEYEPRG
60 70 80 90 100
SRLLVRGLGE HEMEEDEEDY ESSAKLLGMS FMNRSSGLRN SATGYRQSPD
110 120 130 140 150
GACSVPSART MVVCAFVIVV AVSVIMVIYL LPRCTFTKEG CHKKNQSIGL
160 170 180 190 200
IQPFATNGKL FPWAQIRLPT AVVPLRYELS LHPNLTSMTF RGSVTISVQA
210 220 230 240 250
LQVTWNIILH STGHNISRVT FMSAVSSQEK QAEILEYAYH GQIAIVAPEA
260 270 280 290 300
LLAGHNYTLK IEYSANISSS YYGFYGFSYT DESNEKKYFA ATQFEPLAAR
310 320 330 340 350
SAFPCFDEPA FKATFIIKII RDEQYTALSN MPKKSSVVLD DGLVQDEFSE
360 370 380 390 400
SVKMSTYLVA FIVGEMKNLS QDVNGTLVSI YAVPEKIGQV HYALETTVKL
410 420 430 440 450
LEFFQNYFEI QYPLKKLDLV AIPDFEAGAM ENWGLLTFRE ETLLYDSNTS
460 470 480 490 500
SMADRKLVTK IIAHELAHQW FGNLVTMKWW NDLWLNEGFA TFMEYFSLEK
510 520 530 540 550
IFKELSSYED FLDARFKTMK KDSLNSSHPI SSSVQSSEQI EEMFDSLSYF
560 570 580 590 600
KGSSLLLMLK TYLSEDVFQH AVVLYLHNHS YASIQSDDLW DSFNEVTNQT
610 620 630 640 650
LDVKRMMKTW TLQKGFPLVT VQKKGKELFI QQERFFLNMK PEIQPSDTSY
660 670 680 690 700
LWHIPLSYVT EGRNYSKYQS VSLLDKKSGV INLTEEVLWV KVNINMNGYY
710 720 730 740 750
IVHYADDDWE ALIHQLKINP YVLSDKDRAN LINNIFELAG LGKVPLKRAF
760 770 780 790 800
DLINYLGNEN HTAPITEALF QTDLIYNLLE KLGYMDLASR LVTRVFKLLQ
810 820 830 840 850
NQIQQQTWTD EGTPSMRELR SALLEFACTH NLGNCSTTAM KLFDDWMASN
860 870 880 890 900
GTQSLPTDVM TTVFKVGAKT DKGWSFLLGK YISIGSEAEK NKILEALASS
910 920 930 940 950
EDVRKLYWLM KSSLNGDNFR TQKLSFIIRT VGRHFPGHLL AWDFVKENWN
960 970 980 990 1000
KLVQKFPLGS YTIQNIVAGS TYLFSTKTHL SEVQAFFENQ SEATFRLRCV
1010 1020
QEALEVIQLN IQWMEKNLKS LTWWL
Length:1,025
Mass (Da):117,349
Last modified:April 17, 2007 - v3
Checksum:iF84C0EA9D48DC2C0
GO
Isoform 2 (identifier: Q9UIQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.

Show »
Length:1,011
Mass (Da):115,636
Checksum:iFBB54EFECFBA8FD9
GO
Isoform 3 (identifier: Q9UIQ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:1,006
Mass (Da):115,062
Checksum:iF57E71F1AA3C28E3
GO

Sequence cautioni

The sequence BAA09436 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92120 differs from that shown. Reason: Frameshift at position 405.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66D → V in CAB61646 (PubMed:10759854).Curated1
Sequence conflicti66D → V in CAB94753 (PubMed:10759854).Curated1
Sequence conflicti301S → L AA sequence (PubMed:8119729).Curated1
Sequence conflicti386K → N in AAB66672 (PubMed:9177475).Curated1
Sequence conflicti386K → N in AAB66673 (PubMed:9177475).Curated1
Sequence conflicti386K → N in CAB61646 (PubMed:10759854).Curated1
Sequence conflicti386K → N in CAB94753 (PubMed:10759854).Curated1
Sequence conflicti892K → Q in BAA09436 (PubMed:8550619).Curated1
Sequence conflicti944F → L in BAA09436 (PubMed:8550619).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03161686S → P.Corresponds to variant rs3797799dbSNPEnsembl.1
Natural variantiVAR_051567594N → I.Corresponds to variant rs12520455dbSNPEnsembl.1
Natural variantiVAR_012812763A → T.Corresponds to variant rs2303138dbSNPEnsembl.1
Natural variantiVAR_051568913S → T.Corresponds to variant rs17087233dbSNPEnsembl.1
Natural variantiVAR_031617963I → V.Corresponds to variant rs11746232dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0054491 – 19Missing in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0054481 – 14Missing in isoform 2. 2 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50810 mRNA. Translation: BAA09436.1. Different initiation.
U62768 mRNA. Translation: AAB66672.1.
U62769 mRNA. Translation: AAB66673.1.
AJ131023
, AJ131025, AJ131026, AJ131027, AJ131028, AJ131029, AJ131030, AJ131031, AJ131032, AJ131033, AJ131034, AJ131035, AJ131036, AJ131037, AJ131038, AJ131039 Genomic DNA. Translation: CAB61646.1.
AJ131025
, AJ131026, AJ131027, AJ131028, AJ131029, AJ131030, AJ131031, AJ131032, AJ131033, AJ131034, AJ131035, AJ131036, AJ131037, AJ131038, AJ131039 Genomic DNA. Translation: CAB94753.1.
AB208883 mRNA. Translation: BAD92120.1. Frameshift.
CCDSiCCDS4087.1. [Q9UIQ6-1]
CCDS43346.1. [Q9UIQ6-2]
PIRiA59383.
A59384.
RefSeqiNP_005566.2. NM_005575.2. [Q9UIQ6-1]
NP_787116.2. NM_175920.3. [Q9UIQ6-2]
UniGeneiHs.527199.
Hs.656905.

