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Q9UIF8

- BAZ2B_HUMAN

UniProt

Q9UIF8 - BAZ2B_HUMAN

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Protein
Bromodomain adjacent to zinc finger domain protein 2B
Gene
BAZ2B, KIAA1476
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in transcriptional regulation interacting with ISWI.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1931 – 198151PHD-type
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein binding Source: BHF-UCL
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: BHF-UCL
  2. transcription, DNA-templated Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain adjacent to zinc finger domain protein 2B
Alternative name(s):
hWALp4
Gene namesi
Name:BAZ2B
Synonyms:KIAA1476
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:963. BAZ2B.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25273.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21682168Bromodomain adjacent to zinc finger domain protein 2B
PRO_0000211174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1462 – 14621N6-acetyllysine1 Publication
Cross-linki1538 – 1538Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei1680 – 16801Phosphoserine1 Publication
Modified residuei2014 – 20141Phosphothreonine1 Publication
Modified residuei2019 – 20191Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9UIF8.
PaxDbiQ9UIF8.
PRIDEiQ9UIF8.

PTM databases

PhosphoSiteiQ9UIF8.

Expressioni

Tissue specificityi

Expressed at varying levels in several tissues, whereas a smaller transcript was expressed specifically in testis.

Gene expression databases

ArrayExpressiQ9UIF8.
BgeeiQ9UIF8.
CleanExiHS_BAZ2B.
GenevestigatoriQ9UIF8.

Organism-specific databases

HPAiHPA019819.

Interactioni

Subunit structurei

Interacts with acetylated lysine residues on histone H1.4, H2A, H2B, H3 and H4 (in vitro).1 Publication

Protein-protein interaction databases

BioGridi119019. 5 interactions.
IntActiQ9UIF8. 4 interactions.
MINTiMINT-1483920.
STRINGi9606.ENSP00000376534.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2063 – 207715
Helixi2080 – 20823
Helixi2083 – 20853
Turni2091 – 20933
Beta strandi2094 – 20963
Helixi2097 – 21004
Helixi2107 – 21159
Helixi2122 – 213918
Beta strandi2142 – 21443
Helixi2145 – 216521

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E7ONMR-A2062-2166[»]
3G0LX-ray2.03A2054-2168[»]
3Q2FX-ray2.06A2054-2168[»]
4CUPX-ray1.88A2054-2168[»]
4CUQX-ray2.11A2054-2168[»]
4CURX-ray1.84A2054-2168[»]
4CUSX-ray1.78A2054-2168[»]
4CUTX-ray1.84A2054-2168[»]
4CUUX-ray1.80A2054-2168[»]
4IR3X-ray2.00A2054-2168[»]
4IR4X-ray2.05A2054-2168[»]
4IR5X-ray1.70A2054-2168[»]
4IR6X-ray1.80A2054-2168[»]
4NR9X-ray1.98A2054-2168[»]
4NRAX-ray1.85A2054-2168[»]
4NRBX-ray2.08A2054-2168[»]
4NRCX-ray1.86A2054-2168[»]
4QC1X-ray1.99A/B2062-2166[»]
4QC3X-ray1.60A/B2062-2166[»]
ProteinModelPortaliQ9UIF8.
SMRiQ9UIF8. Positions 748-806, 1929-2167.

Miscellaneous databases

EvolutionaryTraceiQ9UIF8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini739 – 81072MBD
Add
BLAST
Domaini1087 – 115266DDT
Add
BLAST
Domaini2077 – 214771Bromo
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili883 – 1061179 Reviewed prediction
Add
BLAST
Coiled coili1334 – 137542 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi149 – 265117Ser-rich
Add
BLAST
Compositional biasi269 – 2757Poly-Glu
Compositional biasi595 – 66672Asp/Glu-rich (acidic)
Add
BLAST
Compositional biasi837 – 86832Arg-rich
Add
BLAST
Compositional biasi902 – 1061160Lys-rich
Add
BLAST
Compositional biasi1296 – 133944Asp-rich
Add
BLAST

Sequence similaritiesi

Belongs to the WAL family.
Contains 1 bromo domain.
Contains 1 DDT domain.

