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Protein

Bromodomain adjacent to zinc finger domain protein 2B

Gene

BAZ2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in transcriptional regulation interacting with ISWI.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1931 – 1981PHD-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: BHF-UCL
  • transcription, DNA-templated Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123636-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain adjacent to zinc finger domain protein 2B
Alternative name(s):
hWALp4
Gene namesi
Name:BAZ2B
Synonyms:KIAA1476
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:963. BAZ2B.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29994.
OpenTargetsiENSG00000123636.
PharmGKBiPA25273.

Chemistry databases

ChEMBLiCHEMBL1741220.
GuidetoPHARMACOLOGYi2722.

Polymorphism and mutation databases

BioMutaiBAZ2B.
DMDMi229462995.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002111741 – 2168Bromodomain adjacent to zinc finger domain protein 2BAdd BLAST2168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1462N6-acetyllysineCombined sources1
Modified residuei1465PhosphoserineCombined sources1
Modified residuei1467PhosphoserineCombined sources1
Modified residuei1680PhosphoserineCombined sources1
Modified residuei2014PhosphothreonineCombined sources1
Modified residuei2019PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UIF8.
PaxDbiQ9UIF8.
PeptideAtlasiQ9UIF8.
PRIDEiQ9UIF8.

PTM databases

iPTMnetiQ9UIF8.
PhosphoSitePlusiQ9UIF8.

Expressioni

Tissue specificityi

Expressed at varying levels in several tissues, whereas a smaller transcript was expressed specifically in testis.

Gene expression databases

BgeeiENSG00000123636.
CleanExiHS_BAZ2B.
ExpressionAtlasiQ9UIF8. baseline and differential.
GenevisibleiQ9UIF8. HS.

Organism-specific databases

HPAiHPA019819.

Interactioni

Subunit structurei

Interacts with acetylated lysine residues on histone H1.4, H2A, H2B, H3 and H4 (in vitro).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP2Q8IY443EBI-10321972,EBI-10171902
FXR2P511163EBI-10321972,EBI-740459
STAC3Q96MF23EBI-10321972,EBI-745680
ZBTB14O438293EBI-10321972,EBI-10176632
ZBTB8AQ96BR93EBI-10321972,EBI-742740

Protein-protein interaction databases

BioGridi119019. 13 interactors.
IntActiQ9UIF8. 11 interactors.
MINTiMINT-1483920.
STRINGi9606.ENSP00000376534.

Chemistry databases

BindingDBiQ9UIF8.