Genome annotation databases

EnsembliENST00000231368; ENSP00000231368; ENSG00000113441. [Q9UIQ6-1]
ENST00000395770; ENSP00000379117; ENSG00000113441. [Q9UIQ6-2]
GeneIDi4012.
KEGGihsa:4012.
UCSCiuc003kmv.2. human. [Q9UIQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50810 mRNA. Translation: BAA09436.1. Different initiation.
U62768 mRNA. Translation: AAB66672.1.
U62769 mRNA. Translation: AAB66673.1.
AJ131023
, AJ131025, AJ131026, AJ131027, AJ131028, AJ131029, AJ131030, AJ131031, AJ131032, AJ131033, AJ131034, AJ131035, AJ131036, AJ131037, AJ131038, AJ131039 Genomic DNA. Translation: CAB61646.1.
AJ131025
, AJ131026, AJ131027, AJ131028, AJ131029, AJ131030, AJ131031, AJ131032, AJ131033, AJ131034, AJ131035, AJ131036, AJ131037, AJ131038, AJ131039 Genomic DNA. Translation: CAB94753.1.
AB208883 mRNA. Translation: BAD92120.1. Frameshift.
CCDSiCCDS4087.1. [Q9UIQ6-1]
CCDS43346.1. [Q9UIQ6-2]
PIRiA59383.
A59384.
RefSeqiNP_005566.2. NM_005575.2. [Q9UIQ6-1]
NP_787116.2. NM_175920.3. [Q9UIQ6-2]
UniGeneiHs.527199.
Hs.656905.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P8QX-ray3.02A/B155-1025[»]
4PJ6X-ray2.96A/B155-1025[»]
4Z7IX-ray3.31A/B155-1025[»]
5C97X-ray3.37A/B155-1025[»]
5JHQX-ray3.20E/F/G/H/I/J/K/L92-107[»]
ProteinModelPortaliQ9UIQ6.
SMRiQ9UIQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110196. 39 interactors.
IntActiQ9UIQ6. 20 interactors.
STRINGi9606.ENSP00000231368.

Chemistry databases

BindingDBiQ9UIQ6.
ChEMBLiCHEMBL2693.
GuidetoPHARMACOLOGYi1570.

Protein family/group databases

MEROPSiM01.011.

PTM databases

iPTMnetiQ9UIQ6.
PhosphoSitePlusiQ9UIQ6.
SwissPalmiQ9UIQ6.

Polymorphism and mutation databases

BioMutaiLNPEP.
DMDMi145559489.

Proteomic databases

EPDiQ9UIQ6.
PaxDbiQ9UIQ6.
PeptideAtlasiQ9UIQ6.
PRIDEiQ9UIQ6.

Protocols and materials databases

DNASUi4012.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231368; ENSP00000231368; ENSG00000113441. [Q9UIQ6-1]
ENST00000395770; ENSP00000379117; ENSG00000113441. [Q9UIQ6-2]
GeneIDi4012.
KEGGihsa:4012.
UCSCiuc003kmv.2. human. [Q9UIQ6-1]

Organism-specific databases

CTDi4012.
DisGeNETi4012.
GeneCardsiLNPEP.
H-InvDBHIX0005054.
HGNCiHGNC:6656. LNPEP.
HPAiHPA043642.
MIMi151300. gene.
neXtProtiNX_Q9UIQ6.
OpenTargetsiENSG00000113441.
PharmGKBiPA30418.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1046. Eukaryota.
COG0308. LUCA.
GeneTreeiENSGT00760000119082.
HOVERGENiHBG108296.
InParanoidiQ9UIQ6.
KOiK01257.
OMAiAKTEKGW.
OrthoDBiEOG091G01GH.
PhylomeDBiQ9UIQ6.
TreeFamiTF300395.

Enzyme and pathway databases

BioCyciZFISH:HS03682-MONOMER.
ReactomeiR-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SABIO-RKQ9UIQ6.

Miscellaneous databases

ChiTaRSiLNPEP. human.
GeneWikiiCystinyl_aminopeptidase.
GenomeRNAii4012.
PMAP-CutDBQ9UIQ6.
PROiQ9UIQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113441.
CleanExiHS_LNPEP.
GenevisibleiQ9UIQ6. HS.

Family and domain databases

InterProiIPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiPF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSiPR00756. ALADIPTASE.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLCAP_HUMAN
AccessioniPrimary (citable) accession number: Q9UIQ6
Secondary accession number(s): O00769
, Q15145, Q59H76, Q9TNQ2, Q9TNQ3, Q9UIQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: April 17, 2007
Last modified: November 30, 2016
This is version 167 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.