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Protein

Kinesin-like protein KIF25

Gene

KIF25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of amino acid starvation-induced autophagy.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: GO_Central
  2. ATP binding Source: UniProtKB-KW
  3. microtubule motor activity Source: GO_Central

GO - Biological processi

  1. metabolic process Source: GOC
  2. microtubule-based movement Source: GO_Central
  3. mitotic sister chromatid segregation Source: ProtInc
  4. negative regulation of autophagy Source: BHF-UCL
  5. organelle organization Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF25
Alternative name(s):
Kinesin-like protein 3
Gene namesi
Name:KIF25
Synonyms:KNSL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6390. KIF25.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. kinesin complex Source: GO_Central
  3. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30179.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Kinesin-like protein KIF25PRO_0000125435Add
BLAST

Proteomic databases

PaxDbiQ9UIL4.
PRIDEiQ9UIL4.

PTM databases

PhosphoSiteiQ9UIL4.

Expressioni

Gene expression databases

BgeeiQ9UIL4.
CleanExiHS_KIF25.
GenevestigatoriQ9UIL4.

Organism-specific databases

HPAiHPA046153.

Interactioni

Protein-protein interaction databases

BioGridi110032. 1 interaction.
IntActiQ9UIL4. 1 interaction.
STRINGi9606.ENSP00000346401.

Structurei

3D structure databases

ProteinModelPortaliQ9UIL4.
SMRiQ9UIL4. Positions 11-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 363357Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00550000074610.
HOGENOMiHOG000203153.
HOVERGENiHBG052254.
InParanoidiQ9UIL4.
KOiK18627.
OMAiKLMELVH.
OrthoDBiEOG76MK88.
PhylomeDBiQ9UIL4.
TreeFamiTF105234.

Family and domain databases

Gene3Di3.40.850.10. 2 hits.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UIL4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTWTSGQLQR EKQARPGSGA VLAFPDDKDL RVYGPAESQS AVFGDVCPLL
60 70 80 90 100
TSLLDGYNVC VMAYGQTGSG KSYTMLGRHS DDGPVLPLDP QSDLGIIPRV
110 120 130 140 150
AEELFRLILE NTSRSPKVEV SIVEVYNNDI FDLLAKDSIA AVSGVKREVV
160 170 180 190 200
TAKDGRTEVA LLASEAVGSA SKLMELVHGG LQLRAKHPTL VHADSSRSHL
210 220 230 240 250
IITVTLTTAS CSDSTADQAC SATLPREQTE AGRAGRSRRA SQGALAPQLV
260 270 280 290 300
PGNPAGHAEQ VQARLQLVDS AGSECVGVSG VTGLALREMA CISRSLAALA
310 320 330 340 350
GVLGALLEHR GHAPYRNSRL THLLQDCLGG DAKLLVILCI SPSQRHLAQT
360 370 380
LQGLGFGIRA RQVQRGPARK KPPSSQTEGK RRPD
Length:384
Mass (Da):40,686
Last modified:January 22, 2002 - v2
Checksum:i7739D463BCFDB429
GO
Isoform 2 (identifier: Q9UIL4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-329: Missing.

Show »
Length:332
Mass (Da):35,235
Checksum:i54CDE14CC3278A5C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281K → M.1 Publication
Corresponds to variant rs4708626 [ dbSNP | Ensembl ].
VAR_059369
Natural varianti41 – 411A → T.
Corresponds to variant rs34049091 [ dbSNP | Ensembl ].
VAR_061280
Natural varianti229 – 2291T → P.
Corresponds to variant rs12197062 [ dbSNP | Ensembl ].
VAR_049687
Natural varianti255 – 2551A → T.
Corresponds to variant rs2073634 [ dbSNP | Ensembl ].
VAR_049688

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei278 – 32952Missing in isoform 2. CuratedVSP_002867Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012722 mRNA. Translation: BAA36417.1.
AB012723 Genomic DNA. Translation: BAA36418.1.
AL589733 Genomic DNA. Translation: CAI12327.1.
CCDSiCCDS43530.1. [Q9UIL4-2]
CCDS5305.1. [Q9UIL4-1]
RefSeqiNP_005346.3. NM_005355.3. [Q9UIL4-2]
NP_085118.2. NM_030615.2. [Q9UIL4-1]
XP_006715536.1. XM_006715473.1. [Q9UIL4-1]
UniGeneiHs.150013.

Genome annotation databases

EnsembliENST00000351261; ENSP00000252688; ENSG00000125337. [Q9UIL4-2]
ENST00000354419; ENSP00000346401; ENSG00000125337. [Q9UIL4-1]
ENST00000443060; ENSP00000388878; ENSG00000125337. [Q9UIL4-1]
GeneIDi3834.
KEGGihsa:3834.
UCSCiuc003qwk.1. human. [Q9UIL4-1]
uc003qwl.1. human. [Q9UIL4-2]

Polymorphism databases

DMDMi20138788.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012722 mRNA. Translation: BAA36417.1.
AB012723 Genomic DNA. Translation: BAA36418.1.
AL589733 Genomic DNA. Translation: CAI12327.1.
CCDSiCCDS43530.1. [Q9UIL4-2]
CCDS5305.1. [Q9UIL4-1]
RefSeqiNP_005346.3. NM_005355.3. [Q9UIL4-2]
NP_085118.2. NM_030615.2. [Q9UIL4-1]
XP_006715536.1. XM_006715473.1. [Q9UIL4-1]
UniGeneiHs.150013.

3D structure databases

ProteinModelPortaliQ9UIL4.
SMRiQ9UIL4. Positions 11-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110032. 1 interaction.
IntActiQ9UIL4. 1 interaction.
STRINGi9606.ENSP00000346401.

PTM databases

PhosphoSiteiQ9UIL4.

Polymorphism databases

DMDMi20138788.

Proteomic databases

PaxDbiQ9UIL4.
PRIDEiQ9UIL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351261; ENSP00000252688; ENSG00000125337. [Q9UIL4-2]
ENST00000354419; ENSP00000346401; ENSG00000125337. [Q9UIL4-1]
ENST00000443060; ENSP00000388878; ENSG00000125337. [Q9UIL4-1]
GeneIDi3834.
KEGGihsa:3834.
UCSCiuc003qwk.1. human. [Q9UIL4-1]
uc003qwl.1. human. [Q9UIL4-2]

Organism-specific databases

CTDi3834.
GeneCardsiGC06P168418.
HGNCiHGNC:6390. KIF25.
HPAiHPA046153.
MIMi603815. gene.
neXtProtiNX_Q9UIL4.
PharmGKBiPA30179.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00550000074610.
HOGENOMiHOG000203153.
HOVERGENiHBG052254.
InParanoidiQ9UIL4.
KOiK18627.
OMAiKLMELVH.
OrthoDBiEOG76MK88.
PhylomeDBiQ9UIL4.
TreeFamiTF105234.

Miscellaneous databases

GenomeRNAii3834.
NextBioi15069.
PROiQ9UIL4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UIL4.
CleanExiHS_KIF25.
GenevestigatoriQ9UIL4.

Family and domain databases

Gene3Di3.40.850.10. 2 hits.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, genomic organization, and alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein."
    Okamoto S., Matsushima M., Nakamura Y.
    Cytogenet. Cell Genet. 83:25-29(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, VARIANT MET-28.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC."
    McKnight N.C., Jefferies H.B., Alemu E.A., Saunders R.E., Howell M., Johansen T., Tooze S.A.
    EMBO J. 31:1931-1946(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiKIF25_HUMAN
AccessioniPrimary (citable) accession number: Q9UIL4
Secondary accession number(s): O94775, Q5SZU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 22, 2002
Last sequence update: January 22, 2002
Last modified: March 3, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.