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Q9UIE0 (ZN230_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 230
Alternative name(s):
Zinc finger protein FDZF2
Gene names
Name:ZNF230
Synonyms:FDZF2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 10 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Zinc finger protein 230
PRO_0000047471

Regions

Domain8 – 7669KRAB
Zinc finger168 – 19023C2H2-type 1
Zinc finger196 – 21823C2H2-type 2
Zinc finger224 – 24623C2H2-type 3
Zinc finger252 – 27423C2H2-type 4
Zinc finger280 – 30223C2H2-type 5
Zinc finger308 – 33023C2H2-type 6
Zinc finger336 – 35823C2H2-type 7
Zinc finger364 – 38623C2H2-type 8
Zinc finger392 – 41423C2H2-type 9
Zinc finger420 – 44223C2H2-type 10; atypical
Region80 – 16788KRNB

Natural variations

Natural variant3101S → C.
Corresponds to variant rs1060877 [ dbSNP | Ensembl ].
VAR_030534
Natural variant4341F → Y.
Corresponds to variant rs6413542 [ dbSNP | Ensembl ].
VAR_030535
Natural variant4411D → E.
Corresponds to variant rs12753 [ dbSNP | Ensembl ].
VAR_014827

Experimental info

Sequence conflict261D → H in AAB62180. Ref.1
Sequence conflict921C → V in AAB62180. Ref.1
Sequence conflict2011R → C in AAB62180. Ref.1
Sequence conflict2141R → H in AAB62180. Ref.1
Sequence conflict2201G → R in AAB62180. Ref.1
Sequence conflict265 – 2662FQ → LK in AAB62180. Ref.1
Sequence conflict2801F → S in AAB62180. Ref.1
Sequence conflict2991C → Y in AAB62180. Ref.1
Sequence conflict308 – 3103YKS → SKC in AAB62180. Ref.1
Sequence conflict383 – 3853QRV → PEG in AAB62180. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9UIE0 [UniParc].

Last modified February 6, 2007. Version 3.
Checksum: 40DBFE785051451D

FASTA47454,542
        10         20         30         40         50         60 
MTTFKEAVTF KDVAVFFTEE ELGLLDPAQR KLYQDVMLEN FTNLLSVGHQ PFHPFHFLRE 

        70         80         90        100        110        120 
EKFWMMETAT QREGNSGGKT IAEAGPHEDC PCQQIWEQTA SDLTQSQDSI INNSHFFEQG 

       130        140        150        160        170        180 
DVPSQVEAGL SIIHTGQKPS QNGKCKQSFS DVAIFDPPQQ FHSGEKSHTC NECGKSFCYI 

       190        200        210        220        230        240 
SALRIHQRVH LREKLSKCDM RGKEFSQSSC LQTRERVHTG EKPFKCEQCG KGFRCRAILQ 

       250        260        270        280        290        300 
VHCKLHTGEK PYICEKCGRA FIHDFQLQKH QIIHTGEKPF KCEICGKSFC LRSSLNRHCM 

       310        320        330        340        350        360 
VHTAEKLYKS EECGKGFTDS LDLHKHQIIH TGQKPYNCKE CGKSFRWSSY LLIHQRIHSG 

       370        380        390        400        410        420 
EKPYRCEECG KGYISKSGLN LHQRVHTGER PYNCKECGKS FSRASSILNH KKLHCRKKPF 

       430        440        450        460        470 
KCEDCGKRLV HRSFCKDQQG DHNGENSSKC EDCGKRYKRR LNLDIILSLF LNDM 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a novel KRAB-containing zinc finger gene, FDZF2."
Wu G., Yu L.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U95044 mRNA. Translation: AAB62180.1.
AC018725 Genomic DNA. Translation: AAF18685.1.
AC067968 Genomic DNA. Translation: AAF66074.1.
BC050340 mRNA. Translation: AAH50340.2.
BC094708 mRNA. Translation: AAH94708.1.
RefSeqNP_006291.2. NM_006300.3.
UniGeneHs.193583.

3D structure databases

ProteinModelPortalQ9UIE0.
SMRQ9UIE0. Positions 7-49, 134-469.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113556. 1 interaction.
IntActQ9UIE0. 2 interactions.

PTM databases

PhosphoSiteQ9UIE0.

Polymorphism databases

DMDM125987869.

Proteomic databases

PRIDEQ9UIE0.

Protocols and materials databases

DNASU7773.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000429154; ENSP00000409318; ENSG00000159882.
GeneID7773.
KEGGhsa:7773.
UCSCuc002oyb.1. human.

Organism-specific databases

CTD7773.
GeneCardsGC19P044507.
HGNCHGNC:13024. ZNF230.
neXtProtNX_Q9UIE0.
PharmGKBPA37603.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9UIE0.
KOK09228.
OMAEAGPHED.
OrthoDBEOG7KSX7Q.
TreeFamTF341885.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9UIE0.
BgeeQ9UIE0.
CleanExHS_ZNF230.
GenevestigatorQ9UIE0.

Family and domain databases

Gene3D3.30.160.60. 9 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi7773.
NextBio30101.
PROQ9UIE0.

Entry information

Entry nameZN230_HUMAN
AccessionPrimary (citable) accession number: Q9UIE0
Secondary accession number(s): O15322 expand/collapse secondary AC list , Q504X7, Q86W84, Q9P1U6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: February 6, 2007
Last modified: March 19, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM