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Protein

PHD finger protein 11

Gene

PHF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulator of Th1-type cytokine gene expression.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri42 – 78C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST37
Zinc fingeri108 – 160PHD-typePROSITE-ProRule annotationAdd BLAST53

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 11
Alternative name(s):
BRCA1 C-terminus-associated protein
Renal carcinoma antigen NY-REN-34
Gene namesi
Name:PHF11
Synonyms:BCAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000136147.16.
HGNCiHGNC:17024. PHF11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51131.
MalaCardsiPHF11.
MIMi147050. phenotype.
OpenTargetsiENSG00000136147.
PharmGKBiPA134947696.

Polymorphism and mutation databases

BioMutaiPHF11.
DMDMi259016330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000593011 – 331PHD finger protein 11Add BLAST331

Proteomic databases

EPDiQ9UIL8.
PaxDbiQ9UIL8.
PeptideAtlasiQ9UIL8.
PRIDEiQ9UIL8.

PTM databases

iPTMnetiQ9UIL8.
PhosphoSitePlusiQ9UIL8.

Expressioni

Tissue specificityi

Highly expressed in T and B-cells, as well as natural killer and mature dendritic cells. Expressed at higher levels in Th1 as compared to Th2 cells. Expressed at low levels in all normal tissues tested, including lung, testis, small intestine, breast, liver and placenta.1 Publication

Gene expression databases

BgeeiENSG00000136147.
CleanExiHS_PHF11.
ExpressionAtlasiQ9UIL8. baseline and differential.
GenevisibleiQ9UIL8. HS.

Organism-specific databases

HPAiHPA016566.
HPA016708.

Interactioni

Subunit structurei

Interacts with BRCA1 and RELA.1 Publication

Protein-protein interaction databases

BioGridi119318. 6 interactors.
IntActiQ9UIL8. 9 interactors.
STRINGi9606.ENSP00000367570.

Structurei

3D structure databases

ProteinModelPortaliQ9UIL8.
SMRiQ9UIL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri42 – 78C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST37
Zinc fingeri108 – 160PHD-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1084. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00530000063780.
HOGENOMiHOG000290637.
HOVERGENiHBG104320.
InParanoidiQ9UIL8.
OMAiFFCAKKD.
OrthoDBiEOG091G0AFW.
PhylomeDBiQ9UIL8.
TreeFamiTF325426.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR034732. EPHD.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00249. PHD. 1 hit.
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiView protein in PROSITE
PS51805. EPHD. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms may be produced.
Isoform 1 (identifier: Q9UIL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQASPPRPE RVLGASSPEA RPAQEALLLP TGVFQVAEKM EKRTCALCPK
60 70 80 90 100
DVEYNVLYFA QSENIAAHEN CLLYSSGLVE CEDQDPLNPD RSFDVESVKK
110 120 130 140 150
EIQRGRKLKC KFCHKRGATV GCDLKNCNKN YHFFCAKKDD AVPQSDGVRG
160 170 180 190 200
IYKLLCQQHA QFPIIAQSAK FSGVKRKRGR KKPLSGNHVQ PPETMKCNTF
210 220 230 240 250
IRQVKEEHGR HTDATVKVPF LKKCKEAGLL NYLLEEILDK VHSIPEKLMD
260 270 280 290 300
ETTSESDYEE IGSALFDCRL FEDTFVNFQA AIEKKIHASQ QRWQQLKEEI
310 320 330
ELLQDLKQTL CSFQENRDLM SSSTSISSLS Y
Length:331
Mass (Da):37,582
Last modified:September 22, 2009 - v3
Checksum:iAD50E4344A8A9FB1
GO
Isoform 2 (identifier: Q9UIL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Show »
Length:292
Mass (Da):33,499
Checksum:i478B07769F91F27B
GO

Sequence cautioni

The sequence AAD42871 differs from that shown. Reason: Frameshift at positions 226 and 253.Curated
The sequence AAH17212 differs from that shown. Reason: Erroneous initiation.Curated

Polymorphismi

Variation in PHF11 seems to be associated with propensity to childhood atopic dermatitis and asthma.

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0380881 – 39Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155105 mRNA. Translation: AAD42871.1. Frameshift.
AB011031 mRNA. Translation: BAA32101.1.
AL139321 Genomic DNA. Translation: CAH71044.1.
AL139321 Genomic DNA. Translation: CAH71046.1.
CH471075 Genomic DNA. Translation: EAX08828.1.
BC017212 mRNA. Translation: AAH17212.2. Different initiation.
CCDSiCCDS31975.1. [Q9UIL8-1]
CCDS41887.1. [Q9UIL8-2]
RefSeqiNP_001035533.1. NM_001040443.2. [Q9UIL8-1]
NP_001035534.1. NM_001040444.2. [Q9UIL8-2]
UniGeneiHs.369039.

Genome annotation databases

EnsembliENST00000357596; ENSP00000350209; ENSG00000136147. [Q9UIL8-2]
ENST00000378319; ENSP00000367570; ENSG00000136147. [Q9UIL8-1]
ENST00000488958; ENSP00000417539; ENSG00000136147. [Q9UIL8-2]
GeneIDi51131.
KEGGihsa:51131.
UCSCiuc001vdb.4. human. [Q9UIL8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPHF11_HUMAN
AccessioniPrimary (citable) accession number: Q9UIL8
Secondary accession number(s): Q5W0A4, Q5W0A6, Q9Y5A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: September 22, 2009
Last modified: September 27, 2017
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot