Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier organic anion transporter family member 3A1

Gene

SLCO3A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).2 Publications

Kineticsi

  1. KM=101 nM for PGE1 (isoform 1)1 Publication
  2. KM=218 nM for PGE1 (isoform 2)1 Publication
  3. KM=219 nM for PGE2 (isoform 1)1 Publication
  4. KM=371 nM for PGE2 (isoform 2)1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    BioCyciZFISH:ENSG00000176463-MONOMER.
    ReactomeiR-HSA-879518. Transport of organic anions.

    Protein family/group databases

    TCDBi2.A.60.1.18. the organo anion transporter (oat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 3A1
    Short name:
    OATP3A1
    Alternative name(s):
    Organic anion transporter polypeptide-related protein 3
    Short name:
    OATP-RP3
    Short name:
    OATPRP3
    Organic anion-transporting polypeptide D
    Short name:
    OATP-D
    PGE1 transporter
    Sodium-independent organic anion transporter D
    Solute carrier family 21 member 11
    Gene namesi
    Name:SLCO3A1
    Synonyms:OATP3A1, OATPD, SLC21A11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:10952. SLCO3A1.

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
    Transmembranei41 – 60Helical; Name=1Sequence analysisAdd BLAST20
    Topological domaini61 – 79ExtracellularSequence analysisAdd BLAST19
    Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini101 – 106CytoplasmicSequence analysis6
    Transmembranei107 – 131Helical; Name=3Sequence analysisAdd BLAST25
    Topological domaini132 – 174ExtracellularSequence analysisAdd BLAST43
    Transmembranei175 – 203Helical; Name=4Sequence analysisAdd BLAST29
    Topological domaini204 – 222CytoplasmicSequence analysisAdd BLAST19
    Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini244 – 261ExtracellularSequence analysisAdd BLAST18
    Transmembranei262 – 286Helical; Name=6Sequence analysisAdd BLAST25
    Topological domaini287 – 344CytoplasmicSequence analysisAdd BLAST58
    Transmembranei345 – 366Helical; Name=7Sequence analysisAdd BLAST22
    Topological domaini367 – 386ExtracellularSequence analysisAdd BLAST20
    Transmembranei387 – 410Helical; Name=8Sequence analysisAdd BLAST24
    Topological domaini411 – 414CytoplasmicSequence analysis4
    Transmembranei415 – 438Helical; Name=9Sequence analysisAdd BLAST24
    Topological domaini439 – 539ExtracellularSequence analysisAdd BLAST101
    Transmembranei540 – 562Helical; Name=10Sequence analysisAdd BLAST23
    Topological domaini563 – 571CytoplasmicSequence analysis9
    Transmembranei572 – 597Helical; Name=11Sequence analysisAdd BLAST26
    Topological domaini598 – 630ExtracellularSequence analysisAdd BLAST33
    Transmembranei631 – 648Helical; Name=12Sequence analysisAdd BLAST18
    Topological domaini649 – 705CytoplasmicSequence analysisAdd BLAST57

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi28232.
    OpenTargetsiENSG00000176463.
    PharmGKBiPA35837.

    Chemistry databases

    ChEMBLiCHEMBL2073685.
    DrugBankiDB00770. Alprostadil.
    DB00345. Aminohippurate.
    DB01053. Benzylpenicillin.
    DB00286. Conjugated Estrogens.
    DB01160. Dinoprost Tromethamine.
    DB00917. Dinoprostone.
    DB01088. Iloprost.
    DB00563. Methotrexate.

    Polymorphism and mutation databases

    BioMutaiSLCO3A1.
    DMDMi296452954.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001910641 – 710Solute carrier organic anion transporter family member 3A1Add BLAST710

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi153N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi381N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
    Disulfide bondi471 ↔ 497PROSITE-ProRule annotation
    Disulfide bondi475 ↔ 486PROSITE-ProRule annotation
    Disulfide bondi477 ↔ 501PROSITE-ProRule annotation
    Glycosylationi502N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi505N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi519N-linked (GlcNAc...)Sequence analysis1

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UIG8.
    PeptideAtlasiQ9UIG8.
    PRIDEiQ9UIG8.

    PTM databases

    iPTMnetiQ9UIG8.
    PhosphoSitePlusiQ9UIG8.
    SwissPalmiQ9UIG8.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex.1 Publication

    Gene expression databases

    BgeeiENSG00000176463.
    CleanExiHS_SLCO3A1.
    ExpressionAtlasiQ9UIG8. baseline and differential.
    GenevisibleiQ9UIG8. HS.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9UIG8. 1 interactor.
    STRINGi9606.ENSP00000320634.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UIG8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini465 – 513Kazal-likePROSITE-ProRule annotationAdd BLAST49

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG3626. Eukaryota.
    ENOG410XRSF. LUCA.
    GeneTreeiENSGT00760000119014.
    HOVERGENiHBG098539.
    InParanoidiQ9UIG8.
    KOiK14353.
    OMAiLKSSAFV.
    OrthoDBiEOG091G03A9.
    PhylomeDBiQ9UIG8.
    TreeFamiTF317540.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 4 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q9UIG8-1) [UniParc]FASTAAdd to basket
    Also known as: OATP3A1-v1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM
    60 70 80 90 100
    LAQGTVGAYL VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG
    110 120 130 140 150
    ARGHRPRLIG CGGIVMALGA LLSALPEFLT HQYKYEAGEI RWGAEGRDVC
    160 170 180 190 200
    AANGSGGDEG PDPDLICRNR TATNMMYLLL IGAQVLLGIG ATPVQPLGVS
    210 220 230 240 250
    YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY VDAVFIDTSN
    260 270 280 290 300
    LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSEPAMESE
    310 320 330 340 350
    QAMLSEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV
    360 370 380 390 400
    FTCIILAACM EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC
    410 420 430 440 450
    LGIFLGGLLV KKLSLSALGA IRMAMLVNLV STACYVSFLF LGCDTGPVAG
    460 470 480 490 500
    VTVPYGNSTA PGSALDPYSP CNNNCECQTD SFTPVCGADG ITYLSACFAG
    510 520 530 540 550
    CNSTNLTGCA CLTTVPAENA TVVPGKCPSP GCQEAFLTFL CVMCICSLIG
    560 570 580 590 600
    AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST
    610 620 630 640 650
    CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK
    660 670 680 690 700
    NYKRYIKNHE GGLSTSEFFA STLTLDNLGR DPVPANQTHR TKFIYNLEDH
    710
    EWCENMESVL
    Length:710
    Mass (Da):76,553
    Last modified:May 18, 2010 - v3
    Checksum:iED56724BA0998553
    GO
    Isoform 2 (identifier: Q9UIG8-2) [UniParc]FASTAAdd to basket
    Also known as: OATP3A1-v2

    The sequence of this isoform differs from the canonical sequence as follows:
         667-692: EFFASTLTLDNLGRDPVPANQTHRTK → TEYQDIETEKTCPESHSPSEDSFVRS
         693-710: Missing.

    Show »
    Length:692
    Mass (Da):74,372
    Checksum:i2C7B72AC4C0E4E88
    GO
    Isoform 3 (identifier: Q9UIG8-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-58: Missing.
         59-60: YL → MN
         641-710: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:582
    Mass (Da):62,203
    Checksum:iE653AA86DA1BA276
    GO
    Isoform 4 (identifier: Q9UIG8-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-281: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:429
    Mass (Da):46,411
    Checksum:i822E718765321BC4
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti40K → R in BAF83561 (PubMed:14702039).Curated1
    Sequence conflicti168R → L in AAH00585 (PubMed:15489334).Curated1
    Sequence conflicti188G → D in BAF83561 (PubMed:14702039).Curated1
    Sequence conflicti202I → Y in BAA89287 (PubMed:10873595).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_054853294E → D.5 PublicationsCorresponds to variant rs1517618dbSNPEnsembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0368331 – 281Missing in isoform 4. 1 PublicationAdd BLAST281
    Alternative sequenceiVSP_0368341 – 58Missing in isoform 3. 1 PublicationAdd BLAST58
    Alternative sequenceiVSP_03683559 – 60YL → MN in isoform 3. 1 Publication2
    Alternative sequenceiVSP_036836641 – 710Missing in isoform 3. 1 PublicationAdd BLAST70
    Alternative sequenceiVSP_036837667 – 692EFFAS…THRTK → TEYQDIETEKTCPESHSPSE DSFVRS in isoform 2. 1 PublicationAdd BLAST26
    Alternative sequenceiVSP_036838693 – 710Missing in isoform 2. 1 PublicationAdd BLAST18

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB031050 mRNA. Translation: BAA89287.1.
    AF205074 mRNA. Translation: AAG42206.1.
    AF187816 mRNA. Translation: AAG43446.1.
    AK290872 mRNA. Translation: BAF83561.1.
    AK057031 mRNA. Translation: BAG51847.1.
    AK097797 mRNA. Translation: BAG53529.1.
    FJ515841 Genomic DNA. Translation: ACS13734.1.
    AC104020 Genomic DNA. No translation available.
    AC104236 Genomic DNA. No translation available.
    AC113190 Genomic DNA. No translation available.
    AC116903 Genomic DNA. No translation available.
    AC135996 Genomic DNA. No translation available.
    BC000585 mRNA. Translation: AAH00585.1.
    CCDSiCCDS10371.1. [Q9UIG8-1]
    CCDS45354.1. [Q9UIG8-2]
    RefSeqiNP_001138516.1. NM_001145044.1. [Q9UIG8-2]
    NP_037404.2. NM_013272.3. [Q9UIG8-1]
    UniGeneiHs.311187.
    Hs.707541.

    Genome annotation databases

    EnsembliENST00000318445; ENSP00000320634; ENSG00000176463. [Q9UIG8-1]
    ENST00000424469; ENSP00000387846; ENSG00000176463. [Q9UIG8-2]
    GeneIDi28232.
    KEGGihsa:28232.
    UCSCiuc002bqx.3. human. [Q9UIG8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB031050 mRNA. Translation: BAA89287.1.
    AF205074 mRNA. Translation: AAG42206.1.
    AF187816 mRNA. Translation: AAG43446.1.
    AK290872 mRNA. Translation: BAF83561.1.
    AK057031 mRNA. Translation: BAG51847.1.
    AK097797 mRNA. Translation: BAG53529.1.
    FJ515841 Genomic DNA. Translation: ACS13734.1.
    AC104020 Genomic DNA. No translation available.
    AC104236 Genomic DNA. No translation available.
    AC113190 Genomic DNA. No translation available.
    AC116903 Genomic DNA. No translation available.
    AC135996 Genomic DNA. No translation available.
    BC000585 mRNA. Translation: AAH00585.1.
    CCDSiCCDS10371.1. [Q9UIG8-1]
    CCDS45354.1. [Q9UIG8-2]
    RefSeqiNP_001138516.1. NM_001145044.1. [Q9UIG8-2]
    NP_037404.2. NM_013272.3. [Q9UIG8-1]
    UniGeneiHs.311187.
    Hs.707541.

    3D structure databases

    ProteinModelPortaliQ9UIG8.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ9UIG8. 1 interactor.
    STRINGi9606.ENSP00000320634.

    Chemistry databases

    ChEMBLiCHEMBL2073685.
    DrugBankiDB00770. Alprostadil.
    DB00345. Aminohippurate.
    DB01053. Benzylpenicillin.
    DB00286. Conjugated Estrogens.
    DB01160. Dinoprost Tromethamine.
    DB00917. Dinoprostone.
    DB01088. Iloprost.
    DB00563. Methotrexate.

    Protein family/group databases

    TCDBi2.A.60.1.18. the organo anion transporter (oat) family.

    PTM databases

    iPTMnetiQ9UIG8.
    PhosphoSitePlusiQ9UIG8.
    SwissPalmiQ9UIG8.

    Polymorphism and mutation databases

    BioMutaiSLCO3A1.
    DMDMi296452954.

    Proteomic databases

    PaxDbiQ9UIG8.
    PeptideAtlasiQ9UIG8.
    PRIDEiQ9UIG8.

    Protocols and materials databases

    DNASUi28232.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000318445; ENSP00000320634; ENSG00000176463. [Q9UIG8-1]
    ENST00000424469; ENSP00000387846; ENSG00000176463. [Q9UIG8-2]
    GeneIDi28232.
    KEGGihsa:28232.
    UCSCiuc002bqx.3. human. [Q9UIG8-1]

    Organism-specific databases

    CTDi28232.
    DisGeNETi28232.
    GeneCardsiSLCO3A1.
    H-InvDBHIX0018979.
    HGNCiHGNC:10952. SLCO3A1.
    MIMi612435. gene.
    neXtProtiNX_Q9UIG8.
    OpenTargetsiENSG00000176463.
    PharmGKBiPA35837.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG3626. Eukaryota.
    ENOG410XRSF. LUCA.
    GeneTreeiENSGT00760000119014.
    HOVERGENiHBG098539.
    InParanoidiQ9UIG8.
    KOiK14353.
    OMAiLKSSAFV.
    OrthoDBiEOG091G03A9.
    PhylomeDBiQ9UIG8.
    TreeFamiTF317540.

    Enzyme and pathway databases

    BioCyciZFISH:ENSG00000176463-MONOMER.
    ReactomeiR-HSA-879518. Transport of organic anions.

    Miscellaneous databases

    ChiTaRSiSLCO3A1. human.
    GeneWikiiSLCO3A1.
    GenomeRNAii28232.
    PROiQ9UIG8.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000176463.
    CleanExiHS_SLCO3A1.
    ExpressionAtlasiQ9UIG8. baseline and differential.
    GenevisibleiQ9UIG8. HS.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 4 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiSO3A1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UIG8
    Secondary accession number(s): A8K4A7
    , B3KPY5, B3KUR7, C6G486, Q9BW73, Q9GZV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: May 18, 2010
    Last modified: November 2, 2016
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.