Q9UIE0 (ZN230_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 230

Alternative name(s):
Zinc finger protein FDZF2

Gene names

Name:	ZNF230
Synonyms:	FDZF2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 10 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	Zinc finger protein 230		PRO_0000047471
Regions
	Domain	8 – 76	69	KRAB
	Zinc finger	168 – 190	23	C2H2-type 1
	Zinc finger	196 – 218	23	C2H2-type 2
	Zinc finger	224 – 246	23	C2H2-type 3
	Zinc finger	252 – 274	23	C2H2-type 4
	Zinc finger	280 – 302	23	C2H2-type 5
	Zinc finger	308 – 330	23	C2H2-type 6
	Zinc finger	336 – 358	23	C2H2-type 7
	Zinc finger	364 – 386	23	C2H2-type 8
	Zinc finger	392 – 414	23	C2H2-type 9
	Zinc finger	420 – 442	23	C2H2-type 10; atypical
	Region	80 – 167	88	KRNB
Natural variations
	Natural variant	310	1	S → C. Corresponds to variant rs1060877 [ dbSNP | Ensembl ].		VAR_030534
	Natural variant	434	1	F → Y. Corresponds to variant rs6413542 [ dbSNP | Ensembl ].		VAR_030535
	Natural variant	441	1	D → E. Corresponds to variant rs12753 [ dbSNP | Ensembl ].		VAR_014827
Experimental info
	Sequence conflict	26	1	D → H in AAB62180. Ref.1
	Sequence conflict	92	1	C → V in AAB62180. Ref.1
	Sequence conflict	201	1	R → C in AAB62180. Ref.1
	Sequence conflict	214	1	R → H in AAB62180. Ref.1
	Sequence conflict	220	1	G → R in AAB62180. Ref.1
	Sequence conflict	265 – 266	2	FQ → LK in AAB62180. Ref.1
	Sequence conflict	280	1	F → S in AAB62180. Ref.1
	Sequence conflict	299	1	C → Y in AAB62180. Ref.1
	Sequence conflict	308 – 310	3	YKS → SKC in AAB62180. Ref.1
	Sequence conflict	383 – 385	3	QRV → PEG in AAB62180. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UIE0 [UniParc]. Last modified February 6, 2007. Version 3. Checksum: 40DBFE785051451D	FASTA	474	54,542
	10 20 30 40 50 60 MTTFKEAVTF KDVAVFFTEE ELGLLDPAQR KLYQDVMLEN FTNLLSVGHQ PFHPFHFLRE 70 80 90 100 110 120 EKFWMMETAT QREGNSGGKT IAEAGPHEDC PCQQIWEQTA SDLTQSQDSI INNSHFFEQG 130 140 150 160 170 180 DVPSQVEAGL SIIHTGQKPS QNGKCKQSFS DVAIFDPPQQ FHSGEKSHTC NECGKSFCYI 190 200 210 220 230 240 SALRIHQRVH LREKLSKCDM RGKEFSQSSC LQTRERVHTG EKPFKCEQCG KGFRCRAILQ 250 260 270 280 290 300 VHCKLHTGEK PYICEKCGRA FIHDFQLQKH QIIHTGEKPF KCEICGKSFC LRSSLNRHCM 310 320 330 340 350 360 VHTAEKLYKS EECGKGFTDS LDLHKHQIIH TGQKPYNCKE CGKSFRWSSY LLIHQRIHSG 370 380 390 400 410 420 EKPYRCEECG KGYISKSGLN LHQRVHTGER PYNCKECGKS FSRASSILNH KKLHCRKKPF 430 440 450 460 470 KCEDCGKRLV HRSFCKDQQG DHNGENSSKC EDCGKRYKRR LNLDIILSLF LNDM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel KRAB-containing zinc finger gene, FDZF2." Wu G., Yu L. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U95044 mRNA. Translation: AAB62180.1. AC018725 Genomic DNA. Translation: AAF18685.1. AC067968 Genomic DNA. Translation: AAF66074.1. BC050340 mRNA. Translation: AAH50340.2. BC094708 mRNA. Translation: AAH94708.1.
IPI	IPI00006278.
RefSeq	NP_006291.2. NM_006300.3.
UniGene	Hs.193583.
3D structure databases
ProteinModelPortal	Q9UIE0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UIE0. 2 interactions.
PTM databases
PhosphoSite	Q9UIE0.
Polymorphism databases
DMDM	125987869.
Proteomic databases
PRIDE	Q9UIE0.
Protocols and materials databases
DNASU	7773.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000429154; ENSP00000409318; ENSG00000159882.
GeneID	7773.
KEGG	hsa:7773.
UCSC	uc002oyb.1. human.
Organism-specific databases
CTD	7773.
GeneCards	GC19P044507.
HGNC	HGNC:13024. ZNF230.
neXtProt	NX_Q9UIE0.
PharmGKB	PA37603.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q9UIE0.
KO	K09228.
OMA	EAGPHED.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
Bgee	Q9UIE0.
CleanEx	HS_ZNF230.
Genevestigator	Q9UIE0.
GermOnline	ENSG00000159882. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 9 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 8 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 7 hits. PS50157. ZINC_FINGER_C2H2_2. 10 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7773.
NextBio	30101.

Entry information

Entry name

ZN230_HUMAN

Accession

Primary (citable) accession number: Q9UIE0
Secondary accession number(s): O15322 , Q504X7, Q86W84, Q9P1U6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 112 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.