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Q9UIG8

- SO3A1_HUMAN

UniProt

Q9UIG8 - SO3A1_HUMAN

Protein

Solute carrier organic anion transporter family member 3A1

Gene

SLCO3A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Mediates the Na+-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).2 Publications

    Kineticsi

    1. KM=101 nM for PGE1 (isoform 1)1 Publication
    2. KM=218 nM for PGE1 (isoform 2)1 Publication
    3. KM=219 nM for PGE2 (isoform 1)1 Publication
    4. KM=371 nM for PGE2 (isoform 2)1 Publication

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. sodium-independent organic anion transport Source: Reactome
    2. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_23988. Transport of organic anions.

    Protein family/group databases

    TCDBi2.A.60.1.18. the organo anion transporter (oat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 3A1
    Short name:
    OATP3A1
    Alternative name(s):
    Organic anion transporter polypeptide-related protein 3
    Short name:
    OATP-RP3
    Short name:
    OATPRP3
    Organic anion-transporting polypeptide D
    Short name:
    OATP-D
    PGE1 transporter
    Sodium-independent organic anion transporter D
    Solute carrier family 21 member 11
    Gene namesi
    Name:SLCO3A1
    Synonyms:OATP3A1, OATPD, SLC21A11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:10952. SLCO3A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35837.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 710710Solute carrier organic anion transporter family member 3A1PRO_0000191064Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi471 ↔ 497PROSITE-ProRule annotation
    Disulfide bondi475 ↔ 486PROSITE-ProRule annotation
    Disulfide bondi477 ↔ 501PROSITE-ProRule annotation
    Glycosylationi502 – 5021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9UIG8.
    PaxDbiQ9UIG8.
    PRIDEiQ9UIG8.

    PTM databases

    PhosphoSiteiQ9UIG8.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex.1 Publication

    Gene expression databases

    ArrayExpressiQ9UIG8.
    BgeeiQ9UIG8.
    CleanExiHS_SLCO3A1.
    GenevestigatoriQ9UIG8.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9UIG8. 1 interaction.
    STRINGi9606.ENSP00000320634.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UIG8.
    SMRiQ9UIG8. Positions 474-499.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini61 – 7919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini101 – 1066CytoplasmicSequence Analysis
    Topological domaini132 – 17443ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini204 – 22219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini244 – 26118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini287 – 34458CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini367 – 38620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini411 – 4144CytoplasmicSequence Analysis
    Topological domaini439 – 539101ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini563 – 5719CytoplasmicSequence Analysis
    Topological domaini598 – 63033ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini649 – 70557CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6020Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei107 – 13125Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei175 – 20329Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei223 – 24321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28625Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei345 – 36622Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei387 – 41024Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei415 – 43824Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei540 – 56223Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei572 – 59726Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei631 – 64818Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini465 – 51349Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320775.
    HOVERGENiHBG098539.
    InParanoidiQ9UIG8.
    KOiK14353.
    OMAiPANQTHR.
    OrthoDBiEOG7GQXV6.
    PhylomeDBiQ9UIG8.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 4 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UIG8-1) [UniParc]FASTAAdd to Basket

    Also known as: OATP3A1-v1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM    50
    LAQGTVGAYL VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG 100
    ARGHRPRLIG CGGIVMALGA LLSALPEFLT HQYKYEAGEI RWGAEGRDVC 150
    AANGSGGDEG PDPDLICRNR TATNMMYLLL IGAQVLLGIG ATPVQPLGVS 200
    YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY VDAVFIDTSN 250
    LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSEPAMESE 300
    QAMLSEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV 350
    FTCIILAACM EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC 400
    LGIFLGGLLV KKLSLSALGA IRMAMLVNLV STACYVSFLF LGCDTGPVAG 450
    VTVPYGNSTA PGSALDPYSP CNNNCECQTD SFTPVCGADG ITYLSACFAG 500
    CNSTNLTGCA CLTTVPAENA TVVPGKCPSP GCQEAFLTFL CVMCICSLIG 550
    AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST 600
    CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK 650
    NYKRYIKNHE GGLSTSEFFA STLTLDNLGR DPVPANQTHR TKFIYNLEDH 700
    EWCENMESVL 710
    Length:710
    Mass (Da):76,553
    Last modified:May 18, 2010 - v3
    Checksum:iED56724BA0998553
    GO
    Isoform 2 (identifier: Q9UIG8-2) [UniParc]FASTAAdd to Basket

    Also known as: OATP3A1-v2

    The sequence of this isoform differs from the canonical sequence as follows:
         667-692: EFFASTLTLDNLGRDPVPANQTHRTK → TEYQDIETEKTCPESHSPSEDSFVRS
         693-710: Missing.

    Show »
    Length:692
    Mass (Da):74,372
    Checksum:i2C7B72AC4C0E4E88
    GO
    Isoform 3 (identifier: Q9UIG8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-58: Missing.
         59-60: YL → MN
         641-710: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:582
    Mass (Da):62,203
    Checksum:iE653AA86DA1BA276
    GO
    Isoform 4 (identifier: Q9UIG8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-281: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:429
    Mass (Da):46,411
    Checksum:i822E718765321BC4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401K → R in BAF83561. (PubMed:14702039)Curated
    Sequence conflicti168 – 1681R → L in AAH00585. (PubMed:15489334)Curated
    Sequence conflicti188 – 1881G → D in BAF83561. (PubMed:14702039)Curated
    Sequence conflicti202 – 2021I → Y in BAA89287. (PubMed:10873595)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti294 – 2941E → D.5 Publications
    Corresponds to variant rs1517618 [ dbSNP | Ensembl ].
    VAR_054853

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 281281Missing in isoform 4. 1 PublicationVSP_036833Add
    BLAST
    Alternative sequencei1 – 5858Missing in isoform 3. 1 PublicationVSP_036834Add
    BLAST
    Alternative sequencei59 – 602YL → MN in isoform 3. 1 PublicationVSP_036835
    Alternative sequencei641 – 71070Missing in isoform 3. 1 PublicationVSP_036836Add
    BLAST
    Alternative sequencei667 – 69226EFFAS…THRTK → TEYQDIETEKTCPESHSPSE DSFVRS in isoform 2. 1 PublicationVSP_036837Add
    BLAST
    Alternative sequencei693 – 71018Missing in isoform 2. 1 PublicationVSP_036838Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031050 mRNA. Translation: BAA89287.1.
    AF205074 mRNA. Translation: AAG42206.1.
    AF187816 mRNA. Translation: AAG43446.1.
    AK290872 mRNA. Translation: BAF83561.1.
    AK057031 mRNA. Translation: BAG51847.1.
    AK097797 mRNA. Translation: BAG53529.1.
    FJ515841 Genomic DNA. Translation: ACS13734.1.
    AC104020 Genomic DNA. No translation available.
    AC104236 Genomic DNA. No translation available.
    AC113190 Genomic DNA. No translation available.
    AC116903 Genomic DNA. No translation available.
    AC135996 Genomic DNA. No translation available.
    BC000585 mRNA. Translation: AAH00585.1.
    CCDSiCCDS10371.1. [Q9UIG8-1]
    CCDS45354.1. [Q9UIG8-2]
    RefSeqiNP_001138516.1. NM_001145044.1. [Q9UIG8-2]
    NP_037404.2. NM_013272.3. [Q9UIG8-1]
    UniGeneiHs.311187.

    Genome annotation databases

    EnsembliENST00000318445; ENSP00000320634; ENSG00000176463. [Q9UIG8-1]
    ENST00000424469; ENSP00000387846; ENSG00000176463. [Q9UIG8-2]
    GeneIDi28232.
    KEGGihsa:28232.
    UCSCiuc002bqx.2. human. [Q9UIG8-1]
    uc002bqy.2. human. [Q9UIG8-2]

    Polymorphism databases

    DMDMi296452954.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031050 mRNA. Translation: BAA89287.1 .
    AF205074 mRNA. Translation: AAG42206.1 .
    AF187816 mRNA. Translation: AAG43446.1 .
    AK290872 mRNA. Translation: BAF83561.1 .
    AK057031 mRNA. Translation: BAG51847.1 .
    AK097797 mRNA. Translation: BAG53529.1 .
    FJ515841 Genomic DNA. Translation: ACS13734.1 .
    AC104020 Genomic DNA. No translation available.
    AC104236 Genomic DNA. No translation available.
    AC113190 Genomic DNA. No translation available.
    AC116903 Genomic DNA. No translation available.
    AC135996 Genomic DNA. No translation available.
    BC000585 mRNA. Translation: AAH00585.1 .
    CCDSi CCDS10371.1. [Q9UIG8-1 ]
    CCDS45354.1. [Q9UIG8-2 ]
    RefSeqi NP_001138516.1. NM_001145044.1. [Q9UIG8-2 ]
    NP_037404.2. NM_013272.3. [Q9UIG8-1 ]
    UniGenei Hs.311187.

    3D structure databases

    ProteinModelPortali Q9UIG8.
    SMRi Q9UIG8. Positions 474-499.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9UIG8. 1 interaction.
    STRINGi 9606.ENSP00000320634.

    Chemistry

    ChEMBLi CHEMBL2073685.
    GuidetoPHARMACOLOGYi 1225.

    Protein family/group databases

    TCDBi 2.A.60.1.18. the organo anion transporter (oat) family.

    PTM databases

    PhosphoSitei Q9UIG8.

    Polymorphism databases

    DMDMi 296452954.

    Proteomic databases

    MaxQBi Q9UIG8.
    PaxDbi Q9UIG8.
    PRIDEi Q9UIG8.

    Protocols and materials databases

    DNASUi 28232.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318445 ; ENSP00000320634 ; ENSG00000176463 . [Q9UIG8-1 ]
    ENST00000424469 ; ENSP00000387846 ; ENSG00000176463 . [Q9UIG8-2 ]
    GeneIDi 28232.
    KEGGi hsa:28232.
    UCSCi uc002bqx.2. human. [Q9UIG8-1 ]
    uc002bqy.2. human. [Q9UIG8-2 ]

    Organism-specific databases

    CTDi 28232.
    GeneCardsi GC15P092396.
    H-InvDB HIX0018979.
    HGNCi HGNC:10952. SLCO3A1.
    MIMi 612435. gene.
    neXtProti NX_Q9UIG8.
    PharmGKBi PA35837.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320775.
    HOVERGENi HBG098539.
    InParanoidi Q9UIG8.
    KOi K14353.
    OMAi PANQTHR.
    OrthoDBi EOG7GQXV6.
    PhylomeDBi Q9UIG8.
    TreeFami TF317540.

    Enzyme and pathway databases

    Reactomei REACT_23988. Transport of organic anions.

    Miscellaneous databases

    ChiTaRSi SLCO3A1. human.
    GeneWikii SLCO3A1.
    GenomeRNAii 28232.
    NextBioi 50548.
    PROi Q9UIG8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UIG8.
    Bgeei Q9UIG8.
    CleanExi HS_SLCO3A1.
    Genevestigatori Q9UIG8.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 4 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family."
      Tamai I., Nezu J., Uchino H., Sai Y., Oku A., Shimane M., Tsuji A.
      Biochem. Biophys. Res. Commun. 273:251-260(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT ASP-294.
      Tissue: Kidney.
    2. "Identification and characterization of novel human OATP family members."
      Wu Y., Hsiang B.H., Zhu Y., Yang W.-P., Kirchgessner T.G.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-294.
    3. "Molecular identification of human PGE1 transporter expressed in cancer."
      Adachi H., Unno M., Matsuno S., Yawo H., Abe T.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-294.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), VARIANT ASP-294.
      Tissue: Mesangial cell and Testis.
    5. NHLBI resequencing and genotyping service (RS&G)
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-294.
      Tissue: Brain.
    8. "Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain."
      Huber R.D., Gao B., Sidler Pfaendler M.-A., Zhang-Fu W., Leuthold S., Hagenbuch B., Folkers G., Meier P.J., Stieger B.
      Am. J. Physiol. 292:C795-C806(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSO3A1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UIG8
    Secondary accession number(s): A8K4A7
    , B3KPY5, B3KUR7, C6G486, Q9BW73, Q9GZV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3