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Q9UIG8 (SO3A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 3A1

Short name=OATP3A1
Alternative name(s):
Organic anion transporter polypeptide-related protein 3
Short name=OATP-RP3
Short name=OATPRP3
Organic anion-transporting polypeptide D
Short name=OATP-D
PGE1 transporter
Sodium-independent organic anion transporter D
Solute carrier family 21 member 11
Gene names
Name:SLCO3A1
Synonyms:OATP3A1, OATPD, SLC21A11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length710 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the Na+-independent transport of organic anions such as estrone-3-sulfate (Ref.1). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (Ref.8). Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex. Ref.8

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Biophysicochemical properties

Kinetic parameters:

KM=101 nM for PGE1 (isoform 1) Ref.8

KM=218 nM for PGE1 (isoform 2)

KM=219 nM for PGE2 (isoform 1)

KM=371 nM for PGE2 (isoform 2)

Ontologies

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UIG8-1)

Also known as: OATP3A1-v1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UIG8-2)

Also known as: OATP3A1-v2;

The sequence of this isoform differs from the canonical sequence as follows:
     667-692: EFFASTLTLDNLGRDPVPANQTHRTK → TEYQDIETEKTCPESHSPSEDSFVRS
     693-710: Missing.
Isoform 3 (identifier: Q9UIG8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.
     59-60: YL → MN
     641-710: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9UIG8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 710710Solute carrier organic anion transporter family member 3A1
PRO_0000191064

Regions

Topological domain1 – 4040Cytoplasmic Potential
Transmembrane41 – 6020Helical; Name=1; Potential
Topological domain61 – 7919Extracellular Potential
Transmembrane80 – 10021Helical; Name=2; Potential
Topological domain101 – 1066Cytoplasmic Potential
Transmembrane107 – 13125Helical; Name=3; Potential
Topological domain132 – 17443Extracellular Potential
Transmembrane175 – 20329Helical; Name=4; Potential
Topological domain204 – 22219Cytoplasmic Potential
Transmembrane223 – 24321Helical; Name=5; Potential
Topological domain244 – 26118Extracellular Potential
Transmembrane262 – 28625Helical; Name=6; Potential
Topological domain287 – 34458Cytoplasmic Potential
Transmembrane345 – 36622Helical; Name=7; Potential
Topological domain367 – 38620Extracellular Potential
Transmembrane387 – 41024Helical; Name=8; Potential
Topological domain411 – 4144Cytoplasmic Potential
Transmembrane415 – 43824Helical; Name=9; Potential
Topological domain439 – 539101Extracellular Potential
Transmembrane540 – 56223Helical; Name=10; Potential
Topological domain563 – 5719Cytoplasmic Potential
Transmembrane572 – 59726Helical; Name=11; Potential
Topological domain598 – 63033Extracellular Potential
Transmembrane631 – 64818Helical; Name=12; Potential
Topological domain649 – 70557Cytoplasmic Potential
Domain465 – 51349Kazal-like

Amino acid modifications

Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation3811N-linked (GlcNAc...) Potential
Glycosylation4571N-linked (GlcNAc...) Potential
Glycosylation5021N-linked (GlcNAc...) Potential
Glycosylation5051N-linked (GlcNAc...) Potential
Glycosylation5191N-linked (GlcNAc...) Potential
Disulfide bond471 ↔ 497 By similarity
Disulfide bond475 ↔ 486 By similarity
Disulfide bond477 ↔ 501 By similarity

Natural variations

Alternative sequence1 – 281281Missing in isoform 4.
VSP_036833
Alternative sequence1 – 5858Missing in isoform 3.
VSP_036834
Alternative sequence59 – 602YL → MN in isoform 3.
VSP_036835
Alternative sequence641 – 71070Missing in isoform 3.
VSP_036836
Alternative sequence667 – 69226EFFAS…THRTK → TEYQDIETEKTCPESHSPSE DSFVRS in isoform 2.
VSP_036837
Alternative sequence693 – 71018Missing in isoform 2.
VSP_036838
Natural variant2941E → D. Ref.1 Ref.2 Ref.3 Ref.4 Ref.7
Corresponds to variant rs1517618 [ dbSNP | Ensembl ].
VAR_054853

Experimental info

Sequence conflict401K → R in BAF83561. Ref.4
Sequence conflict1681R → L in AAH00585. Ref.7
Sequence conflict1881G → D in BAF83561. Ref.4
Sequence conflict2021I → Y in BAA89287. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (OATP3A1-v1) [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: ED56724BA0998553

FASTA71076,553
        10         20         30         40         50         60 
MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM LAQGTVGAYL 

        70         80         90        100        110        120 
VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG ARGHRPRLIG CGGIVMALGA 

       130        140        150        160        170        180 
LLSALPEFLT HQYKYEAGEI RWGAEGRDVC AANGSGGDEG PDPDLICRNR TATNMMYLLL 

       190        200        210        220        230        240 
IGAQVLLGIG ATPVQPLGVS YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY 

       250        260        270        280        290        300 
VDAVFIDTSN LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSEPAMESE 

       310        320        330        340        350        360 
QAMLSEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV FTCIILAACM 

       370        380        390        400        410        420 
EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC LGIFLGGLLV KKLSLSALGA 

       430        440        450        460        470        480 
IRMAMLVNLV STACYVSFLF LGCDTGPVAG VTVPYGNSTA PGSALDPYSP CNNNCECQTD 

       490        500        510        520        530        540 
SFTPVCGADG ITYLSACFAG CNSTNLTGCA CLTTVPAENA TVVPGKCPSP GCQEAFLTFL 

       550        560        570        580        590        600 
CVMCICSLIG AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST 

       610        620        630        640        650        660 
CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK NYKRYIKNHE 

       670        680        690        700        710 
GGLSTSEFFA STLTLDNLGR DPVPANQTHR TKFIYNLEDH EWCENMESVL 

« Hide

Isoform 2 (OATP3A1-v2) [UniParc].

Checksum: 2C7B72AC4C0E4E88
Show »

FASTA69274,372
Isoform 3 [UniParc].

Checksum: E653AA86DA1BA276
Show »

FASTA58262,203
Isoform 4 [UniParc].

Checksum: 822E718765321BC4
Show »

FASTA42946,411

References

« Hide 'large scale' references
[1]"Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family."
Tamai I., Nezu J., Uchino H., Sai Y., Oku A., Shimane M., Tsuji A.
Biochem. Biophys. Res. Commun. 273:251-260(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT ASP-294.
Tissue: Kidney.
[2]"Identification and characterization of novel human OATP family members."
Wu Y., Hsiang B.H., Zhu Y., Yang W.-P., Kirchgessner T.G.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-294.
[3]"Molecular identification of human PGE1 transporter expressed in cancer."
Adachi H., Unno M., Matsuno S., Yawo H., Abe T.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-294.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), VARIANT ASP-294.
Tissue: Mesangial cell and Testis.
[5]NHLBI resequencing and genotyping service (RS&G)
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-294.
Tissue: Brain.
[8]"Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain."
Huber R.D., Gao B., Sidler Pfaendler M.-A., Zhang-Fu W., Leuthold S., Hagenbuch B., Folkers G., Meier P.J., Stieger B.
Am. J. Physiol. 292:C795-C806(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
[9]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB031050 mRNA. Translation: BAA89287.1.
AF205074 mRNA. Translation: AAG42206.1.
AF187816 mRNA. Translation: AAG43446.1.
AK290872 mRNA. Translation: BAF83561.1.
AK057031 mRNA. Translation: BAG51847.1.
AK097797 mRNA. Translation: BAG53529.1.
FJ515841 Genomic DNA. Translation: ACS13734.1.
AC104020 Genomic DNA. No translation available.
AC104236 Genomic DNA. No translation available.
AC113190 Genomic DNA. No translation available.
AC116903 Genomic DNA. No translation available.
AC135996 Genomic DNA. No translation available.
BC000585 mRNA. Translation: AAH00585.1.
RefSeqNP_001138516.1. NM_001145044.1.
NP_037404.2. NM_013272.3.
UniGeneHs.311187.

3D structure databases

ProteinModelPortalQ9UIG8.
SMRQ9UIG8. Positions 211-238, 474-529.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9UIG8. 1 interaction.
STRING9606.ENSP00000320634.

Chemistry

ChEMBLCHEMBL2073685.
GuidetoPHARMACOLOGY1225.

Protein family/group databases

TCDB2.A.60.1.18. the organo anion transporter (oat) family.

PTM databases

PhosphoSiteQ9UIG8.

Polymorphism databases

DMDM296452954.

Proteomic databases

PaxDbQ9UIG8.
PRIDEQ9UIG8.

Protocols and materials databases

DNASU28232.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318445; ENSP00000320634; ENSG00000176463. [Q9UIG8-1]
ENST00000424469; ENSP00000387846; ENSG00000176463. [Q9UIG8-2]
GeneID28232.
KEGGhsa:28232.
UCSCuc002bqx.2. human. [Q9UIG8-1]
uc002bqy.2. human. [Q9UIG8-2]

Organism-specific databases

CTD28232.
GeneCardsGC15P092396.
H-InvDBHIX0018979.
HGNCHGNC:10952. SLCO3A1.
MIM612435. gene.
neXtProtNX_Q9UIG8.
PharmGKBPA35837.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG320775.
HOVERGENHBG098539.
InParanoidQ9UIG8.
KOK14353.
OMAPANQTHR.
OrthoDBEOG7GQXV6.
PhylomeDBQ9UIG8.
TreeFamTF317540.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9UIG8.
BgeeQ9UIG8.
CleanExHS_SLCO3A1.
GenevestigatorQ9UIG8.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 4 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLCO3A1. human.
GeneWikiSLCO3A1.
GenomeRNAi28232.
NextBio50548.
PROQ9UIG8.
SOURCESearch...

Entry information

Entry nameSO3A1_HUMAN
AccessionPrimary (citable) accession number: Q9UIG8
Secondary accession number(s): A8K4A7 expand/collapse secondary AC list , B3KPY5, B3KUR7, C6G486, Q9BW73, Q9GZV2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: May 18, 2010
Last modified: March 19, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM