Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UIF8

- BAZ2B_HUMAN

UniProt

Q9UIF8 - BAZ2B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bromodomain adjacent to zinc finger domain protein 2B

Gene

BAZ2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in transcriptional regulation interacting with ISWI.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1931 – 198151PHD-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: BHF-UCL
  2. transcription, DNA-templated Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain adjacent to zinc finger domain protein 2B
Alternative name(s):
hWALp4
Gene namesi
Name:BAZ2B
Synonyms:KIAA1476
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:963. BAZ2B.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25273.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21682168Bromodomain adjacent to zinc finger domain protein 2BPRO_0000211174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1462 – 14621N6-acetyllysine1 Publication
Cross-linki1538 – 1538Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei1680 – 16801Phosphoserine1 Publication
Modified residuei2014 – 20141Phosphothreonine1 Publication
Modified residuei2019 – 20191Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9UIF8.
PaxDbiQ9UIF8.
PRIDEiQ9UIF8.

PTM databases

PhosphoSiteiQ9UIF8.

Expressioni

Tissue specificityi

Expressed at varying levels in several tissues, whereas a smaller transcript was expressed specifically in testis.

Gene expression databases

BgeeiQ9UIF8.
CleanExiHS_BAZ2B.
ExpressionAtlasiQ9UIF8. baseline and differential.
GenevestigatoriQ9UIF8.

Organism-specific databases

HPAiHPA019819.

Interactioni

Subunit structurei

Interacts with acetylated lysine residues on histone H1.4, H2A, H2B, H3 and H4 (in vitro).1 Publication

Protein-protein interaction databases

BioGridi119019. 5 interactions.
IntActiQ9UIF8. 4 interactions.
MINTiMINT-1483920.
STRINGi9606.ENSP00000376534.

Structurei

Secondary structure

1
2168
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni1935 – 19373Combined sources
Helixi1943 – 19453Combined sources
Beta strandi1946 – 19494Combined sources
Turni1950 – 19523Combined sources
Beta strandi1955 – 19573Combined sources
Turni1958 – 19603Combined sources
Beta strandi1961 – 19633Combined sources
Helixi1976 – 19827Combined sources
Helixi2063 – 207715Combined sources
Helixi2080 – 20823Combined sources
Helixi2083 – 20853Combined sources
Turni2091 – 20933Combined sources
Beta strandi2094 – 20963Combined sources
Helixi2097 – 21004Combined sources
Helixi2107 – 21159Combined sources
Helixi2122 – 213918Combined sources
Beta strandi2142 – 21443Combined sources
Helixi2145 – 216521Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E7ONMR-A2062-2166[»]
3G0LX-ray2.03A2054-2168[»]
3Q2FX-ray2.06A2054-2168[»]
4CUPX-ray1.88A2054-2168[»]
4CUQX-ray2.11A2054-2168[»]
4CURX-ray1.84A2054-2168[»]
4CUSX-ray1.78A2054-2168[»]
4CUTX-ray1.84A2054-2168[»]
4CUUX-ray1.80A2054-2168[»]
4IR3X-ray2.00A2054-2168[»]
4IR4X-ray2.05A2054-2168[»]
4IR5X-ray1.70A2054-2168[»]
4IR6X-ray1.80A2054-2168[»]
4NR9X-ray1.98A2054-2168[»]
4NRAX-ray1.85A2054-2168[»]
4NRBX-ray2.08A2054-2168[»]
4NRCX-ray1.86A2054-2168[»]
4QC1X-ray1.99A/B2062-2166[»]
4QC3X-ray1.60A/B2062-2166[»]
4QF3X-ray1.60A/B1928-1983[»]
ProteinModelPortaliQ9UIF8.
SMRiQ9UIF8. Positions 1928-2166.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UIF8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini739 – 81072MBDPROSITE-ProRule annotationAdd
BLAST
Domaini1087 – 115266DDTPROSITE-ProRule annotationAdd
BLAST
Domaini2077 – 214771BromoPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili883 – 1061179Sequence AnalysisAdd
BLAST
Coiled coili1334 – 137542Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi149 – 265117Ser-richAdd
BLAST
Compositional biasi269 – 2757Poly-Glu
Compositional biasi595 – 66672Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi837 – 86832Arg-richAdd
BLAST
Compositional biasi902 – 1061160Lys-richAdd
BLAST
Compositional biasi1296 – 133944Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the WAL family.Curated
Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 DDT domain.PROSITE-ProRule annotation
Contains 1 MBD (methyl-CpG-binding) domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1931 – 198151PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Bromodomain, Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiCOG5076.
GeneTreeiENSGT00760000119099.
HOGENOMiHOG000231981.
HOVERGENiHBG050670.
InParanoidiQ9UIF8.
OMAiDSDDQAD.
OrthoDBiEOG783MTG.
PhylomeDBiQ9UIF8.
TreeFamiTF329083.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
3.30.890.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR004022. DDT_dom.
IPR018500. DDT_dom_subgr.
IPR018501. DDT_dom_superfamily.
IPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF02791. DDT. 1 hit.
PF01429. MBD. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00571. DDT. 1 hit.
SM00391. MBD. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF54171. SSF54171. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50827. DDT. 1 hit.
PS50982. MBD. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9UIF8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESGERLPSS AASSTTPTSS STPSVASVVS KGGLSTGVAS LSSTINPCGH
60 70 80 90 100
LFRTAGDQPF NLSTVSSAFP MVSHPVFGLH SASSGHSEFG GLGTLGTPTA
110 120 130 140 150
LAAHPQLASF PGAEWWRTTD AHTRTGATFF PPLLGIPPLF APPAQNHDSS
160 170 180 190 200
SFHSRTSGKS NRNGPEKGVN GSINGSNTSS VIGINTSVLS TTASSSMGQT
210 220 230 240 250
KSTSSGGGNR KCNQEQSKNQ PLDARVDKIK DKKPRKKAME SSSNSDSDSG
260 270 280 290 300
TSSDTSSEGI SSSDSDDLEE DEEEEDQSIE ESEDDDSDSE SEAQHKSNNQ
310 320 330 340 350
VLLHGISDPK ADGQKATEKA QEKRIHQPLP LASESQTHSF QSQQKQPQVL
360 370 380 390 400
SQQLPFIFQS SQAKEESVNK HTSVIQSTGL VSNVKPLSLV NQAKKETYMK
410 420 430 440 450
LIVPSPDVLK AGNKNTSEES SLLTSELRSK REQYKQAFPS QLKKQESSKS
460 470 480 490 500
LKKVIAALSN PKATSSSPAH PKQTLENNHP NPFLTNALLG NHQPNGVIQS
510 520 530 540 550
VIQEAPLALT TKTKMQSKIN ENIAAASSTP FSSPVNLSTS GRRTPGNQTP
560 570 580 590 600
VMPSASPILH SQGKEKAVSN NVNPVKTQHH SHPAKSLVEQ FRGTDSDIPS
610 620 630 640 650
SKDSEDSNED EEEDDEEEDE EDDEDDESDD SQSESDSNSE SDTEGSEEED
660 670 680 690 700
DDDKDQDESD SDTEGEKTSM KLNKTTSSVK SPSMSLTGHS TPRNLHIAKA
710 720 730 740 750
PGSAPAALCS ESQSPAFLGT SSSTLTSSPH SGTSKRRRVT DERELRIPLE
760 770 780 790 800
YGWQRETRIR NFGGRLQGEV AYYAPCGKKL RQYPEVIKYL SRNGIMDISR
810 820 830 840 850
DNFSFSAKIR VGDFYEARDG PQGMQWCLLK EEDVIPRIRA MEGRRGRPPN
860 870 880 890 900
PDRQRAREES RMRRRKGRPP NVGNAEFLDN ADAKLLRKLQ AQEIARQAAQ
910 920 930 940 950
IKLLRKLQKQ EQARVAKEAK KQQAIMAAEE KRKQKEQIKI MKQQEKIKRI
960 970 980 990 1000
QQIRMEKELR AQQILEAKKK KKEEAANAKL LEAEKRIKEK EMRRQQAVLL
1010 1020 1030 1040 1050
KHQERERRRQ HMMLMKAMEA RKKAEEKERL KQEKRDEKRL NKERKLEQRR
1060 1070 1080 1090 1100
LELEMAKELK KPNEDMCLAD QKPLPELPRI PGLVLSGSTF SDCLMVVQFL
1110 1120 1130 1140 1150
RNFGKVLGFD VNIDVPNLSV LQEGLLNIGD SMGEVQDLLV RLLSAAVCDP
1160 1170 1180 1190 1200
GLITGYKAKT ALGEHLLNVG VNRDNVSEIL QIFMEAHCGQ TELTESLKTK
1210 1220 1230 1240 1250
AFQAHTPAQK ASVLAFLINE LACSKSVVSE IDKNIDYMSN LRRDKWVVEG
1260 1270 1280 1290 1300
KLRKLRIIHA KKTGKRDTSG GIDLGEEQHP LGTPTPGRKR RRKGGDSDYD
1310 1320 1330 1340 1350
DDDDDDSDDQ GDEDDEDEED KEDKKGKKTD ICEDEDEGDQ AASVEELEKQ
1360 1370 1380 1390 1400
IEKLSKQQSQ YRRKLFDASH SLRSVMFGQD RYRRRYWILP QCGGIFVEGM
1410 1420 1430 1440 1450
ESGEGLEEIA KEREKLKKAE SVQIKEEMFE TSGDSLNCSN TDHCEQKEDL
1460 1470 1480 1490 1500
KEKDNTNLFL QKPGSFSKLS KLLEVAKMPP ESEVMTPKPN AGANGCTLSY
1510 1520 1530 1540 1550
QNSGKHSLGS VQSTATQSNV EKADSNNLFN TGSSGPGKFY SPLPNDQLLK
1560 1570 1580 1590 1600
TLTEKNRQWF SLLPRTPCDD TSLTHADMST ASLVTPQSQP PSKSPSPTPA
1610 1620 1630 1640 1650
PLGSSAQNPV GLNPFALSPL QVKGGVSMMG LQFCGWPTGV VTSNIPFTSS
1660 1670 1680 1690 1700
VPSLGSGLGL SEGNGNSFLT SNVASSKSES PVPQNEKATS AQPAAVEVAK
1710 1720 1730 1740 1750
PVDFPSPKPI PEEMQFGWWR IIDPEDLKAL LKVLHLRGIR EKALQKQIQK
1760 1770 1780 1790 1800
HLDYITQACL KNKDVAIIEL NENEENQVTR DIVENWSVEE QAMEMDLSVL
1810 1820 1830 1840 1850
QQVEDLERRV ASASLQVKGW MCPEPASERE DLVYFEHKSF TKLCKEHDGE
1860 1870 1880 1890 1900
FTGEDESSAH ALERKSDNPL DIAVTRLADL ERNIERRIEE DIAPGLRVWR
1910 1920 1930 1940 1950
RALSEARSAA QVALCIQQLQ KSIAWEKSIM KVYCQICRKG DNEELLLLCD
1960 1970 1980 1990 2000
GCDKGCHTYC HRPKITTIPD GDWFCPACIA KASGQTLKIK KLHVKGKKTN
2010 2020 2030 2040 2050
ESKKGKKVTL TGDTEDEDSA STSSSLKRGN KDLKKRKMEE NTSINLSKQE
2060 2070 2080 2090 2100
SFTSVKKPKR DDSKDLALCS MILTEMETHE DAWPFLLPVN LKLVPGYKKV
2110 2120 2130 2140 2150
IKKPMDFSTI REKLSSGQYP NLETFALDVR LVFDNCETFN EDDSDIGRAG
2160
HNMRKYFEKK WTDTFKVS
Length:2,168
Mass (Da):240,459
Last modified:May 5, 2009 - v3
Checksum:iC64EEEE6243CF779
GO
Isoform 2 (identifier: Q9UIF8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-113: Missing.
     633-730: Missing.

