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Q9UIH9

- KLF15_HUMAN

UniProt

Q9UIH9 - KLF15_HUMAN

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Protein

Krueppel-like factor 15

Gene

KLF15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.By similarity4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri321 – 34525C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37525C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
  3. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. cardiac muscle hypertrophy in response to stress Source: Ensembl
  2. cellular response to peptide Source: Ensembl
  3. glial cell differentiation Source: Ensembl
  4. glomerular visceral epithelial cell differentiation Source: UniProtKB
  5. glucose transport Source: Ensembl
  6. negative regulation of peptidyl-lysine acetylation Source: UniProtKB
  7. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ9UIH9.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 15
Alternative name(s):
Kidney-enriched krueppel-like factor
Gene namesi
Name:KLF15
Synonyms:KKLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:14536. KLF15.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365).2 Publications

Organism-specific databases

PharmGKBiPA30134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Krueppel-like factor 15PRO_0000047187Add
BLAST

Proteomic databases

PaxDbiQ9UIH9.
PRIDEiQ9UIH9.

PTM databases

PhosphoSiteiQ9UIH9.

Expressioni

Tissue specificityi

Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.4 Publications

Inductioni

In podocytes, up-regulated by retinoic acid.1 Publication

Gene expression databases

BgeeiQ9UIH9.
CleanExiHS_KLF15.
GenevestigatoriQ9UIH9.

Organism-specific databases

HPAiHPA028866.

Interactioni

Subunit structurei

Interacts with MYOCD and EP300.2 Publications

Protein-protein interaction databases

BioGridi118818. 5 interactions.
IntActiQ9UIH9. 4 interactions.
MINTiMINT-8417681.
STRINGi9606.ENSP00000296233.

Structurei

Secondary structure

1
416
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi355 – 3573Combined sources
Beta strandi361 – 3644Combined sources
Helixi365 – 3728Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ENTNMR-A346-380[»]
ProteinModelPortaliQ9UIH9.
SMRiQ9UIH9. Positions 318-403.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UIH9.

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri321 – 34525C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37525C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000294058.
HOVERGENiHBG052266.
InParanoidiQ9UIH9.
KOiK09210.
OMAiSSGPMAW.
OrthoDBiEOG7JMGF2.
PhylomeDBiQ9UIH9.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UIH9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDHLLPVDE NFSSPKCPVG YLGDRLVGRR AYHMLPSPVS EDDSDASSPC
60 70 80 90 100
SCSSPDSQAL CSCYGGGLGT ESQDSILDFL LSQATLGSGG GSGSSIGASS
110 120 130 140 150
GPVAWGPWRR AAAPVKGEHF CLPEFPLGDP DDVPRPFQPT LEEIEEFLEE
160 170 180 190 200
NMEPGVKEVP EGNSKDLDAC SQLSAGPHKS HLHPGSSGRE RCSPPPGGAS
210 220 230 240 250
AGGAQGPGGG PTPDGPIPVL LQIQPVPVKQ ESGTGPASPG QAPENVKVAQ
260 270 280 290 300
LLVNIQGQTF ALVPQVVPSS NLNLPSKFVR IAPVPIAAKP VGSGPLGPGP
310 320 330 340 350
AGLLMGQKFP KNPAAELIKM HKCTFPGCSK MYTKSSHLKA HLRRHTGEKP
360 370 380 390 400
FACTWPGCGW RFSRSDELSR HRRSHSGVKP YQCPVCEKKF ARSDHLSKHI
410
KVHRFPRSSR SVRSVN
Length:416
Mass (Da):43,992
Last modified:May 1, 2000 - v1
Checksum:i6335F85141BEB276
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB029254 mRNA. Translation: BAA88561.1.
BC036733 mRNA. Translation: AAH36733.1.
CCDSiCCDS3036.1.
RefSeqiNP_054798.1. NM_014079.3.
XP_005247457.1. XM_005247400.1.
UniGeneiHs.272215.

Genome annotation databases

EnsembliENST00000296233; ENSP00000296233; ENSG00000163884.
GeneIDi28999.
KEGGihsa:28999.
UCSCiuc011bkk.1. human.

Polymorphism databases

DMDMi20138787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB029254 mRNA. Translation: BAA88561.1 .
BC036733 mRNA. Translation: AAH36733.1 .
CCDSi CCDS3036.1.
RefSeqi NP_054798.1. NM_014079.3.
XP_005247457.1. XM_005247400.1.
UniGenei Hs.272215.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ENT NMR - A 346-380 [» ]
ProteinModelPortali Q9UIH9.
SMRi Q9UIH9. Positions 318-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118818. 5 interactions.
IntActi Q9UIH9. 4 interactions.
MINTi MINT-8417681.
STRINGi 9606.ENSP00000296233.

PTM databases

PhosphoSitei Q9UIH9.

Polymorphism databases

DMDMi 20138787.

Proteomic databases

PaxDbi Q9UIH9.
PRIDEi Q9UIH9.

Protocols and materials databases

DNASUi 28999.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296233 ; ENSP00000296233 ; ENSG00000163884 .
GeneIDi 28999.
KEGGi hsa:28999.
UCSCi uc011bkk.1. human.

Organism-specific databases

CTDi 28999.
GeneCardsi GC03M126061.
HGNCi HGNC:14536. KLF15.
HPAi HPA028866.
MIMi 606465. gene.
neXtProti NX_Q9UIH9.
PharmGKBi PA30134.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118998.
HOGENOMi HOG000294058.
HOVERGENi HBG052266.
InParanoidi Q9UIH9.
KOi K09210.
OMAi SSGPMAW.
OrthoDBi EOG7JMGF2.
PhylomeDBi Q9UIH9.
TreeFami TF350556.

Enzyme and pathway databases

SignaLinki Q9UIH9.

Miscellaneous databases

EvolutionaryTracei Q9UIH9.
GeneWikii KLF15.
GenomeRNAii 28999.
NextBioi 51936.
PROi Q9UIH9.
SOURCEi Search...

Gene expression databases

Bgeei Q9UIH9.
CleanExi HS_KLF15.
Genevestigatori Q9UIH9.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor."
    Uchida S., Tanaka Y., Ito H., Saitoh-Ohara F., Inazawa J., Yokoyama K.K., Sasaki S., Marumo F.
    Mol. Cell. Biol. 20:7319-7331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  3. "Solution structure of the second C2H2-type zinc finger domain from human krueppel-like factor 15."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2008) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 346-380.
  4. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts."
    Wang B., Haldar S.M., Lu Y., Ibrahim O.A., Fisch S., Gray S., Leask A., Jain M.K.
    J. Mol. Cell. Cardiol. 45:193-197(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: FUNCTION AS NEGATIVE REGULATOR OF MYOCD, INTERACTION WITH MYOCD.
  7. Cited for: FUNCTION AS NEGATIVE REGULATOR OF TP53 ACETYLATION, TISSUE SPECIFICITY, INVOLVEMENT IN HEART FAILURE.
  8. Cited for: INDUCTION, TISSUE SPECIFICITY.
  9. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO VENTRICULAR ARRHYTHMIAS.
  10. Cited for: FUNCTION AS INHIBITOR OF VASCULAR INFLAMMATION, FUNCTION AS NF-KAPPA-B REPRESSOR, INTERACTION WITH EP300.

Entry informationi

Entry nameiKLF15_HUMAN
AccessioniPrimary (citable) accession number: Q9UIH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3