Q9UIF8 (BAZ2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bromodomain adjacent to zinc finger domain protein 2B

Alternative name(s):
hWALp4

Gene names

Name:	BAZ2B
Synonyms:	KIAA1476

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2168 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in transcriptional regulation interacting with ISWI.
Subunit structure	Interacts with acetylated lysine residues on histone H1.4, H2A, H2B, H3 and H4 (in vitro). Ref.13
Subcellular location	Nucleus Potential.
Tissue specificity	Expressed at varying levels in several tissues, whereas a smaller transcript was expressed specifically in testis.
Sequence similarities	Belongs to the WAL family. Contains 1 bromo domain. Contains 1 DDT domain. Contains 1 MBD (methyl-CpG-binding) domain. Contains 1 PHD-type zinc finger.
Sequence caution	The sequence AAH12576.1 differs from that shown. Reason: Frameshift at position 927. The sequence AAH12576.1 differs from that shown. Reason: contaminating sequence. Potential poly-A sequence. The sequence BAA96000.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB55231.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Bromodomain Coiled coil Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Acetylation Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Non-traceable author statement Ref.1. Source: BHF-UCL transcription, DNA-dependent Non-traceable author statement Ref.1. Source: BHF-UCL
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9UIF8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UIF8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     112-113: Missing.
     633-730: Missing.

Isoform 3 (identifier: Q9UIF8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     789-822: Missing.

Isoform 4 (identifier: Q9UIF8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Isoform 5 (identifier: Q9UIF8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     112-113: Missing.
     789-822: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2168

2168

Bromodomain adjacent to zinc finger domain protein 2B

PRO_0000211174

Regions

Domain

739 – 810

72

MBD

Domain

1087 – 1152

66

DDT

Domain

2077 – 2147

71

Bromo

Zinc finger

1931 – 1981

51

PHD-type

Coiled coil

883 – 1061

179

Potential

Coiled coil

1334 – 1375

42

Potential

Compositional bias

149 – 265

117

Ser-rich

Compositional bias

269 – 275

7

Poly-Glu

Compositional bias

595 – 666

72

Asp/Glu-rich (acidic)

Compositional bias

837 – 868

32

Arg-rich

Compositional bias

902 – 1061

160

Lys-rich

Compositional bias

1296 – 1339

44

Asp-rich

Amino acid modifications

Modified residue

1462

1

N6-acetyllysine Ref.10

Modified residue

1680

1

Phosphoserine Ref.11

Modified residue

2014

1

Phosphothreonine Ref.11

Modified residue

2019

1

Phosphoserine Ref.11

Cross-link

1538

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.9

Natural variations

Alternative sequence

1 – 196

196

Missing in isoform 4.

VSP_037114

Alternative sequence

112 – 113

2

Missing in isoform 2 and isoform 5.

VSP_037115

Alternative sequence

633 – 730

98

Missing in isoform 2.

VSP_000553

Alternative sequence

789 – 822

34

Missing in isoform 3 and isoform 5.

VSP_000554

Natural variant

71

1

M → T. Ref.5
Corresponds to variant rs10202670 [ dbSNP | Ensembl ].

VAR_055549

Natural variant

422

1

L → S. Ref.5 Ref.6
Corresponds to variant rs3213790 [ dbSNP | Ensembl ].

VAR_055550

Natural variant

530

1

P → L.
Corresponds to variant rs3732287 [ dbSNP | Ensembl ].

VAR_055551

Natural variant

702

1

G → V.
Corresponds to variant rs2302924 [ dbSNP | Ensembl ].

VAR_055552

Natural variant

2024

1

S → N.
Corresponds to variant rs415793 [ dbSNP | Ensembl ].

VAR_055553

Experimental info

Sequence conflict

95

1

L → G in AAH12576. Ref.6

Sequence conflict

333

1

S → F in BAA89212. Ref.1

Sequence conflict

823

1

G → E in BAA89212. Ref.1

Sequence conflict

918

1

E → K in AAH12576. Ref.6

Sequence conflict

986

1

R → Q in AAH12576. Ref.6

Sequence conflict

1324

1

K → Q in BAA89212. Ref.1

Sequence conflict

1379

1

Q → P in BAA89212. Ref.1

Sequence conflict

1391

1

Q → R in BAA89212. Ref.1

Sequence conflict

1649

1

S → L in BAA89212. Ref.1

Sequence conflict

2034

1

K → Q in BAA89212. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

2168

Helix Strand Turn

Details...

