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Protein

Krueppel-like factor 15

Gene

KLF15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.By similarity4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri321 – 345C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri351 – 375C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri381 – 403C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
SignaLinkiQ9UIH9.
SIGNORiQ9UIH9.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 15
Alternative name(s):
Kidney-enriched krueppel-like factor
Gene namesi
Name:KLF15
Synonyms:KKLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14536. KLF15.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365).2 Publications

Organism-specific databases

DisGeNETi28999.
OpenTargetsiENSG00000163884.
PharmGKBiPA30134.

Polymorphism and mutation databases

BioMutaiKLF15.
DMDMi20138787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471871 – 416Krueppel-like factor 15Add BLAST416

Proteomic databases

PaxDbiQ9UIH9.
PRIDEiQ9UIH9.

PTM databases

iPTMnetiQ9UIH9.
PhosphoSitePlusiQ9UIH9.

Expressioni

Tissue specificityi

Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.4 Publications

Inductioni

In podocytes, up-regulated by retinoic acid.1 Publication

Gene expression databases

BgeeiENSG00000163884.
CleanExiHS_KLF15.
GenevisibleiQ9UIH9. HS.

Organism-specific databases

HPAiHPA028866.

Interactioni

Subunit structurei

Interacts with MYOCD and EP300.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118818. 15 interactors.
IntActiQ9UIH9. 19 interactors.
MINTiMINT-8417681.
STRINGi9606.ENSP00000296233.

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi355 – 357Combined sources3
Beta strandi361 – 364Combined sources4
Helixi365 – 372Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ENTNMR-A346-380[»]
ProteinModelPortaliQ9UIH9.
SMRiQ9UIH9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UIH9.

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri321 – 345C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri351 – 375C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri381 – 403C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000294058.
HOVERGENiHBG052266.
InParanoidiQ9UIH9.
KOiK09210.
OMAiVKGEHFC.
OrthoDBiEOG091G09JN.
PhylomeDBiQ9UIH9.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9UIH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDHLLPVDE NFSSPKCPVG YLGDRLVGRR AYHMLPSPVS EDDSDASSPC
60 70 80 90 100
SCSSPDSQAL CSCYGGGLGT ESQDSILDFL LSQATLGSGG GSGSSIGASS
110 120 130 140 150
GPVAWGPWRR AAAPVKGEHF CLPEFPLGDP DDVPRPFQPT LEEIEEFLEE
160 170 180 190 200
NMEPGVKEVP EGNSKDLDAC SQLSAGPHKS HLHPGSSGRE RCSPPPGGAS
210 220 230 240 250
AGGAQGPGGG PTPDGPIPVL LQIQPVPVKQ ESGTGPASPG QAPENVKVAQ
260 270 280 290 300
LLVNIQGQTF ALVPQVVPSS NLNLPSKFVR IAPVPIAAKP VGSGPLGPGP
310 320 330 340 350
AGLLMGQKFP KNPAAELIKM HKCTFPGCSK MYTKSSHLKA HLRRHTGEKP
360 370 380 390 400
FACTWPGCGW RFSRSDELSR HRRSHSGVKP YQCPVCEKKF ARSDHLSKHI
410
KVHRFPRSSR SVRSVN
Length:416
Mass (Da):43,992
Last modified:May 1, 2000 - v1
Checksum:i6335F85141BEB276
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029254 mRNA. Translation: BAA88561.1.
BC036733 mRNA. Translation: AAH36733.1.
CCDSiCCDS3036.1.
RefSeqiNP_054798.1. NM_014079.3.
XP_005247457.1. XM_005247400.3.
UniGeneiHs.272215.

Genome annotation databases

EnsembliENST00000296233; ENSP00000296233; ENSG00000163884.
GeneIDi28999.
KEGGihsa:28999.
UCSCiuc011bkk.2. human.

Similar proteinsi

Entry informationi

Entry nameiKLF15_HUMAN
AccessioniPrimary (citable) accession number: Q9UIH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families