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Protein

Tektin-2

Gene

TEKT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Tektin-2
Alternative name(s):
Tektin-t
Testicular tektin
Testicular tektin B1-like protein
Short name:
TEKTB1
Short name:
Tektin-B1
Gene namesi
Name:TEKT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000092850.11
HGNCiHGNC:11725 TEKT2
MIMi608953 gene
neXtProtiNX_Q9UIF3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi27285
OpenTargetsiENSG00000092850
PharmGKBiPA36442

Polymorphism and mutation databases

BioMutaiTEKT2
DMDMi25009466

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001845651 – 430Tektin-2Add BLAST430

Post-translational modificationi

Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9UIF3
PeptideAtlasiQ9UIF3
PRIDEiQ9UIF3

PTM databases

iPTMnetiQ9UIF3
PhosphoSitePlusiQ9UIF3

Expressioni

Tissue specificityi

Expressed at high levels in testis, trachea and fetal lung, and at lower levels in ovary, pituitary, adult lung, fetal brain and fetal kidney.1 Publication

Gene expression databases

BgeeiENSG00000092850
CleanExiHS_TEKT2
ExpressionAtlasiQ9UIF3 baseline and differential
GenevisibleiQ9UIF3 HS

Organism-specific databases

HPAiHPA027248
HPA027461

Interactioni

Subunit structurei

May interact with CCDC172.By similarity

Protein-protein interaction databases

BioGridi118109, 19 interactors
IntActiQ9UIF3, 3 interactors
STRINGi9606.ENSP00000207457

Structurei

3D structure databases

ProteinModelPortaliQ9UIF3
SMRiQ9UIF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili80 – 162Sequence analysisAdd BLAST83
Coiled coili225 – 382Sequence analysisAdd BLAST158

Sequence similaritiesi

Belongs to the tektin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2685 Eukaryota
ENOG410XSCN LUCA
GeneTreeiENSGT00390000016344
HOGENOMiHOG000246943
HOVERGENiHBG101114
InParanoidiQ9UIF3
KOiK18629
OMAiWQEKNTL
OrthoDBiEOG091G09H1
PhylomeDBiQ9UIF3
TreeFamiTF320754

Family and domain databases

InterProiView protein in InterPro
IPR000435 Tektin
PANTHERiPTHR19960 PTHR19960, 1 hit
PRINTSiPR00511 TEKTIN

Sequencei

Sequence statusi: Complete.

Q9UIF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLSVKPSR RFQLPDWHTN SYLLSTNAQL QRDASHQIRQ EARVLRNETN
60 70 80 90 100
NQTIWDEHDN RTRLVERIDT VNRWKEMLDK CLTDLDAEID ALTQMKESAE
110 120 130 140 150
QNLQAKNLPL DVAIECLTLR ESRRDIDVVK DPVEDELHKE VEVIEATKKA
160 170 180 190 200
LQQKVSQAFE QLCLLQEVQQ QLNSDHRGKM ETLEIDRGCL SLNLRSPNIS
210 220 230 240 250
LKVDPTRVPD GSTTLQQWDD FSRFNKDRAE AEMKAATELR EATALTIAET
260 270 280 290 300
NNELEAQRVA TEFAFRKRLR EMEKVYSELK WQEKNTLEEI AELQEDIRHL
310 320 330 340 350
EEDLRTKLLS LKLSHTRLEA RTYRPNVELC RDQAQYGLTD EVHQLEATIA
360 370 380 390 400
ALKQKLAQAQ DALDALCKHL ARLQADIACK ANSMLLDTKC MDTRRKLTVP
410 420 430
AERFVPEVDT FTRTTNSTLS PLKSCQLELA
Length:430
Mass (Da):49,672
Last modified:May 1, 2000 - v1
Checksum:iBD7600E20624DD25
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti329L → F in AAC09343 (PubMed:11751288).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03454946R → C. Corresponds to variant dbSNP:rs12043423Ensembl.1
Natural variantiVAR_053720114I → T. Corresponds to variant dbSNP:rs419653Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054910 mRNA Translation: AAC09343.1
AB033823 mRNA Translation: BAA89350.1
AL138787 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07392.1
BC035620 mRNA Translation: AAH35620.1
CCDSiCCDS401.1
RefSeqiNP_055281.2, NM_014466.2
XP_005270810.1, XM_005270753.2
XP_011539560.1, XM_011541258.2
XP_016856544.1, XM_017001055.1
UniGeneiHs.127111

Genome annotation databases

EnsembliENST00000207457; ENSP00000207457; ENSG00000092850
GeneIDi27285
KEGGihsa:27285
UCSCiuc001bzr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTEKT2_HUMAN
AccessioniPrimary (citable) accession number: Q9UIF3
Secondary accession number(s): A6NIS6, O60638
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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