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Q9UIK5

- TEFF2_HUMAN

UniProt

Q9UIK5 - TEFF2_HUMAN

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Protein

Tomoregulin-2

Gene

TMEFF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.2 Publications

Protein family/group databases

MEROPSiI01.969.

Names & Taxonomyi

Protein namesi
Recommended name:
Tomoregulin-2
Short name:
TR-2
Alternative name(s):
Hyperplastic polyposis protein 1
Transmembrane protein with EGF-like and two follistatin-like domains
Gene namesi
Name:TMEFF2
Synonyms:HPP1, TENB2, TPEF
ORF Names:UNQ178/PRO204
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:11867. TMEFF2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini41 – 320280ExtracellularSequence AnalysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence AnalysisAdd
BLAST
Topological domaini342 – 37433CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36568.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 40401 PublicationAdd
BLAST
Chaini41 – 374334Tomoregulin-2PRO_0000016587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi204 – 2041N-linked (GlcNAc...) (complex); atypical1 Publication
Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi265 ↔ 278By similarity
Disulfide bondi273 ↔ 289By similarity
Disulfide bondi291 ↔ 300By similarity

Post-translational modificationi

N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.2 Publications
A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UIK5.
PRIDEiQ9UIK5.

PTM databases

PhosphoSiteiQ9UIK5.

Miscellaneous databases

PMAP-CutDBQ9UIK5.

Expressioni

Tissue specificityi

Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.6 Publications

Inductioni

Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines.2 Publications

Gene expression databases

BgeeiQ9UIK5.
GenevestigatoriQ9UIK5.

Organism-specific databases

HPAiHPA015587.

Interactioni

Protein-protein interaction databases

BioGridi117189. 2 interactions.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FMWmodel-A264-301[»]
ProteinModelPortaliQ9UIK5.
SMRiQ9UIK5. Positions 157-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 13753Kazal-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini176 – 22954Kazal-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini261 – 30141EGF-likePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni303 – 32018Required for sheddingAdd
BLAST

Sequence similaritiesi

Belongs to the tomoregulin family.Curated
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 2 Kazal-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG245393.
GeneTreeiENSGT00730000110884.
HOVERGENiHBG053816.
InParanoidiQ9UIK5.
OMAiRGLYIPC.
OrthoDBiEOG7JT6WK.
PhylomeDBiQ9UIK5.
TreeFamiTF330868.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002350. Kazal_dom.
[Graphical view]
PfamiPF12661. hEGF. 1 hit.
PF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS51465. KAZAL_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UIK5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLWESPRQC SSWTLCEGFC WLLLLPVMLL IVARPVKLAA FPTSLSDCQT
60 70 80 90 100
PTGWNCSGYD DRENDLFLCD TNTCKFDGEC LRIGDTVTCV CQFKCNNDYV
110 120 130 140 150
PVCGSNGESY QNECYLRQAA CKQQSEILVV SEGSCATDAG SGSGDGVHEG
160 170 180 190 200
SGETSQKETS TCDICQFGAE CDEDAEDVWC VCNIDCSQTN FNPLCASDGK
210 220 230 240 250
SYDNACQIKE ASCQKQEKIE VMSLGRCQDN TTTTTKSEDG HYARTDYAEN
260 270 280 290 300
ANKLEESARE HHIPCPEHYN GFCMHGKCEH SINMQEPSCR CDAGYTGQHC
310 320 330 340 350
EKKDYSVLYV VPGPVRFQYV LIAAVIGTIQ IAVICVVVLC ITRKCPRSNR
360 370
IHRQKQNTGH YSSDNTTRAS TRLI
Length:374
Mass (Da):41,428
Last modified:May 1, 2000 - v1
Checksum:i44452F680FEBDCDB
GO
Isoform 2 (identifier: Q9UIK5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-346: KCP → AKL
     347-374: Missing.

Show »
Length:346
Mass (Da):38,132
Checksum:iA2C7231AD4CD43EA
GO
Isoform 3 (identifier: Q9UIK5-3) [UniParc]FASTAAdd to Basket

Also known as: TMEFF2-S

The sequence of this isoform differs from the canonical sequence as follows:
     147-175: VHEGSGETSQKETSTCDICQFGAECDEDA → GRSCLFTYLKIYWWILLCIFTYVCSISDI
     176-374: Missing.

