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Q9UIL4 (KIF25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF25
Alternative name(s):
Kinesin-like protein 3
Gene names
Name:KIF25
Synonyms:KNSL3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Negative regulator of amino acid starvation-induced autophagy. Ref.3

Subcellular location

Cytoplasmcytoskeleton Probable.

Sequence similarities

Belongs to the kinesin-like protein family.

Contains 1 kinesin-motor domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UIL4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UIL4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     278-329: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Kinesin-like protein KIF25
PRO_0000125435

Regions

Domain1 – 294294Kinesin-motor
Nucleotide binding65 – 728ATP By similarity

Natural variations

Alternative sequence278 – 32952Missing in isoform 2.
VSP_002867
Natural variant281K → M. Ref.1
Corresponds to variant rs4708626 [ dbSNP | Ensembl ].
VAR_059369
Natural variant411A → T.
Corresponds to variant rs34049091 [ dbSNP | Ensembl ].
VAR_061280
Natural variant2291T → P.
Corresponds to variant rs12197062 [ dbSNP | Ensembl ].
VAR_049687
Natural variant2551A → T.
Corresponds to variant rs2073634 [ dbSNP | Ensembl ].
VAR_049688

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 7739D463BCFDB429

FASTA38440,686
        10         20         30         40         50         60 
MTWTSGQLQR EKQARPGSGA VLAFPDDKDL RVYGPAESQS AVFGDVCPLL TSLLDGYNVC 

        70         80         90        100        110        120 
VMAYGQTGSG KSYTMLGRHS DDGPVLPLDP QSDLGIIPRV AEELFRLILE NTSRSPKVEV 

       130        140        150        160        170        180 
SIVEVYNNDI FDLLAKDSIA AVSGVKREVV TAKDGRTEVA LLASEAVGSA SKLMELVHGG 

       190        200        210        220        230        240 
LQLRAKHPTL VHADSSRSHL IITVTLTTAS CSDSTADQAC SATLPREQTE AGRAGRSRRA 

       250        260        270        280        290        300 
SQGALAPQLV PGNPAGHAEQ VQARLQLVDS AGSECVGVSG VTGLALREMA CISRSLAALA 

       310        320        330        340        350        360 
GVLGALLEHR GHAPYRNSRL THLLQDCLGG DAKLLVILCI SPSQRHLAQT LQGLGFGIRA 

       370        380 
RQVQRGPARK KPPSSQTEGK RRPD 

« Hide

Isoform 2 [UniParc].

Checksum: 54CDE14CC3278A5C
Show »

FASTA33235,235

References

« Hide 'large scale' references
[1]"Identification, genomic organization, and alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein."
Okamoto S., Matsushima M., Nakamura Y.
Cytogenet. Cell Genet. 83:25-29(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, VARIANT MET-28.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC."
McKnight N.C., Jefferies H.B., Alemu E.A., Saunders R.E., Howell M., Johansen T., Tooze S.A.
EMBO J. 31:1931-1946(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB012722 mRNA. Translation: BAA36417.1.
AB012723 Genomic DNA. Translation: BAA36418.1.
AL589733 Genomic DNA. Translation: CAI12327.1.
RefSeqNP_005346.3. NM_005355.3.
NP_085118.2. NM_030615.2.
UniGeneHs.150013.

3D structure databases

ProteinModelPortalQ9UIL4.
SMRQ9UIL4. Positions 31-364.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9UIL4. 1 interaction.
STRING9606.ENSP00000346401.

PTM databases

PhosphoSiteQ9UIL4.

Polymorphism databases

DMDM20138788.

Proteomic databases

PaxDbQ9UIL4.
PRIDEQ9UIL4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000351261; ENSP00000252688; ENSG00000125337. [Q9UIL4-2]
ENST00000354419; ENSP00000346401; ENSG00000125337. [Q9UIL4-1]
ENST00000443060; ENSP00000388878; ENSG00000125337. [Q9UIL4-1]
GeneID3834.
KEGGhsa:3834.
UCSCuc003qwk.1. human. [Q9UIL4-1]
uc003qwl.1. human. [Q9UIL4-2]

Organism-specific databases

CTD3834.
GeneCardsGC06P168418.
HGNCHGNC:6390. KIF25.
HPAHPA046153.
MIM603815. gene.
neXtProtNX_Q9UIL4.
PharmGKBPA30179.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5059.
HOGENOMHOG000203153.
HOVERGENHBG052254.
InParanoidQ9UIL4.
OMATHLLQDC.
OrthoDBEOG76MK88.
PhylomeDBQ9UIL4.
TreeFamTF105234.

Gene expression databases

BgeeQ9UIL4.
CleanExHS_KIF25.
GenevestigatorQ9UIL4.

Family and domain databases

Gene3D3.40.850.10. 2 hits.
InterProIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi3834.
NextBio15069.
PROQ9UIL4.
SOURCESearch...

Entry information

Entry nameKIF25_HUMAN
AccessionPrimary (citable) accession number: Q9UIL4
Secondary accession number(s): O94775, Q5SZU9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: April 16, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM