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Q9UIK5 (TEFF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tomoregulin-2

Short name=TR-2
Alternative name(s):
Hyperplastic polyposis protein 1
Transmembrane protein with EGF-like and two follistatin-like domains
Gene names
Name:TMEFF2
Synonyms:HPP1, TENB2, TPEF
ORF Names:UNQ178/PRO204
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. Ref.1 Ref.16

Subcellular location

Isoform 1: Membrane; Single-pass type I membrane protein Potential.

Isoform 2: Membrane; Single-pass type I membrane protein Potential.

Isoform 3: Secreted.

Tissue specificity

Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate. Ref.1 Ref.2 Ref.3 Ref.4 Ref.13 Ref.15

Induction

Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines. Ref.2 Ref.13

Post-translational modification

N-glycosylated. Contains chondroitin sulfate glycosaminoglycans. Ref.3 Ref.17

A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17.

Sequence similarities

Belongs to the tomoregulin family.

Contains 1 EGF-like domain.

Contains 2 Kazal-like domains.

Sequence caution

The sequence BAA90820.1 differs from that shown. Reason: Contaminating sequence. Mitochondrial contamination starting in position 361.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UIK5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UIK5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     344-346: KCP → AKL
     347-374: Missing.
Isoform 3 (identifier: Q9UIK5-3)

Also known as: TMEFF2-S;

The sequence of this isoform differs from the canonical sequence as follows:
     147-175: VHEGSGETSQKETSTCDICQFGAECDEDA → GRSCLFTYLKIYWWILLCIFTYVCSISDI
     176-374: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4040 Ref.14
Chain41 – 374334Tomoregulin-2
PRO_0000016587

Regions

Topological domain41 – 320280Extracellular Potential
Transmembrane321 – 34121Helical; Potential
Topological domain342 – 37433Cytoplasmic Potential
Domain85 – 13753Kazal-like 1
Domain176 – 22954Kazal-like 2
Domain261 – 30141EGF-like
Region303 – 32018Required for shedding

Amino acid modifications

Glycosylation551N-linked (GlcNAc...) Potential
Glycosylation2041N-linked (GlcNAc...) (complex); atypical Ref.17
Glycosylation2301N-linked (GlcNAc...) Potential
Disulfide bond265 ↔ 278 By similarity
Disulfide bond273 ↔ 289 By similarity
Disulfide bond291 ↔ 300 By similarity

Natural variations

Alternative sequence147 – 17529VHEGS…CDEDA → GRSCLFTYLKIYWWILLCIF TYVCSISDI in isoform 3.
VSP_024973
Alternative sequence176 – 374199Missing in isoform 3.
VSP_024974
Alternative sequence344 – 3463KCP → AKL in isoform 2.
VSP_014312
Alternative sequence347 – 37428Missing in isoform 2.
VSP_014313

Experimental info

Sequence conflict281M → V in BAD96411. Ref.8
Sequence conflict631E → G in BAC11030. Ref.6
Sequence conflict2221M → T in BAD96411. Ref.8
Sequence conflict3391L → H in BAD96411. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 44452F680FEBDCDB

FASTA37441,428
        10         20         30         40         50         60 
MVLWESPRQC SSWTLCEGFC WLLLLPVMLL IVARPVKLAA FPTSLSDCQT PTGWNCSGYD 

        70         80         90        100        110        120 
DRENDLFLCD TNTCKFDGEC LRIGDTVTCV CQFKCNNDYV PVCGSNGESY QNECYLRQAA 

       130        140        150        160        170        180 
CKQQSEILVV SEGSCATDAG SGSGDGVHEG SGETSQKETS TCDICQFGAE CDEDAEDVWC 

       190        200        210        220        230        240 
VCNIDCSQTN FNPLCASDGK SYDNACQIKE ASCQKQEKIE VMSLGRCQDN TTTTTKSEDG 

       250        260        270        280        290        300 
HYARTDYAEN ANKLEESARE HHIPCPEHYN GFCMHGKCEH SINMQEPSCR CDAGYTGQHC 

       310        320        330        340        350        360 
EKKDYSVLYV VPGPVRFQYV LIAAVIGTIQ IAVICVVVLC ITRKCPRSNR IHRQKQNTGH 

       370 
YSSDNTTRAS TRLI 

« Hide

Isoform 2 [UniParc].

Checksum: A2C7231AD4CD43EA
Show »

FASTA34638,132
Isoform 3 (TMEFF2-S) [UniParc].

Checksum: 8CF92F9D9FB171DF
Show »

FASTA17519,472

References

« Hide 'large scale' references
[1]"Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons."
Horie M., Mitsumoto Y., Kyushiki H., Kanemoto N., Watanabe A., Taniguchi Y., Nishino N., Okamoto T., Kondo M., Mori T., Noguchi K., Nakamura Y., Takahashi E., Tanigami A.
Genomics 67:146-152(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
Tissue: Brain.
[2]"The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells."
Liang G., Robertson K.D., Talmadge C., Sumegi J., Jones P.A.
Cancer Res. 60:4907-4912(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57, INDUCTION, TISSUE SPECIFICITY.
Tissue: Brain.
[3]"TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence."
Glynne-Jones E., Harper M.E., Seery L.T., James R., Anglin I., Morgan H.E., Taylor K.M., Gee J.M., Nicholson R.I.
Int. J. Cancer 94:178-184(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GLYCOSYLATION, TISSUE SPECIFICITY.
Tissue: Prostatic carcinoma.
[4]"A truncated isoform of TMEFF2 encodes a secreted protein in prostate cancer cells."
Quayle S.N., Sadar M.D.
Genomics 87:633-637(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
[5]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Embryo.
[7]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[8]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[9]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[10]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[12]"A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells."
Uchida T., Wada K., Akamatsu T., Yonezawa M., Noguchi H., Mizoguchi A., Kasuga M., Sakamoto C.
Biochem. Biophys. Res. Commun. 266:593-602(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-360.
[13]"HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers."
Young J., Biden K.G., Simms L.A., Huggard P., Karamatic R., Eyre H.J., Sutherland G.R., Herath N., Barker M., Anderson G.J., Fitzpatrick D.R., Ramm G.A., Jass J.R., Leggett B.A.
Proc. Natl. Acad. Sci. U.S.A. 98:265-270(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57, TISSUE SPECIFICITY, INDUCTION.
Tissue: Colon.
[14]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 41-55.
[15]"Tomoregulin-2 is found extensively in plaques in Alzheimer's disease brain."
Siegel D.A., Davies P., Dobrenis K., Huang M.
J. Neurochem. 98:34-44(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[16]"Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17."
Ali N., Knaeuper V.
J. Biol. Chem. 282:37378-37388(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: CLEAVAGE, FUNCTION.
[17]"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-204.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB017269 mRNA. Translation: BAA87897.1.
AF242221 Genomic DNA. Translation: AAG49451.1.
AF242222 mRNA. Translation: AAG49452.1.
AF179274 mRNA. Translation: AAD55776.2.
DQ133599 mRNA. Translation: AAZ43216.1.
AY358907 mRNA. Translation: AAQ89266.1.
AK074507 mRNA. Translation: BAC11030.1.
CR457390 mRNA. Translation: CAG33671.1.
AK222691 mRNA. Translation: BAD96411.1.
AL157430 mRNA. Translation: CAB75654.1.
AC092644 Genomic DNA. Translation: AAY14874.1.
AC098617 Genomic DNA. Translation: AAX88893.1.
BC008973 mRNA. Translation: AAH08973.1.
AB004064 mRNA. Translation: BAA90820.1. Different termination.
AF264150 Genomic DNA. Translation: AAF91397.1.
PIRT46914.
RefSeqNP_057276.2. NM_016192.2.
XP_005246494.1. XM_005246437.1.
UniGeneHs.144513.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2FMWmodel-A264-301[»]
ProteinModelPortalQ9UIK5.
SMRQ9UIK5. Positions 31-232, 264-303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117189. 2 interactions.

Protein family/group databases

MEROPSI01.969.

PTM databases

PhosphoSiteQ9UIK5.

Polymorphism databases

DMDM71153590.

Proteomic databases

PaxDbQ9UIK5.
PRIDEQ9UIK5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000272771; ENSP00000272771; ENSG00000144339. [Q9UIK5-1]
ENST00000392314; ENSP00000376128; ENSG00000144339. [Q9UIK5-2]
ENST00000409056; ENSP00000386871; ENSG00000144339. [Q9UIK5-3]
GeneID23671.
KEGGhsa:23671.
UCSCuc002utc.3. human. [Q9UIK5-1]
uc002utd.1. human. [Q9UIK5-3]
uc031rqm.1. human. [Q9UIK5-2]

Organism-specific databases

CTD23671.
GeneCardsGC02M192777.
HGNCHGNC:11867. TMEFF2.
HPAHPA015587.
MIM605734. gene.
neXtProtNX_Q9UIK5.
PharmGKBPA36568.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245393.
HOVERGENHBG053816.
InParanoidQ9UIK5.
OMARGLYIPC.
OrthoDBEOG7JT6WK.
PhylomeDBQ9UIK5.
TreeFamTF330868.

Gene expression databases

BgeeQ9UIK5.
GenevestigatorQ9UIK5.

Family and domain databases

InterProIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002350. Kazal_dom.
[Graphical view]
PfamPF12661. hEGF. 1 hit.
PF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTSM00181. EGF. 1 hit.
SM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS51465. KAZAL_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTMEFF2.
GenomeRNAi23671.
NextBio46527.
PMAP-CutDBQ9UIK5.
PROQ9UIK5.
SOURCESearch...

Entry information

Entry nameTEFF2_HUMAN
AccessionPrimary (citable) accession number: Q9UIK5
Secondary accession number(s): Q2FA44 expand/collapse secondary AC list , Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM