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Protein

PHD finger protein 11

Gene

PHF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulator of Th1-type cytokine gene expression.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri107 – 15953PHD-type; degenerateAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 11
Alternative name(s):
BRCA1 C-terminus-associated protein
Renal carcinoma antigen NY-REN-34
Gene namesi
Name:PHF11
Synonyms:BCAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:17024. PHF11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

MalaCardsiPHF11.
MIMi147050. phenotype.
PharmGKBiPA134947696.

Polymorphism and mutation databases

BioMutaiPHF11.
DMDMi259016330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331PHD finger protein 11PRO_0000059301Add
BLAST

Proteomic databases

EPDiQ9UIL8.
MaxQBiQ9UIL8.
PaxDbiQ9UIL8.
PRIDEiQ9UIL8.

PTM databases

PhosphoSiteiQ9UIL8.

Expressioni

Tissue specificityi

Highly expressed in T and B-cells, as well as natural killer and mature dendritic cells. Expressed at higher levels in Th1 as compared to Th2 cells. Expressed at low levels in all normal tissues tested, including lung, testis, small intestine, breast, liver and placenta.1 Publication

Gene expression databases

BgeeiQ9UIL8.
CleanExiHS_PHF11.
ExpressionAtlasiQ9UIL8. baseline and differential.
GenevisibleiQ9UIL8. HS.

Organism-specific databases

HPAiHPA016708.

Interactioni

Subunit structurei

Interacts with BRCA1 and RELA.1 Publication

Protein-protein interaction databases

BioGridi119318. 6 interactions.
IntActiQ9UIL8. 8 interactions.
STRINGi9606.ENSP00000367570.

Structurei

3D structure databases

ProteinModelPortaliQ9UIL8.
SMRiQ9UIL8. Positions 45-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PHD-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri107 – 15953PHD-type; degenerateAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1084. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00530000063780.
HOGENOMiHOG000290637.
HOVERGENiHBG104320.
InParanoidiQ9UIL8.
OMAiFFCAKKD.
OrthoDBiEOG7MPRFR.
PhylomeDBiQ9UIL8.
TreeFamiTF325426.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms may be produced.

Isoform 1 (identifier: Q9UIL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQASPPRPE RVLGASSPEA RPAQEALLLP TGVFQVAEKM EKRTCALCPK
60 70 80 90 100
DVEYNVLYFA QSENIAAHEN CLLYSSGLVE CEDQDPLNPD RSFDVESVKK
110 120 130 140 150
EIQRGRKLKC KFCHKRGATV GCDLKNCNKN YHFFCAKKDD AVPQSDGVRG
160 170 180 190 200
IYKLLCQQHA QFPIIAQSAK FSGVKRKRGR KKPLSGNHVQ PPETMKCNTF
210 220 230 240 250
IRQVKEEHGR HTDATVKVPF LKKCKEAGLL NYLLEEILDK VHSIPEKLMD
260 270 280 290 300
ETTSESDYEE IGSALFDCRL FEDTFVNFQA AIEKKIHASQ QRWQQLKEEI
310 320 330
ELLQDLKQTL CSFQENRDLM SSSTSISSLS Y
Length:331
Mass (Da):37,582
Last modified:September 22, 2009 - v3
Checksum:iAD50E4344A8A9FB1
GO
Isoform 2 (identifier: Q9UIL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Show »
Length:292
Mass (Da):33,499
Checksum:i478B07769F91F27B
GO

Sequence cautioni

The sequence AAD42871.1 differs from that shown. Reason: Frameshift at positions 226 and 253. Curated
The sequence AAH17212.2 differs from that shown. Reason: Erroneous initiation. Curated

Polymorphismi

Variation in PHF11 seems to be associated with propensity to childhood atopic dermatitis and asthma.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3939Missing in isoform 2. 1 PublicationVSP_038088Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155105 mRNA. Translation: AAD42871.1. Frameshift.
AB011031 mRNA. Translation: BAA32101.1.
AL139321 Genomic DNA. Translation: CAH71044.1.
AL139321 Genomic DNA. Translation: CAH71046.1.
CH471075 Genomic DNA. Translation: EAX08828.1.
BC017212 mRNA. Translation: AAH17212.2. Different initiation.
CCDSiCCDS31975.1. [Q9UIL8-1]
CCDS41887.1. [Q9UIL8-2]
RefSeqiNP_001035533.1. NM_001040443.2. [Q9UIL8-1]
NP_001035534.1. NM_001040444.2. [Q9UIL8-2]
XP_006719892.1. XM_006719829.1. [Q9UIL8-2]
XP_006719893.1. XM_006719830.1. [Q9UIL8-2]
XP_011533404.1. XM_011535102.1. [Q9UIL8-2]
UniGeneiHs.369039.

Genome annotation databases

EnsembliENST00000357596; ENSP00000350209; ENSG00000136147. [Q9UIL8-2]
ENST00000378319; ENSP00000367570; ENSG00000136147. [Q9UIL8-1]
ENST00000488958; ENSP00000417539; ENSG00000136147. [Q9UIL8-2]
GeneIDi51131.
KEGGihsa:51131.
UCSCiuc001vdb.4. human. [Q9UIL8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155105 mRNA. Translation: AAD42871.1. Frameshift.
AB011031 mRNA. Translation: BAA32101.1.
AL139321 Genomic DNA. Translation: CAH71044.1.
AL139321 Genomic DNA. Translation: CAH71046.1.
CH471075 Genomic DNA. Translation: EAX08828.1.
BC017212 mRNA. Translation: AAH17212.2. Different initiation.
CCDSiCCDS31975.1. [Q9UIL8-1]
CCDS41887.1. [Q9UIL8-2]
RefSeqiNP_001035533.1. NM_001040443.2. [Q9UIL8-1]
NP_001035534.1. NM_001040444.2. [Q9UIL8-2]
XP_006719892.1. XM_006719829.1. [Q9UIL8-2]
XP_006719893.1. XM_006719830.1. [Q9UIL8-2]
XP_011533404.1. XM_011535102.1. [Q9UIL8-2]
UniGeneiHs.369039.

3D structure databases

ProteinModelPortaliQ9UIL8.
SMRiQ9UIL8. Positions 45-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119318. 6 interactions.
IntActiQ9UIL8. 8 interactions.
STRINGi9606.ENSP00000367570.

PTM databases

PhosphoSiteiQ9UIL8.

Polymorphism and mutation databases

BioMutaiPHF11.
DMDMi259016330.

Proteomic databases

EPDiQ9UIL8.
MaxQBiQ9UIL8.
PaxDbiQ9UIL8.
PRIDEiQ9UIL8.

Protocols and materials databases

DNASUi51131.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357596; ENSP00000350209; ENSG00000136147. [Q9UIL8-2]
ENST00000378319; ENSP00000367570; ENSG00000136147. [Q9UIL8-1]
ENST00000488958; ENSP00000417539; ENSG00000136147. [Q9UIL8-2]
GeneIDi51131.
KEGGihsa:51131.
UCSCiuc001vdb.4. human. [Q9UIL8-1]

Organism-specific databases

CTDi51131.
GeneCardsiPHF11.
HGNCiHGNC:17024. PHF11.
HPAiHPA016708.
MalaCardsiPHF11.
MIMi147050. phenotype.
607796. gene.
neXtProtiNX_Q9UIL8.
PharmGKBiPA134947696.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1084. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00530000063780.
HOGENOMiHOG000290637.
HOVERGENiHBG104320.
InParanoidiQ9UIL8.
OMAiFFCAKKD.
OrthoDBiEOG7MPRFR.
PhylomeDBiQ9UIL8.
TreeFamiTF325426.

Miscellaneous databases

ChiTaRSiPHF11. human.
GenomeRNAii51131.
NextBioi53961.
PROiQ9UIL8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UIL8.
CleanExiHS_PHF11.
ExpressionAtlasiQ9UIL8. baseline and differential.
GenevisibleiQ9UIL8. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), IDENTIFICATION AS A RENAL CANCER ANTIGEN.
    Tissue: Renal cell carcinoma.
  2. "A BRCA1 C-terminus-associated protein BCAP is encoded at B-CLL deleted region in 13q14."
    Kato H., Seki N., Seto M., Ishida M.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: B-cell.
  6. Cited for: ALTERNATIVE SPLICING, ASSOCIATION WITH ASTHMA.
  7. "Polymorphisms within the PHF11 gene at chromosome 13q14 are associated with childhood atopic dermatitis."
    Jang N., Stewart G., Jones G.
    Genes Immun. 6:262-264(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH ATOPIC DERMATITIS.
  8. "Functional characterization of the atopy-associated gene PHF11."
    Clarke E., Rahman N., Page N., Rolph M.S., Stewart G.J., Jones G.J.
    J. Allergy Clin. Immunol. 121:1148-1154(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, INTERACTION WITH RELA, ASSOCIATION WITH ASTHMA.

Entry informationi

Entry nameiPHF11_HUMAN
AccessioniPrimary (citable) accession number: Q9UIL8
Secondary accession number(s): Q5W0A4, Q5W0A6, Q9Y5A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: September 22, 2009
Last modified: May 11, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.