Structurei

Secondary structure

12168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni1935 – 1937Combined sources3
Helixi1943 – 1945Combined sources3
Beta strandi1946 – 1949Combined sources4
Turni1950 – 1952Combined sources3
Beta strandi1955 – 1957Combined sources3
Turni1958 – 1960Combined sources3
Beta strandi1961 – 1963Combined sources3
Helixi1976 – 1982Combined sources7
Helixi2063 – 2077Combined sources15
Helixi2080 – 2082Combined sources3
Helixi2083 – 2085Combined sources3
Turni2091 – 2093Combined sources3
Beta strandi2094 – 2096Combined sources3
Helixi2097 – 2100Combined sources4
Helixi2107 – 2115Combined sources9
Helixi2122 – 2139Combined sources18
Beta strandi2142 – 2144Combined sources3
Helixi2145 – 2165Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E7ONMR-A2062-2166[»]
3G0LX-ray2.03A2054-2168[»]
3Q2FX-ray2.06A2054-2168[»]
4CUPX-ray1.88A2054-2168[»]
4CUQX-ray2.11A2054-2168[»]
4CURX-ray1.84A2054-2168[»]
4CUSX-ray1.78A2054-2168[»]
4CUTX-ray1.84A2054-2168[»]
4CUUX-ray1.80A2054-2168[»]
4IR3X-ray2.00A2054-2168[»]
4IR4X-ray2.05A2054-2168[»]
4IR5X-ray1.70A2054-2168[»]
4IR6X-ray1.80A2054-2168[»]
4NR9X-ray1.98A2054-2168[»]
4NRAX-ray1.85A2054-2168[»]
4NRBX-ray2.08A2054-2168[»]
4NRCX-ray1.86A2054-2168[»]
4QC1X-ray1.99A/B2062-2166[»]
4QC3X-ray1.60A/B2062-2166[»]
4QF3X-ray1.60A/B1928-1983[»]
4RVRX-ray1.98A2054-2168[»]
4XUAX-ray1.75A2054-2168[»]
4XUBX-ray1.98A2054-2168[»]
5CQ3X-ray1.93A2054-2168[»]
5CQ4X-ray1.78A2054-2168[»]
5CQ5X-ray1.96A2054-2168[»]
5CQ6X-ray1.97A2054-2168[»]
5CQ7X-ray1.86A2054-2166[»]
5CQ8X-ray1.65A2054-2168[»]
5CQAX-ray2.13A2054-2166[»]
5CU8X-ray2.05A2054-2166[»]
5CUAX-ray1.89A2054-2168[»]
5CUBX-ray2.10A2054-2166[»]
5CUCX-ray1.85A2054-2166[»]
5CUDX-ray1.75A2054-2168[»]
5CUEX-ray2.08A2054-2166[»]
5CUGX-ray1.78A2054-2168[»]
5DYUX-ray1.65A2054-2167[»]
5DYXX-ray1.85A2054-2167[»]
5E73X-ray1.71A2054-2167[»]
5E74X-ray1.78A2054-2167[»]
5E9IX-ray1.96A2054-2167[»]
5E9KX-ray2.07A2054-2167[»]
5E9LX-ray1.90A2054-2167[»]
5E9MX-ray1.78A2054-2167[»]
5E9YX-ray1.65A2054-2167[»]
ProteinModelPortaliQ9UIF8.
SMRiQ9UIF8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UIF8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini739 – 810MBDPROSITE-ProRule annotationAdd BLAST72
Domaini1087 – 1152DDTPROSITE-ProRule annotationAdd BLAST66
Domaini2077 – 2147BromoPROSITE-ProRule annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili883 – 1061Sequence analysisAdd BLAST179
Coiled coili1334 – 1375Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi149 – 265Ser-richAdd BLAST117
Compositional biasi269 – 275Poly-Glu7
Compositional biasi595 – 666Asp/Glu-rich (acidic)Add BLAST72
Compositional biasi837 – 868Arg-richAdd BLAST32
Compositional biasi902 – 1061Lys-richAdd BLAST160
Compositional biasi1296 – 1339Asp-richAdd BLAST44

