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Q9UII5

- ZN107_HUMAN

UniProt

Q9UII5 - ZN107_HUMAN

Protein

Zinc finger protein 107

Gene

ZNF107

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri76 – 9823C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri104 – 12623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri132 – 15423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri160 – 18223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri188 – 21023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri216 – 23823C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri244 – 26623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri272 – 29423C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri300 – 32223C2H2-type 9; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri328 – 35023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri356 – 37823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri384 – 40623C2H2-type 12; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri412 – 43423C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri440 – 46223C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri468 – 49023C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri496 – 51823C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri524 – 54623C2H2-type 17; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri552 – 57423C2H2-type 18; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri580 – 60223C2H2-type 19; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri608 – 63023C2H2-type 20PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri636 – 65823C2H2-type 21PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri664 – 68623C2H2-type 22PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri692 – 71423C2H2-type 23PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri720 – 74223C2H2-type 24PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri748 – 77023C2H2-type 25; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 107
    Alternative name(s):
    Zinc finger protein 588
    Zinc finger protein ZFD25
    Gene namesi
    Name:ZNF107
    Synonyms:ZFD25, ZNF588
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:12887. ZNF107.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37476.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 783783Zinc finger protein 107PRO_0000047681Add
    BLAST

    Proteomic databases

    MaxQBiQ9UII5.
    PaxDbiQ9UII5.
    PRIDEiQ9UII5.

    PTM databases

    PhosphoSiteiQ9UII5.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, skeletal muscle, kidney and pancreas. Weakly expressed in aorta, liver and lung.

    Gene expression databases

    ArrayExpressiQ9UII5.
    BgeeiQ9UII5.
    CleanExiHS_ZNF107.
    GenevestigatoriQ9UII5.

    Interactioni

    Protein-protein interaction databases

    BioGridi119533. 4 interactions.
    IntActiQ9UII5. 2 interactions.
    MINTiMINT-1194942.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UII5.
    SMRiQ9UII5. Positions 74-778.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 25 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri76 – 9823C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri104 – 12623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri132 – 15423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri160 – 18223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri188 – 21023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri216 – 23823C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri244 – 26623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri272 – 29423C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri300 – 32223C2H2-type 9; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri328 – 35023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri356 – 37823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri384 – 40623C2H2-type 12; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri412 – 43423C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri440 – 46223C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri468 – 49023C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri496 – 51823C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri524 – 54623C2H2-type 17; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri552 – 57423C2H2-type 18; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri580 – 60223C2H2-type 19; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri608 – 63023C2H2-type 20PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri636 – 65823C2H2-type 21PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri664 – 68623C2H2-type 22PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri692 – 71423C2H2-type 23PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri720 – 74223C2H2-type 24PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri748 – 77023C2H2-type 25; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9UII5.
    KOiK09228.
    OMAiFEEHGKA.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9UII5.
    TreeFamiTF343410.

    Family and domain databases

    Gene3Di3.30.160.60. 25 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 22 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 16 hits.
    PS50157. ZINC_FINGER_C2H2_2. 24 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UII5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAKPPVMSF HFAQDLWPEQ NIKDSFQKVT LRRYGKCEYE NLQLRKGCKH    50
    VDECTGHKGG HNTVNQCLTA TPSKIFQCNK YVKVFDKFSN SNRYKRRHTG 100
    NKHFKCKECS KSFCVLSQLT QHRRIHTRVN SYKCEECGKA FNWFSTLTKH 150
    KRIHTGEKPY KCEECGKAFN QSSQLTRHKI IHTEEKPNKC EECGKAFKQA 200
    SHLTIHKIIH TGEKPYKYEE CGKVFSQSSH LTTQKILHTG ENLYKCKECG 250
    KAFNLFSNLT NHKRIHAGEK PYKCKECGRA FNISSNLNKQ EKIHTGGKLN 300
    KCEECDKAFN RSLKLTAHKK ILMEEKPYKC EECGKVFNQF STLTRHKIIH 350
    TGEKPYKCKE CGKAFNQSSN LTEHKKIHTA EKSYKCEECG KAFNQHSNLI 400
    NHRKIYSGEK PYKCEECGKA FNRSSTLTRH KKIHTGEKPY KCEECDRAFS 450
    QSSNLTEHKK IHTGEKPYKC EECGKAFNRF STLTKHKRIH TGEKPYKCEE 500
    CGKAFNQSYQ LTRHKIVHTK EKLNKCEEFG KAFKQSSHRT IHKIIHTGEK 550
    PYKCEEHGKV FNQSSNLTTQ KIIHTGENLY KFEEHGKAFN LFSNITNHKI 600
    IYTGEKPHKC EECGKAYNRF SNLTIHKRIH TGEKPYQCAE CGKAFNCSST 650
    LNRHKIIHTG EKPYKCKECG KAFNLSSTLT AHKKIHTGEK PYKCEECGKA 700
    FNQSSNLTTH KKIHTSEKPY KCEECGKSFN QFSSLNIHKI IHTGEKPYKC 750
    GDYGRAFNLS SNLTTHKKIH TGEKPYKCEY GKT 783
    Length:783
    Mass (Da):90,673
    Last modified:May 1, 2000 - v1
    Checksum:i84882575525DC34C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027251 mRNA. Translation: BAA85623.1.
    BC047243 mRNA. Translation: AAH47243.1.
    CCDSiCCDS5527.1.
    RefSeqiNP_001013768.1. NM_001013746.2.
    NP_057304.1. NM_016220.4.
    XP_005250458.1. XM_005250401.2.
    XP_006716085.1. XM_006716022.1.
    UniGeneiHs.50216.
    Hs.732661.

    Genome annotation databases

    EnsembliENST00000344930; ENSP00000343443; ENSG00000196247.
    ENST00000395391; ENSP00000378789; ENSG00000196247.
    ENST00000423627; ENSP00000400037; ENSG00000196247.
    GeneIDi51427.
    KEGGihsa:51427.
    UCSCiuc003ttd.3. human.

    Polymorphism databases

    DMDMi21542325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027251 mRNA. Translation: BAA85623.1 .
    BC047243 mRNA. Translation: AAH47243.1 .
    CCDSi CCDS5527.1.
    RefSeqi NP_001013768.1. NM_001013746.2.
    NP_057304.1. NM_016220.4.
    XP_005250458.1. XM_005250401.2.
    XP_006716085.1. XM_006716022.1.
    UniGenei Hs.50216.
    Hs.732661.

    3D structure databases

    ProteinModelPortali Q9UII5.
    SMRi Q9UII5. Positions 74-778.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119533. 4 interactions.
    IntActi Q9UII5. 2 interactions.
    MINTi MINT-1194942.

    PTM databases

    PhosphoSitei Q9UII5.

    Polymorphism databases

    DMDMi 21542325.

    Proteomic databases

    MaxQBi Q9UII5.
    PaxDbi Q9UII5.
    PRIDEi Q9UII5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344930 ; ENSP00000343443 ; ENSG00000196247 .
    ENST00000395391 ; ENSP00000378789 ; ENSG00000196247 .
    ENST00000423627 ; ENSP00000400037 ; ENSG00000196247 .
    GeneIDi 51427.
    KEGGi hsa:51427.
    UCSCi uc003ttd.3. human.

    Organism-specific databases

    CTDi 51427.
    GeneCardsi GC07P064126.
    HGNCi HGNC:12887. ZNF107.
    MIMi 603989. gene.
    neXtProti NX_Q9UII5.
    PharmGKBi PA37476.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9UII5.
    KOi K09228.
    OMAi FEEHGKA.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9UII5.
    TreeFami TF343410.

    Miscellaneous databases

    GenomeRNAii 51427.
    NextBioi 54981.
    PROi Q9UII5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UII5.
    Bgeei Q9UII5.
    CleanExi HS_ZNF107.
    Genevestigatori Q9UII5.

    Family and domain databases

    Gene3Di 3.30.160.60. 25 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 22 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 16 hits.
    PS50157. ZINC_FINGER_C2H2_2. 24 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel gene encoding a zinc finger protein with 25 fingers."
      Li X.-A., Kokame K., Okubo K., Shimokado K., Tsukamoto Y., Miyata T., Kato H., Yutani C.
      Biochim. Biophys. Acta 1489:405-412(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiZN107_HUMAN
    AccessioniPrimary (citable) accession number: Q9UII5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3