Q9UIF9 (BAZ2A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bromodomain adjacent to zinc finger domain protein 2A

Alternative name(s):
Transcription termination factor I-interacting protein 5
Short name=TTF-I-interacting protein 5
Short name=Tip5
hWALp3

Gene names

Name:	BAZ2A
Synonyms:	KIAA0314, TIP5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1905 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing By similarity.
Subunit structure	Component of the NoRC complex, at least composed of SMARCA5/SNF2H and BAZ2A/TIP5. Interacts with TTF1; required for recruitment of the NoRC complex to rDNA. Interacts with DNMT1, DNM3B, HDAC1 and SIN3A By similarity.
Subcellular location	Nucleus › nucleolus By similarity. Note: Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus By similarity.
Tissue specificity	Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.
Domain	The bromo domain and the PHD-type zinc finger recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac). These 2 domains play a central role in the recritment of chromatin silencing proteins such as DNMT1, DNMT3B and HDAC1. The MBD (methyl-CpG-binding) domain, also named TAM domain, specifically recognizes and binds a conserved stem-loop structure the association within pRNA. Binding to pRNA induces a conformational change of BAZ2A/TIP5 and is essential for targeting the NoRC complex to the nucleolus By similarity.
Post-translational modification	Acetylation at Lys-680 by KAT8/MOF promotes its dissociation from pRNA, affecting heterochromatin formation, nucleosome positioning and rDNA silencing. Deacetylation by SIRT1 in late S phase enhances pRNA-binding, allowing de novo DNA methylation and heterochromatin formation. Acetylation is high during S phase and declines to background levels in late S phase when the silent copies of rRNA genes are replicated By similarity.
Sequence similarities	Belongs to the WAL family. Contains 4 A.T hook DNA-binding domains. Contains 1 bromo domain. Contains 1 DDT domain. Contains 1 MBD (methyl-CpG-binding) domain. Contains 1 PHD-type zinc finger.
Sequence caution	The sequence AAB60864.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAG51228.1 differs from that shown. Reason: Erroneous termination at position 168. Translated as Tyr.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Bromodomain Coiled coil Repeat Zinc-finger
Ligand	DNA-binding Metal-binding RNA-binding Zinc
Molecular function	Chromatin regulator Repressor
