Q9UIH9 (KLF15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Krueppel-like factor 15

Alternative name(s):
Kidney-enriched krueppel-like factor

Gene names

Name:	KLF15
Synonyms:	KKLF

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional activator. Binds to the GA element of the CLCNKA promoter.
Subcellular location	Nucleus Ref.1.
Tissue specificity	Highly expressed in liver, followed by heart, skeletal muscle, and kidney. Not expressed in bone marrow or lymphoid tissues. Ref.1
Sequence similarities	Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glial cell differentiation Inferred from electronic annotation. Source: Compara glucose transport Inferred from electronic annotation. Source: Compara
Cellular_component	nucleolus Inferred from direct assay. Source: HPA
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred by curator PubMed 19767294. Source: BHF-UCL zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 416

416

Krueppel-like factor 15

PRO_0000047187

Regions

Zinc finger

321 – 345

25

C2H2-type 1

Zinc finger

351 – 375

25

C2H2-type 2

Zinc finger

381 – 403

23

C2H2-type 3

Secondary structure

1

.

.

.

.

.

.

416

Helix Strand Turn

Details...

Beta strand

355 – 357

3

Beta strand

361 – 364

4

Helix

365 – 372

8

Sequences

	Sequence		Length	Mass (Da)
	Q9UIH9 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 6335F85141BEB276	FASTA	416	43,992
	10 20 30 40 50 60 MVDHLLPVDE NFSSPKCPVG YLGDRLVGRR AYHMLPSPVS EDDSDASSPC SCSSPDSQAL 70 80 90 100 110 120 CSCYGGGLGT ESQDSILDFL LSQATLGSGG GSGSSIGASS GPVAWGPWRR AAAPVKGEHF 130 140 150 160 170 180 CLPEFPLGDP DDVPRPFQPT LEEIEEFLEE NMEPGVKEVP EGNSKDLDAC SQLSAGPHKS 190 200 210 220 230 240 HLHPGSSGRE RCSPPPGGAS AGGAQGPGGG PTPDGPIPVL LQIQPVPVKQ ESGTGPASPG 250 260 270 280 290 300 QAPENVKVAQ LLVNIQGQTF ALVPQVVPSS NLNLPSKFVR IAPVPIAAKP VGSGPLGPGP 310 320 330 340 350 360 AGLLMGQKFP KNPAAELIKM HKCTFPGCSK MYTKSSHLKA HLRRHTGEKP FACTWPGCGW 370 380 390 400 410 RFSRSDELSR HRRSHSGVKP YQCPVCEKKF ARSDHLSKHI KVHRFPRSSR SVRSVN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor." Uchida S., Tanaka Y., Ito H., Saitoh-Ohara F., Inazawa J., Yokoyama K.K., Sasaki S., Marumo F. Mol. Cell. Biol. 20:7319-7331(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Kidney.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[3]	"Solution structure of the second C2H2-type zinc finger domain from human krueppel-like factor 15." RIKEN structural genomics initiative (RSGI) Submitted (APR-2008) to the PDB data bank Cited for: STRUCTURE BY NMR OF 346-380.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB029254 mRNA. Translation: BAA88561.1.
BC036733 mRNA. Translation: AAH36733.1.

IPI

IPI00022405.

RefSeq

NP_054798.1. NM_014079.3.

UniGene

Hs.272215.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2ENT	NMR	-	A	346-380	[»]

ProteinModelPortal

Q9UIH9.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9UIH9. 3 interactions.

STRING

9606.ENSP00000296233.

PTM databases

PhosphoSite

Q9UIH9.

Polymorphism databases

DMDM

20138787.

Proteomic databases

PaxDb

Q9UIH9.

PRIDE

Q9UIH9.

Protocols and materials databases

DNASU

28999.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000296233; ENSP00000296233; ENSG00000163884.

GeneID

28999.

KEGG

hsa:28999.

UCSC

uc011bkk.1. human.

Organism-specific databases

CTD

28999.

GeneCards

GC03M126061.

HGNC

HGNC:14536. KLF15.

HPA

HPA028866.

MIM

606465. gene.

neXtProt

NX_Q9UIH9.

PharmGKB

PA30134.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5048.

HOGENOM

HOG000294058.

HOVERGEN

HBG052266.

InParanoid

Q9UIH9.

KO

K09210.

OMA

SSGPMAW.

OrthoDB

EOG46WZ98.

PhylomeDB

Q9UIH9.

Gene expression databases

Bgee

Q9UIH9.

CleanEx

HS_KLF15.

Genevestigator

Q9UIH9.

GermOnline

ENSG00000163884. Homo sapiens.

Family and domain databases

Gene3D

3.30.160.60. 3 hits.

InterPro

IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

SMART

SM00355. ZnF_C2H2. 3 hits.
[Graphical view]

PROSITE

PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9UIH9.

GenomeRNAi

28999.

NextBio

51936.

SOURCE

Search...

Entry information

Entry name

KLF15_HUMAN

Accession

Primary (citable) accession number: Q9UIH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.