Q9UIK5 (TEFF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tomoregulin-2
Short name=TR-2

Alternative name(s):
Hyperplastic polyposis protein 1
Transmembrane protein with EGF-like and two follistatin-like domains

Gene names

Name:	TMEFF2
Synonyms:	HPP1, TENB2, TPEF
ORF Names:	UNQ178/PRO204

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. Ref.1 Ref.16
Subcellular location	Isoform 1: Membrane; Single-pass type I membrane protein Potential. Isoform 2: Membrane; Single-pass type I membrane protein Potential. Isoform 3: Secreted.
Tissue specificity	Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate. Ref.1 Ref.2 Ref.3 Ref.4 Ref.13 Ref.15
Induction	Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines. Ref.2 Ref.13
Post-translational modification	N-glycosylated. Contains chondroitin sulfate glycosaminoglycans. Ref.3 A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17.
Sequence similarities	Belongs to the tomoregulin family. Contains 1 EGF-like domain. Contains 2 Kazal-like domains.
Sequence caution	The sequence BAA90820.1 differs from that shown. Reason: Contaminating sequence. Mitochondrial contamination starting in position 361.

Ontologies

Keywords
Cellular component	Membrane Secreted
Coding sequence diversity	Alternative splicing
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Non-traceable author statement Ref.1Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UIK5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UIK5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     344-346: KCP → AKL
     347-374: Missing.

Isoform 3 (identifier: Q9UIK5-3)

Also known as: TMEFF2-S;

The sequence of this isoform differs from the canonical sequence as follows:
     147-175: VHEGSGETSQKETSTCDICQFGAECDEDA → GRSCLFTYLKIYWWILLCIFTYVCSISDI
     176-374: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 40	40	Ref.14
	Chain	41 – 374	334	Tomoregulin-2		PRO_0000016587
Regions
	Topological domain	41 – 320	280	Extracellular Potential
	Transmembrane	321 – 341	21	Helical; Potential
	Topological domain	342 – 374	33	Cytoplasmic Potential
	Domain	85 – 137	53	Kazal-like 1
	Domain	176 – 229	54	Kazal-like 2
	Domain	261 – 301	41	EGF-like
	Region	303 – 320	18	Required for shedding
Amino acid modifications
	Glycosylation	55	1	N-linked (GlcNAc...) Potential
	Glycosylation	230	1	N-linked (GlcNAc...) Potential
	Disulfide bond	265 ↔ 278		By similarity
	Disulfide bond	273 ↔ 289		By similarity
	Disulfide bond	291 ↔ 300		By similarity
Natural variations
	Alternative sequence	147 – 175	29	VHEGS…CDEDA → GRSCLFTYLKIYWWILLCIF TYVCSISDI in isoform 3.		VSP_024973
	Alternative sequence	176 – 374	199	Missing in isoform 3.		VSP_024974
	Alternative sequence	344 – 346	3	KCP → AKL in isoform 2.		VSP_014312
	Alternative sequence	347 – 374	28	Missing in isoform 2.		VSP_014313
Experimental info
	Sequence conflict	28	1	M → V in BAD96411. Ref.8
	Sequence conflict	63	1	E → G in BAC11030. Ref.6
	Sequence conflict	222	1	M → T in BAD96411. Ref.8
	Sequence conflict	339	1	L → H in BAD96411. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 44452F680FEBDCDB	FASTA	374	41,428
	10 20 30 40 50 60 MVLWESPRQC SSWTLCEGFC WLLLLPVMLL IVARPVKLAA FPTSLSDCQT PTGWNCSGYD 70 80 90 100 110 120 DRENDLFLCD TNTCKFDGEC LRIGDTVTCV CQFKCNNDYV PVCGSNGESY QNECYLRQAA 130 140 150 160 170 180 CKQQSEILVV SEGSCATDAG SGSGDGVHEG SGETSQKETS TCDICQFGAE CDEDAEDVWC 190 200 210 220 230 240 VCNIDCSQTN FNPLCASDGK SYDNACQIKE ASCQKQEKIE VMSLGRCQDN TTTTTKSEDG 250 260 270 280 290 300 HYARTDYAEN ANKLEESARE HHIPCPEHYN GFCMHGKCEH SINMQEPSCR CDAGYTGQHC 310 320 330 340 350 360 EKKDYSVLYV VPGPVRFQYV LIAAVIGTIQ IAVICVVVLC ITRKCPRSNR IHRQKQNTGH 370 YSSDNTTRAS TRLI
	Isoform 2 [UniParc]. Checksum: A2C7231AD4CD43EA	FASTA	346	38,132
	10 20 30 40 50 60 MVLWESPRQC SSWTLCEGFC WLLLLPVMLL IVARPVKLAA FPTSLSDCQT PTGWNCSGYD 70 80 90 100 110 120 DRENDLFLCD TNTCKFDGEC LRIGDTVTCV CQFKCNNDYV PVCGSNGESY QNECYLRQAA 130 140 150 160 170 180 CKQQSEILVV SEGSCATDAG SGSGDGVHEG SGETSQKETS TCDICQFGAE CDEDAEDVWC 190 200 210 220 230 240 VCNIDCSQTN FNPLCASDGK SYDNACQIKE ASCQKQEKIE VMSLGRCQDN TTTTTKSEDG 250 260 270 280 290 300 HYARTDYAEN ANKLEESARE HHIPCPEHYN GFCMHGKCEH SINMQEPSCR CDAGYTGQHC 310 320 330 340 EKKDYSVLYV VPGPVRFQYV LIAAVIGTIQ IAVICVVVLC ITRAKL
	Isoform 3 (TMEFF2-S) [UniParc]. Checksum: 8CF92F9D9FB171DF	FASTA	175	19,472
	10 20 30 40 50 60 MVLWESPRQC SSWTLCEGFC WLLLLPVMLL IVARPVKLAA FPTSLSDCQT PTGWNCSGYD 70 80 90 100 110 120 DRENDLFLCD TNTCKFDGEC LRIGDTVTCV CQFKCNNDYV PVCGSNGESY QNECYLRQAA 130 140 150 160 170 CKQQSEILVV SEGSCATDAG SGSGDGGRSC LFTYLKIYWW ILLCIFTYVC SISDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons." Horie M., Mitsumoto Y., Kyushiki H., Kanemoto N., Watanabe A., Taniguchi Y., Nishino N., Okamoto T., Kondo M., Mori T., Noguchi K., Nakamura Y., Takahashi E., Tanigami A. Genomics 67:146-152(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Brain.
[2]	"The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells." Liang G., Robertson K.D., Talmadge C., Sumegi J., Jones P.A. Cancer Res. 60:4907-4912(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57, INDUCTION, TISSUE SPECIFICITY. Tissue: Brain.
[3]	"TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence." Glynne-Jones E., Harper M.E., Seery L.T., James R., Anglin I., Morgan H.E., Taylor K.M., Gee J.M., Nicholson R.I. Int. J. Cancer 94:178-184(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GLYCOSYLATION, TISSUE SPECIFICITY. Tissue: Prostatic carcinoma.
[4]	"A truncated isoform of TMEFF2 encodes a secreted protein in prostate cancer cells." Quayle S.N., Sadar M.D. Genomics 87:633-637(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
[5]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Embryo.
[7]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[8]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[9]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[10]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[12]	"A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells." Uchida T., Wada K., Akamatsu T., Yonezawa M., Noguchi H., Mizoguchi A., Kasuga M., Sakamoto C. Biochem. Biophys. Res. Commun. 266:593-602(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-360.
[13]	"HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers." Young J., Biden K.G., Simms L.A., Huggard P., Karamatic R., Eyre H.J., Sutherland G.R., Herath N., Barker M., Anderson G.J., Fitzpatrick D.R., Ramm G.A., Jass J.R., Leggett B.A. Proc. Natl. Acad. Sci. U.S.A. 98:265-270(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57, TISSUE SPECIFICITY, INDUCTION. Tissue: Colon.
[14]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 41-55.
[15]	"Tomoregulin-2 is found extensively in plaques in Alzheimer's disease brain." Siegel D.A., Davies P., Dobrenis K., Huang M. J. Neurochem. 98:34-44(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[16]	"Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17." Ali N., Knaeuper V. J. Biol. Chem. 282:37378-37388(2007) [PubMed] [Europe PMC] [Abstract] Cited for: CLEAVAGE, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB017269 mRNA. Translation: BAA87897.1.
AF242221 Genomic DNA. Translation: AAG49451.1.
AF242222 mRNA. Translation: AAG49452.1.
AF179274 mRNA. Translation: AAD55776.2.
DQ133599 mRNA. Translation: AAZ43216.1.
AY358907 mRNA. Translation: AAQ89266.1.
AK074507 mRNA. Translation: BAC11030.1.
CR457390 mRNA. Translation: CAG33671.1.
AK222691 mRNA. Translation: BAD96411.1.
AL157430 mRNA. Translation: CAB75654.1.
AC092644 Genomic DNA. Translation: AAY14874.1.
AC098617 Genomic DNA. Translation: AAX88893.1.
BC008973 mRNA. Translation: AAH08973.1.
AB004064 mRNA. Translation: BAA90820.1. Different termination.
AF264150 Genomic DNA. Translation: AAF91397.1.