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA methylation Inferred from sequence or structural similarity. Source: UniProtKB chromatin remodeling Non-traceable author statement PubMed 11532953. Source: UniProtKB chromatin silencing at rDNA Inferred from sequence or structural similarity. Source: UniProtKB heterochromatin assembly involved in chromatin silencing Inferred from electronic annotation. Source: Compara histone H3-K9 methylation Inferred from electronic annotation. Source: Compara histone H4 deacetylation Inferred from electronic annotation. Source: Compara histone H4-K20 methylation Inferred from electronic annotation. Source: Compara histone deacetylation Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	chromatin silencing complex Inferred from sequence or structural similarity. Source: UniProtKB nucleolus Inferred from sequence or structural similarity. Source: UniProtKB rDNA heterochromatin Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from sequence or structural similarity. Source: UniProtKB histone acetyl-lysine binding Inferred from sequence or structural similarity. Source: UniProtKB ligand-dependent nuclear receptor binding Non-traceable author statement Ref.1. Source: BHF-UCL zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NCK1	P16333	2	EBI-934890,EBI-389883

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: Q9UIF9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q9UIF9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: N → NEAN
     178-207: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9UIF9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1434-1437: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1905	1905	Bromodomain adjacent to zinc finger domain protein 2A		PRO_0000211172
Regions
	Domain	546 – 617	72	MBD
	Domain	848 – 913	66	DDT
	Domain	1810 – 1880	71	Bromo
	DNA binding	649 – 661	13	A.T hook 1
	DNA binding	670 – 682	13	A.T hook 2
	DNA binding	1186 – 1198	13	A.T hook 3
	DNA binding	1404 – 1416	13	A.T hook 4
	Zinc finger	1676 – 1726	51	PHD-type
	Coiled coil	693 – 792	100	Potential
	Compositional bias	660 – 799	140	Lys-rich
	Compositional bias	1212 – 1277	66	Glu-rich
	Compositional bias	1290 – 1411	122	Pro-rich
	Compositional bias	1759 – 1762	4	Poly-Arg
Amino acid modifications
	Modified residue	134	1	Phosphoserine Ref.15
	Modified residue	509	1	Phosphoserine Ref.14 Ref.15
	Modified residue	680	1	N6-acetyllysine; by KAT8 Ref.12
	Modified residue	1051	1	Phosphoserine By similarity
	Modified residue	1397	1	Phosphoserine Ref.13 Ref.14 Ref.15
	Modified residue	1559	1	Phosphoserine Ref.10
	Modified residue	1747	1	Phosphoserine Ref.11
	Modified residue	1770	1	Phosphoserine Ref.11 Ref.14
	Modified residue	1783	1	Phosphoserine Ref.11 Ref.13 Ref.14 Ref.15
	Modified residue	1785	1	Phosphoserine Ref.15
Natural variations
	Alternative sequence	6	1	N → NEAN in isoform 1.		VSP_037960
	Alternative sequence	178 – 207	30	Missing in isoform 1.		VSP_019111
	Alternative sequence	1434 – 1437	4	Missing in isoform 3.		VSP_037961
	Natural variant	498	1	V → E. Corresponds to variant rs2230579 [ dbSNP | Ensembl ].		VAR_055548
Experimental info
	Sequence conflict	106	1	N → S in CAH18232. Ref.2
	Sequence conflict	148	1	E → K in BAA89211. Ref.1
	Sequence conflict	155	1	Q → H in BAA89211. Ref.1
	Sequence conflict	207	1	Q → P in CAH18232. Ref.2
	Sequence conflict	210	1	G → C in BAA89211. Ref.1
	Sequence conflict	236	1	G → C in BAA89211. Ref.1
	Sequence conflict	503	1	A → T in CAH18232. Ref.2
	Sequence conflict	601	1	V → L in BAA89211. Ref.1
	Sequence conflict	727	1	Q → L in BAA89211. Ref.1
	Sequence conflict	747	1	Q → H in BAA89211. Ref.1
	Sequence conflict	812	1	R → K in BAA89211. Ref.1
	Sequence conflict	978	1	L → P in BAA89211. Ref.1
	Sequence conflict	1032 – 1033	2	EG → GR in BAA89211. Ref.1
	Sequence conflict	1190	1	G → S in BAA89211. Ref.1
	Sequence conflict	1193	1	R → L in BAA89211. Ref.1
	Sequence conflict	1199	1	S → F in BAA89211. Ref.1
	Sequence conflict	1205	1	L → F in BAA89211. Ref.1
	Sequence conflict	1229	1	A → V in BAA89211. Ref.1
	Sequence conflict	1274	1	S → N in CAH18232. Ref.2
	Sequence conflict	1319	1	P → L in BAA89211. Ref.1
	Sequence conflict	1322	1	L → F in BAA89211. Ref.1
	Sequence conflict	1340	1	P → L in BAA89211. Ref.1
	Sequence conflict	1443	1	R → P in BAA89211. Ref.1
	Sequence conflict	1568	1	R → P in BAA89211. Ref.1
	Sequence conflict	1598	1	E → K in BAA89211. Ref.1
	Sequence conflict	1643	1	V → I in BAA89211. Ref.1
	Sequence conflict	1649	1	E → Q in BAA89211. Ref.1
	Sequence conflict	1656	1	Q → H in BAA89211. Ref.1
	Sequence conflict	1663	1	Q → H in BAA89211. Ref.1
	Sequence conflict	1766	1	R → K in BAA89211. Ref.1
	Sequence conflict	1781	1	G → R in BAA89211. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified September 1, 2009. Version 4. Checksum: F364E2AC4BF89EA2	FASTA	1,905	211,198
	10 20 30 40 50 60 MEMEANDHFN FTGLPPAPAA SGLKPSPSSG EGLYTNGSPM NFPQQGKSLN GDVNVNGLST 70 80 90 100 110 120 VSHTTTSGIL NSAPHSSSTS HLHHPSVAYD CLWNYSQYPS ANPGSNLKDP PLLSQFSGGQ 130 140 150 160 170 180 YPLNGILGGS RQPSSPSHNT NLRAGSQEFW ANGTQSPMGL NFDSQELYDS FPDQNFEVMP 190 200 210 220 230 240 NGPPSFFTSP QTSPMLGSSI QTFAPSQEVG SGIHPDEAAE KEMTSVVAEN GTGLVGSLEL 250 260 270 280 290 300 EEEQPELKMC GYNGSVPSVE SLHQEVSVLV PDPTVSCLDD PSHLPDQLED TPILSEDSLE 310 320 330 340 350 360 PFNSLAPEPV SGGLYGIDDT ELMGAEDKLP LEDSPVISAL DCPSLNNATA FSLLADDSQT 370 380 390 400 410 420 STSIFASPTS PPVLGESVLQ DNSFDLNNGS DAEQEEMETQ SSDFPPSLTQ PAPDQSSTIQ 430 440 450 460 470 480 LHPATSPAVS PTTSPAVSLV VSPAASPEIS PEVCPAASTV VSPAVFSVVS PASSAVLPAV 490 500 510 520 530 540 SLEVPLTASV TSPKASPVTS PAAAFPTASP ANKDVSSFLE TTADVEEITG EGLTASGSGD 550 560 570 580 590 600 VMRRRIATPE EVRLPLQHGW RREVRIKKGS HRWQGETWYY GPCGKRMKQF PEVIKYLSRN 610 620 630 640 650 660 VVHSVRREHF SFSPRMPVGD FFEERDTPEG LQWVQLSAEE IPSRIQAITG KRGRPRNTEK 670 680 690 700 710 720 AKTKEVPKVK