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Q9UIM3

- FKBPL_HUMAN

UniProt

Q9UIM3 - FKBPL_HUMAN

Protein

FK506-binding protein-like

Gene

FKBPL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.1 Publication

    GO - Molecular functioni

    1. FK506 binding Source: RefGenome
    2. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. protein peptidyl-prolyl isomerization Source: RefGenome
    3. response to radiation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FK506-binding protein-like
    Alternative name(s):
    WAF-1/CIP1 stabilizing protein 39
    Short name:
    WISp39
    Gene namesi
    Name:FKBPL
    Synonyms:DIR1, NG7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:13949. FKBPL.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: RefGenome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi287 – 2871K → A: Abolishes HSP90AB1 binding; when associated with A-291. 1 Publication
    Mutagenesisi291 – 2911R → A: Abolishes HSP90AB1 binding; when associated with A-287. 1 Publication

    Organism-specific databases

    PharmGKBiPA28167.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349FK506-binding protein-likePRO_0000289878Add
    BLAST

    Proteomic databases

    MaxQBiQ9UIM3.
    PaxDbiQ9UIM3.
    PRIDEiQ9UIM3.

    PTM databases

    PhosphoSiteiQ9UIM3.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed with higher levels in testis.1 Publication

    Gene expression databases

    BgeeiQ9UIM3.
    CleanExiHS_FKBPL.
    GenevestigatoriQ9UIM3.

    Organism-specific databases

    HPAiHPA043478.

    Interactioni

    Subunit structurei

    Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ANKRD49Q8WVL72EBI-719882,EBI-9381820

    Protein-protein interaction databases

    BioGridi122007. 8 interactions.
    IntActiQ9UIM3. 53 interactions.
    MINTiMINT-1373594.
    STRINGi9606.ENSP00000397530.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UIM3.
    SMRiQ9UIM3. Positions 101-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati210 – 24334TPR 1Add
    BLAST
    Repeati252 – 28534TPR 2Add
    BLAST
    Repeati286 – 31934TPR 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiNOG307697.
    HOGENOMiHOG000272638.
    HOVERGENiHBG099465.
    InParanoidiQ9UIM3.
    OMAiDSWELEA.
    OrthoDBiEOG7HTHHD.
    PhylomeDBiQ9UIM3.
    TreeFamiTF105297.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR023566. PPIase_FKBP.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00515. TPR_1. 1 hit.
    [Graphical view]
    SMARTiSM00028. TPR. 3 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UIM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE    50
    VSPDPASQIL EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP 100
    DGSFVKKIVI RGHGLDKPKL GSCCRVLALG FPFGSGPPEG WTELTMGVGP 150
    WREETWGELI EKCLESMCQG EEAELQLPGH SGPPVRLTLA SFTQGRDSWE 200
    LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL LTLPPPGPPE 250
    RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG 300
    NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFG 349
    Length:349
    Mass (Da):38,176
    Last modified:May 1, 2000 - v1
    Checksum:i428EDD70FD9C807C
    GO

    Sequence cautioni

    The sequence BAB15663.1 differs from that shown. Reason: Frameshift at positions 201, 205 and 319.
    The sequence CAG33655.1 differs from that shown. Reason: Frameshift at position 201.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti203 – 2031T → I in CAG33655. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti90 – 901A → T.1 Publication
    Corresponds to variant rs28732176 [ dbSNP | Ensembl ].
    VAR_061546

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF139374 Genomic DNA. Translation: AAF67785.1.
    AK027119 mRNA. Translation: BAB15663.1. Frameshift.
    AK291418 mRNA. Translation: BAF84107.1.
    U89337 Genomic DNA. Translation: AAF04864.1.
    AL662828 Genomic DNA. Translation: CAI17420.1.
    AL662884 Genomic DNA. Translation: CAI18338.1.
    CR753803 Genomic DNA. Translation: CAQ09554.1.
    CR925796 Genomic DNA. Translation: CAQ10265.1.
    CH471081 Genomic DNA. Translation: EAX03586.1.
    BC004168 mRNA. Translation: AAH04168.1.
    BC011966 mRNA. Translation: AAH11966.1.
    CR457374 mRNA. Translation: CAG33655.1. Frameshift.
    CCDSiCCDS4738.1.
    RefSeqiNP_071393.2. NM_022110.3.
    UniGeneiHs.520042.

    Genome annotation databases

    EnsembliENST00000375156; ENSP00000364298; ENSG00000204315.
    ENST00000425378; ENSP00000397530; ENSG00000230907.
    ENST00000443350; ENSP00000398812; ENSG00000223666.
    ENST00000456854; ENSP00000412439; ENSG00000224200.
    GeneIDi63943.
    KEGGihsa:63943.
    UCSCiuc003nzr.3. human.

    Polymorphism databases

    DMDMi74762773.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF139374 Genomic DNA. Translation: AAF67785.1 .
    AK027119 mRNA. Translation: BAB15663.1 . Frameshift.
    AK291418 mRNA. Translation: BAF84107.1 .
    U89337 Genomic DNA. Translation: AAF04864.1 .
    AL662828 Genomic DNA. Translation: CAI17420.1 .
    AL662884 Genomic DNA. Translation: CAI18338.1 .
    CR753803 Genomic DNA. Translation: CAQ09554.1 .
    CR925796 Genomic DNA. Translation: CAQ10265.1 .
    CH471081 Genomic DNA. Translation: EAX03586.1 .
    BC004168 mRNA. Translation: AAH04168.1 .
    BC011966 mRNA. Translation: AAH11966.1 .
    CR457374 mRNA. Translation: CAG33655.1 . Frameshift.
    CCDSi CCDS4738.1.
    RefSeqi NP_071393.2. NM_022110.3.
    UniGenei Hs.520042.

    3D structure databases

    ProteinModelPortali Q9UIM3.
    SMRi Q9UIM3. Positions 101-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122007. 8 interactions.
    IntActi Q9UIM3. 53 interactions.
    MINTi MINT-1373594.
    STRINGi 9606.ENSP00000397530.

    PTM databases

    PhosphoSitei Q9UIM3.

    Polymorphism databases

    DMDMi 74762773.

    Proteomic databases

    MaxQBi Q9UIM3.
    PaxDbi Q9UIM3.
    PRIDEi Q9UIM3.

    Protocols and materials databases

    DNASUi 63943.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375156 ; ENSP00000364298 ; ENSG00000204315 .
    ENST00000425378 ; ENSP00000397530 ; ENSG00000230907 .
    ENST00000443350 ; ENSP00000398812 ; ENSG00000223666 .
    ENST00000456854 ; ENSP00000412439 ; ENSG00000224200 .
    GeneIDi 63943.
    KEGGi hsa:63943.
    UCSCi uc003nzr.3. human.

    Organism-specific databases

    CTDi 63943.
    GeneCardsi GC06M032099.
    GC06Mj32044.
    GC06Mk32072.
    GC06Mm32172.
    HGNCi HGNC:13949. FKBPL.
    HPAi HPA043478.
    neXtProti NX_Q9UIM3.
    PharmGKBi PA28167.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307697.
    HOGENOMi HOG000272638.
    HOVERGENi HBG099465.
    InParanoidi Q9UIM3.
    OMAi DSWELEA.
    OrthoDBi EOG7HTHHD.
    PhylomeDBi Q9UIM3.
    TreeFami TF105297.

    Miscellaneous databases

    ChiTaRSi FKBPL. human.
    GeneWikii FKBPL.
    GenomeRNAii 63943.
    NextBioi 65716.
    PROi Q9UIM3.

    Gene expression databases

    Bgeei Q9UIM3.
    CleanExi HS_FKBPL.
    Genevestigatori Q9UIM3.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR023566. PPIase_FKBP.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00515. TPR_1. 1 hit.
    [Graphical view ]
    SMARTi SM00028. TPR. 3 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human stress response-related gene with a potential role in induced radioresistance."
      Robson T., Joiner M.C., Wilson G.D., McCullough W., Price M.E., Logan I., Jones H., McKeown S.R., Hirst D.G.
      Radiat. Res. 152:451-461(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Lung.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestine.
    3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-90.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Ovary.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-203.
    8. "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein."
      Jascur T., Brickner H., Salles-Passador I., Barbier V., El Khissiin A., Smith B., Fotedar R., Fotedar A.
      Mol. Cell 17:237-249(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-287 AND ARG-291, INTERACTION WITH CDKN1A AND HSP90AB1.

    Entry informationi

    Entry nameiFKBPL_HUMAN
    AccessioniPrimary (citable) accession number: Q9UIM3
    Secondary accession number(s): A8K5V3, B0UYX8, Q9H5G3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3