Show »
Length:175
Mass (Da):19,472
Checksum:i8CF92F9D9FB171DF
GO

Sequence cautioni

The sequence BAA90820.1 differs from that shown. Reason: Contaminating sequence. Mitochondrial contamination starting in position 361.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281M → V in BAD96411. 1 PublicationCurated
Sequence conflicti63 – 631E → G in BAC11030. (PubMed:14702039)Curated
Sequence conflicti222 – 2221M → T in BAD96411. 1 PublicationCurated
Sequence conflicti339 – 3391L → H in BAD96411. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei147 – 17529VHEGS…CDEDA → GRSCLFTYLKIYWWILLCIF TYVCSISDI in isoform 3. 1 PublicationVSP_024973Add
BLAST
Alternative sequencei176 – 374199Missing in isoform 3. 1 PublicationVSP_024974Add
BLAST
Alternative sequencei344 – 3463KCP → AKL in isoform 2. 2 PublicationsVSP_014312
Alternative sequencei347 – 37428Missing in isoform 2. 2 PublicationsVSP_014313Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017269 mRNA. Translation: BAA87897.1.
AF242221 Genomic DNA. Translation: AAG49451.1.
AF242222 mRNA. Translation: AAG49452.1.
AF179274 mRNA. Translation: AAD55776.2.
DQ133599 mRNA. Translation: AAZ43216.1.
AY358907 mRNA. Translation: AAQ89266.1.
AK074507 mRNA. Translation: BAC11030.1.
CR457390 mRNA. Translation: CAG33671.1.
AK222691 mRNA. Translation: BAD96411.1.
AL157430 mRNA. Translation: CAB75654.1.
AC092644 Genomic DNA. Translation: AAY14874.1.
AC098617 Genomic DNA. Translation: AAX88893.1.
BC008973 mRNA. Translation: AAH08973.1.
AB004064 mRNA. Translation: BAA90820.1. Different termination.
AF264150 Genomic DNA. Translation: AAF91397.1.
CCDSiCCDS2314.1. [Q9UIK5-1]
PIRiT46914.
RefSeqiNP_057276.2. NM_016192.2. [Q9UIK5-1]
XP_005246494.1. XM_005246437.1. [Q9UIK5-2]
UniGeneiHs.144513.

Genome annotation databases

EnsembliENST00000272771; ENSP00000272771; ENSG00000144339. [Q9UIK5-1]
ENST00000392314; ENSP00000376128; ENSG00000144339. [Q9UIK5-2]
ENST00000409056; ENSP00000386871; ENSG00000144339. [Q9UIK5-3]
GeneIDi23671.
KEGGihsa:23671.
UCSCiuc002utc.3. human. [Q9UIK5-1]
uc002utd.1. human. [Q9UIK5-3]
uc031rqm.1. human. [Q9UIK5-2]

Polymorphism databases

DMDMi71153590.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017269 mRNA. Translation: BAA87897.1 .
AF242221 Genomic DNA. Translation: AAG49451.1 .
AF242222 mRNA. Translation: AAG49452.1 .
AF179274 mRNA. Translation: AAD55776.2 .
DQ133599 mRNA. Translation: AAZ43216.1 .
AY358907 mRNA. Translation: AAQ89266.1 .
AK074507 mRNA. Translation: BAC11030.1 .
CR457390 mRNA. Translation: CAG33671.1 .
AK222691 mRNA. Translation: BAD96411.1 .
AL157430 mRNA. Translation: CAB75654.1 .
AC092644 Genomic DNA. Translation: AAY14874.1 .
AC098617 Genomic DNA. Translation: AAX88893.1 .
BC008973 mRNA. Translation: AAH08973.1 .
AB004064 mRNA. Translation: BAA90820.1 . Different termination.
AF264150 Genomic DNA. Translation: AAF91397.1 .
CCDSi CCDS2314.1. [Q9UIK5-1 ]
PIRi T46914.
RefSeqi NP_057276.2. NM_016192.2. [Q9UIK5-1 ]
XP_005246494.1. XM_005246437.1. [Q9UIK5-2 ]
UniGenei Hs.144513.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FMW model - A 264-301 [» ]
ProteinModelPortali Q9UIK5.
SMRi Q9UIK5. Positions 157-228.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117189. 2 interactions.

