Reviewed, UniProtKB/Swiss-Prot Q9UIJ5 (ZDHC2_HUMAN)

Names and origin

Protein names

Recommended name:
    Palmitoyltransferase ZDHHC2
    EC=2.3.1.-
Alternative name(s):
    Zinc finger DHHC domain-containing protein 2
      Short name=DHHC-2
    Zinc finger protein 372
    Reduced expression associated with metastasis protein
      Short name=Ream
    Reduced expression in cancer protein
      Short name=Rec

Gene names

Name:	ZDHHC2
Synonyms:	REAM, REC, ZNF372

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Palmitoyltransferase specific for GAP43 and DLG4/PSD95 By similarity.
Catalytic activity	Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Ubiquitously expressed. Reduced expression in colorectal cancers. Ref.1
Domain	The DHHC domain is required for palmitoyltransferase activity By similarity.
Involvement in disease	Mutations in ZDHHC2 are found in hepatocellular carcinoma and colorectal cancer.
Sequence similarities	Belongs to the DHHC palmitoyltransferase family. Contains 1 DHHC-type zinc finger.

Ontologies

Keywords
Cellular component	Membrane
Disease	Disease mutation
Domain	Transmembrane Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Palmitoyltransferase ZDHHC2		PRO_0000212859
Regions
	Transmembrane	17 – 37	21	Potential
	Transmembrane	55 – 75	21	Potential
	Transmembrane	171 – 191	21	Potential
	Transmembrane	209 – 229	21	Potential
	Zinc finger	127 – 177	51	DHHC-type
Natural variations
	Natural variant	306	1	S → F in hepatocellular carcinoma; somatic mutation. Ref.1		VAR_015229
	Natural variant	356	1	M → I in colorectal cancer; somatic mutation. Ref.1		VAR_015230

Sequences

	Sequence		Length	Mass (Da)
	Q9UIJ5-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: B7BFB82837B7EE98	FASTA	367	42,022
	10 20 30 40 50 60 MAPSGPGSSA RRRCRRVLYW IPVVFITLLL GWSYYAYAIQ LCIVSMENTG EQVVCLMAYH 70 80 90 100 110 120 LLFAMFVWSY WKTIFTLPMN PSKEFHLSYA EKDLLEREPR GEAHQEVLRR AAKDLPIYTR 130 140 150 160 170 180 TMSGAIRYCD RCQLIKPDRC HHCSVCDKCI LKMDHHCPWV NNCVGFSNYK FFLLFLAYSL 190 200 210 220 230 240 LYCLFIAATD LQYFIKFWTN GLPDTQAKFH IMFLFFAAAM FSVSLSSLFG YHCWLVSKNK 250 260 270 280 290 300 STLEAFRSPV FRHGTDKNGF SLGFSKNMRQ VFGDEKKYWL LPIFSSLGDG CSFPTCLVNQ 310 320 330 340 350 360 DPEQASTPAG LNSTAKNLEN HQFPAKPLRE SQSHLLTDSQ SWTESSINPG KCKAGMSNPA LTMENET

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis." Oyama T., Miyoshi Y., Koyama K., Nakagawa H., Yamori T., Ito T., Matsuda H., Arakawa H., Nakamura Y. Genes Chromosomes Cancer 29:9-15(2000) [PubMed: 10918388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT HEPATOCELLULAR CARCINOMA PHE-306, VARIANT COLORECTAL CANCER ILE-356.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Duodenum.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB023584 mRNA. Translation: BAA88923.1. BC039253 mRNA. Translation: AAH39253.1. BC050272 mRNA. Translation: AAH50272.1.
IPI	IPI00008896.
RefSeq	NP_057437.1.
UniGene	Hs.443852
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q9UIJ5.
Genome annotation databases
Ensembl	ENSG00000104219. Homo sapiens. [Contig view]
GeneID	51201.
KEGG	hsa:51201.
Organism-specific databases
GeneCards	GC08P017058.
HGNC	HGNC:18469. ZDHHC2.
PharmGKB	PA38336.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9UIJ5.
HOVERGEN	Q9UIJ5.
Gene expression databases
ArrayExpress	Q9UIJ5.
Bgee	Q9UIJ5.
CleanEx	HS_ZDHHC2.
GermOnline	ENSG00000104219. Homo sapiens.
Family and domain databases
InterPro	IPR001594. Znf_DHHC. [Graphical view]
Pfam	PF01529. zf-DHHC. 1 hit. [Graphical view]
ProDom	PD003041. Znf_DHHC. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS50216. ZF_DHHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	54234.

Entry information

Entry name

ZDHC2_HUMAN

Accession

Primary (citable) accession number: Q9UIJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)