RGRGRPPKVK ITELLNKTDN RPLKKLEAQE TLNEEDKAKI AKSKKKMRQK 730 740 750 760 770 780 VQRGECQTTI QGQARNKRKQ ETKSLKQKEA KKKSKAEKEK GKTKQEKLKE KVKREKKEKV 790 800 810 820 830 840 KMKEKEEVTK AKPACKADKT LATQRRLEER QRQQMILEEM KKPTEDMCLT DHQPLPDFSR 850 860 870 880 890 900 VPGLTLPSGA FSDCLTIVEF LHSFGKVLGF DPAKDVPSLG VLQEGLLCQG DSLGEVQDLL 910 920 930 940 950 960 VRLLKAALHD PGFPSYCQSL KILGEKVSEI PLTRDNVSEI LRCFLMAYGV EPALCDRLRT 970 980 990 1000 1010 1020 QPFQAQPPQQ KAAVLAFLVH ELNGSTLIIN EIDKTLESMS SYRKNKWIVE GRLRRLKTVL 1030 1040 1050 1060 1070 1080 AKRTGRSEVE MEGPEECLGR RRSSRIMEET SGMEEEEEEE SIAAVPGRRG RRDGEVDATA 1090 1100 1110 1120 1130 1140 SSIPELERQI EKLSKRQLFF RKKLLHSSQM LRAVSLGQDR YRRRYWVLPY LAGIFVEGTE 1150 1160 1170 1180 1190 1200 GNLVPEEVIK KETDSLKVAA HASLNPALFS MKMELAGSNT TASSPARARG RPRKTKPGSM 1210 1220 1230 1240 1250 1260 QPRHLKSPVR GQDSEQPQAQ LQPEAQLHAP AQPQPQLQLQ LQSHKGFLEQ EGSPLSLGQS 1270 1280 1290 1300 1310 1320 QHDLSQSAFL SWLSQTQSHS SLLSSSVLTP DSSPGKLDPA PSQPPEEPEP DEAESSPDPQ 1330 1340 1350 1360 1370 1380 ALWFNISAQM PCNAAPTPPP AVSEDQPTPS PQQLASSKPM NRPSAANPCS PVQFSSTPLA 1390 1400 1410 1420 1430 1440 GLAPKRRAGD PGEMPQSPTG LGQPKRRGRP PSKFFKQMEQ RYLTQLTAQP VPPEMCSGWW 1450 1460 1470 1480 1490 1500 WIRDPEMLDA MLKALHPRGI REKALHKHLN KHRDFLQEVC LRPSADPIFE PRQLPAFQEG 1510 1520 1530 1540 1550 1560 IMSWSPKEKT YETDLAVLQW VEELEQRVIM SDLQIRGWTC PSPDSTREDL AYCEHLSDSQ 1570 1580 1590 1600 1610 1620 EDITWRGRGR EGLAPQRKTT NPLDLAVMRL AALEQNVERR YLREPLWPTH EVVLEKALLS 1630 1640 1650 1660 1670 1680 TPNGAPEGTT TEISYEITPR IRVWRQTLER CRSAAQVCLC LGQLERSIAW EKSVNKVTCL 1690 1700 1710 1720 1730 1740 VCRKGDNDEF LLLCDGCDRG CHIYCHRPKM EAVPEGDWFC TVCLAQQVEG EFTQKPGFPK 1750 1760 1770 1780 1790 1800 RGQKRKSGYS LNFSEGDGRR RRVLLRGRES PAAGPRYSEE GLSPSKRRRL SMRNHHSDLT 1810 1820 1830 1840 1850 1860 FCEIILMEME SHDAAWPFLE PVNPRLVSGY RRIIKNPMDF STMRERLLRG GYTSSEEFAA 1870 1880 1890 1900 DALLVFDNCQ TFNEDDSEVG KAGHIMRRFF ESRWEEFYQG KQANL
	Isoform 1 [UniParc]. Checksum: 8F197C2BE4F4EB4A	FASTA	1,878	208,390
	10 20 30 40 50 60 MEMEANEAND HFNFTGLPPA PAASGLKPSP SSGEGLYTNG SPMNFPQQGK SLNGDVNVNG 70 80 90 100 110 120 LSTVSHTTTS GILNSAPHSS STSHLHHPSV AYDCLWNYSQ YPSANPGSNL KDPPLLSQFS 130 140 150 160 170 180 GGQYPLNGIL GGSRQPSSPS HNTNLRAGSQ EFWANGTQSP MGLNFDSQEL YDSFPDQNFE 190 200 210 220 230 240 EVGSGIHPDE AAEKEMTSVV AENGTGLVGS LELEEEQPEL KMCGYNGSVP SVESLHQEVS 250 260 270 280 290 300 VLVPDPTVSC LDDPSHLPDQ LEDTPILSED SLEPFNSLAP EPVSGGLYGI DDTELMGAED 310 320 330 340 350 360 KLPLEDSPVI SALDCPSLNN ATAFSLLADD SQTSTSIFAS PTSPPVLGES VLQDNSFDLN 370 380 390 400 410 420 NGSDAEQEEM ETQSSDFPPS LTQPAPDQSS TIQLHPATSP AVSPTTSPAV SLVVSPAASP 430 440 450 460 470 480 EISPEVCPAA STVVSPAVFS VVSPASSAVL PAVSLEVPLT ASVTSPKASP VTSPAAAFPT 490 500 510 520 530 540 ASPANKDVSS FLETTADVEE ITGEGLTASG SGDVMRRRIA TPEEVRLPLQ HGWRREVRIK 550 560 570 580 590 600 KGSHRWQGET WYYGPCGKRM KQFPEVIKYL SRNVVHSVRR EHFSFSPRMP VGDFFEERDT 610 620 630 640 650 660 PEGLQWVQLS AEEIPSRIQA ITGKRGRPRN TEKAKTKEVP KVKRGRGRPP KVKITELLNK 670 680 690 700 710 720 TDNRPLKKLE AQETLNEEDK AKIAKSKKKM RQKVQRGECQ TTIQGQARNK RKQETKSLKQ 730 740 750 760 770 780 KEAKKKSKAE KEKGKTKQEK LKEKVKREKK EKVKMKEKEE VTKAKPACKA DKTLATQRRL 790 800 810 820 830 840 EERQRQQMIL EEMKKPTEDM CLTDHQPLPD FSRVPGLTLP SGAFSDCLTI VEFLHSFGKV 850 860 870 880 890 900 LGFDPAKDVP SLGVLQEGLL CQGDSLGEVQ DLLVRLLKAA LHDPGFPSYC QSLKILGEKV 910 920 930 940 950 960 SEIPLTRDNV SEILRCFLMA YGVEPALCDR LRTQPFQAQP PQQKAAVLAF LVHELNGSTL 970 980 990 1000 1010 1020 IINEIDKTLE SMSSYRKNKW IVEGRLRRLK TVLAKRTGRS EVEMEGPEEC LGRRRSSRIM 1030 1040 1050 1060 1070 1080 EETSGMEEEE EEESIAAVPG RRGRRDGEVD ATASSIPELE RQIEKLSKRQ LFFRKKLLHS 1090 1100 1110 1120 1130 1140 SQMLRAVSLG QDRYRRRYWV LPYLAGIFVE GTEGNLVPEE VIKKETDSLK VAAHASLNPA 1150 1160 1170 1180 1190 1200 LFSMKMELAG SNTTASSPAR ARGRPRKTKP GSMQPRHLKS PVRGQDSEQP QAQLQPEAQL 1210 1220 1230 1240 1250 1260 HAPAQPQPQL QLQLQSHKGF LEQEGSPLSL GQSQHDLSQS AFLSWLSQTQ SHSSLLSSSV 1270 1280 1290 1300 1310 1320 LTPDSSPGKL DPAPSQPPEE PEPDEAESSP DPQALWFNIS AQMPCNAAPT PPPAVSEDQP 1330 1340 1350 1360 1370 1380 TPSPQQLASS KPMNRPSAAN PCSPVQFSST PLAGLAPKRR AGDPGEMPQS PTGLGQPKRR 1390 1400 1410 1420 1430 1440 GRPPSKFFKQ MEQRYLTQLT AQPVPPEMCS GWWWIRDPEM LDAMLKALHP RGIREKALHK 1450 1460 1470 1480 1490 1500 HLNKHRDFLQ EVCLRPSADP IFEPRQLPAF QEGIMSWSPK EKTYETDLAV LQWVEELEQR 1510 1520 1530 1540 1550 1560 VIMSDLQIRG WTCPSPDSTR EDLAYCEHLS DSQEDITWRG RGREGLAPQR KTTNPLDLAV 1570 1580 1590 1600 1610 1620 MRLAALEQNV ERRYLREPLW PTHEVVLEKA LLSTPNGAPE GTTTEISYEI TPRIRVWRQT 1630 1640 1650 1660 1670 1680 LERCRSAAQV CLCLGQLERS IAWEKSVNKV TCLVCRKGDN DEFLLLCDGC DRGCHIYCHR 1690 1700 1710 1720 1730 1740 PKMEAVPEGD WFCTVCLAQQ VEGEFTQKPG FPKRGQKRKS GYSLNFSEGD GRRRRVLLRG 1750 1760 1770 1780 1790 1800 RESPAAGPRY SEEGLSPSKR RRLSMRNHHS DLTFCEIILM EMESHDAAWP FLEPVNPRLV 1810 1820 1830 1840 1850 1860 SGYRRIIKNP MDFSTMRERL LRGGYTSSEE FAADALLVFD NCQTFNEDDS EVGKAGHIMR 1870 RFFESRWEEF YQGKQANL
	Isoform 3 [UniParc]. Checksum: 00A922530275504E	FASTA	1,901	210,747
	10 20 30 40 50 60 MEMEANDHFN FTGLPPAPAA SGLKPSPSSG EGLYTNGSPM NFPQQGKSLN GDVNVNGLST 70 80 90 100 110 120 VSHTTTSGIL NSAPHSSSTS HLHHPSVAYD CLWNYSQYPS ANPGSNLKDP PLLSQFSGGQ 130 140 150 160 170 180 YPLNGILGGS RQPSSPSHNT NLRAGSQEFW ANGTQSPMGL NFDSQELYDS FPDQNFEVMP 190 200 210 220 230 240 NGPPSFFTSP QTSPMLGSSI QTFAPSQEVG SGIHPDEAAE KEMTSVVAEN GTGLVGSLEL 250 260 270 280 290 300 EEEQPELKMC GYNGSVPSVE SLHQEVSVLV PDPTVSCLDD PSHLPDQLED TPILSEDSLE 310 320 330 340 350 360 PFNSLAPEPV SGGLYGIDDT ELMGAEDKLP LEDSPVISAL DCPSLNNATA FSLLADDSQT 370 380 390 400 410 420 STSIFASPTS PPVLGESVLQ DNSFDLNNGS DAEQEEMETQ SSDFPPSLTQ PAPDQSSTIQ 430 440 450 460 470 480 LHPATSPAVS PTTSPAVSLV VSPAASPEIS PEVCPAASTV VSPAVFSVVS PASSAVLPAV 490 500 510 520 530 540 SLEVPLTASV TSPKASPVTS PAAAFPTASP ANKDVSSFLE TTADVEEITG EGLTASGSGD 550 560 570 580 590 600 VMRRRIATPE EVRLPLQHGW RREVRIKKGS HRWQGETWYY GPCGKRMKQF PEVIKYLSRN 610 620 630 640 650 660 VVHSVRREHF SFSPRMPVGD FFEERDTPEG LQWVQLSAEE IPSRIQAITG KRGRPRNTEK 670 680 690 700 710 720 AKTKEVPKVK RGRGRPPKVK ITELLNKTDN RPLKKLEAQE TLNEEDKAKI AKSKKKMRQK 730 740 750 760 770 780 VQRGECQTTI QGQARNKRKQ ETKSLKQKEA KKKSKAEKEK GKTKQEKLKE KVKREKKEKV 790 800 810 820 830 840 KMKEKEEVTK AKPACKADKT LATQRRLEER QRQQMILEEM KKPTEDMCLT DHQPLPDFSR 850 860 870 880 890 900 VPGLTLPSGA FSDCLTIVEF LHSFGKVLGF DPAKDVPSLG VLQEGLLCQG DSLGEVQDLL 910 920 930 940 950 960 VRLLKAALHD PGFPSYCQSL KILGEKVSEI PLTRDNVSEI LRCFLMAYGV EPALCDRLRT 970 980 990 1000 1010 1020 QPFQAQPPQQ KAAVLAFLVH ELNGSTLIIN EIDKTLESMS SYRKNKWIVE GRLRRLKTVL 1030 1040 1050 1060 1070 1080 AKRTGRSEVE MEGPEECLGR RRSSRIMEET SGMEEEEEEE SIAAVPGRRG RRDGEVDATA 1090 1100 1110 1120 1130 1140 SSIPELERQI EKLSKRQLFF RKKLLHSSQM LRAVSLGQDR YRRRYWVLPY LAGIFVEGTE 1150 1160 1170 1180 1190 1200 GNLVPEEVIK KETDSLKVAA HASLNPALFS MKMELAGSNT TASSPARARG RPRKTKPGSM 1210 1220 1230 1240 1250 1260 QPRHLKSPVR GQDSEQPQAQ LQPEAQLHAP AQPQPQLQLQ LQSHKGFLEQ EGSPLSLGQS 1270 1280 1290 1300 1310 1320 QHDLSQSAFL SWLSQTQSHS SLLSSSVLTP DSSPGKLDPA PSQPPEEPEP DEAESSPDPQ 1330 1340 1350 1360 1370 1380 ALWFNISAQM PCNAAPTPPP AVSEDQPTPS PQQLASSKPM NRPSAANPCS PVQFSSTPLA 1390 1400 1410 1420 1430 1440 GLAPKRRAGD PGEMPQSPTG LGQPKRRGRP PSKFFKQMEQ RYLTQLTAQP VPPGWWWIRD 1450 1460 1470 1480 1490 1500 PEMLDAMLKA LHPRGIREKA LHKHLNKHRD FLQEVCLRPS ADPIFEPRQL PAFQEGIMSW 1510 1520 1530 1540 1550 1560 SPKEKTYETD LAVLQWVEEL EQRVIMSDLQ IRGWTCPSPD STREDLAYCE HLSDSQEDIT 1570 1580 1590 1600 1610 1620 WRGRGREGLA PQRKTTNPLD LAVMRLAALE QNVERRYLRE PLWPTHEVVL EKALLSTPNG 1630 1640 1650 1660 1670 1680 APEGTTTEIS YEITPRIRVW RQTLERCRSA AQVCLCLGQL ERSIAWEKSV NKVTCLVCRK 1690 1700 1710 1720 1730 1740 GDNDEFLLLC DGCDRGCHIY CHRPKMEAVP EGDWFCTVCL AQQVEGEFTQ KPGFPKRGQK 1750 1760 1770 1780 1790 1800 RKSGYSLNFS EGDGRRRRVL LRGRESPAAG PRYSEEGLSP SKRRRLSMRN HHSDLTFCEI 1810 1820 1830 1840 1850 1860 ILMEMESHDA AWPFLEPVNP RLVSGYRRII KNPMDFSTMR ERLLRGGYTS SEEFAADALL 1870 1880 1890 1900 VFDNCQTFNE DDSEVGKAGH IMRRFFESRW EEFYQGKQAN L

References

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[1]	"A novel family of bromodomain genes." Jones M.H., Hamana N., Nezu J., Shimane M. Genomics 63:40-45(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Fetal kidney.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-1905 (ISOFORM 2). Tissue: Brain.
[5]	Ohara O., Nagase T., Kikuno R., Nomura N. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-1905 (ISOFORMS 1/2). Tissue: Placenta.
[7]	Jansa P., Grummt I. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 359-753. Tissue: Lung.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1065-1905. Tissue: Lymph.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1559, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1747; SER-1770 AND SER-1783, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing." Zhou Y., Schmitz K.M., Mayer C., Yuan X., Akhtar A., Grummt I. Nat. Cell Biol. 11:1010-1016(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION AT LYS-680.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1397 AND SER-1783, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509; SER-1397; SER-1770 AND SER-1783, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134; SER-509; SER-1397; SER-1783 AND SER-1785, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB032254 mRNA. Translation: BAA89211.1. CR749379 mRNA. Translation: CAH18232.1. AC090681 Genomic DNA. No translation available. AB002312 mRNA. Translation: BAA20773.2. AK023830 mRNA. Translation: BAG51228.1. Sequence problems. AF000422 mRNA. Translation: AAB60864.1. Sequence problems. BC008965 mRNA. Translation: AAH08965.2.
IPI	IPI00296388. IPI00759742. IPI00943770.
RefSeq	NP_038477.2. NM_013449.3.
UniGene	Hs.314263.
3D structure databases
ProteinModelPortal	Q9UIF9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UIF9. 7 interactions.
MINT	MINT-7240976.
STRING	9606.ENSP00000368754.
PTM databases
PhosphoSite	Q9UIF9.
Polymorphism databases
DMDM	257051081.
Proteomic databases
PaxDb	Q9UIF9.
PRIDE	Q9UIF9.
Protocols and materials databases
DNASU	11176.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000549787; ENSP00000448760; ENSG00000076108. ENST00000551812; ENSP00000446880; ENSG00000076108.
GeneID	11176.
KEGG	hsa:11176.
UCSC	uc001slp.1. human. uc009zow.1. human.
Organism-specific databases
CTD	11176.
GeneCards	GC12M056954.
H-InvDB	HIX0010736.
HGNC	HGNC:962. BAZ2A.
HPA	HPA005782.
MIM	605682. gene.
neXtProt	NX_Q9UIF9.
PharmGKB	PA25272.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5076.
HOGENOM	HOG000169644.
HOVERGEN	HBG107494.
KO	K15224.
OMA	WIVEGRL.
OrthoDB	EOG44QT05.
Gene expression databases
ArrayExpress	Q9UIF9.
Bgee	Q9UIF9.
CleanEx	HS_BAZ2A.
Genevestigator	Q9UIF9.
GermOnline	ENSG00000076108. Homo sapiens.
Family and domain databases
Gene3D	1.20.920.10. 1 hit. 3.30.40.10. 1 hit. 3.30.890.10. 1 hit.
InterPro	IPR017956. AT_hook_DNA-bd_motif. IPR001487. Bromodomain. IPR018359. Bromodomain_CS. IPR004022. DDT_dom. IPR018500. DDT_dom_subgr. IPR018501. DDT_dom_superfamily. IPR016177. DNA-bd_integrase-typ. IPR001739. Methyl_CpG_DNA-bd. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF00439. Bromodomain. 1 hit. PF02791. DDT. 1 hit. PF01429. MBD. 1 hit. PF00628. PHD. 1 hit. [Graphical view]
PRINTS	PR00503. BROMODOMAIN.
SMART	SM00384. AT_hook. 4 hits. SM00297. BROMO. 1 hit. SM00571. DDT. 1 hit. SM00391. MBD. 1 hit. SM00249. PHD. 1 hit. [Graphical view]
SUPFAM	SSF47370. Bromodomain. 1 hit. SSF54171. DNA-binding_integrase-type. 1 hit. SSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITE	PS00633. BROMODOMAIN_1. 1 hit. PS50014. BROMODOMAIN_2. 1 hit. PS50827. DDT. 1 hit. PS50982. MBD. 1 hit. PS01359. ZF_PHD_1. False negative. PS50016. ZF_PHD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BAZ2A. human.
GenomeRNAi	11176.
NextBio	42525.
SOURCE	Search...

Entry information

Entry name

BAZ2A_HUMAN

Accession

Primary (citable) accession number: Q9UIF9
Secondary accession number(s): B3KN66 , O00536, O15030, Q68DI8, Q96H26

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	September 1, 2009
Last modified:	May 1, 2013
This is version 127 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.