Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

FK506-binding protein-like

Gene

FKBPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.1 Publication

GO - Molecular functioni

  1. FK506 binding Source: GO_Central
  2. peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

  1. chaperone-mediated protein folding Source: GO_Central
  2. protein peptidyl-prolyl isomerization Source: GO_Central
  3. response to radiation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein-like
Alternative name(s):
WAF-1/CIP1 stabilizing protein 39
Short name:
WISp39
Gene namesi
Name:FKBPL
Synonyms:DIR1, NG7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 6, Unplaced

Organism-specific databases

HGNCiHGNC:13949. FKBPL.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi287 – 2871K → A: Abolishes HSP90AB1 binding; when associated with A-291. 1 Publication
Mutagenesisi291 – 2911R → A: Abolishes HSP90AB1 binding; when associated with A-287. 1 Publication

Organism-specific databases

PharmGKBiPA28167.

Polymorphism and mutation databases

BioMutaiFKBPL.
DMDMi74762773.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349FK506-binding protein-likePRO_0000289878Add
BLAST

Proteomic databases

MaxQBiQ9UIM3.
PaxDbiQ9UIM3.
PRIDEiQ9UIM3.

PTM databases

PhosphoSiteiQ9UIM3.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher levels in testis.1 Publication

Gene expression databases

BgeeiQ9UIM3.
CleanExiHS_FKBPL.
ExpressionAtlasiQ9UIM3. baseline and differential.
GenevestigatoriQ9UIM3.

Organism-specific databases

HPAiHPA043478.

Interactioni

Subunit structurei

Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.

Binary interactionsi

WithEntry#Exp.IntActNotes
ANKRD49Q8WVL72EBI-719882,EBI-9381820
CALCOCO2Q131373EBI-719882,EBI-739580

Protein-protein interaction databases

BioGridi122007. 15 interactions.
IntActiQ9UIM3. 54 interactions.
MINTiMINT-1373594.
STRINGi9606.ENSP00000397530.

Structurei

3D structure databases

ProteinModelPortaliQ9UIM3.
SMRiQ9UIM3. Positions 101-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati210 – 24334TPR 1Add
BLAST
Repeati252 – 28534TPR 2Add
BLAST
Repeati286 – 31934TPR 3Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG307697.
GeneTreeiENSGT00680000100108.
HOGENOMiHOG000272638.
HOVERGENiHBG099465.
InParanoidiQ9UIM3.
OMAiDSWELEA.
OrthoDBiEOG7HTHHD.
PhylomeDBiQ9UIM3.
TreeFamiTF105297.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UIM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE
60 70 80 90 100
VSPDPASQIL EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP
110 120 130 140 150
DGSFVKKIVI RGHGLDKPKL GSCCRVLALG FPFGSGPPEG WTELTMGVGP
160 170 180 190 200
WREETWGELI EKCLESMCQG EEAELQLPGH SGPPVRLTLA SFTQGRDSWE
210 220 230 240 250
LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL LTLPPPGPPE
260 270 280 290 300
RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG
310 320 330 340
NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFG
Length:349
Mass (Da):38,176
Last modified:May 1, 2000 - v1
Checksum:i428EDD70FD9C807C
GO

Sequence cautioni

The sequence BAB15663.1 differs from that shown. Reason: Frameshift at positions 201, 205 and 319. Curated
The sequence CAG33655.1 differs from that shown. Reason: Frameshift at position 201. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031T → I in CAG33655 (Ref. 7) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901A → T.1 Publication
Corresponds to variant rs28732176 [ dbSNP | Ensembl ].
VAR_061546

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139374 Genomic DNA. Translation: AAF67785.1.
AK027119 mRNA. Translation: BAB15663.1. Frameshift.
AK291418 mRNA. Translation: BAF84107.1.
U89337 Genomic DNA. Translation: AAF04864.1.
AL662828 Genomic DNA. Translation: CAI17420.1.
AL662884 Genomic DNA. Translation: CAI18338.1.
CR753803 Genomic DNA. Translation: CAQ09554.1.
CR925796 Genomic DNA. Translation: CAQ10265.1.
CH471081 Genomic DNA. Translation: EAX03586.1.
BC004168 mRNA. Translation: AAH04168.1.
BC011966 mRNA. Translation: AAH11966.1.
CR457374 mRNA. Translation: CAG33655.1. Frameshift.
CCDSiCCDS4738.1.
RefSeqiNP_071393.2. NM_022110.3.
UniGeneiHs.520042.

Genome annotation databases

EnsembliENST00000375156; ENSP00000364298; ENSG00000204315.
ENST00000425378; ENSP00000397530; ENSG00000230907.
ENST00000443350; ENSP00000398812; ENSG00000223666.
ENST00000456854; ENSP00000412439; ENSG00000224200.
GeneIDi63943.
KEGGihsa:63943.
UCSCiuc003nzr.3. human.

Polymorphism and mutation databases

BioMutaiFKBPL.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139374 Genomic DNA. Translation: AAF67785.1.
AK027119 mRNA. Translation: BAB15663.1. Frameshift.
AK291418 mRNA. Translation: BAF84107.1.
U89337 Genomic DNA. Translation: AAF04864.1.
AL662828 Genomic DNA. Translation: CAI17420.1.
AL662884 Genomic DNA. Translation: CAI18338.1.
CR753803 Genomic DNA. Translation: CAQ09554.1.
CR925796 Genomic DNA. Translation: CAQ10265.1.
CH471081 Genomic DNA. Translation: EAX03586.1.
BC004168 mRNA. Translation: AAH04168.1.
BC011966 mRNA. Translation: AAH11966.1.
CR457374 mRNA. Translation: CAG33655.1. Frameshift.
CCDSiCCDS4738.1.
RefSeqiNP_071393.2. NM_022110.3.
UniGeneiHs.520042.

3D structure databases

ProteinModelPortaliQ9UIM3.
SMRiQ9UIM3. Positions 101-336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122007. 15 interactions.
IntActiQ9UIM3. 54 interactions.
MINTiMINT-1373594.
STRINGi9606.ENSP00000397530.

PTM databases

PhosphoSiteiQ9UIM3.

Polymorphism and mutation databases

BioMutaiFKBPL.
DMDMi74762773.

Proteomic databases

MaxQBiQ9UIM3.
PaxDbiQ9UIM3.
PRIDEiQ9UIM3.

Protocols and materials databases

DNASUi63943.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375156; ENSP00000364298; ENSG00000204315.
ENST00000425378; ENSP00000397530; ENSG00000230907.
ENST00000443350; ENSP00000398812; ENSG00000223666.
ENST00000456854; ENSP00000412439; ENSG00000224200.
GeneIDi63943.
KEGGihsa:63943.
UCSCiuc003nzr.3. human.

Organism-specific databases

CTDi63943.
GeneCardsiGC06M032101.
GC06Mj32044.
GC06Mk32072.
GC06Mm32172.
HGNCiHGNC:13949. FKBPL.
HPAiHPA043478.
neXtProtiNX_Q9UIM3.
PharmGKBiPA28167.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG307697.
GeneTreeiENSGT00680000100108.
HOGENOMiHOG000272638.
HOVERGENiHBG099465.
InParanoidiQ9UIM3.
OMAiDSWELEA.
OrthoDBiEOG7HTHHD.
PhylomeDBiQ9UIM3.
TreeFamiTF105297.

Miscellaneous databases

ChiTaRSiFKBPL. human.
GeneWikiiFKBPL.
GenomeRNAii63943.
NextBioi65716.
PROiQ9UIM3.

Gene expression databases

BgeeiQ9UIM3.
CleanExiHS_FKBPL.
ExpressionAtlasiQ9UIM3. baseline and differential.
GenevestigatoriQ9UIM3.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human stress response-related gene with a potential role in induced radioresistance."
    Robson T., Joiner M.C., Wilson G.D., McCullough W., Price M.E., Logan I., Jones H., McKeown S.R., Hirst D.G.
    Radiat. Res. 152:451-461(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lung.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-90.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Ovary.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-203.
  8. "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein."
    Jascur T., Brickner H., Salles-Passador I., Barbier V., El Khissiin A., Smith B., Fotedar R., Fotedar A.
    Mol. Cell 17:237-249(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-287 AND ARG-291, INTERACTION WITH CDKN1A AND HSP90AB1.

Entry informationi

Entry nameiFKBPL_HUMAN
AccessioniPrimary (citable) accession number: Q9UIM3
Secondary accession number(s): A8K5V3, B0UYX8, Q9H5G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 2000
Last modified: April 29, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.