Protein family/group databases

MEROPSi I01.969.

PTM databases

PhosphoSitei Q9UIK5.

Polymorphism databases

DMDMi 71153590.

Proteomic databases

PaxDbi Q9UIK5.
PRIDEi Q9UIK5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000272771 ; ENSP00000272771 ; ENSG00000144339 . [Q9UIK5-1 ]
ENST00000392314 ; ENSP00000376128 ; ENSG00000144339 . [Q9UIK5-2 ]
ENST00000409056 ; ENSP00000386871 ; ENSG00000144339 . [Q9UIK5-3 ]
GeneIDi 23671.
KEGGi hsa:23671.
UCSCi uc002utc.3. human. [Q9UIK5-1 ]
uc002utd.1. human. [Q9UIK5-3 ]
uc031rqm.1. human. [Q9UIK5-2 ]

Organism-specific databases

CTDi 23671.
GeneCardsi GC02M192777.
HGNCi HGNC:11867. TMEFF2.
HPAi HPA015587.
MIMi 605734. gene.
neXtProti NX_Q9UIK5.
PharmGKBi PA36568.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG245393.
GeneTreei ENSGT00730000110884.
HOVERGENi HBG053816.
InParanoidi Q9UIK5.
OMAi RGLYIPC.
OrthoDBi EOG7JT6WK.
PhylomeDBi Q9UIK5.
TreeFami TF330868.

Miscellaneous databases

ChiTaRSi TMEFF2. human.
GeneWikii TMEFF2.
GenomeRNAii 23671.
NextBioi 46527.
PMAP-CutDB Q9UIK5.
PROi Q9UIK5.
SOURCEi Search...

Gene expression databases

Bgeei Q9UIK5.
Genevestigatori Q9UIK5.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002350. Kazal_dom.
[Graphical view ]
Pfami PF12661. hEGF. 1 hit.
PF07648. Kazal_2. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
SM00280. KAZAL. 2 hits.
[Graphical view ]
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS51465. KAZAL_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons."
    Horie M., Mitsumoto Y., Kyushiki H., Kanemoto N., Watanabe A., Taniguchi Y., Nishino N., Okamoto T., Kondo M., Mori T., Noguchi K., Nakamura Y., Takahashi E., Tanigami A.
    Genomics 67:146-152(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells."
    Liang G., Robertson K.D., Talmadge C., Sumegi J., Jones P.A.
    Cancer Res. 60:4907-4912(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57, INDUCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence."
    Glynne-Jones E., Harper M.E., Seery L.T., James R., Anglin I., Morgan H.E., Taylor K.M., Gee J.M., Nicholson R.I.
    Int. J. Cancer 94:178-184(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GLYCOSYLATION, TISSUE SPECIFICITY.
    Tissue: Prostatic carcinoma.
  4. "A truncated isoform of TMEFF2 encodes a secreted protein in prostate cancer cells."
    Quayle S.N., Sadar M.D.
    Genomics 87:633-637(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  8. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  10. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  12. "A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells."
    Uchida T., Wada K., Akamatsu T., Yonezawa M., Noguchi H., Mizoguchi A., Kasuga M., Sakamoto C.
    Biochem. Biophys. Res. Commun. 266:593-602(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-360.
  13. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57, TISSUE SPECIFICITY, INDUCTION.
    Tissue: Colon.
  14. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 41-55.
  15. "Tomoregulin-2 is found extensively in plaques in Alzheimer's disease brain."
    Siegel D.A., Davies P., Dobrenis K., Huang M.
    J. Neurochem. 98:34-44(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  16. "Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17."
    Ali N., Knaeuper V.
    J. Biol. Chem. 282:37378-37388(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE, FUNCTION.
  17. Cited for: GLYCOSYLATION AT ASN-204.

Entry informationi

Entry nameiTEFF2_HUMAN
AccessioniPrimary (citable) accession number: Q9UIK5
Secondary accession number(s): Q2FA44
, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3