Keywords - Domaini

Bromodomain, Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiCOG5076.
HOGENOMiHOG000231981.
HOVERGENiHBG050670.
InParanoidiQ9UIF8.
OMAiDSDDQAD.
OrthoDBiEOG783MTG.
PhylomeDBiQ9UIF8.
TreeFamiTF329083.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
3.30.890.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR004022. DDT_dom.
IPR018500. DDT_dom_subgr.
IPR018501. DDT_dom_superfamily.
IPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF02791. DDT. 1 hit.
PF01429. MBD. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00571. DDT. 1 hit.
SM00391. MBD. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF54171. SSF54171. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50827. DDT. 1 hit.
PS50982. MBD. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9UIF8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MESGERLPSS AASSTTPTSS STPSVASVVS KGGLSTGVAS LSSTINPCGH     50
LFRTAGDQPF NLSTVSSAFP MVSHPVFGLH SASSGHSEFG GLGTLGTPTA 100
LAAHPQLASF PGAEWWRTTD AHTRTGATFF PPLLGIPPLF APPAQNHDSS 150
SFHSRTSGKS NRNGPEKGVN GSINGSNTSS VIGINTSVLS TTASSSMGQT 200
KSTSSGGGNR KCNQEQSKNQ PLDARVDKIK DKKPRKKAME SSSNSDSDSG 250
TSSDTSSEGI SSSDSDDLEE DEEEEDQSIE ESEDDDSDSE SEAQHKSNNQ 300
VLLHGISDPK ADGQKATEKA QEKRIHQPLP LASESQTHSF QSQQKQPQVL 350
SQQLPFIFQS SQAKEESVNK HTSVIQSTGL VSNVKPLSLV NQAKKETYMK 400
LIVPSPDVLK AGNKNTSEES SLLTSELRSK REQYKQAFPS QLKKQESSKS 450
LKKVIAALSN PKATSSSPAH PKQTLENNHP NPFLTNALLG NHQPNGVIQS 500
VIQEAPLALT TKTKMQSKIN ENIAAASSTP FSSPVNLSTS GRRTPGNQTP 550
VMPSASPILH SQGKEKAVSN NVNPVKTQHH SHPAKSLVEQ FRGTDSDIPS 600
SKDSEDSNED EEEDDEEEDE EDDEDDESDD SQSESDSNSE SDTEGSEEED 650
DDDKDQDESD SDTEGEKTSM KLNKTTSSVK SPSMSLTGHS TPRNLHIAKA 700
PGSAPAALCS ESQSPAFLGT SSSTLTSSPH SGTSKRRRVT DERELRIPLE 750
YGWQRETRIR NFGGRLQGEV AYYAPCGKKL RQYPEVIKYL SRNGIMDISR 800
DNFSFSAKIR VGDFYEARDG PQGMQWCLLK EEDVIPRIRA MEGRRGRPPN 850
PDRQRAREES RMRRRKGRPP NVGNAEFLDN ADAKLLRKLQ AQEIARQAAQ 900
IKLLRKLQKQ EQARVAKEAK KQQAIMAAEE KRKQKEQIKI MKQQEKIKRI 950
QQIRMEKELR AQQILEAKKK KKEEAANAKL LEAEKRIKEK EMRRQQAVLL 1000
KHQERERRRQ HMMLMKAMEA RKKAEEKERL KQEKRDEKRL NKERKLEQRR 1050
LELEMAKELK KPNEDMCLAD QKPLPELPRI PGLVLSGSTF SDCLMVVQFL 1100
RNFGKVLGFD VNIDVPNLSV LQEGLLNIGD SMGEVQDLLV RLLSAAVCDP 1150
GLITGYKAKT ALGEHLLNVG VNRDNVSEIL QIFMEAHCGQ TELTESLKTK 1200
AFQAHTPAQK ASVLAFLINE LACSKSVVSE IDKNIDYMSN LRRDKWVVEG 1250
KLRKLRIIHA KKTGKRDTSG GIDLGEEQHP LGTPTPGRKR RRKGGDSDYD 1300
DDDDDDSDDQ GDEDDEDEED KEDKKGKKTD ICEDEDEGDQ AASVEELEKQ 1350
IEKLSKQQSQ YRRKLFDASH SLRSVMFGQD RYRRRYWILP QCGGIFVEGM 1400
ESGEGLEEIA KEREKLKKAE SVQIKEEMFE TSGDSLNCSN TDHCEQKEDL 1450
KEKDNTNLFL QKPGSFSKLS KLLEVAKMPP ESEVMTPKPN AGANGCTLSY 1500
QNSGKHSLGS VQSTATQSNV EKADSNNLFN TGSSGPGKFY SPLPNDQLLK 1550
TLTEKNRQWF SLLPRTPCDD TSLTHADMST ASLVTPQSQP PSKSPSPTPA 1600
PLGSSAQNPV GLNPFALSPL QVKGGVSMMG LQFCGWPTGV VTSNIPFTSS 1650
VPSLGSGLGL SEGNGNSFLT SNVASSKSES PVPQNEKATS AQPAAVEVAK 1700
PVDFPSPKPI PEEMQFGWWR IIDPEDLKAL LKVLHLRGIR EKALQKQIQK 1750
HLDYITQACL KNKDVAIIEL NENEENQVTR DIVENWSVEE QAMEMDLSVL 1800
QQVEDLERRV ASASLQVKGW MCPEPASERE DLVYFEHKSF TKLCKEHDGE 1850
FTGEDESSAH ALERKSDNPL DIAVTRLADL ERNIERRIEE DIAPGLRVWR 1900
RALSEARSAA QVALCIQQLQ KSIAWEKSIM KVYCQICRKG DNEELLLLCD 1950
GCDKGCHTYC HRPKITTIPD GDWFCPACIA KASGQTLKIK KLHVKGKKTN 2000
ESKKGKKVTL TGDTEDEDSA STSSSLKRGN KDLKKRKMEE NTSINLSKQE 2050
SFTSVKKPKR DDSKDLALCS MILTEMETHE DAWPFLLPVN LKLVPGYKKV 2100
IKKPMDFSTI REKLSSGQYP NLETFALDVR LVFDNCETFN EDDSDIGRAG 2150
HNMRKYFEKK WTDTFKVS 2168
Length:2,168
Mass (Da):240,459
Last modified:May 5, 2009 - v3
Checksum:iC64EEEE6243CF779
GO
Isoform 2 (identifier: Q9UIF8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-113: Missing.
     633-730: Missing.

Show »
Length:2,068
Mass (Da):230,154
Checksum:i324018D11EF97BAD
GO
Isoform 3 (identifier: Q9UIF8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     789-822: Missing.

Show »
Length:2,134
Mass (Da):236,551
Checksum:i6320F9BC6B744581
GO
Isoform 4 (identifier: Q9UIF8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Show »
Length:1,972
Mass (Da):220,710
Checksum:iB3BA3FD40027174C
GO
Isoform 5 (identifier: Q9UIF8-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-113: Missing.
     789-822: Missing.

Show »
Length:2,132
Mass (Da):236,423
Checksum:i28286671FC56180F
GO

Sequence cautioni

The sequence AAH12576.1 differs from that shown. Reason: contaminating sequence. Potential poly-A sequence.
The sequence AAH12576.1 differs from that shown. Reason: Frameshift at position 927.
The sequence BAA96000.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAB55231.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711M → T.1 Publication
Corresponds to variant rs10202670 [ dbSNP | Ensembl ].
VAR_055549
Natural varianti422 – 4221L → S.2 Publications
Corresponds to variant rs3213790 [ dbSNP | Ensembl ].
VAR_055550
Natural varianti530 – 5301P → L.
Corresponds to variant rs3732287 [ dbSNP | Ensembl ].
VAR_055551
Natural varianti702 – 7021G → V.
Corresponds to variant rs2302924 [ dbSNP | Ensembl ].
VAR_055552
Natural varianti2024 – 20241S → N.
Corresponds to variant rs415793 [ dbSNP | Ensembl ].
VAR_055553

