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Q9UIL4

- KIF25_HUMAN

UniProt

Q9UIL4 - KIF25_HUMAN

Protein

Kinesin-like protein KIF25

Gene

KIF25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Negative regulator of amino acid starvation-induced autophagy.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: InterPro

    GO - Biological processi

    1. microtubule-based movement Source: InterPro
    2. mitotic sister chromatid segregation Source: ProtInc
    3. negative regulation of autophagy Source: BHF-UCL
    4. organelle organization Source: ProtInc

    Keywords - Molecular functioni

    Motor protein

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF25
    Alternative name(s):
    Kinesin-like protein 3
    Gene namesi
    Name:KIF25
    Synonyms:KNSL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:6390. KIF25.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. kinesin complex Source: ProtInc
    3. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30179.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Kinesin-like protein KIF25PRO_0000125435Add
    BLAST

    Proteomic databases

    PaxDbiQ9UIL4.
    PRIDEiQ9UIL4.

    PTM databases

    PhosphoSiteiQ9UIL4.

    Expressioni

    Gene expression databases

    BgeeiQ9UIL4.
    CleanExiHS_KIF25.
    GenevestigatoriQ9UIL4.

    Organism-specific databases

    HPAiHPA046153.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9UIL4. 1 interaction.
    STRINGi9606.ENSP00000346401.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UIL4.
    SMRiQ9UIL4. Positions 11-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 363357Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5059.
    HOGENOMiHOG000203153.
    HOVERGENiHBG052254.
    InParanoidiQ9UIL4.
    OMAiTHLLQDC.
    OrthoDBiEOG76MK88.
    PhylomeDBiQ9UIL4.
    TreeFamiTF105234.

    Family and domain databases

    Gene3Di3.40.850.10. 2 hits.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UIL4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTWTSGQLQR EKQARPGSGA VLAFPDDKDL RVYGPAESQS AVFGDVCPLL    50
    TSLLDGYNVC VMAYGQTGSG KSYTMLGRHS DDGPVLPLDP QSDLGIIPRV 100
    AEELFRLILE NTSRSPKVEV SIVEVYNNDI FDLLAKDSIA AVSGVKREVV 150
    TAKDGRTEVA LLASEAVGSA SKLMELVHGG LQLRAKHPTL VHADSSRSHL 200
    IITVTLTTAS CSDSTADQAC SATLPREQTE AGRAGRSRRA SQGALAPQLV 250
    PGNPAGHAEQ VQARLQLVDS AGSECVGVSG VTGLALREMA CISRSLAALA 300
    GVLGALLEHR GHAPYRNSRL THLLQDCLGG DAKLLVILCI SPSQRHLAQT 350
    LQGLGFGIRA RQVQRGPARK KPPSSQTEGK RRPD 384
    Length:384
    Mass (Da):40,686
    Last modified:January 23, 2002 - v2
    Checksum:i7739D463BCFDB429
    GO
    Isoform 2 (identifier: Q9UIL4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         278-329: Missing.

    Show »
    Length:332
    Mass (Da):35,235
    Checksum:i54CDE14CC3278A5C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281K → M.1 Publication
    Corresponds to variant rs4708626 [ dbSNP | Ensembl ].
    VAR_059369
    Natural varianti41 – 411A → T.
    Corresponds to variant rs34049091 [ dbSNP | Ensembl ].
    VAR_061280
    Natural varianti229 – 2291T → P.
    Corresponds to variant rs12197062 [ dbSNP | Ensembl ].
    VAR_049687
    Natural varianti255 – 2551A → T.
    Corresponds to variant rs2073634 [ dbSNP | Ensembl ].
    VAR_049688

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei278 – 32952Missing in isoform 2. CuratedVSP_002867Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB012722 mRNA. Translation: BAA36417.1.
    AB012723 Genomic DNA. Translation: BAA36418.1.
    AL589733 Genomic DNA. Translation: CAI12327.1.
    CCDSiCCDS43530.1. [Q9UIL4-2]
    CCDS5305.1. [Q9UIL4-1]
    RefSeqiNP_005346.3. NM_005355.3. [Q9UIL4-2]
    NP_085118.2. NM_030615.2. [Q9UIL4-1]
    XP_006715536.1. XM_006715473.1. [Q9UIL4-1]
    UniGeneiHs.150013.

    Genome annotation databases

    EnsembliENST00000351261; ENSP00000252688; ENSG00000125337. [Q9UIL4-2]
    ENST00000354419; ENSP00000346401; ENSG00000125337. [Q9UIL4-1]
    ENST00000443060; ENSP00000388878; ENSG00000125337. [Q9UIL4-1]
    GeneIDi3834.
    KEGGihsa:3834.
    UCSCiuc003qwk.1. human. [Q9UIL4-1]
    uc003qwl.1. human. [Q9UIL4-2]

    Polymorphism databases

    DMDMi20138788.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB012722 mRNA. Translation: BAA36417.1 .
    AB012723 Genomic DNA. Translation: BAA36418.1 .
    AL589733 Genomic DNA. Translation: CAI12327.1 .
    CCDSi CCDS43530.1. [Q9UIL4-2 ]
    CCDS5305.1. [Q9UIL4-1 ]
    RefSeqi NP_005346.3. NM_005355.3. [Q9UIL4-2 ]
    NP_085118.2. NM_030615.2. [Q9UIL4-1 ]
    XP_006715536.1. XM_006715473.1. [Q9UIL4-1 ]
    UniGenei Hs.150013.

    3D structure databases

    ProteinModelPortali Q9UIL4.
    SMRi Q9UIL4. Positions 11-364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9UIL4. 1 interaction.
    STRINGi 9606.ENSP00000346401.

    PTM databases

    PhosphoSitei Q9UIL4.

    Polymorphism databases

    DMDMi 20138788.

    Proteomic databases

    PaxDbi Q9UIL4.
    PRIDEi Q9UIL4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000351261 ; ENSP00000252688 ; ENSG00000125337 . [Q9UIL4-2 ]
    ENST00000354419 ; ENSP00000346401 ; ENSG00000125337 . [Q9UIL4-1 ]
    ENST00000443060 ; ENSP00000388878 ; ENSG00000125337 . [Q9UIL4-1 ]
    GeneIDi 3834.
    KEGGi hsa:3834.
    UCSCi uc003qwk.1. human. [Q9UIL4-1 ]
    uc003qwl.1. human. [Q9UIL4-2 ]

    Organism-specific databases

    CTDi 3834.
    GeneCardsi GC06P168418.
    HGNCi HGNC:6390. KIF25.
    HPAi HPA046153.
    MIMi 603815. gene.
    neXtProti NX_Q9UIL4.
    PharmGKBi PA30179.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOGENOMi HOG000203153.
    HOVERGENi HBG052254.
    InParanoidi Q9UIL4.
    OMAi THLLQDC.
    OrthoDBi EOG76MK88.
    PhylomeDBi Q9UIL4.
    TreeFami TF105234.

    Miscellaneous databases

    GenomeRNAii 3834.
    NextBioi 15069.
    PROi Q9UIL4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UIL4.
    CleanExi HS_KIF25.
    Genevestigatori Q9UIL4.

    Family and domain databases

    Gene3Di 3.40.850.10. 2 hits.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, genomic organization, and alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein."
      Okamoto S., Matsushima M., Nakamura Y.
      Cytogenet. Cell Genet. 83:25-29(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, VARIANT MET-28.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC."
      McKnight N.C., Jefferies H.B., Alemu E.A., Saunders R.E., Howell M., Johansen T., Tooze S.A.
      EMBO J. 31:1931-1946(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiKIF25_HUMAN
    AccessioniPrimary (citable) accession number: Q9UIL4
    Secondary accession number(s): O94775, Q5SZU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3