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Q9UIH9

- KLF15_HUMAN

UniProt

Q9UIH9 - KLF15_HUMAN

Protein

Krueppel-like factor 15

Gene

KLF15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart By similarity. Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 By similarity. Involved in podocyte differentiation By similarity. Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.By similarity4 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri321 – 34525C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri351 – 37525C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri381 – 40323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
    4. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to peptide Source: Ensembl
    2. glial cell differentiation Source: Ensembl
    3. glomerular visceral epithelial cell differentiation Source: UniProtKB
    4. glucose transport Source: Ensembl
    5. negative regulation of peptidyl-lysine acetylation Source: UniProtKB
    6. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ9UIH9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 15
    Alternative name(s):
    Kidney-enriched krueppel-like factor
    Gene namesi
    Name:KLF15
    Synonyms:KKLF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:14536. KLF15.

    Subcellular locationi

    Nucleus 2 Publications

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365).2 Publications

    Organism-specific databases

    PharmGKBiPA30134.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Krueppel-like factor 15PRO_0000047187Add
    BLAST

    Proteomic databases

    PaxDbiQ9UIH9.
    PRIDEiQ9UIH9.

    PTM databases

    PhosphoSiteiQ9UIH9.

    Expressioni

    Tissue specificityi

    Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.4 Publications

    Inductioni

    In podocytes, up-regulated by retinoic acid.1 Publication

    Gene expression databases

    BgeeiQ9UIH9.
    CleanExiHS_KLF15.
    GenevestigatoriQ9UIH9.

    Organism-specific databases

    HPAiHPA028866.

    Interactioni

    Subunit structurei

    Interacts with MYOCD and EP300.2 Publications

    Protein-protein interaction databases

    BioGridi118818. 4 interactions.
    IntActiQ9UIH9. 4 interactions.
    MINTiMINT-8417681.
    STRINGi9606.ENSP00000296233.

    Structurei

    Secondary structure

    1
    416
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi355 – 3573
    Beta strandi361 – 3644
    Helixi365 – 3728

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ENTNMR-A346-380[»]
    ProteinModelPortaliQ9UIH9.
    SMRiQ9UIH9. Positions 318-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UIH9.

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri321 – 34525C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri351 – 37525C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri381 – 40323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000294058.
    HOVERGENiHBG052266.
    InParanoidiQ9UIH9.
    KOiK09210.
    OMAiSSGPMAW.
    OrthoDBiEOG7JMGF2.
    PhylomeDBiQ9UIH9.
    TreeFamiTF350556.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UIH9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDHLLPVDE NFSSPKCPVG YLGDRLVGRR AYHMLPSPVS EDDSDASSPC    50
    SCSSPDSQAL CSCYGGGLGT ESQDSILDFL LSQATLGSGG GSGSSIGASS 100
    GPVAWGPWRR AAAPVKGEHF CLPEFPLGDP DDVPRPFQPT LEEIEEFLEE 150
    NMEPGVKEVP EGNSKDLDAC SQLSAGPHKS HLHPGSSGRE RCSPPPGGAS 200
    AGGAQGPGGG PTPDGPIPVL LQIQPVPVKQ ESGTGPASPG QAPENVKVAQ 250
    LLVNIQGQTF ALVPQVVPSS NLNLPSKFVR IAPVPIAAKP VGSGPLGPGP 300
    AGLLMGQKFP KNPAAELIKM HKCTFPGCSK MYTKSSHLKA HLRRHTGEKP 350
    FACTWPGCGW RFSRSDELSR HRRSHSGVKP YQCPVCEKKF ARSDHLSKHI 400
    KVHRFPRSSR SVRSVN 416
    Length:416
    Mass (Da):43,992
    Last modified:May 1, 2000 - v1
    Checksum:i6335F85141BEB276
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029254 mRNA. Translation: BAA88561.1.
    BC036733 mRNA. Translation: AAH36733.1.
    CCDSiCCDS3036.1.
    RefSeqiNP_054798.1. NM_014079.3.
    XP_005247457.1. XM_005247400.1.
    UniGeneiHs.272215.