Show »
Length:2,068
Mass (Da):230,154
Checksum:i324018D11EF97BAD
GO
Isoform 3 (identifier: Q9UIF8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     789-822: Missing.

Show »
Length:2,134
Mass (Da):236,551
Checksum:i6320F9BC6B744581
GO
Isoform 4 (identifier: Q9UIF8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Show »
Length:1,972
Mass (Da):220,710
Checksum:iB3BA3FD40027174C
GO
Isoform 5 (identifier: Q9UIF8-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-113: Missing.
     789-822: Missing.

Show »
Length:2,132
Mass (Da):236,423
Checksum:i28286671FC56180F
GO

Sequence cautioni

The sequence AAH12576.1 differs from that shown. Reason: contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH12576.1 differs from that shown. Reason: Frameshift at position 927. Curated
The sequence BAA96000.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB55231.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951L → G in AAH12576. (PubMed:15489334)Curated
Sequence conflicti333 – 3331S → F in BAA89212. (PubMed:10662543)Curated
Sequence conflicti823 – 8231G → E in BAA89212. (PubMed:10662543)Curated
Sequence conflicti918 – 9181E → K in AAH12576. (PubMed:15489334)Curated
Sequence conflicti986 – 9861R → Q in AAH12576. (PubMed:15489334)Curated
Sequence conflicti1324 – 13241K → Q in BAA89212. (PubMed:10662543)Curated
Sequence conflicti1379 – 13791Q → P in BAA89212. (PubMed:10662543)Curated
Sequence conflicti1391 – 13911Q → R in BAA89212. (PubMed:10662543)Curated
Sequence conflicti1649 – 16491S → L in BAA89212. (PubMed:10662543)Curated
Sequence conflicti2034 – 20341K → Q in BAA89212. (PubMed:10662543)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711M → T.1 Publication
Corresponds to variant rs10202670 [ dbSNP | Ensembl ].
VAR_055549
Natural varianti422 – 4221L → S.2 Publications
Corresponds to variant rs3213790 [ dbSNP | Ensembl ].
VAR_055550
Natural varianti530 – 5301P → L.
Corresponds to variant rs3732287 [ dbSNP | Ensembl ].
VAR_055551
Natural varianti702 – 7021G → V.
Corresponds to variant rs2302924 [ dbSNP | Ensembl ].
VAR_055552
Natural varianti2024 – 20241S → N.
Corresponds to variant rs415793 [ dbSNP | Ensembl ].
VAR_055553

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 196196Missing in isoform 4. 1 PublicationVSP_037114Add
BLAST
Alternative sequencei112 – 1132Missing in isoform 2 and isoform 5. 2 PublicationsVSP_037115
Alternative sequencei633 – 73098Missing in isoform 2. 1 PublicationVSP_000553Add
BLAST
Alternative sequencei789 – 82234Missing in isoform 3 and isoform 5. 2 PublicationsVSP_000554Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032255 mRNA. Translation: BAA89212.1.
AB040909 mRNA. Translation: BAA96000.2. Different initiation.
AL080173 mRNA. Translation: CAB45759.1.
AL834381 mRNA. Translation: CAD39044.2.
CH471058 Genomic DNA. Translation: EAX11404.1.
CH471058 Genomic DNA. Translation: EAX11405.1.
CH471058 Genomic DNA. Translation: EAX11407.1.
BC012576 mRNA. Translation: AAH12576.1. Sequence problems.
AK027612 mRNA. Translation: BAB55231.1. Different initiation.
CCDSiCCDS2209.2. [Q9UIF8-1]
CCDS74594.1. [Q9UIF8-5]
PIRiT12495.
RefSeqiNP_001276904.1. NM_001289975.1. [Q9UIF8-5]
NP_038478.2. NM_013450.3. [Q9UIF8-1]
UniGeneiHs.470369.
Hs.731786.

Genome annotation databases

EnsembliENST00000392782; ENSP00000376533; ENSG00000123636. [Q9UIF8-5]
ENST00000392783; ENSP00000376534; ENSG00000123636. [Q9UIF8-1]
GeneIDi29994.
KEGGihsa:29994.
UCSCiuc002uao.3. human. [Q9UIF8-1]
uc002uap.3. human. [Q9UIF8-5]

Polymorphism databases

DMDMi229462995.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032255 mRNA. Translation: BAA89212.1 .
AB040909 mRNA. Translation: BAA96000.2 . Different initiation.
AL080173 mRNA. Translation: CAB45759.1 .
AL834381 mRNA. Translation: CAD39044.2 .
CH471058 Genomic DNA. Translation: EAX11404.1 .
CH471058 Genomic DNA. Translation: EAX11405.1 .
CH471058 Genomic DNA. Translation: EAX11407.1 .
BC012576 mRNA. Translation: AAH12576.1 . Sequence problems.
AK027612 mRNA. Translation: BAB55231.1 . Different initiation.
CCDSi CCDS2209.2. [Q9UIF8-1 ]
CCDS74594.1. [Q9UIF8-5 ]
PIRi T12495.
RefSeqi NP_001276904.1. NM_001289975.1. [Q9UIF8-5 ]
NP_038478.2. NM_013450.3. [Q9UIF8-1 ]
UniGenei Hs.470369.
Hs.731786.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2E7O NMR - A 2062-2166 [» ]
3G0L X-ray 2.03 A 2054-2168 [» ]
3Q2F X-ray 2.06 A 2054-2168 [» ]
4CUP X-ray 1.88 A 2054-2168 [» ]
4CUQ X-ray 2.11 A 2054-2168 [» ]
4CUR X-ray 1.84 A 2054-2168 [» ]
4CUS X-ray 1.78 A 2054-2168 [» ]
4CUT X-ray 1.84 A 2054-2168 [» ]
4CUU X-ray 1.80 A 2054-2168 [» ]
4IR3 X-ray 2.00 A 2054-2168 [» ]
4IR4 X-ray 2.05 A 2054-2168 [» ]
4IR5 X-ray 1.70 A 2054-2168 [» ]
4IR6 X-ray 1.80 A 2054-2168 [» ]
4NR9 X-ray 1.98 A 2054-2168 [» ]
4NRA X-ray 1.85 A 2054-2168 [» ]
4NRB X-ray 2.08 A 2054-2168 [» ]
4NRC X-ray 1.86 A 2054-2168 [» ]
4QC1 X-ray 1.99 A/B 2062-2166 [» ]
4QC3 X-ray 1.60 A/B 2062-2166 [» ]
4QF3 X-ray 1.60 A/B 1928-1983 [» ]
ProteinModelPortali Q9UIF8.
SMRi Q9UIF8. Positions 1928-2166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119019. 5 interactions.
IntActi Q9UIF8. 4 interactions.
MINTi MINT-1483920.
STRINGi 9606.ENSP00000376534.

Chemistry

BindingDBi Q9UIF8.
ChEMBLi CHEMBL1741220.

PTM databases

PhosphoSitei Q9UIF8.

Polymorphism databases

DMDMi 229462995.

Proteomic databases

MaxQBi Q9UIF8.
PaxDbi Q9UIF8.
PRIDEi Q9UIF8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000392782 ; ENSP00000376533 ; ENSG00000123636 . [Q9UIF8-5 ]
ENST00000392783 ; ENSP00000376534 ; ENSG00000123636 . [Q9UIF8-1 ]
GeneIDi 29994.
KEGGi hsa:29994.
UCSCi uc002uao.3. human. [Q9UIF8-1 ]
uc002uap.3. human. [Q9UIF8-5 ]

Organism-specific databases

CTDi 29994.
GeneCardsi GC02M160139.
H-InvDB HIX0002531.
HGNCi HGNC:963. BAZ2B.
HPAi HPA019819.
MIMi 605683. gene.
neXtProti NX_Q9UIF8.
PharmGKBi PA25273.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5076.
GeneTreei ENSGT00760000119099.
HOGENOMi HOG000231981.
HOVERGENi HBG050670.
InParanoidi Q9UIF8.
OMAi DSDDQAD.
OrthoDBi EOG783MTG.
PhylomeDBi Q9UIF8.
TreeFami TF329083.

Miscellaneous databases

ChiTaRSi BAZ2B. human.
EvolutionaryTracei Q9UIF8.
GenomeRNAii 29994.
NextBioi 52792.
PROi Q9UIF8.
SOURCEi Search...

Gene expression databases

Bgeei Q9UIF8.
CleanExi HS_BAZ2B.
ExpressionAtlasi Q9UIF8. baseline and differential.
Genevestigatori Q9UIF8.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
3.30.890.10. 1 hit.
InterProi IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR004022. DDT_dom.
IPR018500. DDT_dom_subgr.
IPR018501. DDT_dom_superfamily.
IPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00439. Bromodomain. 1 hit.
PF02791. DDT. 1 hit.
PF01429. MBD. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
SM00571. DDT. 1 hit.
SM00391. MBD. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF54171. SSF54171. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50827. DDT. 1 hit.
PS50982. MBD. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    Tissue: Testis.
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Brain.
  3. Ohara O., Nagase T., Kikuno R.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-967 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1720-2168 (ISOFORMS 1/2/3/4/5), VARIANTS THR-71 AND SER-422.
    Tissue: Melanoma and Testis.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-986 (ISOFORM 2), VARIANT SER-422.
    Tissue: Skeletal muscle.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 670-1411 (ISOFORM 3).
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1538.
    Tissue: Mammary cancer.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1462, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1680; THR-2014 AND SER-2019, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Solution structure of the bromodomain from human bromodomain adjacent to zinc finger domain 2B."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUL-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 2062-2166.
  13. Cited for: X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF 2054-2168, SUBUNIT.

Entry informationi

Entry nameiBAZ2B_HUMAN
AccessioniPrimary (citable) accession number: Q9UIF8
Secondary accession number(s): D3DPA8
, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 5, 2009
Last modified: November 26, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3