Q9UIJ5 (ZDHC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Palmitoyltransferase ZDHHC2
EC=2.3.1.-

Alternative name(s):
Reduced expression associated with metastasis protein
Short name=Ream
Reduced expression in cancer protein
Short name=Rec
Zinc finger DHHC domain-containing protein 2
Short name=DHHC-2
Zinc finger protein 372

Gene names

Name:	ZDHHC2
Synonyms:	REAM, REC, ZNF372

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Palmitoyltransferase specific for GAP43 and DLG4/PSD95 By similarity.
Catalytic activity	Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis. Ref.1
Domain	The DHHC domain is required for palmitoyltransferase activity By similarity.
Involvement in disease	Note=Mutations in ZDHHC2 are found in hepatocellular carcinoma and colorectal cancer.
Sequence similarities	Belongs to the DHHC palmitoyltransferase family. Contains 1 DHHC-type zinc finger.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Palmitoyltransferase ZDHHC2		PRO_0000212859
Regions
	Transmembrane	17 – 37	21	Helical; Potential
	Transmembrane	55 – 75	21	Helical; Potential
	Transmembrane	171 – 191	21	Helical; Potential
	Transmembrane	209 – 229	21	Helical; Potential
	Zinc finger	127 – 177	51	DHHC-type
Natural variations
	Natural variant	306	1	S → F in a hepatocellular carcinoma sample; somatic mutation. Ref.1		VAR_015229
	Natural variant	356	1	M → I in a colorectal cancer sample; somatic mutation. Ref.1		VAR_015230

Sequences

	Sequence		Length	Mass (Da)
	Q9UIJ5 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: B7BFB82837B7EE98	FASTA	367	42,022
	10 20 30 40 50 60 MAPSGPGSSA RRRCRRVLYW IPVVFITLLL GWSYYAYAIQ LCIVSMENTG EQVVCLMAYH 70 80 90 100 110 120 LLFAMFVWSY WKTIFTLPMN PSKEFHLSYA EKDLLEREPR GEAHQEVLRR AAKDLPIYTR 130 140 150 160 170 180 TMSGAIRYCD RCQLIKPDRC HHCSVCDKCI LKMDHHCPWV NNCVGFSNYK FFLLFLAYSL 190 200 210 220 230 240 LYCLFIAATD LQYFIKFWTN GLPDTQAKFH IMFLFFAAAM FSVSLSSLFG YHCWLVSKNK 250 260 270 280 290 300 STLEAFRSPV FRHGTDKNGF SLGFSKNMRQ VFGDEKKYWL LPIFSSLGDG CSFPTCLVNQ 310 320 330 340 350 360 DPEQASTPAG LNSTAKNLEN HQFPAKPLRE SQSHLLTDSQ SWTESSINPG KCKAGMSNPA LTMENET

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis." Oyama T., Miyoshi Y., Koyama K., Nakagawa H., Yamori T., Ito T., Matsuda H., Arakawa H., Nakamura Y. Genes Chromosomes Cancer 29:9-15(2000) [PubMed: 10918388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS PHE-306 AND ILE-356.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Duodenum.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB023584 mRNA. Translation: BAA88923.1. CH471080 Genomic DNA. Translation: EAW63824.1. CH471080 Genomic DNA. Translation: EAW63825.1. BC039253 mRNA. Translation: AAH39253.1. BC050272 mRNA. Translation: AAH50272.1.
IPI	IPI00008896.
RefSeq	NP_057437.1. NM_016353.4.
UniGene	Hs.726197.
3D structure databases
ProteinModelPortal	Q9UIJ5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UIJ5.
Polymorphism databases
DMDM	28202111.
Proteomic databases
PRIDE	Q9UIJ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262096; ENSP00000262096; ENSG00000104219.
GeneID	51201.
KEGG	hsa:51201.
UCSC	uc003wxe.1. human.
Organism-specific databases
CTD	51201.
GeneCards	GC08P017058.
H-InvDB	HIX0007333.
HGNC	HGNC:18469. ZDHHC2.
neXtProt	NX_Q9UIJ5.
PharmGKB	PA38336.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14768.
GeneTree	ENSGT00570000078748.
HOGENOM	HBG443608.
HOVERGEN	HBG055108.
InParanoid	Q9UIJ5.
OMA	SWTESST.
OrthoDB	EOG4GTKD9.
PhylomeDB	Q9UIJ5.
Gene expression databases
ArrayExpress	Q9UIJ5.
Bgee	Q9UIJ5.
CleanEx	HS_ZDHHC2.
Genevestigator	Q9UIJ5.
GermOnline	ENSG00000104219. Homo sapiens.
Family and domain databases
InterPro	IPR001594. Znf_DHHC_palmitoyltrfase. [Graphical view]
Pfam	PF01529. zf-DHHC. 1 hit. [Graphical view]
PROSITE	PS50216. ZF_DHHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	54234.

Entry information

Entry name

ZDHC2_HUMAN

Accession

Primary (citable) accession number: Q9UIJ5
Secondary accession number(s): D3DSP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.