    Genome annotation databases

    EnsembliENST00000296233; ENSP00000296233; ENSG00000163884.
    GeneIDi28999.
    KEGGihsa:28999.
    UCSCiuc011bkk.1. human.

    Polymorphism databases

    DMDMi20138787.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029254 mRNA. Translation: BAA88561.1 .
    BC036733 mRNA. Translation: AAH36733.1 .
    CCDSi CCDS3036.1.
    RefSeqi NP_054798.1. NM_014079.3.
    XP_005247457.1. XM_005247400.1.
    UniGenei Hs.272215.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ENT NMR - A 346-380 [» ]
    ProteinModelPortali Q9UIH9.
    SMRi Q9UIH9. Positions 318-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118818. 4 interactions.
    IntActi Q9UIH9. 4 interactions.
    MINTi MINT-8417681.
    STRINGi 9606.ENSP00000296233.

    PTM databases

    PhosphoSitei Q9UIH9.

    Polymorphism databases

    DMDMi 20138787.

    Proteomic databases

    PaxDbi Q9UIH9.
    PRIDEi Q9UIH9.

    Protocols and materials databases

    DNASUi 28999.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296233 ; ENSP00000296233 ; ENSG00000163884 .
    GeneIDi 28999.
    KEGGi hsa:28999.
    UCSCi uc011bkk.1. human.

    Organism-specific databases

    CTDi 28999.
    GeneCardsi GC03M126061.
    HGNCi HGNC:14536. KLF15.
    HPAi HPA028866.
    MIMi 606465. gene.
    neXtProti NX_Q9UIH9.
    PharmGKBi PA30134.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000294058.
    HOVERGENi HBG052266.
    InParanoidi Q9UIH9.
    KOi K09210.
    OMAi SSGPMAW.
    OrthoDBi EOG7JMGF2.
    PhylomeDBi Q9UIH9.
    TreeFami TF350556.

    Enzyme and pathway databases

    SignaLinki Q9UIH9.

    Miscellaneous databases

    EvolutionaryTracei Q9UIH9.
    GeneWikii KLF15.
    GenomeRNAii 28999.
    NextBioi 51936.
    PROi Q9UIH9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UIH9.
    CleanExi HS_KLF15.
    Genevestigatori Q9UIH9.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor."
      Uchida S., Tanaka Y., Ito H., Saitoh-Ohara F., Inazawa J., Yokoyama K.K., Sasaki S., Marumo F.
      Mol. Cell. Biol. 20:7319-7331(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    3. "Solution structure of the second C2H2-type zinc finger domain from human krueppel-like factor 15."
      RIKEN structural genomics initiative (RSGI)
      Submitted (APR-2008) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 346-380.
    4. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts."
      Wang B., Haldar S.M., Lu Y., Ibrahim O.A., Fisch S., Gray S., Leask A., Jain M.K.
      J. Mol. Cell. Cardiol. 45:193-197(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: FUNCTION AS NEGATIVE REGULATOR OF MYOCD, INTERACTION WITH MYOCD.
    7. Cited for: FUNCTION AS NEGATIVE REGULATOR OF TP53 ACETYLATION, TISSUE SPECIFICITY, INVOLVEMENT IN HEART FAILURE.
    8. Cited for: INDUCTION, TISSUE SPECIFICITY.
    9. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO VENTRICULAR ARRHYTHMIAS.
    10. Cited for: FUNCTION AS INHIBITOR OF VASCULAR INFLAMMATION, FUNCTION AS NF-KAPPA-B REPRESSOR, INTERACTION WITH EP300.

    Entry informationi

    Entry nameiKLF15_HUMAN
    AccessioniPrimary (citable) accession number: Q9UIH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3