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Protein

FK506-binding protein-like

Gene

FKBPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.1 Publication

GO - Molecular functioni

GO - Biological processi

  • chaperone-mediated protein folding Source: GO_Central
  • protein stabilization Source: Reactome
  • response to radiation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177906-MONOMER.
ReactomeiR-HSA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein-like
Alternative name(s):
WAF-1/CIP1 stabilizing protein 39
Short name:
WISp39
Gene namesi
Name:FKBPL
Synonyms:DIR1, NG7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13949. FKBPL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi287K → A: Abolishes HSP90AB1 binding; when associated with A-291. 1 Publication1
Mutagenesisi291R → A: Abolishes HSP90AB1 binding; when associated with A-287. 1 Publication1

Organism-specific databases

DisGeNETi63943.
OpenTargetsiENSG00000204315.
ENSG00000223666.
ENSG00000230907.
PharmGKBiPA28167.

Polymorphism and mutation databases

BioMutaiFKBPL.
DMDMi74762773.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002898781 – 349FK506-binding protein-likeAdd BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UIM3.
MaxQBiQ9UIM3.
PaxDbiQ9UIM3.
PeptideAtlasiQ9UIM3.
PRIDEiQ9UIM3.

PTM databases

iPTMnetiQ9UIM3.
PhosphoSitePlusiQ9UIM3.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher levels in testis.1 Publication

Gene expression databases

BgeeiENSG00000204315.
CleanExiHS_FKBPL.
ExpressionAtlasiQ9UIM3. baseline and differential.
GenevisibleiQ9UIM3. HS.

Organism-specific databases

HPAiHPA043478.

Interactioni

Subunit structurei

Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.

Binary interactionsi

WithEntry#Exp.IntActNotes
ANKRD49Q8WVL72EBI-719882,EBI-9381820
CALCOCO2Q131373EBI-719882,EBI-739580

Protein-protein interaction databases

BioGridi122007. 24 interactors.
IntActiQ9UIM3. 55 interactors.
MINTiMINT-1373594.
STRINGi9606.ENSP00000364298.

Structurei

3D structure databases

ProteinModelPortaliQ9UIM3.
SMRiQ9UIM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati210 – 243TPR 1Add BLAST34
Repeati252 – 285TPR 2Add BLAST34
Repeati286 – 319TPR 3Add BLAST34

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00680000100108.
HOGENOMiHOG000272638.
HOVERGENiHBG099465.
InParanoidiQ9UIM3.
KOiK20097.
OMAiDSWELEA.
OrthoDBiEOG091G0G4G.
PhylomeDBiQ9UIM3.
TreeFamiTF105297.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UIM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE
60 70 80 90 100
VSPDPASQIL EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP
110 120 130 140 150
DGSFVKKIVI RGHGLDKPKL GSCCRVLALG FPFGSGPPEG WTELTMGVGP
160 170 180 190 200
WREETWGELI EKCLESMCQG EEAELQLPGH SGPPVRLTLA SFTQGRDSWE
210 220 230 240 250
LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL LTLPPPGPPE
260 270 280 290 300
RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG
310 320 330 340
NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFG
Length:349
Mass (Da):38,176
Last modified:May 1, 2000 - v1
Checksum:i428EDD70FD9C807C
GO

Sequence cautioni

The sequence BAB15663 differs from that shown. Reason: Frameshift at positions 201, 205 and 319.Curated
The sequence CAG33655 differs from that shown. Reason: Frameshift at position 201.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203T → I in CAG33655 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06154690A → T.1 PublicationCorresponds to variant rs28732176dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139374 Genomic DNA. Translation: AAF67785.1.
AK027119 mRNA. Translation: BAB15663.1. Frameshift.
AK291418 mRNA. Translation: BAF84107.1.
U89337 Genomic DNA. Translation: AAF04864.1.
AL662828 Genomic DNA. Translation: CAI17420.1.
AL662884 Genomic DNA. Translation: CAI18338.1.
CR753803 Genomic DNA. Translation: CAQ09554.1.
CR925796 Genomic DNA. Translation: CAQ10265.1.
CH471081 Genomic DNA. Translation: EAX03586.1.
BC004168 mRNA. Translation: AAH04168.1.
BC011966 mRNA. Translation: AAH11966.1.
CR457374 mRNA. Translation: CAG33655.1. Frameshift.
CCDSiCCDS4738.1.
RefSeqiNP_071393.2. NM_022110.3.
UniGeneiHs.520042.

