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Q9UIF8 (BAZ2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bromodomain adjacent to zinc finger domain protein 2B
Alternative name(s):
hWALp4
Gene names
Name:BAZ2B
Synonyms:KIAA1476
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2168 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in transcriptional regulation interacting with ISWI.

Subunit structure

Interacts with acetylated lysine residues on histone H1.4, H2A, H2B, H3 and H4 (in vitro). Ref.13

Subcellular location

Nucleus Potential.

Tissue specificity

Expressed at varying levels in several tissues, whereas a smaller transcript was expressed specifically in testis.

Sequence similarities

Belongs to the WAL family.

Contains 1 bromo domain.

Contains 1 DDT domain.

Contains 1 MBD (methyl-CpG-binding) domain.

Contains 1 PHD-type zinc finger.

Sequence caution

The sequence AAH12576.1 differs from that shown. Reason: Frameshift at position 927.

The sequence AAH12576.1 differs from that shown. Reason: contaminating sequence. Potential poly-A sequence.

The sequence BAA96000.2 differs from that shown. Reason: Erroneous initiation.

The sequence BAB55231.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9UIF8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UIF8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     112-113: Missing.
     633-730: Missing.
Isoform 3 (identifier: Q9UIF8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     789-822: Missing.
Isoform 4 (identifier: Q9UIF8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.
Isoform 5 (identifier: Q9UIF8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     112-113: Missing.
     789-822: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21682168Bromodomain adjacent to zinc finger domain protein 2B
PRO_0000211174

Regions

Domain739 – 81072MBD
Domain1087 – 115266DDT
Domain2077 – 214771Bromo
Zinc finger1931 – 198151PHD-type
Coiled coil883 – 1061179 Potential
Coiled coil1334 – 137542 Potential
Compositional bias149 – 265117Ser-rich
Compositional bias269 – 2757Poly-Glu
Compositional bias595 – 66672Asp/Glu-rich (acidic)
Compositional bias837 – 86832Arg-rich
Compositional bias902 – 1061160Lys-rich
Compositional bias1296 – 133944Asp-rich

Amino acid modifications

Modified residue14621N6-acetyllysine Ref.10
Modified residue16801Phosphoserine Ref.11
Modified residue20141Phosphothreonine Ref.11
Modified residue20191Phosphoserine Ref.11
Cross-link1538Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.9

Natural variations

Alternative sequence1 – 196196Missing in isoform 4.
VSP_037114
Alternative sequence112 – 1132Missing in isoform 2 and isoform 5.
VSP_037115
Alternative sequence633 – 73098Missing in isoform 2.
VSP_000553
Alternative sequence789 – 82234Missing in isoform 3 and isoform 5.
VSP_000554
Natural variant711M → T. Ref.5
Corresponds to variant rs10202670 [ dbSNP | Ensembl ].
VAR_055549
Natural variant4221L → S. Ref.5 Ref.6
Corresponds to variant rs3213790 [ dbSNP | Ensembl ].
VAR_055550
Natural variant5301P → L.
Corresponds to variant rs3732287 [ dbSNP | Ensembl ].
VAR_055551
Natural variant7021G → V.
Corresponds to variant rs2302924 [ dbSNP | Ensembl ].
VAR_055552
Natural variant20241S → N.
Corresponds to variant rs415793 [ dbSNP | Ensembl ].
VAR_055553

Experimental info

Sequence conflict951L → G in AAH12576. Ref.6
Sequence conflict3331S → F in BAA89212. Ref.1
Sequence conflict8231G → E in BAA89212. Ref.1
Sequence conflict9181E → K in AAH12576. Ref.6
Sequence conflict9861R → Q in AAH12576. Ref.6
Sequence conflict13241K → Q in BAA89212. Ref.1
Sequence conflict13791Q → P in BAA89212. Ref.1
Sequence conflict13911Q → R in BAA89212. Ref.1
Sequence conflict16491S → L in BAA89212. Ref.1
Sequence conflict20341K → Q in BAA89212. Ref.1

Secondary structure

................ 2168
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 5, 2009. Version 3.
Checksum: C64EEEE6243CF779

FASTA2,168240,459
        10         20         30         40         50         60 
MESGERLPSS AASSTTPTSS STPSVASVVS KGGLSTGVAS LSSTINPCGH LFRTAGDQPF 

        70         80         90        100        110        120 
NLSTVSSAFP MVSHPVFGLH SASSGHSEFG GLGTLGTPTA LAAHPQLASF PGAEWWRTTD 

