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Protein

Palmitoyltransferase ZDHHC2

Gene

ZDHHC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase specific for GAP43 and DLG4/PSD95.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

  • cellular protein metabolic process Source: Reactome
  • protein palmitoylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.225. 2681.
ReactomeiR-HSA-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC2 (EC:2.3.1.225)
Alternative name(s):
Reduced expression associated with metastasis protein
Short name:
Ream
Reduced expression in cancer protein
Short name:
Rec
Zinc finger DHHC domain-containing protein 2
Short name:
DHHC-2
Zinc finger protein 372
Gene namesi
Name:ZDHHC2
Synonyms:REAM, REC, ZNF372
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18469. ZDHHC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Transmembranei55 – 7521HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • integral component of plasma membrane Source: Ensembl
  • plasma membrane Source: Reactome
  • recycling endosome membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38336.

Polymorphism and mutation databases

BioMutaiZDHHC2.
DMDMi28202111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Palmitoyltransferase ZDHHC2PRO_0000212859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411PhosphoserineCombined sources

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9UIJ5.
PaxDbiQ9UIJ5.
PeptideAtlasiQ9UIJ5.
PRIDEiQ9UIJ5.

PTM databases

iPTMnetiQ9UIJ5.
PhosphoSiteiQ9UIJ5.
SwissPalmiQ9UIJ5.

Expressioni

Tissue specificityi

Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis.1 Publication

Gene expression databases

BgeeiQ9UIJ5.
CleanExiHS_ZDHHC2.
ExpressionAtlasiQ9UIJ5. baseline and differential.
GenevisibleiQ9UIJ5. HS.

Organism-specific databases

HPAiHPA023331.

Interactioni

Protein-protein interaction databases

BioGridi119374. 2 interactions.
MINTiMINT-4651088.
STRINGi9606.ENSP00000262096.

Structurei

3D structure databases

ProteinModelPortaliQ9UIJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 17751DHHCPROSITE-ProRule annotationAdd
BLAST

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1315. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129766.
HOGENOMiHOG000234777.
HOVERGENiHBG055108.
InParanoidiQ9UIJ5.
KOiK20028.
OMAiVCLIAYH.
OrthoDBiEOG71ZP21.
PhylomeDBiQ9UIJ5.
TreeFamiTF316044.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UIJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSGPGSSA RRRCRRVLYW IPVVFITLLL GWSYYAYAIQ LCIVSMENTG
60 70 80 90 100
EQVVCLMAYH LLFAMFVWSY WKTIFTLPMN PSKEFHLSYA EKDLLEREPR
110 120 130 140 150
GEAHQEVLRR AAKDLPIYTR TMSGAIRYCD RCQLIKPDRC HHCSVCDKCI
160 170 180 190 200
LKMDHHCPWV NNCVGFSNYK FFLLFLAYSL LYCLFIAATD LQYFIKFWTN
210 220 230 240 250
GLPDTQAKFH IMFLFFAAAM FSVSLSSLFG YHCWLVSKNK STLEAFRSPV
260 270 280 290 300
FRHGTDKNGF SLGFSKNMRQ VFGDEKKYWL LPIFSSLGDG CSFPTCLVNQ
310 320 330 340 350
DPEQASTPAG LNSTAKNLEN HQFPAKPLRE SQSHLLTDSQ SWTESSINPG
360
KCKAGMSNPA LTMENET
Length:367
Mass (Da):42,022
Last modified:May 1, 2000 - v1
Checksum:iB7BFB82837B7EE98
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti306 – 3061S → F in a hepatocellular carcinoma sample; somatic mutation. 1 Publication
VAR_015229
Natural varianti356 – 3561M → I in a colorectal cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs568589179 [ dbSNP | Ensembl ].
VAR_015230

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023584 mRNA. Translation: BAA88923.1.
CH471080 Genomic DNA. Translation: EAW63824.1.
CH471080 Genomic DNA. Translation: EAW63825.1.
BC039253 mRNA. Translation: AAH39253.1.
BC050272 mRNA. Translation: AAH50272.1.
CCDSiCCDS47810.1.
RefSeqiNP_057437.1. NM_016353.4.
UniGeneiHs.744097.

Genome annotation databases

EnsembliENST00000262096; ENSP00000262096; ENSG00000104219.
GeneIDi51201.
KEGGihsa:51201.
UCSCiuc003wxe.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023584 mRNA. Translation: BAA88923.1.
CH471080 Genomic DNA. Translation: EAW63824.1.
CH471080 Genomic DNA. Translation: EAW63825.1.
BC039253 mRNA. Translation: AAH39253.1.
BC050272 mRNA. Translation: AAH50272.1.
CCDSiCCDS47810.1.
RefSeqiNP_057437.1. NM_016353.4.
UniGeneiHs.744097.

3D structure databases

ProteinModelPortaliQ9UIJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119374. 2 interactions.
MINTiMINT-4651088.
STRINGi9606.ENSP00000262096.

PTM databases

iPTMnetiQ9UIJ5.
PhosphoSiteiQ9UIJ5.
SwissPalmiQ9UIJ5.

Polymorphism and mutation databases

BioMutaiZDHHC2.
DMDMi28202111.

Proteomic databases

EPDiQ9UIJ5.
PaxDbiQ9UIJ5.
PeptideAtlasiQ9UIJ5.
PRIDEiQ9UIJ5.

Protocols and materials databases

DNASUi51201.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262096; ENSP00000262096; ENSG00000104219.
GeneIDi51201.
KEGGihsa:51201.
UCSCiuc003wxe.4. human.

Organism-specific databases

CTDi51201.
GeneCardsiZDHHC2.
HGNCiHGNC:18469. ZDHHC2.
HPAiHPA023331.
neXtProtiNX_Q9UIJ5.
PharmGKBiPA38336.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1315. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129766.
HOGENOMiHOG000234777.
HOVERGENiHBG055108.
InParanoidiQ9UIJ5.
KOiK20028.
OMAiVCLIAYH.
OrthoDBiEOG71ZP21.
PhylomeDBiQ9UIJ5.
TreeFamiTF316044.

Enzyme and pathway databases

BRENDAi2.3.1.225. 2681.
ReactomeiR-HSA-5683826. Surfactant metabolism.

Miscellaneous databases

ChiTaRSiZDHHC2. human.
GeneWikiiZDHHC2_(gene).
GenomeRNAii51201.
PROiQ9UIJ5.

Gene expression databases

BgeeiQ9UIJ5.
CleanExiHS_ZDHHC2.
ExpressionAtlasiQ9UIJ5. baseline and differential.
GenevisibleiQ9UIJ5. HS.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis."
    Oyama T., Miyoshi Y., Koyama K., Nakagawa H., Yamori T., Ito T., Matsuda H., Arakawa H., Nakamura Y.
    Genes Chromosomes Cancer 29:9-15(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS PHE-306 AND ILE-356.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Duodenum.
  4. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiZDHC2_HUMAN
AccessioniPrimary (citable) accession number: Q9UIJ5
Secondary accession number(s): D3DSP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.