Genome annotation databases

EnsembliENST00000375156; ENSP00000364298; ENSG00000204315.
ENST00000425378; ENSP00000397530; ENSG00000230907.
ENST00000443350; ENSP00000398812; ENSG00000223666.
ENST00000456854; ENSP00000412439; ENSG00000224200.
GeneIDi63943.
KEGGihsa:63943.
UCSCiuc003nzr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139374 Genomic DNA. Translation: AAF67785.1.
AK027119 mRNA. Translation: BAB15663.1. Frameshift.
AK291418 mRNA. Translation: BAF84107.1.
U89337 Genomic DNA. Translation: AAF04864.1.
AL662828 Genomic DNA. Translation: CAI17420.1.
AL662884 Genomic DNA. Translation: CAI18338.1.
CR753803 Genomic DNA. Translation: CAQ09554.1.
CR925796 Genomic DNA. Translation: CAQ10265.1.
CH471081 Genomic DNA. Translation: EAX03586.1.
BC004168 mRNA. Translation: AAH04168.1.
BC011966 mRNA. Translation: AAH11966.1.
CR457374 mRNA. Translation: CAG33655.1. Frameshift.
CCDSiCCDS4738.1.
RefSeqiNP_071393.2. NM_022110.3.
UniGeneiHs.520042.

3D structure databases

ProteinModelPortaliQ9UIM3.
SMRiQ9UIM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122007. 24 interactors.
IntActiQ9UIM3. 55 interactors.
MINTiMINT-1373594.
STRINGi9606.ENSP00000364298.

PTM databases

iPTMnetiQ9UIM3.
PhosphoSitePlusiQ9UIM3.

Polymorphism and mutation databases

BioMutaiFKBPL.
DMDMi74762773.

Proteomic databases

EPDiQ9UIM3.
MaxQBiQ9UIM3.
PaxDbiQ9UIM3.
PeptideAtlasiQ9UIM3.
PRIDEiQ9UIM3.

Protocols and materials databases

DNASUi63943.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375156; ENSP00000364298; ENSG00000204315.
ENST00000425378; ENSP00000397530; ENSG00000230907.
ENST00000443350; ENSP00000398812; ENSG00000223666.
ENST00000456854; ENSP00000412439; ENSG00000224200.
GeneIDi63943.
KEGGihsa:63943.
UCSCiuc003nzr.4. human.

Organism-specific databases

CTDi63943.
DisGeNETi63943.
GeneCardsiFKBPL.
HGNCiHGNC:13949. FKBPL.
HPAiHPA043478.
neXtProtiNX_Q9UIM3.
OpenTargetsiENSG00000204315.
ENSG00000223666.
ENSG00000230907.
PharmGKBiPA28167.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00680000100108.
HOGENOMiHOG000272638.
HOVERGENiHBG099465.
InParanoidiQ9UIM3.
KOiK20097.
OMAiDSWELEA.
OrthoDBiEOG091G0G4G.
PhylomeDBiQ9UIM3.
TreeFamiTF105297.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177906-MONOMER.
ReactomeiR-HSA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.

Miscellaneous databases

ChiTaRSiFKBPL. human.
GeneWikiiFKBPL.
GenomeRNAii63943.
PROiQ9UIM3.

Gene expression databases

BgeeiENSG00000204315.
CleanExiHS_FKBPL.
ExpressionAtlasiQ9UIM3. baseline and differential.
GenevisibleiQ9UIM3. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBPL_HUMAN
AccessioniPrimary (citable) accession number: Q9UIM3
Secondary accession number(s): A8K5V3, B0UYX8, Q9H5G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.