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 196196Missing in isoform 4.
VSP_037114Add
BLAST
Alternative sequencei112 – 1132Missing in isoform 2 and isoform 5.
VSP_037115
Alternative sequencei633 – 73098Missing in isoform 2.
VSP_000553Add
BLAST
Alternative sequencei789 – 82234Missing in isoform 3 and isoform 5.
VSP_000554Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951L → G in AAH12576. 1 Publication
Sequence conflicti333 – 3331S → F in BAA89212. 1 Publication
Sequence conflicti823 – 8231G → E in BAA89212. 1 Publication
Sequence conflicti918 – 9181E → K in AAH12576. 1 Publication
Sequence conflicti986 – 9861R → Q in AAH12576. 1 Publication
Sequence conflicti1324 – 13241K → Q in BAA89212. 1 Publication
Sequence conflicti1379 – 13791Q → P in BAA89212. 1 Publication
Sequence conflicti1391 – 13911Q → R in BAA89212. 1 Publication
Sequence conflicti1649 – 16491S → L in BAA89212. 1 Publication
Sequence conflicti2034 – 20341K → Q in BAA89212. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032255 mRNA. Translation: BAA89212.1.
AB040909 mRNA. Translation: BAA96000.2. Different initiation.
AL080173 mRNA. Translation: CAB45759.1.
AL834381 mRNA. Translation: CAD39044.2.
CH471058 Genomic DNA. Translation: EAX11404.1.
CH471058 Genomic DNA. Translation: EAX11405.1.
CH471058 Genomic DNA. Translation: EAX11407.1.
BC012576 mRNA. Translation: AAH12576.1. Sequence problems.
AK027612 mRNA. Translation: BAB55231.1. Different initiation.
CCDSiCCDS2209.2. [Q9UIF8-1]
PIRiT12495.
RefSeqiNP_001276904.1. NM_001289975.1. [Q9UIF8-5]
NP_038478.2. NM_013450.3. [Q9UIF8-1]
UniGeneiHs.470369.
Hs.731786.

Genome annotation databases

EnsembliENST00000343439; ENSP00000339670; ENSG00000123636. [Q9UIF8-2]
ENST00000355831; ENSP00000348087; ENSG00000123636. [Q9UIF8-3]
ENST00000392782; ENSP00000376533; ENSG00000123636. [Q9UIF8-5]
ENST00000392783; ENSP00000376534; ENSG00000123636. [Q9UIF8-1]
GeneIDi29994.
KEGGihsa:29994.
UCSCiuc002uao.3. human. [Q9UIF8-1]
uc002uap.3. human. [Q9UIF8-5]

Polymorphism databases

DMDMi229462995.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032255 mRNA. Translation: BAA89212.1 .
AB040909 mRNA. Translation: BAA96000.2 . Different initiation.
AL080173 mRNA. Translation: CAB45759.1 .
AL834381 mRNA. Translation: CAD39044.2 .
CH471058 Genomic DNA. Translation: EAX11404.1 .
CH471058 Genomic DNA. Translation: EAX11405.1 .
CH471058 Genomic DNA. Translation: EAX11407.1 .
BC012576 mRNA. Translation: AAH12576.1 . Sequence problems.
AK027612 mRNA. Translation: BAB55231.1 . Different initiation.
CCDSi CCDS2209.2. [Q9UIF8-1 ]
PIRi T12495.
RefSeqi NP_001276904.1. NM_001289975.1. [Q9UIF8-5 ]
NP_038478.2. NM_013450.3. [Q9UIF8-1 ]
UniGenei Hs.470369.
Hs.731786.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2E7O NMR - A 2062-2166 [» ]
3G0L X-ray 2.03 A 2054-2168 [» ]
3Q2F X-ray 2.06 A 2054-2168 [» ]
4CUP X-ray 1.88 A 2054-2168 [» ]
4CUQ X-ray 2.11 A 2054-2168 [» ]
4CUR X-ray 1.84 A 2054-2168 [» ]
4CUS X-ray 1.78 A 2054-2168 [» ]
4CUT X-ray 1.84 A 2054-2168 [» ]
4CUU X-ray 1.80 A 2054-2168 [» ]
4IR3 X-ray 2.00 A 2054-2168 [» ]
4IR4 X-ray 2.05 A 2054-2168 [» ]
4IR5 X-ray 1.70 A 2054-2168 [» ]
4IR6 X-ray 1.80 A 2054-2168 [» ]
4NR9 X-ray 1.98 A 2054-2168 [» ]
4NRA X-ray 1.85 A 2054-2168 [» ]
4NRB X-ray 2.08 A 2054-2168 [» ]
4NRC X-ray 1.86 A 2054-2168 [» ]
4QC1 X-ray 1.99 A/B 2062-2166 [» ]
4QC3 X-ray 1.60 A/B 2062-2166 [» ]
ProteinModelPortali Q9UIF8.
SMRi Q9UIF8. Positions 748-806, 1929-2167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119019. 5 interactions.
IntActi Q9UIF8. 4 interactions.
MINTi MINT-1483920.
STRINGi 9606.ENSP00000376534.