       130        140        150        160        170        180 
AHTRTGATFF PPLLGIPPLF APPAQNHDSS SFHSRTSGKS NRNGPEKGVN GSINGSNTSS 

       190        200        210        220        230        240 
VIGINTSVLS TTASSSMGQT KSTSSGGGNR KCNQEQSKNQ PLDARVDKIK DKKPRKKAME 

       250        260        270        280        290        300 
SSSNSDSDSG TSSDTSSEGI SSSDSDDLEE DEEEEDQSIE ESEDDDSDSE SEAQHKSNNQ 

       310        320        330        340        350        360 
VLLHGISDPK ADGQKATEKA QEKRIHQPLP LASESQTHSF QSQQKQPQVL SQQLPFIFQS 

       370        380        390        400        410        420 
SQAKEESVNK HTSVIQSTGL VSNVKPLSLV NQAKKETYMK LIVPSPDVLK AGNKNTSEES 

       430        440        450        460        470        480 
SLLTSELRSK REQYKQAFPS QLKKQESSKS LKKVIAALSN PKATSSSPAH PKQTLENNHP 

       490        500        510        520        530        540 
NPFLTNALLG NHQPNGVIQS VIQEAPLALT TKTKMQSKIN ENIAAASSTP FSSPVNLSTS 

       550        560        570        580        590        600 
GRRTPGNQTP VMPSASPILH SQGKEKAVSN NVNPVKTQHH SHPAKSLVEQ FRGTDSDIPS 

       610        620        630        640        650        660 
SKDSEDSNED EEEDDEEEDE EDDEDDESDD SQSESDSNSE SDTEGSEEED DDDKDQDESD 

       670        680        690        700        710        720 
SDTEGEKTSM KLNKTTSSVK SPSMSLTGHS TPRNLHIAKA PGSAPAALCS ESQSPAFLGT 

       730        740        750        760        770        780 
SSSTLTSSPH SGTSKRRRVT DERELRIPLE YGWQRETRIR NFGGRLQGEV AYYAPCGKKL 

       790        800        810        820        830        840 
RQYPEVIKYL SRNGIMDISR DNFSFSAKIR VGDFYEARDG PQGMQWCLLK EEDVIPRIRA 

       850        860        870        880        890        900 
MEGRRGRPPN PDRQRAREES RMRRRKGRPP NVGNAEFLDN ADAKLLRKLQ AQEIARQAAQ 

       910        920        930        940        950        960 
IKLLRKLQKQ EQARVAKEAK KQQAIMAAEE KRKQKEQIKI MKQQEKIKRI QQIRMEKELR 

       970        980        990       1000       1010       1020 
AQQILEAKKK KKEEAANAKL LEAEKRIKEK EMRRQQAVLL KHQERERRRQ HMMLMKAMEA 

      1030       1040       1050       1060       1070       1080 
RKKAEEKERL KQEKRDEKRL NKERKLEQRR LELEMAKELK KPNEDMCLAD QKPLPELPRI 

      1090       1100       1110       1120       1130       1140 
PGLVLSGSTF SDCLMVVQFL RNFGKVLGFD VNIDVPNLSV LQEGLLNIGD SMGEVQDLLV 

      1150       1160       1170       1180       1190       1200 
RLLSAAVCDP GLITGYKAKT ALGEHLLNVG VNRDNVSEIL QIFMEAHCGQ TELTESLKTK 

      1210       1220       1230       1240       1250       1260 
AFQAHTPAQK ASVLAFLINE LACSKSVVSE IDKNIDYMSN LRRDKWVVEG KLRKLRIIHA 

      1270       1280       1290       1300       1310       1320 
KKTGKRDTSG GIDLGEEQHP LGTPTPGRKR RRKGGDSDYD DDDDDDSDDQ GDEDDEDEED 

      1330       1340       1350       1360       1370       1380 
KEDKKGKKTD ICEDEDEGDQ AASVEELEKQ IEKLSKQQSQ YRRKLFDASH SLRSVMFGQD 

      1390       1400       1410       1420       1430       1440 
RYRRRYWILP QCGGIFVEGM ESGEGLEEIA KEREKLKKAE SVQIKEEMFE TSGDSLNCSN 

      1450       1460       1470       1480       1490       1500 
TDHCEQKEDL KEKDNTNLFL QKPGSFSKLS KLLEVAKMPP ESEVMTPKPN AGANGCTLSY 

