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Q9UIL4

- KIF25_HUMAN

UniProt

Q9UIL4 - KIF25_HUMAN

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Protein

Kinesin-like protein KIF25

Gene
KIF25, KNSL3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Negative regulator of amino acid starvation-induced autophagy.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule motor activity Source: InterPro

GO - Biological processi

  1. microtubule-based movement Source: InterPro
  2. mitotic sister chromatid segregation Source: ProtInc
  3. negative regulation of autophagy Source: BHF-UCL
  4. organelle organization Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF25
Alternative name(s):
Kinesin-like protein 3
Gene namesi
Name:KIF25
Synonyms:KNSL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:6390. KIF25.

Subcellular locationi

Cytoplasmcytoskeleton Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. kinesin complex Source: ProtInc
  3. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30179.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Kinesin-like protein KIF25PRO_0000125435Add
BLAST

Proteomic databases

PaxDbiQ9UIL4.
PRIDEiQ9UIL4.

PTM databases

PhosphoSiteiQ9UIL4.

Expressioni

Gene expression databases

BgeeiQ9UIL4.
CleanExiHS_KIF25.
GenevestigatoriQ9UIL4.

Organism-specific databases

HPAiHPA046153.

Interactioni

Protein-protein interaction databases

IntActiQ9UIL4. 1 interaction.
STRINGi9606.ENSP00000346401.

Structurei

3D structure databases

ProteinModelPortaliQ9UIL4.
SMRiQ9UIL4. Positions 11-364.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 363357Kinesin motorAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5059.
HOGENOMiHOG000203153.
HOVERGENiHBG052254.
InParanoidiQ9UIL4.
OMAiTHLLQDC.
OrthoDBiEOG76MK88.
PhylomeDBiQ9UIL4.
TreeFamiTF105234.

Family and domain databases

Gene3Di3.40.850.10. 2 hits.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UIL4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTWTSGQLQR EKQARPGSGA VLAFPDDKDL RVYGPAESQS AVFGDVCPLL    50
TSLLDGYNVC VMAYGQTGSG KSYTMLGRHS DDGPVLPLDP QSDLGIIPRV 100
AEELFRLILE NTSRSPKVEV SIVEVYNNDI FDLLAKDSIA AVSGVKREVV 150
TAKDGRTEVA LLASEAVGSA SKLMELVHGG LQLRAKHPTL VHADSSRSHL 200
IITVTLTTAS CSDSTADQAC SATLPREQTE AGRAGRSRRA SQGALAPQLV 250
PGNPAGHAEQ VQARLQLVDS AGSECVGVSG VTGLALREMA CISRSLAALA 300
GVLGALLEHR GHAPYRNSRL THLLQDCLGG DAKLLVILCI SPSQRHLAQT 350
LQGLGFGIRA RQVQRGPARK KPPSSQTEGK RRPD 384
Length:384
Mass (Da):40,686
Last modified:January 23, 2002 - v2
Checksum:i7739D463BCFDB429
GO
Isoform 2 (identifier: Q9UIL4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-329: Missing.

Show »
Length:332
Mass (Da):35,235
Checksum:i54CDE14CC3278A5C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281K → M.1 Publication
Corresponds to variant rs4708626 [ dbSNP | Ensembl ].
VAR_059369
Natural varianti41 – 411A → T.
Corresponds to variant rs34049091 [ dbSNP | Ensembl ].
VAR_061280
Natural varianti229 – 2291T → P.
Corresponds to variant rs12197062 [ dbSNP | Ensembl ].
VAR_049687
Natural varianti255 – 2551A → T.
Corresponds to variant rs2073634 [ dbSNP | Ensembl ].
VAR_049688

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei278 – 32952Missing in isoform 2. VSP_002867Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB012722 mRNA. Translation: BAA36417.1.
AB012723 Genomic DNA. Translation: BAA36418.1.
AL589733 Genomic DNA. Translation: CAI12327.1.
CCDSiCCDS43530.1. [Q9UIL4-2]
CCDS5305.1. [Q9UIL4-1]
RefSeqiNP_005346.3. NM_005355.3. [Q9UIL4-2]
NP_085118.2. NM_030615.2. [Q9UIL4-1]
XP_006715536.1. XM_006715473.1. [Q9UIL4-1]
UniGeneiHs.150013.

Genome annotation databases

EnsembliENST00000351261; ENSP00000252688; ENSG00000125337. [Q9UIL4-2]
ENST00000354419; ENSP00000346401; ENSG00000125337. [Q9UIL4-1]
ENST00000443060; ENSP00000388878; ENSG00000125337. [Q9UIL4-1]
GeneIDi3834.
KEGGihsa:3834.
UCSCiuc003qwk.1. human. [Q9UIL4-1]
uc003qwl.1. human. [Q9UIL4-2]

Polymorphism databases

DMDMi20138788.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB012722 mRNA. Translation: BAA36417.1 .
AB012723 Genomic DNA. Translation: BAA36418.1 .
AL589733 Genomic DNA. Translation: CAI12327.1 .
CCDSi CCDS43530.1. [Q9UIL4-2 ]
CCDS5305.1. [Q9UIL4-1 ]
RefSeqi NP_005346.3. NM_005355.3. [Q9UIL4-2 ]
NP_085118.2. NM_030615.2. [Q9UIL4-1 ]
XP_006715536.1. XM_006715473.1. [Q9UIL4-1 ]
UniGenei Hs.150013.

3D structure databases

ProteinModelPortali Q9UIL4.
SMRi Q9UIL4. Positions 11-364.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9UIL4. 1 interaction.
STRINGi 9606.ENSP00000346401.

PTM databases

PhosphoSitei Q9UIL4.

Polymorphism databases

DMDMi 20138788.

Proteomic databases

PaxDbi Q9UIL4.
PRIDEi Q9UIL4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000351261 ; ENSP00000252688 ; ENSG00000125337 . [Q9UIL4-2 ]
ENST00000354419 ; ENSP00000346401 ; ENSG00000125337 . [Q9UIL4-1 ]
ENST00000443060 ; ENSP00000388878 ; ENSG00000125337 . [Q9UIL4-1 ]
GeneIDi 3834.
KEGGi hsa:3834.
UCSCi uc003qwk.1. human. [Q9UIL4-1 ]
uc003qwl.1. human. [Q9UIL4-2 ]

Organism-specific databases

CTDi 3834.
GeneCardsi GC06P168418.
HGNCi HGNC:6390. KIF25.
HPAi HPA046153.
MIMi 603815. gene.
neXtProti NX_Q9UIL4.
PharmGKBi PA30179.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
HOGENOMi HOG000203153.
HOVERGENi HBG052254.
InParanoidi Q9UIL4.
OMAi THLLQDC.
OrthoDBi EOG76MK88.
PhylomeDBi Q9UIL4.
TreeFami TF105234.

Miscellaneous databases

GenomeRNAii 3834.
NextBioi 15069.
PROi Q9UIL4.
SOURCEi Search...

Gene expression databases

Bgeei Q9UIL4.
CleanExi HS_KIF25.
Genevestigatori Q9UIL4.

Family and domain databases

Gene3Di 3.40.850.10. 2 hits.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, genomic organization, and alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein."
    Okamoto S., Matsushima M., Nakamura Y.
    Cytogenet. Cell Genet. 83:25-29(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, VARIANT MET-28.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC."
    McKnight N.C., Jefferies H.B., Alemu E.A., Saunders R.E., Howell M., Johansen T., Tooze S.A.
    EMBO J. 31:1931-1946(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiKIF25_HUMAN
AccessioniPrimary (citable) accession number: Q9UIL4
Secondary accession number(s): O94775, Q5SZU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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