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Q9UIE0

- ZN230_HUMAN

UniProt

Q9UIE0 - ZN230_HUMAN

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Protein
Zinc finger protein 230
Gene
ZNF230, FDZF2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri168 – 19023C2H2-type 1
Add
BLAST
Zinc fingeri196 – 21823C2H2-type 2
Add
BLAST
Zinc fingeri224 – 24623C2H2-type 3
Add
BLAST
Zinc fingeri252 – 27423C2H2-type 4
Add
BLAST
Zinc fingeri280 – 30223C2H2-type 5
Add
BLAST
Zinc fingeri308 – 33023C2H2-type 6
Add
BLAST
Zinc fingeri336 – 35823C2H2-type 7
Add
BLAST
Zinc fingeri364 – 38623C2H2-type 8
Add
BLAST
Zinc fingeri392 – 41423C2H2-type 9
Add
BLAST
Zinc fingeri420 – 44223C2H2-type 10; atypical
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 230
Alternative name(s):
Zinc finger protein FDZF2
Gene namesi
Name:ZNF230
Synonyms:FDZF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13024. ZNF230.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37603.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Zinc finger protein 230
PRO_0000047471Add
BLAST

Proteomic databases

PRIDEiQ9UIE0.

PTM databases

PhosphoSiteiQ9UIE0.

Expressioni

Gene expression databases

ArrayExpressiQ9UIE0.
BgeeiQ9UIE0.
CleanExiHS_ZNF230.
GenevestigatoriQ9UIE0.

Interactioni

Protein-protein interaction databases

BioGridi113556. 1 interaction.
IntActiQ9UIE0. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9UIE0.
SMRiQ9UIE0. Positions 7-49, 134-463.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7669KRAB
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 16788KRNB
Add
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UIE0.
KOiK09228.
OMAiEAGPHED.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9UIE0.
TreeFamiTF341885.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UIE0-1 [UniParc]FASTAAdd to Basket

« Hide

MTTFKEAVTF KDVAVFFTEE ELGLLDPAQR KLYQDVMLEN FTNLLSVGHQ    50
PFHPFHFLRE EKFWMMETAT QREGNSGGKT IAEAGPHEDC PCQQIWEQTA 100
SDLTQSQDSI INNSHFFEQG DVPSQVEAGL SIIHTGQKPS QNGKCKQSFS 150
DVAIFDPPQQ FHSGEKSHTC NECGKSFCYI SALRIHQRVH LREKLSKCDM 200
RGKEFSQSSC LQTRERVHTG EKPFKCEQCG KGFRCRAILQ VHCKLHTGEK 250
PYICEKCGRA FIHDFQLQKH QIIHTGEKPF KCEICGKSFC LRSSLNRHCM 300
VHTAEKLYKS EECGKGFTDS LDLHKHQIIH TGQKPYNCKE CGKSFRWSSY 350
LLIHQRIHSG EKPYRCEECG KGYISKSGLN LHQRVHTGER PYNCKECGKS 400
FSRASSILNH KKLHCRKKPF KCEDCGKRLV HRSFCKDQQG DHNGENSSKC 450
EDCGKRYKRR LNLDIILSLF LNDM 474
Length:474
Mass (Da):54,542
Last modified:February 6, 2007 - v3
Checksum:i40DBFE785051451D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti310 – 3101S → C.
Corresponds to variant rs1060877 [ dbSNP | Ensembl ].
VAR_030534
Natural varianti434 – 4341F → Y.
Corresponds to variant rs6413542 [ dbSNP | Ensembl ].
VAR_030535
Natural varianti441 – 4411D → E.
Corresponds to variant rs12753 [ dbSNP | Ensembl ].
VAR_014827

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261D → H in AAB62180. 1 Publication
Sequence conflicti92 – 921C → V in AAB62180. 1 Publication
Sequence conflicti201 – 2011R → C in AAB62180. 1 Publication
Sequence conflicti214 – 2141R → H in AAB62180. 1 Publication
Sequence conflicti220 – 2201G → R in AAB62180. 1 Publication
Sequence conflicti265 – 2662FQ → LK in AAB62180. 1 Publication
Sequence conflicti280 – 2801F → S in AAB62180. 1 Publication
Sequence conflicti299 – 2991C → Y in AAB62180. 1 Publication
Sequence conflicti308 – 3103YKS → SKC in AAB62180. 1 Publication
Sequence conflicti383 – 3853QRV → PEG in AAB62180. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U95044 mRNA. Translation: AAB62180.1.
AC018725 Genomic DNA. Translation: AAF18685.1.
AC067968 Genomic DNA. Translation: AAF66074.1.
BC050340 mRNA. Translation: AAH50340.2.
BC094708 mRNA. Translation: AAH94708.1.
CCDSiCCDS33044.1.
RefSeqiNP_006291.2. NM_006300.3.
UniGeneiHs.193583.

Genome annotation databases

EnsembliENST00000429154; ENSP00000409318; ENSG00000159882.
GeneIDi7773.
KEGGihsa:7773.
UCSCiuc002oyb.1. human.

Polymorphism databases

DMDMi125987869.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U95044 mRNA. Translation: AAB62180.1 .
AC018725 Genomic DNA. Translation: AAF18685.1 .
AC067968 Genomic DNA. Translation: AAF66074.1 .
BC050340 mRNA. Translation: AAH50340.2 .
BC094708 mRNA. Translation: AAH94708.1 .
CCDSi CCDS33044.1.
RefSeqi NP_006291.2. NM_006300.3.
UniGenei Hs.193583.

3D structure databases

ProteinModelPortali Q9UIE0.
SMRi Q9UIE0. Positions 7-49, 134-463.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113556. 1 interaction.
IntActi Q9UIE0. 2 interactions.

PTM databases

PhosphoSitei Q9UIE0.

Polymorphism databases

DMDMi 125987869.

Proteomic databases

PRIDEi Q9UIE0.

Protocols and materials databases

DNASUi 7773.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000429154 ; ENSP00000409318 ; ENSG00000159882 .
GeneIDi 7773.
KEGGi hsa:7773.
UCSCi uc002oyb.1. human.

Organism-specific databases

CTDi 7773.
GeneCardsi GC19P044507.
HGNCi HGNC:13024. ZNF230.
neXtProti NX_Q9UIE0.
PharmGKBi PA37603.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9UIE0.
KOi K09228.
OMAi EAGPHED.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9UIE0.
TreeFami TF341885.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 7773.
NextBioi 30101.
PROi Q9UIE0.

Gene expression databases

ArrayExpressi Q9UIE0.
Bgeei Q9UIE0.
CleanExi HS_ZNF230.
Genevestigatori Q9UIE0.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel KRAB-containing zinc finger gene, FDZF2."
    Wu G., Yu L.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN230_HUMAN
AccessioniPrimary (citable) accession number: Q9UIE0
Secondary accession number(s): O15322
, Q504X7, Q86W84, Q9P1U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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