IPI

IPI00296286.
IPI00607750.
IPI00845371.

PIR

T46914.

RefSeq

NP_057276.2. NM_016192.2.

UniGene

Hs.144513.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FMW	model	-	A	264-301	[»]

ProteinModelPortal

Q9UIK5.

ModBase

Search...

Protein family/group databases

MEROPS

I01.969.

PTM databases

PhosphoSite

Q9UIK5.

Polymorphism databases

DMDM

71153590.

Proteomic databases

PaxDb

Q9UIK5.

PRIDE

Q9UIK5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000272771; ENSP00000272771; ENSG00000144339.
ENST00000392314; ENSP00000376128; ENSG00000144339.
ENST00000409056; ENSP00000386871; ENSG00000144339.

GeneID

23671.

KEGG

hsa:23671.

UCSC

uc002utc.3. human.
uc002utd.1. human.

Organism-specific databases

CTD

23671.

GeneCards

GC02M192777.

HGNC

HGNC:11867. TMEFF2.

HPA

HPA015587.

MIM

605734. gene.

neXtProt

NX_Q9UIK5.

PharmGKB

PA36568.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG245393.

HOVERGEN

HBG053816.

InParanoid

Q9UIK5.

OMA

CPRTNRI.

OrthoDB

EOG43BMNZ.

PhylomeDB

Q9UIK5.

Gene expression databases

Bgee

Q9UIK5.

Genevestigator

Q9UIK5.

GermOnline

ENSG00000144339. Homo sapiens.

Family and domain databases

InterPro

IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002350. Kazal_dom.
[Graphical view]

Pfam

PF12661. hEGF. 1 hit.
PF07648. Kazal_2. 2 hits.
[Graphical view]

SMART

SM00181. EGF. 1 hit.
SM00280. KAZAL. 2 hits.
[Graphical view]

PROSITE

PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS51465. KAZAL_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

23671.

NextBio

46527.

PMAP-CutDB

Q9UIK5.

SOURCE

Search...

Entry information

Entry name

TEFF2_HUMAN

Accession

Primary (citable) accession number: Q9UIK5
Secondary accession number(s): Q2FA44 , Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.