      1510       1520       1530       1540       1550       1560 
QNSGKHSLGS VQSTATQSNV EKADSNNLFN TGSSGPGKFY SPLPNDQLLK TLTEKNRQWF 

      1570       1580       1590       1600       1610       1620 
SLLPRTPCDD TSLTHADMST ASLVTPQSQP PSKSPSPTPA PLGSSAQNPV GLNPFALSPL 

      1630       1640       1650       1660       1670       1680 
QVKGGVSMMG LQFCGWPTGV VTSNIPFTSS VPSLGSGLGL SEGNGNSFLT SNVASSKSES 

      1690       1700       1710       1720       1730       1740 
PVPQNEKATS AQPAAVEVAK PVDFPSPKPI PEEMQFGWWR IIDPEDLKAL LKVLHLRGIR 

      1750       1760       1770       1780       1790       1800 
EKALQKQIQK HLDYITQACL KNKDVAIIEL NENEENQVTR DIVENWSVEE QAMEMDLSVL 

      1810       1820       1830       1840       1850       1860 
QQVEDLERRV ASASLQVKGW MCPEPASERE DLVYFEHKSF TKLCKEHDGE FTGEDESSAH 

      1870       1880       1890       1900       1910       1920 
ALERKSDNPL DIAVTRLADL ERNIERRIEE DIAPGLRVWR RALSEARSAA QVALCIQQLQ 

      1930       1940       1950       1960       1970       1980 
KSIAWEKSIM KVYCQICRKG DNEELLLLCD GCDKGCHTYC HRPKITTIPD GDWFCPACIA 

      1990       2000       2010       2020       2030       2040 
KASGQTLKIK KLHVKGKKTN ESKKGKKVTL TGDTEDEDSA STSSSLKRGN KDLKKRKMEE 

      2050       2060       2070       2080       2090       2100 
NTSINLSKQE SFTSVKKPKR DDSKDLALCS MILTEMETHE DAWPFLLPVN LKLVPGYKKV 

      2110       2120       2130       2140       2150       2160 
IKKPMDFSTI REKLSSGQYP NLETFALDVR LVFDNCETFN EDDSDIGRAG HNMRKYFEKK 


WTDTFKVS 

« Hide

Isoform 2 [UniParc].

Checksum: 324018D11EF97BAD
Show »

FASTA2,068230,154
Isoform 3 [UniParc].

Checksum: 6320F9BC6B744581
Show »

FASTA2,134236,551
Isoform 4 [UniParc].

Checksum: B3BA3FD40027174C
Show »

FASTA1,972220,710
Isoform 5 [UniParc].

Checksum: 28286671FC56180F
Show »

FASTA2,132236,423

References

« Hide 'large scale' references
[1]"A novel family of bromodomain genes."
Jones M.H., Hamana N., Nezu J., Shimane M.
Genomics 63:40-45(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
Tissue: Testis.
[2]"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
Tissue: Brain.
[3]Ohara O., Nagase T., Kikuno R.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-967 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1720-2168 (ISOFORMS 1/2/3/4/5), VARIANTS THR-71 AND SER-422.
Tissue: Melanoma and Testis.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-986 (ISOFORM 2), VARIANT SER-422.
Tissue: Skeletal muscle.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 670-1411 (ISOFORM 3).
[8]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1538.
Tissue: Mammary cancer.
[10]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1462, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1680; THR-2014 AND SER-2019, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Solution structure of the bromodomain from human bromodomain adjacent to zinc finger domain 2B."
RIKEN structural genomics initiative (RSGI)
Submitted (JUL-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 2062-2166.
[13]"Histone recognition and large-scale structural analysis of the human bromodomain family."
Filippakopoulos P., Picaud S., Mangos M., Keates T., Lambert J.P., Barsyte-Lovejoy D., Felletar I., Volkmer R., Muller S., Pawson T., Gingras A.C., Arrowsmith C.H., Knapp S.
Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF 2054-2168, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB032255 mRNA. Translation: BAA89212.1.
AB040909 mRNA. Translation: BAA96000.2. Different initiation.
AL080173 mRNA. Translation: CAB45759.1.
AL834381 mRNA. Translation: CAD39044.2.
CH471058 Genomic DNA. Translation: EAX11404.1.
CH471058 Genomic DNA. Translation: EAX11405.1.
CH471058 Genomic DNA. Translation: EAX11407.1.
BC012576 mRNA. Translation: AAH12576.1. Sequence problems.
AK027612 mRNA. Translation: BAB55231.1. Different initiation.
CCDSCCDS2209.2. [Q9UIF8-1]
PIRT12495.
RefSeqNP_001276904.1. NM_001289975.1. [Q9UIF8-5]
NP_038478.2. NM_013450.3. [Q9UIF8-1]
UniGeneHs.470369.
Hs.731786.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2E7ONMR-A2062-2166[»]
3G0LX-ray2.03A2054-2168[»]
3Q2FX-ray2.06A2054-2168[»]
4CUPX-ray1.88A2054-2168[»]
4CUQX-ray2.11A2054-2168[»]
4CURX-ray1.84A2054-2168[»]
4CUSX-ray1.78A2054-2168[»]
4CUTX-ray1.84A2054-2168[»]
4CUUX-ray1.80A2054-2168[»]
4IR3X-ray2.00A2054-2168[»]
4IR4X-ray2.05A2054-2168[»]
4IR5X-ray1.70A2054-2168[»]
4IR6X-ray1.80A2054-2168[»]
4NR9X-ray1.98A2054-2168[»]
4NRAX-ray1.85A2054-2168[»]
4NRBX-ray2.08A2054-2168[»]
4NRCX-ray1.86A2054-2168[»]
4QC1X-ray1.99A/B2062-2166[»]
4QC3X-ray1.60A/B2062-2166[»]
ProteinModelPortalQ9UIF8.
SMRQ9UIF8. Positions 748-806, 1929-2167.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119019. 5 interactions.
IntActQ9UIF8. 4 interactions.
MINTMINT-1483920.
STRING9606.ENSP00000376534.

Chemistry

BindingDBQ9UIF8.
ChEMBLCHEMBL1741220.

PTM databases

PhosphoSiteQ9UIF8.

Polymorphism databases

DMDM229462995.

Proteomic databases

MaxQBQ9UIF8.
PaxDbQ9UIF8.
PRIDEQ9UIF8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343439; ENSP00000339670; ENSG00000123636. [Q9UIF8-2]
ENST00000355831; ENSP00000348087; ENSG00000123636. [Q9UIF8-3]
ENST00000392782; ENSP00000376533; ENSG00000123636. [Q9UIF8-5]
ENST00000392783; ENSP00000376534; ENSG00000123636. [Q9UIF8-1]
GeneID29994.
KEGGhsa:29994.
UCSCuc002uao.3. human. [Q9UIF8-1]
uc002uap.3. human. [Q9UIF8-5]

Organism-specific databases

CTD29994.
GeneCardsGC02M160139.
H-InvDBHIX0002531.
HGNCHGNC:963. BAZ2B.
HPAHPA019819.
MIM605683. gene.
neXtProtNX_Q9UIF8.
PharmGKBPA25273.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5076.
HOGENOMHOG000231981.
HOVERGENHBG050670.
InParanoidQ9UIF8.
OMADSDDQAD.
OrthoDBEOG783MTG.
PhylomeDBQ9UIF8.
TreeFamTF329083.

Gene expression databases

ArrayExpressQ9UIF8.
BgeeQ9UIF8.
CleanExHS_BAZ2B.
GenevestigatorQ9UIF8.

Family and domain databases

Gene3D1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
3.30.890.10. 1 hit.
InterProIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR004022. DDT_dom.
IPR018500. DDT_dom_subgr.
IPR018501. DDT_dom_superfamily.
IPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00439. Bromodomain. 1 hit.
PF02791. DDT. 1 hit.
PF01429. MBD. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
PRINTSPR00503. BROMODOMAIN.
SMARTSM00297. BROMO. 1 hit.
SM00571. DDT. 1 hit.
SM00391. MBD. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMSSF47370. SSF47370. 1 hit.
SSF54171. SSF54171. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50827. DDT. 1 hit.
PS50982. MBD. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
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Other

ChiTaRSBAZ2B. human.
EvolutionaryTraceQ9UIF8.
GenomeRNAi29994.
NextBio52792.
PROQ9UIF8.
SOURCESearch...

Entry information

Entry nameBAZ2B_HUMAN
AccessionPrimary (citable) accession number: Q9UIF8
Secondary accession number(s): D3DPA8 expand/collapse secondary AC list , Q96EA1, Q96SQ8, Q9P252, Q9Y4N8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM