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Protein

Zinc finger protein 230

Gene

ZNF230

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri168 – 190C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 10; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 230
Alternative name(s):
Zinc finger protein FDZF2
Gene namesi
Name:ZNF230
Synonyms:FDZF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000159882.12.
HGNCiHGNC:13024. ZNF230.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7773.
OpenTargetsiENSG00000159882.
PharmGKBiPA37603.

Polymorphism and mutation databases

BioMutaiZNF230.
DMDMi125987869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474711 – 474Zinc finger protein 230Add BLAST474

Proteomic databases

PaxDbiQ9UIE0.
PeptideAtlasiQ9UIE0.
PRIDEiQ9UIE0.

PTM databases

iPTMnetiQ9UIE0.
PhosphoSitePlusiQ9UIE0.

Expressioni

Gene expression databases

BgeeiENSG00000159882.
CleanExiHS_ZNF230.
ExpressionAtlasiQ9UIE0. baseline and differential.
GenevisibleiQ9UIE0. HS.

Organism-specific databases

HPAiHPA006172.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113556. 6 interactors.
IntActiQ9UIE0. 8 interactors.
STRINGi9606.ENSP00000409318.

Structurei

3D structure databases

ProteinModelPortaliQ9UIE0.
SMRiQ9UIE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 76KRABPROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 167KRNBAdd BLAST88

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri168 – 190C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 10; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00870000136402.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UIE0.
KOiK09228.
OMAiCDMRGKE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UIE0.
TreeFamiTF341885.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.

Sequencei

Sequence statusi: Complete.

Q9UIE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFKEAVTF KDVAVFFTEE ELGLLDPAQR KLYQDVMLEN FTNLLSVGHQ
60 70 80 90 100
PFHPFHFLRE EKFWMMETAT QREGNSGGKT IAEAGPHEDC PCQQIWEQTA
110 120 130 140 150
SDLTQSQDSI INNSHFFEQG DVPSQVEAGL SIIHTGQKPS QNGKCKQSFS
160 170 180 190 200
DVAIFDPPQQ FHSGEKSHTC NECGKSFCYI SALRIHQRVH LREKLSKCDM
210 220 230 240 250
RGKEFSQSSC LQTRERVHTG EKPFKCEQCG KGFRCRAILQ VHCKLHTGEK
260 270 280 290 300
PYICEKCGRA FIHDFQLQKH QIIHTGEKPF KCEICGKSFC LRSSLNRHCM
310 320 330 340 350
VHTAEKLYKS EECGKGFTDS LDLHKHQIIH TGQKPYNCKE CGKSFRWSSY
360 370 380 390 400
LLIHQRIHSG EKPYRCEECG KGYISKSGLN LHQRVHTGER PYNCKECGKS
410 420 430 440 450
FSRASSILNH KKLHCRKKPF KCEDCGKRLV HRSFCKDQQG DHNGENSSKC
460 470
EDCGKRYKRR LNLDIILSLF LNDM
Length:474
Mass (Da):54,542
Last modified:February 6, 2007 - v3
Checksum:i40DBFE785051451D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26D → H in AAB62180 (Ref. 1) Curated1
Sequence conflicti92C → V in AAB62180 (Ref. 1) Curated1
Sequence conflicti201R → C in AAB62180 (Ref. 1) Curated1
Sequence conflicti214R → H in AAB62180 (Ref. 1) Curated1
Sequence conflicti220G → R in AAB62180 (Ref. 1) Curated1
Sequence conflicti265 – 266FQ → LK in AAB62180 (Ref. 1) Curated2
Sequence conflicti280F → S in AAB62180 (Ref. 1) Curated1
Sequence conflicti299C → Y in AAB62180 (Ref. 1) Curated1
Sequence conflicti308 – 310YKS → SKC in AAB62180 (Ref. 1) Curated3
Sequence conflicti383 – 385QRV → PEG in AAB62180 (Ref. 1) Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030534310S → C. Corresponds to variant dbSNP:rs1060877Ensembl.1
Natural variantiVAR_030535434F → Y. Corresponds to variant dbSNP:rs6413542Ensembl.1
Natural variantiVAR_014827441D → E. Corresponds to variant dbSNP:rs12753Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95044 mRNA. Translation: AAB62180.1.
AC018725 Genomic DNA. Translation: AAF18685.1.
AC067968 Genomic DNA. Translation: AAF66074.1.
BC050340 mRNA. Translation: AAH50340.2.
BC094708 mRNA. Translation: AAH94708.1.
CCDSiCCDS33044.1.
RefSeqiNP_006291.2. NM_006300.3.
UniGeneiHs.193583.

Genome annotation databases

EnsembliENST00000429154; ENSP00000409318; ENSG00000159882.
GeneIDi7773.
KEGGihsa:7773.
UCSCiuc002oyb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN230_HUMAN
AccessioniPrimary (citable) accession number: Q9UIE0
Secondary accession number(s): O15322
, Q504X7, Q86W84, Q9P1U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: February 6, 2007
Last modified: November 22, 2017
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families