Helix

2065 – 2077

13

Helix

2080 – 2085

6

Turn

2091 – 2093

3

Beta strand

2094 – 2096

3

Helix

2097 – 2100

4

Helix

2107 – 2115

9

Helix

2122 – 2139

18

Beta strand

2142 – 2144

3

Helix

2145 – 2165

21

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 5, 2009. Version 3. Checksum: C64EEEE6243CF779	FASTA	2,168	240,459
	10 20 30 40 50 60 MESGERLPSS AASSTTPTSS STPSVASVVS KGGLSTGVAS LSSTINPCGH LFRTAGDQPF 70 80 90 100 110 120 NLSTVSSAFP MVSHPVFGLH SASSGHSEFG GLGTLGTPTA LAAHPQLASF PGAEWWRTTD 130 140 150 160 170 180 AHTRTGATFF PPLLGIPPLF APPAQNHDSS SFHSRTSGKS NRNGPEKGVN GSINGSNTSS 190 200 210 220 230 240 VIGINTSVLS TTASSSMGQT KSTSSGGGNR KCNQEQSKNQ PLDARVDKIK DKKPRKKAME 250 260 270 280 290 300 SSSNSDSDSG TSSDTSSEGI SSSDSDDLEE DEEEEDQSIE ESEDDDSDSE SEAQHKSNNQ 310 320 330 340 350 360 VLLHGISDPK ADGQKATEKA QEKRIHQPLP LASESQTHSF QSQQKQPQVL SQQLPFIFQS 370 380 390 400 410 420 SQAKEESVNK HTSVIQSTGL VSNVKPLSLV NQAKKETYMK LIVPSPDVLK AGNKNTSEES 430 440 450 460 470 480 SLLTSELRSK REQYKQAFPS QLKKQESSKS LKKVIAALSN PKATSSSPAH PKQTLENNHP 490 500 510 520 530 540 NPFLTNALLG NHQPNGVIQS VIQEAPLALT TKTKMQSKIN ENIAAASSTP FSSPVNLSTS 550 560 570 580 590 600 GRRTPGNQTP VMPSASPILH SQGKEKAVSN NVNPVKTQHH SHPAKSLVEQ FRGTDSDIPS 610 620 630 640 650 660 SKDSEDSNED EEEDDEEEDE EDDEDDESDD SQSESDSNSE SDTEGSEEED DDDKDQDESD 670 680 690 700 710 720 SDTEGEKTSM KLNKTTSSVK SPSMSLTGHS TPRNLHIAKA PGSAPAALCS ESQSPAFLGT 730 740 750 760 770 780 SSSTLTSSPH SGTSKRRRVT DERELRIPLE YGWQRETRIR NFGGRLQGEV AYYAPCGKKL 790 800 810 820 830 840 RQYPEVIKYL SRNGIMDISR DNFSFSAKIR VGDFYEARDG PQGMQWCLLK EEDVIPRIRA 850 860 870 880 890 900 MEGRRGRPPN PDRQRAREES RMRRRKGRPP NVGNAEFLDN ADAKLLRKLQ AQEIARQAAQ 910 920 930 940 950 960 IKLLRKLQKQ EQARVAKEAK KQQAIMAAEE KRKQKEQIKI MKQQEKIKRI QQIRMEKELR 970 980 990 1000 1010 1020 AQQILEAKKK KKEEAANAKL LEAEKRIKEK EMRRQQAVLL KHQERERRRQ HMMLMKAMEA 1030 1040 1050 1060 1070 1080 RKKAEEKERL KQEKRDEKRL NKERKLEQRR LELEMAKELK KPNEDMCLAD QKPLPELPRI 1090 1100 1110 1120 1130 1140 PGLVLSGSTF SDCLMVVQFL RNFGKVLGFD VNIDVPNLSV LQEGLLNIGD SMGEVQDLLV 1150 1160 1170 1180 1190 1200 RLLSAAVCDP GLITGYKAKT ALGEHLLNVG VNRDNVSEIL QIFMEAHCGQ TELTESLKTK 1210 1220 1230 1240 1250 1260 AFQAHTPAQK ASVLAFLINE LACSKSVVSE IDKNIDYMSN LRRDKWVVEG KLRKLRIIHA 1270 1280 1290 1300 1310 1320 KKTGKRDTSG GIDLGEEQHP LGTPTPGRKR RRKGGDSDYD DDDDDDSDDQ GDEDDEDEED 1330 1340 1350 1360 1370 1380 KEDKKGKKTD ICEDEDEGDQ AASVEELEKQ IEKLSKQQSQ YRRKLFDASH SLRSVMFGQD 1390 1400 1410 1420 1430 1440 RYRRRYWILP QCGGIFVEGM ESGEGLEEIA KEREKLKKAE SVQIKEEMFE TSGDSLNCSN 1450 1460 1470 1480 1490 1500 TDHCEQKEDL KEKDNTNLFL QKPGSFSKLS KLLEVAKMPP ESEVMTPKPN AGANGCTLSY 1510 1520 1530 1540 1550 1560 QNSGKHSLGS VQSTATQSNV EKADSNNLFN TGSSGPGKFY SPLPNDQLLK TLTEKNRQWF 1570 1580 1590 1600 1610 1620 SLLPRTPCDD TSLTHADMST ASLVTPQSQP PSKSPSPTPA PLGSSAQNPV GLNPFALSPL 1630 1640 1650 1660 1670 1680 QVKGGVSMMG LQFCGWPTGV VTSNIPFTSS VPSLGSGLGL SEGNGNSFLT SNVASSKSES 1690 1700 1710 1720 1730 1740 PVPQNEKATS AQPAAVEVAK PVDFPSPKPI PEEMQFGWWR IIDPEDLKAL LKVLHLRGIR 1750 1760 1770 1780 1790 1800 EKALQKQIQK HLDYITQACL KNKDVAIIEL NENEENQVTR DIVENWSVEE QAMEMDLSVL 1810 1820 1830 1840 1850 1860 QQVEDLERRV ASASLQVKGW MCPEPASERE DLVYFEHKSF TKLCKEHDGE FTGEDESSAH 1870 1880 1890 1900 1910 1920 ALERKSDNPL DIAVTRLADL ERNIERRIEE DIAPGLRVWR RALSEARSAA QVALCIQQLQ 1930 1940 1950 1960 1970 1980 KSIAWEKSIM KVYCQICRKG DNEELLLLCD GCDKGCHTYC HRPKITTIPD GDWFCPACIA 1990 2000 2010 2020 2030 2040 KASGQTLKIK KLHVKGKKTN ESKKGKKVTL TGDTEDEDSA STSSSLKRGN KDLKKRKMEE 2050 2060 2070 2080 2090 2100 NTSINLSKQE SFTSVKKPKR DDSKDLALCS MILTEMETHE DAWPFLLPVN LKLVPGYKKV 2110 2120 2130 2140 2150 2160 IKKPMDFSTI REKLSSGQYP NLETFALDVR LVFDNCETFN EDDSDIGRAG HNMRKYFEKK WTDTFKVS
	Isoform 2 [UniParc]. Checksum: 324018D11EF97BAD	FASTA	2,068	230,154
	10 20 30 40 50 60 MESGERLPSS AASSTTPTSS STPSVASVVS KGGLSTGVAS LSSTINPCGH LFRTAGDQPF 70 80 90 100 110 120 NLSTVSSAFP MVSHPVFGLH SASSGHSEFG GLGTLGTPTA LAAHPQLASF PEWWRTTDAH 130 140 150 160 170 180 TRTGATFFPP LLGIPPLFAP PAQNHDSSSF HSRTSGKSNR NGPEKGVNGS INGSNTSSVI 190 200 210 220 230 240 GINTSVLSTT ASSSMGQTKS TSSGGGNRKC NQEQSKNQPL DARVDKIKDK KPRKKAMESS 250 260 270 280 290 300 SNSDSDSGTS SDTSSEGISS SDSDDLEEDE EEEDQSIEES EDDDSDSESE AQHKSNNQVL 310 320 330 340 350 360 LHGISDPKAD GQKATEKAQE KRIHQPLPLA SESQTHSFQS QQKQPQVLSQ QLPFIFQSSQ 370 380 390 400 410 420 AKEESVNKHT SVIQSTGLVS NVKPLSLVNQ AKKETYMKLI VPSPDVLKAG NKNTSEESSL 430 440 450 460 470 480 LTSELRSKRE QYKQAFPSQL KKQESSKSLK KVIAALSNPK ATSSSPAHPK QTLENNHPNP 490 500 510 520 530 540 FLTNALLGNH QPNGVIQSVI QEAPLALTTK TKMQSKINEN IAAASSTPFS SPVNLSTSGR 550 560 570 580 590 600 RTPGNQTPVM PSASPILHSQ GKEKAVSNNV NPVKTQHHSH PAKSLVEQFR GTDSDIPSSK 610 620 630 640 650 660 DSEDSNEDEE EDDEEEDEED DEDDESDDSQ SGTSKRRRVT DERELRIPLE YGWQRETRIR 670 680 690 700 710 720 NFGGRLQGEV AYYAPCGKKL RQYPEVIKYL SRNGIMDISR DNFSFSAKIR VGDFYEARDG 730 740 750 760 770 780 PQGMQWCLLK EEDVIPRIRA MEGRRGRPPN PDRQRAREES RMRRRKGRPP NVGNAEFLDN 790 800 810 820 830 840 ADAKLLRKLQ AQEIARQAAQ IKLLRKLQKQ EQARVAKEAK KQQAIMAAEE KRKQKEQIKI 850 860 870 880 890 900 MKQQEKIKRI QQIRMEKELR AQQILEAKKK KKEEAANAKL LEAEKRIKEK EMRRQQAVLL 910 920 930 940 950 960 KHQERERRRQ HMMLMKAMEA RKKAEEKERL KQEKRDEKRL NKERKLEQRR LELEMAKELK 970 980 990 1000 1010 1020 KPNEDMCLAD QKPLPELPRI PGLVLSGSTF SDCLMVVQFL RNFGKVLGFD VNIDVPNLSV 1030 1040 1050 1060 1070 1080 LQEGLLNIGD SMGEVQDLLV RLLSAAVCDP GLITGYKAKT ALGEHLLNVG VNRDNVSEIL 1090 1100 1110 1120 1130 1140 QIFMEAHCGQ TELTESLKTK AFQAHTPAQK ASVLAFLINE LACSKSVVSE IDKNIDYMSN 1150 1160 1170 1180 1190 1200 LRRDKWVVEG KLRKLRIIHA KKTGKRDTSG GIDLGEEQHP LGTPTPGRKR RRKGGDSDYD 1210 1220 1230 1240 1250 1260 DDDDDDSDDQ GDEDDEDEED KEDKKGKKTD ICEDEDEGDQ AASVEELEKQ IEKLSKQQSQ 1270 1280 1290 1300 1310 1320 YRRKLFDASH SLRSVMFGQD RYRRRYWILP QCGGIFVEGM ESGEGLEEIA KEREKLKKAE 1330 1340 1350 1360 1370 1380 SVQIKEEMFE TSGDSLNCSN TDHCEQKEDL KEKDNTNLFL QKPGSFSKLS KLLEVAKMPP 1390 1400 1410 1420 1430 1440 ESEVMTPKPN AGANGCTLSY QNSGKHSLGS VQSTATQSNV EKADSNNLFN TGSSGPGKFY 1450 1460 1470 1480 1490 1500 SPLPNDQLLK TLTEKNRQWF SLLPRTPCDD TSLTHADMST ASLVTPQSQP PSKSPSPTPA 1510 1520 1530 1540 1550 1560 PLGSSAQNPV GLNPFALSPL QVKGGVSMMG LQFCGWPTGV VTSNIPFTSS VPSLGSGLGL 1570 1580 1590 1600 1610 1620 SEGNGNSFLT SNVASSKSES PVPQNEKATS AQPAAVEVAK PVDFPSPKPI PEEMQFGWWR 1630 1640 1650 1660 1670 1680 IIDPEDLKAL LKVLHLRGIR EKALQKQIQK HLDYITQACL KNKDVAIIEL NENEENQVTR 1690 1700 1710 1720 1730 1740 DIVENWSVEE QAMEMDLSVL QQVEDLERRV ASASLQVKGW MCPEPASERE DLVYFEHKSF 1750 1760 1770 1780 1790 1800 TKLCKEHDGE FTGEDESSAH ALERKSDNPL DIAVTRLADL ERNIERRIEE DIAPGLRVWR 1810 1820 1830 1840 1850 1860 RALSEARSAA QVALCIQQLQ KSIAWEKSIM KVYCQICRKG DNEELLLLCD GCDKGCHTYC 1870 1880 1890 1900 1910 1920 HRPKITTIPD GDWFCPACIA KASGQTLKIK KLHVKGKKTN ESKKGKKVTL TGDTEDEDSA 1930 1940 1950 1960 1970 1980 STSSSLKRGN KDLKKRKMEE NTSINLSKQE SFTSVKKPKR DDSKDLALCS MILTEMETHE 1990 2000 2010 2020 2030 2040 DAWPFLLPVN LKLVPGYKKV IKKPMDFSTI REKLSSGQYP NLETFALDVR LVFDNCETFN 2050 2060 EDDSDIGRAG HNMRKYFEKK WTDTFKVS
	Isoform 3 [UniParc]. Checksum: 6320F9BC6B744581	FASTA	2,134	236,551
	10 20 30 40 50 60 MESGERLPSS AASSTTPTSS STPSVASVVS KGGLSTGVAS LSSTINPCGH LFRTAGDQPF 70 80 90 100 110 120 NLSTVSSAFP MVSHPVFGLH SASSGHSEFG GLGTLGTPTA LAAHPQLASF PGAEWWRTTD 130 140 150 160 170 180 AHTRTGATFF PPLLGIPPLF APPAQNHDSS SFHSRTSGKS NRNGPEKGVN GSINGSNTSS 190 200 210 220 230 240 VIGINTSVLS TTASSSMGQT KSTSSGGGNR KCNQEQSKNQ PLDARVDKIK DKKPRKKAME 250 260 270 280 290 300 SSSNSDSDSG TSSDTSSEGI SSSDSDDLEE DEEEEDQSIE ESEDDDSDSE SEAQHKSNNQ 310 320 330 340 350 360 VLLHGISDPK ADGQKATEKA QEKRIHQPLP LASESQTHSF QSQQKQPQVL SQQLPFIFQS 370 380 390 400 410 420 SQAKEESVNK HTSVIQSTGL VSNVKPLSLV NQAKKETYMK LIVPSPDVLK AGNKNTSEES 430 440 450 460 470 480 SLLTSELRSK REQYKQAFPS QLKKQESSKS LKKVIAALSN PKATSSSPAH PKQTLENNHP 490 500 510 520 530 540 NPFLTNALLG NHQPNGVIQS VIQEAPLALT TKTKMQSKIN ENIAAASSTP FSSPVNLSTS 550 560 570 580 590 600 GRRTPGNQTP VMPSASPILH SQGKEKAVSN NVNPVKTQHH SHPAKSLVEQ FRGTDSDIPS 610 620 630 640 650 660 SKDSEDSNED EEEDDEEEDE EDDEDDESDD SQSESDSNSE SDTEGSEEED DDDKDQDESD 670 680 690 700 710 720 SDTEGEKTSM KLNKTTSSVK SPSMSLTGHS TPRNLHIAKA PGSAPAALCS ESQSPAFLGT 730 740 750 760 770 780 SSSTLTSSPH SGTSKRRRVT DERELRIPLE YGWQRETRIR NFGGRLQGEV AYYAPCGKKL 790 800 810 820 830 840 RQYPEVIKGM QWCLLKEEDV IPRIRAMEGR RGRPPNPDRQ RAREESRMRR RKGRPPNVGN 850 860 870 880 890 900 AEFLDNADAK LLRKLQAQEI ARQAAQIKLL RKLQKQEQAR VAKEAKKQQA IMAAEEKRKQ 910 920 930 940 950 960 KEQIKIMKQQ EKIKRIQQIR MEKELRAQQI LEAKKKKKEE AANAKLLEAE KRIKEKEMRR 970 980 990 1000 1010 1020 QQAVLLKHQE RERRRQHMML MKAMEARKKA EEKERLKQEK RDEKRLNKER KLEQRRLELE 1030 1040 1050 1060 1070 1080 MAKELKKPNE DMCLADQKPL PELPRIPGLV LSGSTFSDCL MVVQFLRNFG KVLGFDVNID 1090 1100 1110 1120 1130 1140 VPNLSVLQEG LLNIGDSMGE VQDLLVRLLS AAVCDPGLIT GYKAKTALGE HLLNVGVNRD 1150 1160 1170 1180 1190 1200 NVSEILQIFM EAHCGQTELT ESLKTKAFQA HTPAQKASVL AFLINELACS KSVVSEIDKN 1210 1220 1230 1240 1250 1260 IDYMSNLRRD KWVVEGKLRK LRIIHAKKTG KRDTSGGIDL GEEQHPLGTP TPGRKRRRKG 1270 1280 1290 1300 1310 1320 GDSDYDDDDD DDSDDQGDED DEDEEDKEDK KGKKTDICED EDEGDQAASV EELEKQIEKL 1330 1340 1350 1360 1370 1380 SKQQSQYRRK LFDASHSLRS VMFGQDRYRR RYWILPQCGG IFVEGMESGE GLEEIAKERE 1390 1400 1410 1420 1430 1440 KLKKAESVQI KEEMFETSGD SLNCSNTDHC EQKEDLKEKD NTNLFLQKPG SFSKLSKLLE 1450 1460 1470 1480 1490 1500 VAKMPPESEV MTPKPNAGAN GCTLSYQNSG KHSLGSVQST ATQSNVEKAD SNNLFNTGSS 1510 1520 1530 1540 1550 1560 GPGKFYSPLP NDQLLKTLTE KNRQWFSLLP RTPCDDTSLT HADMSTASLV TPQSQPPSKS 1570 1580 1590 1600 1610 1620 PSPTPAPLGS SAQNPVGLNP FALSPLQVKG GVSMMGLQFC GWPTGVVTSN IPFTSSVPSL 1630 1640 1650 1660 1670 1680 GSGLGLSEGN GNSFLTSNVA SSKSESPVPQ NEKATSAQPA AVEVAKPVDF PSPKPIPEEM 1690 1700 1710 1720 1730 1740 QFGWWRIIDP EDLKALLKVL HLRGIREKAL QKQIQKHLDY ITQACLKNKD VAIIELNENE 1750 1760 1770 1780 1790 1800 ENQVTRDIVE NWSVEEQAME MDLSVLQQVE DLERRVASAS LQVKGWMCPE PASEREDLVY 1810 1820 1830 1840 1850 1860 FEHKSFTKLC KEHDGEFTGE DESSAHALER KSDNPLDIAV TRLADLERNI ERRIEEDIAP 1870 1880 1890 1900 1910 1920 GLRVWRRALS EARSAAQVAL CIQQLQKSIA WEKSIMKVYC QICRKGDNEE LLLLCDGCDK 1930 1940 1950 1960 1970 1980 GCHTYCHRPK ITTIPDGDWF CPACIAKASG QTLKIKKLHV KGKKTNESKK GKKVTLTGDT 1990 2000 2010 2020 2030 2040 EDEDSASTSS SLKRGNKDLK KRKMEENTSI NLSKQESFTS VKKPKRDDSK DLALCSMILT 2050 2060 2070 2080 2090 2100 EMETHEDAWP FLLPVNLKLV PGYKKVIKKP MDFSTIREKL SSGQYPNLET FALDVRLVFD 2110 2120 2130 NCETFNEDDS DIGRAGHNMR KYFEKKWTDT FKVS
	Isoform 4 [UniParc]. Checksum: B3BA3FD40027174C	FASTA	1,972	220,710
	10 20 30 40 50 60 MGQTKSTSSG GGNRKCNQEQ SKNQPLDARV DKIKDKKPRK KAMESSSNSD SDSGTSSDTS 70 80 90 100 110 120 SEGISSSDSD DLEEDEEEED QSIEESEDDD SDSESEAQHK SNNQVLLHGI SDPKADGQKA 130 140 150 160 170 180 TEKAQEKRIH QPLPLASESQ THSFQSQQKQ PQVLSQQLPF IFQSSQAKEE SVNKHTSVIQ 190 200 210 220 230 240 STGLVSNVKP LSLVNQAKKE TYMKLIVPSP DVLKAGNKNT SEESSLLTSE LRSKREQYKQ 250 260 270 280 290 300 AFPSQLKKQE SSKSLKKVIA ALSNPKATSS SPAHPKQTLE NNHPNPFLTN ALLGNHQPNG 310 320 330 340 350 360 VIQSVIQEAP LALTTKTKMQ SKINENIAAA SSTPFSSPVN LSTSGRRTPG NQTPVMPSAS 370 380 390 400 410 420 PILHSQGKEK AVSNNVNPVK TQHHSHPAKS LVEQFRGTDS DIPSSKDSED SNEDEEEDDE 430 440 450 460 470 480 EEDEEDDEDD ESDDSQSESD SNSESDTEGS EEEDDDDKDQ DESDSDTEGE KTSMKLNKTT 490 500 510 520 530 540 SSVKSPSMSL TGHSTPRNLH IAKAPGSAPA ALCSESQSPA FLGTSSSTLT SSPHSGTSKR 550 560 570 580 590 600 RRVTDERELR IPLEYGWQRE TRIRNFGGRL QGEVAYYAPC GKKLRQYPEV IKYLSRNGIM 610 620 630 640 650 660 DISRDNFSFS AKIRVGDFYE ARDGPQGMQW CLLKEEDVIP RIRAMEGRRG RPPNPDRQRA 670 680 690 700 710 720 REESRMRRRK GRPPNVGNAE FLDNADAKLL RKLQAQEIAR QAAQIKLLRK LQKQEQARVA 730 740 750 760 770 780 KEAKKQQAIM AAEEKRKQKE QIKIMKQQEK IKRIQQIRME KELRAQQILE AKKKKKEEAA 790 800 810 820 830 840 NAKLLEAEKR IKEKEMRRQQ AVLLKHQERE RRRQHMMLMK AMEARKKAEE KERLKQEKRD 850 860 870 880 890 900 EKRLNKERKL EQRRLELEMA KELKKPNEDM CLADQKPLPE LPRIPGLVLS GSTFSDCLMV 910 920 930 940 950 960 VQFLRNFGKV LGFDVNIDVP NLSVLQEGLL NIGDSMGEVQ DLLVRLLSAA VCDPGLITGY 970 980 990 1000 1010 1020 KAKTALGEHL LNVGVNRDNV SEILQIFMEA HCGQTELTES LKTKAFQAHT PAQKASVLAF 1030 1040 1050 1060 1070 1080 LINELACSKS VVSEIDKNID YMSNLRRDKW VVEGKLRKLR IIHAKKTGKR DTSGGIDLGE 1090 1100 1110 1120 1130 1140 EQHPLGTPTP GRKRRRKGGD SDYDDDDDDD SDDQGDEDDE DEEDKEDKKG KKTDICEDED 1150 1160 1170 1180 1190 1200 EGDQAASVEE LEKQIEKLSK QQSQYRRKLF DASHSLRSVM FGQDRYRRRY WILPQCGGIF 1210 1220 1230 1240 1250 1260 VEGMESGEGL EEIAKEREKL KKAESVQIKE EMFETSGDSL NCSNTDHCEQ KEDLKEKDNT 1270 1280 1290 1300 1310 1320 NLFLQKPGSF SKLSKLLEVA KMPPESEVMT PKPNAGANGC TLSYQNSGKH SLGSVQSTAT 1330 1340 1350 1360 1370 1380 QSNVEKADSN NLFNTGSSGP GKFYSPLPND QLLKTLTEKN RQWFSLLPRT PCDDTSLTHA 1390 1400 1410 1420 1430 1440 DMSTASLVTP QSQPPSKSPS PTPAPLGSSA QNPVGLNPFA LSPLQVKGGV SMMGLQFCGW 1450 1460 1470 1480 1490 1500 PTGVVTSNIP FTSSVPSLGS GLGLSEGNGN SFLTSNVASS KSESPVPQNE KATSAQPAAV 1510 1520 1530 1540 1550 1560 EVAKPVDFPS PKPIPEEMQF GWWRIIDPED LKALLKVLHL RGIREKALQK QIQKHLDYIT 1570 1580 1590 1600 1610 1620 QACLKNKDVA IIELNENEEN QVTRDIVENW SVEEQAMEMD LSVLQQVEDL ERRVASASLQ 1630 1640 1650 1660 1670 1680 VKGWMCPEPA SEREDLVYFE HKSFTKLCKE HDGEFTGEDE SSAHALERKS DNPLDIAVTR 1690 1700 1710 1720 1730 1740 LADLERNIER RIEEDIAPGL RVWRRALSEA RSAAQVALCI QQLQKSIAWE KSIMKVYCQI 1750 1760 1770 1780 1790 1800 CRKGDNEELL LLCDGCDKGC HTYCHRPKIT TIPDGDWFCP ACIAKASGQT LKIKKLHVKG 1810 1820 1830 1840 1850 1860 KKTNESKKGK KVTLTGDTED EDSASTSSSL KRGNKDLKKR KMEENTSINL SKQESFTSVK 1870 1880 1890 1900 1910 1920 KPKRDDSKDL ALCSMILTEM ETHEDAWPFL LPVNLKLVPG YKKVIKKPMD FSTIREKLSS 1930 1940 1950 1960 1970 GQYPNLETFA LDVRLVFDNC ETFNEDDSDI GRAGHNMRKY FEKKWTDTFK VS
	Isoform 5 [UniParc]. Checksum: 28286671FC56180F	FASTA	2,132	236,423
	10 20 30 40 50 60 MESGERLPSS AASSTTPTSS STPSVASVVS KGGLSTGVAS LSSTINPCGH LFRTAGDQPF 70 80 90 100 110 120 NLSTVSSAFP MVSHPVFGLH SASSGHSEFG GLGTLGTPTA LAAHPQLASF PEWWRTTDAH 130 140 150 160 170 180 TRTGATFFPP LLGIPPLFAP PAQNHDSSSF HSRTSGKSNR NGPEKGVNGS INGSNTSSVI 190 200 210 220 230 240 GINTSVLSTT ASSSMGQTKS TSSGGGNRKC NQEQSKNQPL DARVDKIKDK KPRKKAMESS 250 260 270 280 290 300 SNSDSDSGTS SDTSSEGISS SDSDDLEEDE EEEDQSIEES EDDDSDSESE AQHKSNNQVL 310 320 330 340 350 360 LHGISDPKAD GQKATEKAQE KRIHQPLPLA SESQTHSFQS QQKQPQVLSQ QLPFIFQSSQ 370 380 390 400 410 420 AKEESVNKHT SVIQSTGLVS NVKPLSLVNQ AKKETYMKLI VPSPDVLKAG NKNTSEESSL 430 440 450 460 470 480 LTSELRSKRE QYKQAFPSQL KKQESSKSLK KVIAALSNPK ATSSSPAHPK QTLENNHPNP 490 500 510 520 530 540 FLTNALLGNH QPNGVIQSVI QEAPLALTTK TKMQSKINEN IAAASSTPFS SPVNLSTSGR 550 560 570 580 590 600 RTPGNQTPVM PSASPILHSQ GKEKAVSNNV NPVKTQHHSH PAKSLVEQFR GTDSDIPSSK 610 620 630 640 650 660 DSEDSNEDEE EDDEEEDEED DEDDESDDSQ SESDSNSESD TEGSEEEDDD DKDQDESDSD 670 680 690 700 710 720 TEGEKTSMKL NKTTSSVKSP SMSLTGHSTP RNLHIAKAPG SAPAALCSES QSPAFLGTSS 730 740 750 760 770 780 STLTSSPHSG TSKRRRVTDE RELRIPLEYG WQRETRIRNF GGRLQGEVAY YAPCGKKLRQ 790 800 810 820 830 840 YPEVIKGMQW CLLKEEDVIP RIRAMEGRRG RPPNPDRQRA REESRMRRRK GRPPNVGNAE 850 860 870 880 890 900 FLDNADAKLL RKLQAQEIAR QAAQIKLLRK LQKQEQARVA KEAKKQQAIM AAEEKRKQKE 910 920 930 940 950 960 QIKIMKQQEK IKRIQQIRME KELRAQQILE AKKKKKEEAA NAKLLEAEKR IKEKEMRRQQ 970 980 990 1000 1010 1020 AVLLKHQERE RRRQHMMLMK AMEARKKAEE KERLKQEKRD EKRLNKERKL EQRRLELEMA 1030 1040 1050 1060 1070 1080 KELKKPNEDM CLADQKPLPE LPRIPGLVLS GSTFSDCLMV VQFLRNFGKV LGFDVNIDVP 1090 1100 1110 1120 1130 1140 NLSVLQEGLL NIGDSMGEVQ DLLVRLLSAA VCDPGLITGY KAKTALGEHL LNVGVNRDNV 1150 1160 1170 1180 1190 1200 SEILQIFMEA HCGQTELTES LKTKAFQAHT PAQKASVLAF LINELACSKS VVSEIDKNID 1210 1220 1230 1240 1250 1260 YMSNLRRDKW VVEGKLRKLR IIHAKKTGKR DTSGGIDLGE EQHPLGTPTP GRKRRRKGGD 1270 1280 1290 1300 1310 1320 SDYDDDDDDD SDDQGDEDDE DEEDKEDKKG KKTDICEDED EGDQAASVEE LEKQIEKLSK 1330 1340 1350 1360 1370 1380 QQSQYRRKLF DASHSLRSVM FGQDRYRRRY WILPQCGGIF VEGMESGEGL EEIAKEREKL 1390 1400 1410 1420 1430 1440 KKAESVQIKE EMFETSGDSL NCSNTDHCEQ KEDLKEKDNT NLFLQKPGSF SKLSKLLEVA 