Sequence similaritiesi

Belongs to the WAL family.Curated
Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 DDT domain.PROSITE-ProRule annotation
Contains 1 MBD (methyl-CpG-binding) domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1931 – 1981PHD-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Bromodomain, Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1245. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119099.
HOGENOMiHOG000231981.
HOVERGENiHBG050670.
InParanoidiQ9UIF8.
OMAiQMKSGVS.
OrthoDBiEOG091G00WO.
PhylomeDBiQ9UIF8.
TreeFamiTF329083.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
3.30.890.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR018501. DDT_dom.
IPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR028941. WHIM2_dom.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF02791. DDT. 1 hit.
PF01429. MBD. 1 hit.
PF00628. PHD. 1 hit.
PF15613. WSD. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00571. DDT. 1 hit.
SM00391. MBD. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF54171. SSF54171. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50827. DDT. 1 hit.
PS50982. MBD. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9UIF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESGERLPSS AASSTTPTSS STPSVASVVS KGGLSTGVAS LSSTINPCGH
60 70 80 90 100
LFRTAGDQPF NLSTVSSAFP MVSHPVFGLH SASSGHSEFG GLGTLGTPTA
110 120 130 140 150
LAAHPQLASF PGAEWWRTTD AHTRTGATFF PPLLGIPPLF APPAQNHDSS
160 170 180 190 200
SFHSRTSGKS NRNGPEKGVN GSINGSNTSS VIGINTSVLS TTASSSMGQT
210 220 230 240 250
KSTSSGGGNR KCNQEQSKNQ PLDARVDKIK DKKPRKKAME SSSNSDSDSG
260 270 280 290 300
TSSDTSSEGI SSSDSDDLEE DEEEEDQSIE ESEDDDSDSE SEAQHKSNNQ
310 320 330 340 350
VLLHGISDPK ADGQKATEKA QEKRIHQPLP LASESQTHSF QSQQKQPQVL
360 370 380 390 400
SQQLPFIFQS SQAKEESVNK HTSVIQSTGL VSNVKPLSLV NQAKKETYMK
410 420 430 440 450
LIVPSPDVLK AGNKNTSEES SLLTSELRSK REQYKQAFPS QLKKQESSKS
460 470 480 490 500
LKKVIAALSN PKATSSSPAH PKQTLENNHP NPFLTNALLG NHQPNGVIQS
510 520 530 540 550
VIQEAPLALT TKTKMQSKIN ENIAAASSTP FSSPVNLSTS GRRTPGNQTP
560 570 580 590 600
VMPSASPILH SQGKEKAVSN NVNPVKTQHH SHPAKSLVEQ FRGTDSDIPS
610 620 630 640 650
SKDSEDSNED EEEDDEEEDE EDDEDDESDD SQSESDSNSE SDTEGSEEED
660 670 680 690 700
DDDKDQDESD SDTEGEKTSM KLNKTTSSVK SPSMSLTGHS TPRNLHIAKA
710 720 730 740 750
PGSAPAALCS ESQSPAFLGT SSSTLTSSPH SGTSKRRRVT DERELRIPLE
760 770 780 790 800
YGWQRETRIR NFGGRLQGEV AYYAPCGKKL RQYPEVIKYL SRNGIMDISR
810 820 830 840 850
DNFSFSAKIR VGDFYEARDG PQGMQWCLLK EEDVIPRIRA MEGRRGRPPN
860 870 880 890 900
PDRQRAREES RMRRRKGRPP NVGNAEFLDN ADAKLLRKLQ AQEIARQAAQ
910 920 930 940 950
IKLLRKLQKQ EQARVAKEAK KQQAIMAAEE KRKQKEQIKI MKQQEKIKRI
960 970 980 990 1000
QQIRMEKELR AQQILEAKKK KKEEAANAKL LEAEKRIKEK EMRRQQAVLL
1010 1020 1030 1040 1050
KHQERERRRQ HMMLMKAMEA RKKAEEKERL KQEKRDEKRL NKERKLEQRR
1060 1070 1080 1090 1100
LELEMAKELK KPNEDMCLAD QKPLPELPRI PGLVLSGSTF SDCLMVVQFL
1110 1120 1130 1140 1150
RNFGKVLGFD VNIDVPNLSV LQEGLLNIGD SMGEVQDLLV RLLSAAVCDP
1160 1170 1180 1190 1200
GLITGYKAKT ALGEHLLNVG VNRDNVSEIL QIFMEAHCGQ TELTESLKTK
1210 1220 1230 1240 1250
AFQAHTPAQK ASVLAFLINE LACSKSVVSE IDKNIDYMSN LRRDKWVVEG
1260 1270 1280 1290 1300
KLRKLRIIHA KKTGKRDTSG GIDLGEEQHP LGTPTPGRKR RRKGGDSDYD
1310 1320 1330 1340 1350
DDDDDDSDDQ GDEDDEDEED KEDKKGKKTD ICEDEDEGDQ AASVEELEKQ
1360 1370 1380 1390 1400
IEKLSKQQSQ YRRKLFDASH SLRSVMFGQD RYRRRYWILP QCGGIFVEGM
1410 1420 1430 1440 1450
ESGEGLEEIA KEREKLKKAE SVQIKEEMFE TSGDSLNCSN TDHCEQKEDL
1460 1470 1480 1490 1500
KEKDNTNLFL QKPGSFSKLS KLLEVAKMPP ESEVMTPKPN AGANGCTLSY
1510 1520 1530 1540 1550
QNSGKHSLGS VQSTATQSNV EKADSNNLFN TGSSGPGKFY SPLPNDQLLK
1560 1570 1580 1590 1600
TLTEKNRQWF SLLPRTPCDD TSLTHADMST ASLVTPQSQP PSKSPSPTPA
1610 1620 1630 1640 1650
PLGSSAQNPV GLNPFALSPL QVKGGVSMMG LQFCGWPTGV VTSNIPFTSS
1660 1670 1680 1690 1700
VPSLGSGLGL SEGNGNSFLT SNVASSKSES PVPQNEKATS AQPAAVEVAK
1710 1720 1730 1740 1750
PVDFPSPKPI PEEMQFGWWR IIDPEDLKAL LKVLHLRGIR EKALQKQIQK
1760 1770 1780 1790 1800
HLDYITQACL KNKDVAIIEL NENEENQVTR DIVENWSVEE QAMEMDLSVL
1810 1820 1830 1840 1850
QQVEDLERRV ASASLQVKGW MCPEPASERE DLVYFEHKSF TKLCKEHDGE
1860 1870 1880 1890 1900
FTGEDESSAH ALERKSDNPL DIAVTRLADL ERNIERRIEE DIAPGLRVWR
1910 1920 1930 1940 1950
RALSEARSAA QVALCIQQLQ KSIAWEKSIM KVYCQICRKG DNEELLLLCD
1960 1970 1980 1990 2000
GCDKGCHTYC HRPKITTIPD GDWFCPACIA KASGQTLKIK KLHVKGKKTN
2010 2020 2030 2040 2050
ESKKGKKVTL TGDTEDEDSA STSSSLKRGN KDLKKRKMEE NTSINLSKQE
2060 2070 2080 2090 2100
SFTSVKKPKR DDSKDLALCS MILTEMETHE DAWPFLLPVN LKLVPGYKKV
2110 2120 2130 2140 2150
IKKPMDFSTI REKLSSGQYP NLETFALDVR LVFDNCETFN EDDSDIGRAG
2160
HNMRKYFEKK WTDTFKVS
Length:2,168
Mass (Da):240,459
Last modified:May 5, 2009 - v3
Checksum:iC64EEEE6243CF779
GO
Isoform 2 (identifier: Q9UIF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-113: Missing.
     633-730: Missing.

Show »
Length:2,068
Mass (Da):230,154
Checksum:i324018D11EF97BAD
GO
Isoform 3 (identifier: Q9UIF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     789-822: Missing.

Show »
Length:2,134
Mass (Da):236,551
Checksum:i6320F9BC6B744581
GO
Isoform 4 (identifier: Q9UIF8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Show »
Length:1,972
Mass (Da):220,710
Checksum:iB3BA3FD40027174C
GO
Isoform 5 (identifier: Q9UIF8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-113: Missing.
     789-822: Missing.

Show »
Length:2,132
Mass (Da):236,423
Checksum:i28286671FC56180F
GO

Sequence cautioni

The sequence AAH12576 differs from that shown. contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH12576 differs from that shown. Reason: Frameshift at position 927.Curated
The sequence BAA96000 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55231 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95L → G in AAH12576 (PubMed:15489334).Curated1
Sequence conflicti333S → F in BAA89212 (PubMed:10662543).Curated1
Sequence conflicti823G → E in BAA89212 (PubMed:10662543).Curated1
Sequence conflicti918E → K in AAH12576 (PubMed:15489334).Curated1
Sequence conflicti986R → Q in AAH12576 (PubMed:15489334).Curated1
Sequence conflicti1324K → Q in BAA89212 (PubMed:10662543).Curated1
Sequence conflicti1379Q → P in BAA89212 (PubMed:10662543).Curated1
Sequence conflicti1391Q → R in BAA89212 (PubMed:10662543).Curated1
Sequence conflicti1649S → L in BAA89212 (PubMed:10662543).Curated1
Sequence conflicti2034K → Q in BAA89212 (PubMed:10662543).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05554971M → T.1 PublicationCorresponds to variant rs10202670dbSNPEnsembl.1
Natural variantiVAR_055550422L → S.2 PublicationsCorresponds to variant rs3213790dbSNPEnsembl.1
Natural variantiVAR_055551530P → L.Corresponds to variant rs3732287dbSNPEnsembl.1
Natural variantiVAR_055552702G → V.Corresponds to variant rs2302924dbSNPEnsembl.1
Natural variantiVAR_0555532024S → N.Corresponds to variant rs415793dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0371141 – 196Missing in isoform 4. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_037115112 – 113Missing in isoform 2 and isoform 5. 2 Publications2
Alternative sequenceiVSP_000553633 – 730Missing in isoform 2. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_000554789 – 822Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032255 mRNA. Translation: BAA89212.1.
AB040909 mRNA. Translation: BAA96000.2. Different initiation.
AL080173 mRNA. Translation: CAB45759.1.
AL834381 mRNA. Translation: CAD39044.2.
CH471058 Genomic DNA. Translation: EAX11404.1.
CH471058 Genomic DNA. Translation: EAX11405.1.
CH471058 Genomic DNA. Translation: EAX11407.1.
BC012576 mRNA. Translation: AAH12576.1. Sequence problems.
AK027612 mRNA. Translation: BAB55231.1. Different initiation.
CCDSiCCDS2209.2. [Q9UIF8-1]
CCDS74594.1. [Q9UIF8-5]
PIRiT12495.
RefSeqiNP_001276904.1. NM_001289975.1. [Q9UIF8-5]
NP_038478.2. NM_013450.3. [Q9UIF8-1]
UniGeneiHs.470369.
Hs.731786.

Genome annotation databases

EnsembliENST00000392782; ENSP00000376533; ENSG00000123636. [Q9UIF8-5]
ENST00000392783; ENSP00000376534; ENSG00000123636. [Q9UIF8-1]
GeneIDi29994.
KEGGihsa:29994.
UCSCiuc002uao.4. human. [Q9UIF8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032255 mRNA. Translation: BAA89212.1.
AB040909 mRNA. Translation: BAA96000.2. Different initiation.
AL080173 mRNA. Translation: CAB45759.1.
AL834381 mRNA. Translation: CAD39044.2.
CH471058 Genomic DNA. Translation: EAX11404.1.
CH471058 Genomic DNA. Translation: EAX11405.1.
CH471058 Genomic DNA. Translation: EAX11407.1.
BC012576 mRNA. Translation: AAH12576.1. Sequence problems.
AK027612 mRNA. Translation: BAB55231.1. Different initiation.
CCDSiCCDS2209.2. [Q9UIF8-1]
CCDS74594.1. [Q9UIF8-5]
PIRiT12495.
RefSeqiNP_001276904.1. NM_001289975.1. [Q9UIF8-5]
NP_038478.2. NM_013450.3. [Q9UIF8-1]
UniGeneiHs.470369.
Hs.731786.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E7ONMR-A2062-2166[»]
3G0LX-ray2.03A2054-2168[»]
3Q2FX-ray2.06A2054-2168[»]
4CUPX-ray1.88A2054-2168[»]
4CUQX-ray2.11A2054-2168[»]
4CURX-ray1.84A2054-2168[»]
4CUSX-ray1.78A2054-2168[»]
4CUTX-ray1.84A2054-2168[»]
4CUUX-ray1.80A2054-2168[»]
4IR3X-ray2.00A2054-2168[»]
4IR4X-ray2.05A2054-2168[»]
4IR5X-ray1.70A2054-2168[»]
4IR6X-ray1.80A2054-2168[»]
4NR9X-ray1.98A2054-2168[»]
4NRAX-ray1.85A2054-2168[»]
4NRBX-ray2.08A2054-2168[»]
4NRCX-ray1.86A2054-2168[»]
4QC1X-ray1.99A/B2062-2166[»]
4QC3X-ray1.60A/B2062-2166[»]
4QF3X-ray1.60A/B1928-1983[»]
4RVRX-ray1.98A2054-2168[»]
4XUAX-ray1.75A2054-2168[»]
4XUBX-ray1.98A2054-2168[»]
5CQ3X-ray1.93A2054-2168[»]
5CQ4X-ray1.78A2054-2168[»]
5CQ5X-ray1.96A2054-2168[»]
5CQ6X-ray1.97A2054-2168[»]
5CQ7X-ray1.86A2054-2166[»]
5CQ8X-ray1.65A2054-2168[»]
5CQAX-ray2.13A2054-2166[»]
5CU8X-ray2.05A2054-2166[»]
5CUAX-ray1.89A2054-2168[»]
5CUBX-ray2.10A2054-2166[»]
5CUCX-ray1.85A2054-2166[»]
5CUDX-ray1.75A2054-2168[»]
5CUEX-ray2.08A2054-2166[»]
5CUGX-ray1.78A2054-2168[»]
5DYUX-ray1.65A2054-2167[»]
5DYXX-ray1.85A2054-2167[»]
5E73X-ray1.71A2054-2167[»]
5E74X-ray1.78A2054-2167[»]
5E9IX-ray1.96A2054-2167[»]
5E9KX-ray2.07A2054-2167[»]
5E9LX-ray1.90A2054-2167[»]
5E9MX-ray1.78A2054-2167[»]
5E9YX-ray1.65A2054-2167[»]
ProteinModelPortaliQ9UIF8.
SMRiQ9UIF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119019. 13 interactors.
IntActiQ9UIF8. 11 interactors.
MINTiMINT-1483920.
STRINGi9606.ENSP00000376534.

