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Q9UII5

- ZN107_HUMAN

UniProt

Q9UII5 - ZN107_HUMAN

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Protein

Zinc finger protein 107

Gene

ZNF107

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri76 – 9823C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri104 – 12623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 15423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 9; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 12; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 51823C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54623C2H2-type 17; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri552 – 57423C2H2-type 18; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri580 – 60223C2H2-type 19; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri608 – 63023C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri636 – 65823C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri664 – 68623C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri692 – 71423C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri720 – 74223C2H2-type 24PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri748 – 77023C2H2-type 25; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 107
Alternative name(s):
Zinc finger protein 588
Zinc finger protein ZFD25
Gene namesi
Name:ZNF107
Synonyms:ZFD25, ZNF588
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:12887. ZNF107.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 783783Zinc finger protein 107PRO_0000047681Add
BLAST

Proteomic databases

MaxQBiQ9UII5.
PaxDbiQ9UII5.
PRIDEiQ9UII5.

PTM databases

PhosphoSiteiQ9UII5.

Expressioni

Tissue specificityi

Expressed in brain, heart, skeletal muscle, kidney and pancreas. Weakly expressed in aorta, liver and lung.

Gene expression databases

BgeeiQ9UII5.
CleanExiHS_ZNF107.
ExpressionAtlasiQ9UII5. baseline and differential.
GenevestigatoriQ9UII5.

Interactioni

Protein-protein interaction databases

BioGridi119533. 4 interactions.
IntActiQ9UII5. 2 interactions.
MINTiMINT-1194942.

Structurei

3D structure databases

ProteinModelPortaliQ9UII5.
SMRiQ9UII5. Positions 74-778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 25 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri76 – 9823C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri104 – 12623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 15423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 9; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 12; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 51823C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54623C2H2-type 17; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri552 – 57423C2H2-type 18; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri580 – 60223C2H2-type 19; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri608 – 63023C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri636 – 65823C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri664 – 68623C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri692 – 71423C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri720 – 74223C2H2-type 24PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri748 – 77023C2H2-type 25; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118979.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UII5.
KOiK09228.
OMAiFEEHGKA.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9UII5.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 25 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 22 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 24 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UII5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAKPPVMSF HFAQDLWPEQ NIKDSFQKVT LRRYGKCEYE NLQLRKGCKH
60 70 80 90 100
VDECTGHKGG HNTVNQCLTA TPSKIFQCNK YVKVFDKFSN SNRYKRRHTG
110 120 130 140 150
NKHFKCKECS KSFCVLSQLT QHRRIHTRVN SYKCEECGKA FNWFSTLTKH
160 170 180 190 200
KRIHTGEKPY KCEECGKAFN QSSQLTRHKI IHTEEKPNKC EECGKAFKQA
210 220 230 240 250
SHLTIHKIIH TGEKPYKYEE CGKVFSQSSH LTTQKILHTG ENLYKCKECG
260 270 280 290 300
KAFNLFSNLT NHKRIHAGEK PYKCKECGRA FNISSNLNKQ EKIHTGGKLN
310 320 330 340 350
KCEECDKAFN RSLKLTAHKK ILMEEKPYKC EECGKVFNQF STLTRHKIIH
360 370 380 390 400
TGEKPYKCKE CGKAFNQSSN LTEHKKIHTA EKSYKCEECG KAFNQHSNLI
410 420 430 440 450
NHRKIYSGEK PYKCEECGKA FNRSSTLTRH KKIHTGEKPY KCEECDRAFS
460 470 480 490 500
QSSNLTEHKK IHTGEKPYKC EECGKAFNRF STLTKHKRIH TGEKPYKCEE
510 520 530 540 550
CGKAFNQSYQ LTRHKIVHTK EKLNKCEEFG KAFKQSSHRT IHKIIHTGEK
560 570 580 590 600
PYKCEEHGKV FNQSSNLTTQ KIIHTGENLY KFEEHGKAFN LFSNITNHKI
610 620 630 640 650
IYTGEKPHKC EECGKAYNRF SNLTIHKRIH TGEKPYQCAE CGKAFNCSST
660 670 680 690 700
LNRHKIIHTG EKPYKCKECG KAFNLSSTLT AHKKIHTGEK PYKCEECGKA
710 720 730 740 750
FNQSSNLTTH KKIHTSEKPY KCEECGKSFN QFSSLNIHKI IHTGEKPYKC
760 770 780
GDYGRAFNLS SNLTTHKKIH TGEKPYKCEY GKT
Length:783
Mass (Da):90,673
Last modified:May 1, 2000 - v1
Checksum:i84882575525DC34C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027251 mRNA. Translation: BAA85623.1.
BC047243 mRNA. Translation: AAH47243.1.
CCDSiCCDS5527.1.
RefSeqiNP_001013768.1. NM_001013746.2.
NP_057304.1. NM_016220.4.
XP_005250458.1. XM_005250401.2.
XP_006716085.1. XM_006716022.1.
UniGeneiHs.50216.
Hs.732661.

Genome annotation databases

EnsembliENST00000344930; ENSP00000343443; ENSG00000196247.
ENST00000395391; ENSP00000378789; ENSG00000196247.
ENST00000423627; ENSP00000400037; ENSG00000196247.
GeneIDi51427.
KEGGihsa:51427.
UCSCiuc003ttd.3. human.

Polymorphism databases

DMDMi21542325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027251 mRNA. Translation: BAA85623.1 .
BC047243 mRNA. Translation: AAH47243.1 .
CCDSi CCDS5527.1.
RefSeqi NP_001013768.1. NM_001013746.2.
NP_057304.1. NM_016220.4.
XP_005250458.1. XM_005250401.2.
XP_006716085.1. XM_006716022.1.
UniGenei Hs.50216.
Hs.732661.

3D structure databases

ProteinModelPortali Q9UII5.
SMRi Q9UII5. Positions 74-778.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119533. 4 interactions.
IntActi Q9UII5. 2 interactions.
MINTi MINT-1194942.

PTM databases

PhosphoSitei Q9UII5.

Polymorphism databases

DMDMi 21542325.

Proteomic databases

MaxQBi Q9UII5.
PaxDbi Q9UII5.
PRIDEi Q9UII5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344930 ; ENSP00000343443 ; ENSG00000196247 .
ENST00000395391 ; ENSP00000378789 ; ENSG00000196247 .
ENST00000423627 ; ENSP00000400037 ; ENSG00000196247 .
GeneIDi 51427.
KEGGi hsa:51427.
UCSCi uc003ttd.3. human.

Organism-specific databases

CTDi 51427.
GeneCardsi GC07P064126.
HGNCi HGNC:12887. ZNF107.
MIMi 603989. gene.
neXtProti NX_Q9UII5.
PharmGKBi PA37476.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118979.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9UII5.
KOi K09228.
OMAi FEEHGKA.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9UII5.
TreeFami TF343410.

Miscellaneous databases

GenomeRNAii 51427.
NextBioi 54981.
PROi Q9UII5.
SOURCEi Search...

Gene expression databases

Bgeei Q9UII5.
CleanExi HS_ZNF107.
ExpressionAtlasi Q9UII5. baseline and differential.
Genevestigatori Q9UII5.

Family and domain databases

Gene3Di 3.30.160.60. 25 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 22 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 24 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel gene encoding a zinc finger protein with 25 fingers."
    Li X.-A., Kokame K., Okubo K., Shimokado K., Tsukamoto Y., Miyata T., Kato H., Yutani C.
    Biochim. Biophys. Acta 1489:405-412(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN107_HUMAN
AccessioniPrimary (citable) accession number: Q9UII5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3