1450 1460 1470 1480 1490 1500 KMPPESEVMT PKPNAGANGC TLSYQNSGKH SLGSVQSTAT QSNVEKADSN NLFNTGSSGP 1510 1520 1530 1540 1550 1560 GKFYSPLPND QLLKTLTEKN RQWFSLLPRT PCDDTSLTHA DMSTASLVTP QSQPPSKSPS 1570 1580 1590 1600 1610 1620 PTPAPLGSSA QNPVGLNPFA LSPLQVKGGV SMMGLQFCGW PTGVVTSNIP FTSSVPSLGS 1630 1640 1650 1660 1670 1680 GLGLSEGNGN SFLTSNVASS KSESPVPQNE KATSAQPAAV EVAKPVDFPS PKPIPEEMQF 1690 1700 1710 1720 1730 1740 GWWRIIDPED LKALLKVLHL RGIREKALQK QIQKHLDYIT QACLKNKDVA IIELNENEEN 1750 1760 1770 1780 1790 1800 QVTRDIVENW SVEEQAMEMD LSVLQQVEDL ERRVASASLQ VKGWMCPEPA SEREDLVYFE 1810 1820 1830 1840 1850 1860 HKSFTKLCKE HDGEFTGEDE SSAHALERKS DNPLDIAVTR LADLERNIER RIEEDIAPGL 1870 1880 1890 1900 1910 1920 RVWRRALSEA RSAAQVALCI QQLQKSIAWE KSIMKVYCQI CRKGDNEELL LLCDGCDKGC 1930 1940 1950 1960 1970 1980 HTYCHRPKIT TIPDGDWFCP ACIAKASGQT LKIKKLHVKG KKTNESKKGK KVTLTGDTED 1990 2000 2010 2020 2030 2040 EDSASTSSSL KRGNKDLKKR KMEENTSINL SKQESFTSVK KPKRDDSKDL ALCSMILTEM 2050 2060 2070 2080 2090 2100 ETHEDAWPFL LPVNLKLVPG YKKVIKKPMD FSTIREKLSS GQYPNLETFA LDVRLVFDNC 2110 2120 2130 ETFNEDDSDI GRAGHNMRKY FEKKWTDTFK VS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel family of bromodomain genes." Jones M.H., Hamana N., Nezu J., Shimane M. Genomics 63:40-45(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Testis.
[2]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.
[3]	Ohara O., Nagase T., Kikuno R. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-967 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1720-2168 (ISOFORMS 1/2/3/4/5), VARIANTS THR-71 AND SER-422. Tissue: Melanoma and Testis.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-986 (ISOFORM 2), VARIANT SER-422. Tissue: Skeletal muscle.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 670-1411 (ISOFORM 3).
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1538, MASS SPECTROMETRY. Tissue: Mammary cancer.
[10]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1462, MASS SPECTROMETRY.
[11]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1680; THR-2014 AND SER-2019, MASS SPECTROMETRY.
[12]	"Solution structure of the bromodomain from human bromodomain adjacent to zinc finger domain 2B." RIKEN structural genomics initiative (RSGI) Submitted (JUL-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 2062-2166.
[13]	"Histone recognition and large-scale structural analysis of the human bromodomain family." Filippakopoulos P., Picaud S., Mangos M., Keates T., Lambert J.P., Barsyte-Lovejoy D., Felletar I., Volkmer R., Muller S., Pawson T., Gingras A.C., Arrowsmith C.H., Knapp S. Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF 2054-2168, SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB032255 mRNA. Translation: BAA89212.1.
AB040909 mRNA. Translation: BAA96000.2. Different initiation.
AL080173 mRNA. Translation: CAB45759.1.
AL834381 mRNA. Translation: CAD39044.2.
CH471058 Genomic DNA. Translation: EAX11404.1.
CH471058 Genomic DNA. Translation: EAX11405.1.
CH471058 Genomic DNA. Translation: EAX11407.1.
BC012576 mRNA. Translation: AAH12576.1. Sequence problems.
AK027612 mRNA. Translation: BAB55231.1. Different initiation.

