Q9UIL4 (KIF25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF25

Alternative name(s):
Kinesin-like protein 3

Gene names

Name:	KIF25
Synonyms:	KNSL3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Negative regulator of amino acid starvation-induced autophagy. Ref.3
Subcellular location	Cytoplasm › cytoskeleton Probable.
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule-based movement Inferred from electronic annotation. Source: InterPro mitotic sister chromatid segregation Traceable author statement Ref.1. Source: ProtInc negative regulation of autophagy Inferred from mutant phenotype Ref.3. Source: BHF-UCL
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW kinesin complex Traceable author statement Ref.1. Source: ProtInc microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UIL4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UIL4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     278-329: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Kinesin-like protein KIF25		PRO_0000125435
Regions
	Domain	1 – 294	294	Kinesin-motor
	Nucleotide binding	65 – 72	8	ATP By similarity
Natural variations
	Alternative sequence	278 – 329	52	Missing in isoform 2.		VSP_002867
	Natural variant	28	1	K → M. Ref.1 Corresponds to variant rs4708626 [ dbSNP | Ensembl ].		VAR_059369
	Natural variant	41	1	A → T. Corresponds to variant rs34049091 [ dbSNP | Ensembl ].		VAR_061280
	Natural variant	229	1	T → P. Corresponds to variant rs12197062 [ dbSNP | Ensembl ].		VAR_049687
	Natural variant	255	1	A → T. Corresponds to variant rs2073634 [ dbSNP | Ensembl ].		VAR_049688

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 7739D463BCFDB429	FASTA	384	40,686
	10 20 30 40 50 60 MTWTSGQLQR EKQARPGSGA VLAFPDDKDL RVYGPAESQS AVFGDVCPLL TSLLDGYNVC 70 80 90 100 110 120 VMAYGQTGSG KSYTMLGRHS DDGPVLPLDP QSDLGIIPRV AEELFRLILE NTSRSPKVEV 130 140 150 160 170 180 SIVEVYNNDI FDLLAKDSIA AVSGVKREVV TAKDGRTEVA LLASEAVGSA SKLMELVHGG 190 200 210 220 230 240 LQLRAKHPTL VHADSSRSHL IITVTLTTAS CSDSTADQAC SATLPREQTE AGRAGRSRRA 250 260 270 280 290 300 SQGALAPQLV PGNPAGHAEQ VQARLQLVDS AGSECVGVSG VTGLALREMA CISRSLAALA 310 320 330 340 350 360 GVLGALLEHR GHAPYRNSRL THLLQDCLGG DAKLLVILCI SPSQRHLAQT LQGLGFGIRA 370 380 RQVQRGPARK KPPSSQTEGK RRPD
	Isoform 2 [UniParc]. Checksum: 54CDE14CC3278A5C	FASTA	332	35,235
	10 20 30 40 50 60 MTWTSGQLQR EKQARPGSGA VLAFPDDKDL RVYGPAESQS AVFGDVCPLL TSLLDGYNVC 70 80 90 100 110 120 VMAYGQTGSG KSYTMLGRHS DDGPVLPLDP QSDLGIIPRV AEELFRLILE NTSRSPKVEV 130 140 150 160 170 180 SIVEVYNNDI FDLLAKDSIA AVSGVKREVV TAKDGRTEVA LLASEAVGSA SKLMELVHGG 190 200 210 220 230 240 LQLRAKHPTL VHADSSRSHL IITVTLTTAS CSDSTADQAC SATLPREQTE AGRAGRSRRA 250 260 270 280 290 300 SQGALAPQLV PGNPAGHAEQ VQARLQLVDS AGSECVGGDA KLLVILCISP SQRHLAQTLQ 310 320 330 GLGFGIRARQ VQRGPARKKP PSSQTEGKRR PD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification, genomic organization, and alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein." Okamoto S., Matsushima M., Nakamura Y. Cytogenet. Cell Genet. 83:25-29(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, VARIANT MET-28.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC." McKnight N.C., Jefferies H.B., Alemu E.A., Saunders R.E., Howell M., Johansen T., Tooze S.A. EMBO J. 31:1931-1946(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB012722 mRNA. Translation: BAA36417.1. AB012723 Genomic DNA. Translation: BAA36418.1. AL589733 Genomic DNA. Translation: CAI12327.1.
IPI	IPI00290718. IPI00290719.
RefSeq	NP_005346.3. NM_005355.3. NP_085118.2. NM_030615.2.
UniGene	Hs.150013.
3D structure databases
ProteinModelPortal	Q9UIL4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UIL4. 1 interaction.
STRING	9606.ENSP00000346401.
PTM databases
PhosphoSite	Q9UIL4.
Polymorphism databases
DMDM	20138788.
Proteomic databases
PaxDb	Q9UIL4.
PRIDE	Q9UIL4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000351261; ENSP00000252688; ENSG00000125337. ENST00000354419; ENSP00000346401; ENSG00000125337. ENST00000443060; ENSP00000388878; ENSG00000125337.
GeneID	3834.
KEGG	hsa:3834.
UCSC	uc003qwk.1. human. uc003qwl.1. human.
Organism-specific databases
CTD	3834.
GeneCards	GC06P168418.
HGNC	HGNC:6390. KIF25.
HPA	HPA046153.
MIM	603815. gene.
neXtProt	NX_Q9UIL4.
PharmGKB	PA30179.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5059.
HOGENOM	HOG000203153.
HOVERGEN	HBG052254.
InParanoid	Q9UIL4.
OMA	THLLQDC.
PhylomeDB	Q9UIL4.
Gene expression databases
Bgee	Q9UIL4.
CleanEx	HS_KIF25.
Genevestigator	Q9UIL4.
GermOnline	ENSG00000125337. Homo sapiens.
Family and domain databases
Gene3D	3.40.850.10. 2 hits.
InterPro	IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. [Graphical view]
Pfam	PF00225. Kinesin. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. [Graphical view]
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3834.
NextBio	15069.
SOURCE	Search...

Entry information

Entry name

KIF25_HUMAN

Accession

Primary (citable) accession number: Q9UIL4
Secondary accession number(s): O94775, Q5SZU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	January 23, 2002
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.