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Protein

Short coiled-coil protein

Gene

SCOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulator of amino acid starvation-induced autophagy.1 Publication

GO - Biological processi

  • positive regulation of macroautophagy Source: BHF-UCL
  • regulation of protein complex stability Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Short coiled-coil protein
Gene namesi
Name:SCOC
Synonyms:SCOCO
ORF Names:HRIHFB2072
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:20335. SCOC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134972148.

Polymorphism and mutation databases

BioMutaiSCOC.
DMDMi189046186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Short coiled-coil proteinPRO_0000334164Add
BLAST

Proteomic databases

EPDiQ9UIL1.
MaxQBiQ9UIL1.
PaxDbiQ9UIL1.
PRIDEiQ9UIL1.

PTM databases

iPTMnetiQ9UIL1.
PhosphoSiteiQ9UIL1.

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain, heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9UIL1.
CleanExiHS_SCOC.
ExpressionAtlasiQ9UIL1. baseline and differential.
GenevisibleiQ9UIL1. HS.

Interactioni

Subunit structurei

Interacts with ARL1, ARL2 and ARL3. Directly interacts with FEZ1 and UVRAG. The interaction with UVRAG is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. Interacts with NRBF2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-2686537,EBI-10171697
SCHIP1Q9P0W54EBI-2686537,EBI-1397509
TCF4P158843EBI-2686537,EBI-533224

Protein-protein interaction databases

BioGridi121943. 30 interactions.
IntActiQ9UIL1. 12 interactions.
STRINGi9606.ENSP00000377751.

Structurei

Secondary structure

1
159
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni87 – 893Combined sources
Helixi90 – 14455Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BWDX-ray2.70A/B/C78-159[»]
ProteinModelPortaliQ9UIL1.
SMRiQ9UIL1. Positions 86-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili77 – 13559Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SCOC family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3650. Eukaryota.
ENOG4111R9Q. LUCA.
GeneTreeiENSGT00390000008828.
InParanoidiQ9UIL1.
OMAiEMMNADM.
OrthoDBiEOG7QK0FF.
PhylomeDBiQ9UIL1.
TreeFamiTF323340.

Family and domain databases

InterProiIPR019357. DUF2205_coiled-coil.
[Graphical view]
PfamiPF10224. DUF2205. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UIL1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRRVFSSQD WRASGWDGMG FFSRRTFCGR SGRSCRGQLV QVSRPEVSAG
60 70 80 90 100
SLLLPAPQAE DHSSRILYPR PKSLLPKMMN ADMDAVDAEN QVELEEKTRL
110 120 130 140 150
INQVLELQHT LEDLSARVDA VKEENLKLKS ENQVLGQYIE NLMSASSVFQ

TTDTKSKRK
Length:159
Mass (Da):18,045
Last modified:May 20, 2008 - v2
Checksum:iF0EDFE11873E9B0B
GO
Isoform 2 (identifier: Q9UIL1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     38-60: QLVQVSRPEVSAGSLLLPAPQAE → MDGSRKEEEEDSTFTNISLADDI

Note: No experimental confirmation available.Curated
Show »
Length:122
Mass (Da):13,929
Checksum:i92BE3D1DE794E341
GO
Isoform 3 (identifier: Q9UIL1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     38-60: QLVQVSRPEVSAGSLLLPAPQAE → MDGSRKEEEEDSTFTNISLADDI
     85-85: Missing.

Note: No experimental confirmation available.
Show »
Length:121
Mass (Da):13,857
Checksum:iE1963D3A904C50EE
GO
Isoform 4 (identifier: Q9UIL1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-112: Missing.

Note: No experimental confirmation available.
Show »
Length:131
Mass (Da):14,801
Checksum:iB5B50B740CE13E7A
GO

Sequence cautioni

The sequence AAK01707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAP97732.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 324GRSG → HEGR in AAK01707 (PubMed:11303027).Curated
Sequence conflicti29 – 324GRSG → HEGR in AAP97732 (Ref. 6) Curated
Isoform 2 (identifier: Q9UIL1-2)
Sequence conflicti14 – 141F → L in BAB55375 (PubMed:15815621).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3737Missing in isoform 2 and isoform 3. 2 PublicationsVSP_033642Add
BLAST
Alternative sequencei38 – 6023QLVQV…APQAE → MDGSRKEEEEDSTFTNISLA DDI in isoform 2 and isoform 3. 2 PublicationsVSP_033643Add
BLAST
Alternative sequencei85 – 11228Missing in isoform 4. 1 PublicationVSP_033644Add
BLAST
Alternative sequencei85 – 851Missing in isoform 3. 1 PublicationVSP_033645

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027797 mRNA. Translation: BAB55375.1.
AC093671 Genomic DNA. No translation available.
AC114771 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05102.1.
CH471056 Genomic DNA. Translation: EAX05104.1.
CH471056 Genomic DNA. Translation: EAX05103.1.
BC016511 mRNA. Translation: AAH16511.2.
BC062684 mRNA. Translation: AAH62684.1.
AF330205 mRNA. Translation: AAK01707.1. Different initiation.
AF448857 mRNA. Translation: AAP97732.1. Different initiation.
AB015335 mRNA. Translation: BAA88116.1.
CCDSiCCDS3750.1. [Q9UIL1-2]
CCDS54806.1. [Q9UIL1-1]
CCDS54807.1. [Q9UIL1-4]
RefSeqiNP_001146918.1. NM_001153446.1. [Q9UIL1-2]
NP_001146956.1. NM_001153484.1. [Q9UIL1-1]
NP_001147024.1. NM_001153552.1. [Q9UIL1-4]
NP_001147057.1. NM_001153585.1. [Q9UIL1-2]
NP_001147107.1. NM_001153635.1. [Q9UIL1-3]
NP_001147135.1. NM_001153663.1.
NP_001147162.1. NM_001153690.1.
NP_115936.2. NM_032547.2. [Q9UIL1-2]
UniGeneiHs.480815.

Genome annotation databases

EnsembliENST00000338517; ENSP00000345262; ENSG00000153130. [Q9UIL1-2]
ENST00000394203; ENSP00000377753; ENSG00000153130. [Q9UIL1-2]
ENST00000394205; ENSP00000377755; ENSG00000153130. [Q9UIL1-2]
ENST00000506597; ENSP00000426649; ENSG00000153130. [Q9UIL1-4]
ENST00000608372; ENSP00000477352; ENSG00000153130. [Q9UIL1-1]
ENST00000614192; ENSP00000477812; ENSG00000153130. [Q9UIL1-1]
GeneIDi60592.
KEGGihsa:60592.
UCSCiuc003iib.2. human. [Q9UIL1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027797 mRNA. Translation: BAB55375.1.
AC093671 Genomic DNA. No translation available.
AC114771 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05102.1.
CH471056 Genomic DNA. Translation: EAX05104.1.
CH471056 Genomic DNA. Translation: EAX05103.1.
BC016511 mRNA. Translation: AAH16511.2.
BC062684 mRNA. Translation: AAH62684.1.
AF330205 mRNA. Translation: AAK01707.1. Different initiation.
AF448857 mRNA. Translation: AAP97732.1. Different initiation.
AB015335 mRNA. Translation: BAA88116.1.
CCDSiCCDS3750.1. [Q9UIL1-2]
CCDS54806.1. [Q9UIL1-1]
CCDS54807.1. [Q9UIL1-4]
RefSeqiNP_001146918.1. NM_001153446.1. [Q9UIL1-2]
NP_001146956.1. NM_001153484.1. [Q9UIL1-1]
NP_001147024.1. NM_001153552.1. [Q9UIL1-4]
NP_001147057.1. NM_001153585.1. [Q9UIL1-2]
NP_001147107.1. NM_001153635.1. [Q9UIL1-3]
NP_001147135.1. NM_001153663.1.
NP_001147162.1. NM_001153690.1.
NP_115936.2. NM_032547.2. [Q9UIL1-2]
UniGeneiHs.480815.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BWDX-ray2.70A/B/C78-159[»]
ProteinModelPortaliQ9UIL1.
SMRiQ9UIL1. Positions 86-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121943. 30 interactions.
IntActiQ9UIL1. 12 interactions.
STRINGi9606.ENSP00000377751.

PTM databases

iPTMnetiQ9UIL1.
PhosphoSiteiQ9UIL1.

Polymorphism and mutation databases

BioMutaiSCOC.
DMDMi189046186.

Proteomic databases

EPDiQ9UIL1.
MaxQBiQ9UIL1.
PaxDbiQ9UIL1.
PRIDEiQ9UIL1.

Protocols and materials databases

DNASUi60592.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338517; ENSP00000345262; ENSG00000153130. [Q9UIL1-2]
ENST00000394203; ENSP00000377753; ENSG00000153130. [Q9UIL1-2]
ENST00000394205; ENSP00000377755; ENSG00000153130. [Q9UIL1-2]
ENST00000506597; ENSP00000426649; ENSG00000153130. [Q9UIL1-4]
ENST00000608372; ENSP00000477352; ENSG00000153130. [Q9UIL1-1]
ENST00000614192; ENSP00000477812; ENSG00000153130. [Q9UIL1-1]
GeneIDi60592.
KEGGihsa:60592.
UCSCiuc003iib.2. human. [Q9UIL1-1]

Organism-specific databases

CTDi60592.
GeneCardsiSCOC.
HGNCiHGNC:20335. SCOC.
neXtProtiNX_Q9UIL1.
PharmGKBiPA134972148.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3650. Eukaryota.
ENOG4111R9Q. LUCA.
GeneTreeiENSGT00390000008828.
InParanoidiQ9UIL1.
OMAiEMMNADM.
OrthoDBiEOG7QK0FF.
PhylomeDBiQ9UIL1.
TreeFamiTF323340.

Miscellaneous databases

ChiTaRSiSCOC. human.
GenomeRNAii60592.
NextBioi65453.
PROiQ9UIL1.

Gene expression databases

BgeeiQ9UIL1.
CleanExiHS_SCOC.
ExpressionAtlasiQ9UIL1. baseline and differential.
GenevisibleiQ9UIL1. HS.

Family and domain databases

InterProiIPR019357. DUF2205_coiled-coil.
[Graphical view]
PfamiPF10224. DUF2205. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-159 (ISOFORM 1).
    Tissue: Lung and Ovary.
  5. "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins."
    Van Valkenburgh H., Shern J.F., Sharer J.D., Zhu X., Kahn R.A.
    J. Biol. Chem. 276:22826-22837(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-159 (ISOFORM 1), INTERACTION WITH ARL1; ARL2 AND ARL3, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  6. Guo J.H., Yu L.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 29-159 (ISOFORM 4).
    Tissue: Brain.
  7. "Selection system for genes encoding nuclear-targeted proteins."
    Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.
    Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-159 (ISOFORM 1).
    Tissue: Fetal brain.
  8. "Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC."
    McKnight N.C., Jefferies H.B., Alemu E.A., Saunders R.E., Howell M., Johansen T., Tooze S.A.
    EMBO J. 31:1931-1946(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FEZ1; NRBF2 AND UVRAG, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSCOC_HUMAN
AccessioniPrimary (citable) accession number: Q9UIL1
Secondary accession number(s): B7WPH7
, D3DNY7, E9PB65, Q6P5T9, Q7L2Y0, Q7Z4P2, Q96JY9, Q9BZB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: March 16, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.