IPI

IPI00061354.
IPI00220295.
IPI00873703.
IPI00916292.
IPI00929198.

PIR

T12495.

RefSeq

NP_038478.2. NM_013450.2.

UniGene

Hs.470369.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2E7O	NMR	-	A	2062-2166	[»]
3G0L	X-ray	2.03	A	2054-2168	[»]
3Q2F	X-ray	2.06	A	2054-2168	[»]
4IR3	X-ray	2.00	A	2054-2168	[»]
4IR4	X-ray	2.05	A	2054-2168	[»]
4IR5	X-ray	1.70	A	2054-2168	[»]
4IR6	X-ray	1.80	A	2054-2168	[»]

ProteinModelPortal

Q9UIF8.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9UIF8. 4 interactions.

MINT

MINT-1483920.

STRING

9606.ENSP00000376534.

PTM databases

PhosphoSite

Q9UIF8.

Polymorphism databases

DMDM

229462995.

Proteomic databases

PaxDb

Q9UIF8.

PRIDE

Q9UIF8.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000343439; ENSP00000339670; ENSG00000123636.
ENST00000355831; ENSP00000348087; ENSG00000123636.
ENST00000392782; ENSP00000376533; ENSG00000123636.
ENST00000392783; ENSP00000376534; ENSG00000123636.

GeneID

29994.

KEGG

hsa:29994.

UCSC

uc002uao.3. human.
uc002uap.3. human.

Organism-specific databases

CTD

29994.

GeneCards

GC02M160139.

H-InvDB

HIX0002531.

HGNC

HGNC:963. BAZ2B.

HPA

HPA019819.

MIM

605683. gene.

neXtProt

NX_Q9UIF8.

PharmGKB

PA25273.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5076.

HOGENOM

HOG000231981.

HOVERGEN

HBG050670.

InParanoid

Q9UIF8.

OMA

DSDDQAD.

OrthoDB

EOG4WH8JW.

Gene expression databases

ArrayExpress

Q9UIF8.

Bgee

Q9UIF8.

CleanEx

HS_BAZ2B.

Genevestigator

Q9UIF8.

GermOnline

ENSG00000123636. Homo sapiens.

Family and domain databases

Gene3D

1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
3.30.890.10. 1 hit.

InterPro

IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR004022. DDT_dom.
IPR018500. DDT_dom_subgr.
IPR018501. DDT_dom_superfamily.
IPR016177. DNA-bd_integrase-typ.
IPR001739. Methyl_CpG_DNA-bd.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Pfam

PF00439. Bromodomain. 1 hit.
PF02791. DDT. 1 hit.
PF01429. MBD. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]

PRINTS

PR00503. BROMODOMAIN.

SMART

SM00297. BROMO. 1 hit.
SM00571. DDT. 1 hit.
SM00391. MBD. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]

SUPFAM

SSF47370. Bromodomain. 1 hit.
SSF54171. DNA-binding_integrase-type. 1 hit.
SSF57903. FYVE_PHD_ZnF. 1 hit.

PROSITE

PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50827. DDT. 1 hit.
PS50982. MBD. 1 hit.
PS01359. ZF_PHD_1. False negative.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q9UIF8.

ChEMBL

CHEMBL1741220.

ChiTaRS

BAZ2B. human.

EvolutionaryTrace

Q9UIF8.

GenomeRNAi

29994.

NextBio

52792.

SOURCE

Search...

Entry information

Entry name

BAZ2B_HUMAN

Accession

Primary (citable) accession number: Q9UIF8
Secondary accession number(s): D3DPA8 , Q96EA1, Q96SQ8, Q9P252, Q9Y4N8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 127 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.