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Protein

Tektin-2

Gene

TEKT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Tektin-2
Alternative name(s):
Tektin-t
Testicular tektin
Testicular tektin B1-like protein
Short name:
TEKTB1
Short name:
Tektin-B1
Gene namesi
Name:TEKT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11725. TEKT2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • microtubule Source: UniProtKB-KW
  • motile cilium Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36442.

Polymorphism and mutation databases

BioMutaiTEKT2.
DMDMi25009466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Tektin-2PRO_0000184565Add
BLAST

Post-translational modificationi

Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9UIF3.
PeptideAtlasiQ9UIF3.
PRIDEiQ9UIF3.

PTM databases

iPTMnetiQ9UIF3.
PhosphoSiteiQ9UIF3.

Expressioni

Tissue specificityi

Expressed at high levels in testis, trachea and fetal lung, and at lower levels in ovary, pituitary, adult lung, fetal brain and fetal kidney.1 Publication

Gene expression databases

BgeeiQ9UIF3.
CleanExiHS_TEKT2.
ExpressionAtlasiQ9UIF3. baseline and differential.
GenevisibleiQ9UIF3. HS.

Organism-specific databases

HPAiHPA027248.
HPA027461.

Interactioni

Protein-protein interaction databases

BioGridi118109. 17 interactions.
STRINGi9606.ENSP00000207457.

Structurei

3D structure databases

ProteinModelPortaliQ9UIF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili80 – 16283Sequence analysisAdd
BLAST
Coiled coili225 – 382158Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the tektin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2685. Eukaryota.
ENOG410XSCN. LUCA.
GeneTreeiENSGT00390000016344.
HOGENOMiHOG000246943.
HOVERGENiHBG101114.
InParanoidiQ9UIF3.
KOiK18629.
OMAiMDTRRKL.
OrthoDBiEOG7HMS11.
PhylomeDBiQ9UIF3.
TreeFamiTF320754.

Family and domain databases

InterProiIPR000435. Tektin.
[Graphical view]
PANTHERiPTHR19960. PTHR19960. 1 hit.
PRINTSiPR00511. TEKTIN.

Sequencei

Sequence statusi: Complete.

Q9UIF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLSVKPSR RFQLPDWHTN SYLLSTNAQL QRDASHQIRQ EARVLRNETN
60 70 80 90 100
NQTIWDEHDN RTRLVERIDT VNRWKEMLDK CLTDLDAEID ALTQMKESAE
110 120 130 140 150
QNLQAKNLPL DVAIECLTLR ESRRDIDVVK DPVEDELHKE VEVIEATKKA
160 170 180 190 200
LQQKVSQAFE QLCLLQEVQQ QLNSDHRGKM ETLEIDRGCL SLNLRSPNIS
210 220 230 240 250
LKVDPTRVPD GSTTLQQWDD FSRFNKDRAE AEMKAATELR EATALTIAET
260 270 280 290 300
NNELEAQRVA TEFAFRKRLR EMEKVYSELK WQEKNTLEEI AELQEDIRHL
310 320 330 340 350
EEDLRTKLLS LKLSHTRLEA RTYRPNVELC RDQAQYGLTD EVHQLEATIA
360 370 380 390 400
ALKQKLAQAQ DALDALCKHL ARLQADIACK ANSMLLDTKC MDTRRKLTVP
410 420 430
AERFVPEVDT FTRTTNSTLS PLKSCQLELA
Length:430
Mass (Da):49,672
Last modified:May 1, 2000 - v1
Checksum:iBD7600E20624DD25
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti329 – 3291L → F in AAC09343 (PubMed:11751288).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461R → C.
Corresponds to variant rs12043423 [ dbSNP | Ensembl ].
VAR_034549
Natural varianti114 – 1141I → T.
Corresponds to variant rs419653 [ dbSNP | Ensembl ].
VAR_053720

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054910 mRNA. Translation: AAC09343.1.
AB033823 mRNA. Translation: BAA89350.1.
AL138787 Genomic DNA. Translation: CAC21454.1.
CH471059 Genomic DNA. Translation: EAX07392.1.
BC035620 mRNA. Translation: AAH35620.1.
CCDSiCCDS401.1.
RefSeqiNP_055281.2. NM_014466.2.
XP_005270810.1. XM_005270753.1.
XP_011539560.1. XM_011541258.1.
UniGeneiHs.127111.

Genome annotation databases

EnsembliENST00000207457; ENSP00000207457; ENSG00000092850.
GeneIDi27285.
KEGGihsa:27285.
UCSCiuc001bzr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054910 mRNA. Translation: AAC09343.1.
AB033823 mRNA. Translation: BAA89350.1.
AL138787 Genomic DNA. Translation: CAC21454.1.
CH471059 Genomic DNA. Translation: EAX07392.1.
BC035620 mRNA. Translation: AAH35620.1.
CCDSiCCDS401.1.
RefSeqiNP_055281.2. NM_014466.2.
XP_005270810.1. XM_005270753.1.
XP_011539560.1. XM_011541258.1.
UniGeneiHs.127111.

3D structure databases

ProteinModelPortaliQ9UIF3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118109. 17 interactions.
STRINGi9606.ENSP00000207457.

PTM databases

iPTMnetiQ9UIF3.
PhosphoSiteiQ9UIF3.

Polymorphism and mutation databases

BioMutaiTEKT2.
DMDMi25009466.

Proteomic databases

PaxDbiQ9UIF3.
PeptideAtlasiQ9UIF3.
PRIDEiQ9UIF3.

Protocols and materials databases

DNASUi27285.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000207457; ENSP00000207457; ENSG00000092850.
GeneIDi27285.
KEGGihsa:27285.
UCSCiuc001bzr.3. human.

Organism-specific databases

CTDi27285.
GeneCardsiTEKT2.
HGNCiHGNC:11725. TEKT2.
HPAiHPA027248.
HPA027461.
MIMi608953. gene.
neXtProtiNX_Q9UIF3.
PharmGKBiPA36442.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2685. Eukaryota.
ENOG410XSCN. LUCA.
GeneTreeiENSGT00390000016344.
HOGENOMiHOG000246943.
HOVERGENiHBG101114.
InParanoidiQ9UIF3.
KOiK18629.
OMAiMDTRRKL.
OrthoDBiEOG7HMS11.
PhylomeDBiQ9UIF3.
TreeFamiTF320754.

Miscellaneous databases

GenomeRNAii27285.
PROiQ9UIF3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UIF3.
CleanExiHS_TEKT2.
ExpressionAtlasiQ9UIF3. baseline and differential.
GenevisibleiQ9UIF3. HS.

Family and domain databases

InterProiIPR000435. Tektin.
[Graphical view]
PANTHERiPTHR19960. PTHR19960. 1 hit.
PRINTSiPR00511. TEKTIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 188-195; 259-266; 322-331; 356-368 AND 404-413, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTEKT2_HUMAN
AccessioniPrimary (citable) accession number: Q9UIF3
Secondary accession number(s): A6NIS6, O60638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.