Chemistry

BindingDBi Q9UIF8.
ChEMBLi CHEMBL1741220.

PTM databases

PhosphoSitei Q9UIF8.

Polymorphism databases

DMDMi 229462995.

Proteomic databases

MaxQBi Q9UIF8.
PaxDbi Q9UIF8.
PRIDEi Q9UIF8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343439 ; ENSP00000339670 ; ENSG00000123636 . [Q9UIF8-2 ]
ENST00000355831 ; ENSP00000348087 ; ENSG00000123636 . [Q9UIF8-3 ]
ENST00000392782 ; ENSP00000376533 ; ENSG00000123636 . [Q9UIF8-5 ]
ENST00000392783 ; ENSP00000376534 ; ENSG00000123636 . [Q9UIF8-1 ]
GeneIDi 29994.
KEGGi hsa:29994.
UCSCi uc002uao.3. human. [Q9UIF8-1 ]
uc002uap.3. human. [Q9UIF8-5 ]

Organism-specific databases

CTDi 29994.
GeneCardsi GC02M160139.
H-InvDB HIX0002531.
HGNCi HGNC:963. BAZ2B.
HPAi HPA019819.
MIMi 605683. gene.
neXtProti NX_Q9UIF8.
PharmGKBi PA25273.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5076.
HOGENOMi HOG000231981.
HOVERGENi HBG050670.
InParanoidi Q9UIF8.
OMAi DSDDQAD.
OrthoDBi EOG783MTG.
PhylomeDBi Q9UIF8.
TreeFami TF329083.

Miscellaneous databases

ChiTaRSi BAZ2B. human.
EvolutionaryTracei Q9UIF8.
GenomeRNAii 29994.
NextBioi 52792.
PROi Q9UIF8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UIF8.
Bgeei Q9UIF8.
CleanExi HS_BAZ2B.
Genevestigatori Q9UIF8.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
3.30.890.10. 1 hit.
InterProi IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR004022. DDT_dom.
IPR018500. DDT_dom_subgr.
IPR018501. DDT_dom_superfamily.
IPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00439. Bromodomain. 1 hit.
PF02791. DDT. 1 hit.
PF01429. MBD. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
SM00571. DDT. 1 hit.
SM00391. MBD. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF54171. SSF54171. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50827. DDT. 1 hit.
PS50982. MBD. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    Tissue: Testis.
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Brain.
  3. Ohara O., Nagase T., Kikuno R.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-967 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1720-2168 (ISOFORMS 1/2/3/4/5), VARIANTS THR-71 AND SER-422.
    Tissue: Melanoma and Testis.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-986 (ISOFORM 2), VARIANT SER-422.
    Tissue: Skeletal muscle.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 670-1411 (ISOFORM 3).
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1538.
    Tissue: Mammary cancer.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1462, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1680; THR-2014 AND SER-2019, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Solution structure of the bromodomain from human bromodomain adjacent to zinc finger domain 2B."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUL-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 2062-2166.
  13. Cited for: X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF 2054-2168, SUBUNIT.

Entry informationi

Entry nameiBAZ2B_HUMAN
AccessioniPrimary (citable) accession number: Q9UIF8
Secondary accession number(s): D3DPA8
, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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