Chemistry databases

BindingDBiQ9UIF8.
ChEMBLiCHEMBL1741220.
GuidetoPHARMACOLOGYi2722.

PTM databases

iPTMnetiQ9UIF8.
PhosphoSitePlusiQ9UIF8.

Polymorphism and mutation databases

BioMutaiBAZ2B.
DMDMi229462995.

Proteomic databases

EPDiQ9UIF8.
PaxDbiQ9UIF8.
PeptideAtlasiQ9UIF8.
PRIDEiQ9UIF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392782; ENSP00000376533; ENSG00000123636. [Q9UIF8-5]
ENST00000392783; ENSP00000376534; ENSG00000123636. [Q9UIF8-1]
GeneIDi29994.
KEGGihsa:29994.
UCSCiuc002uao.4. human. [Q9UIF8-1]

Organism-specific databases

CTDi29994.
DisGeNETi29994.
GeneCardsiBAZ2B.
H-InvDBHIX0002531.
HGNCiHGNC:963. BAZ2B.
HPAiHPA019819.
MIMi605683. gene.
neXtProtiNX_Q9UIF8.
OpenTargetsiENSG00000123636.
PharmGKBiPA25273.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1245. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119099.
HOGENOMiHOG000231981.
HOVERGENiHBG050670.
InParanoidiQ9UIF8.
OMAiQMKSGVS.
OrthoDBiEOG091G00WO.
PhylomeDBiQ9UIF8.
TreeFamiTF329083.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123636-MONOMER.

Miscellaneous databases

ChiTaRSiBAZ2B. human.
EvolutionaryTraceiQ9UIF8.
GenomeRNAii29994.
PROiQ9UIF8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123636.
CleanExiHS_BAZ2B.
ExpressionAtlasiQ9UIF8. baseline and differential.
GenevisibleiQ9UIF8. HS.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
3.30.890.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR018501. DDT_dom.
IPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR028941. WHIM2_dom.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF02791. DDT. 1 hit.
PF01429. MBD. 1 hit.
PF00628. PHD. 1 hit.
PF15613. WSD. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00571. DDT. 1 hit.
SM00391. MBD. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF54171. SSF54171. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50827. DDT. 1 hit.
PS50982. MBD. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAZ2B_HUMAN
AccessioniPrimary (citable) accession number: Q9UIF8
Secondary accession number(s): D3DPA8
, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 163 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.