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Q9UIE0

- ZN230_HUMAN

UniProt

Q9UIE0 - ZN230_HUMAN

Protein

Zinc finger protein 230

Gene

ZNF230

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri168 – 19023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri196 – 21823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri224 – 24623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri252 – 27423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri280 – 30223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri308 – 33023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44223C2H2-type 10; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 230
    Alternative name(s):
    Zinc finger protein FDZF2
    Gene namesi
    Name:ZNF230
    Synonyms:FDZF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13024. ZNF230.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37603.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474Zinc finger protein 230PRO_0000047471Add
    BLAST

    Proteomic databases

    PRIDEiQ9UIE0.

    PTM databases

    PhosphoSiteiQ9UIE0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UIE0.
    BgeeiQ9UIE0.
    CleanExiHS_ZNF230.
    GenevestigatoriQ9UIE0.

    Interactioni

    Protein-protein interaction databases

    BioGridi113556. 1 interaction.
    IntActiQ9UIE0. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UIE0.
    SMRiQ9UIE0. Positions 7-49, 134-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 7669KRABPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni80 – 16788KRNBAdd
    BLAST

    Sequence similaritiesi

    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri168 – 19023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri196 – 21823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri224 – 24623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri252 – 27423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri280 – 30223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri308 – 33023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44223C2H2-type 10; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9UIE0.
    KOiK09228.
    OMAiEAGPHED.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9UIE0.
    TreeFamiTF341885.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UIE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTFKEAVTF KDVAVFFTEE ELGLLDPAQR KLYQDVMLEN FTNLLSVGHQ    50
    PFHPFHFLRE EKFWMMETAT QREGNSGGKT IAEAGPHEDC PCQQIWEQTA 100
    SDLTQSQDSI INNSHFFEQG DVPSQVEAGL SIIHTGQKPS QNGKCKQSFS 150
    DVAIFDPPQQ FHSGEKSHTC NECGKSFCYI SALRIHQRVH LREKLSKCDM 200
    RGKEFSQSSC LQTRERVHTG EKPFKCEQCG KGFRCRAILQ VHCKLHTGEK 250
    PYICEKCGRA FIHDFQLQKH QIIHTGEKPF KCEICGKSFC LRSSLNRHCM 300
    VHTAEKLYKS EECGKGFTDS LDLHKHQIIH TGQKPYNCKE CGKSFRWSSY 350
    LLIHQRIHSG EKPYRCEECG KGYISKSGLN LHQRVHTGER PYNCKECGKS 400
    FSRASSILNH KKLHCRKKPF KCEDCGKRLV HRSFCKDQQG DHNGENSSKC 450
    EDCGKRYKRR LNLDIILSLF LNDM 474
    Length:474
    Mass (Da):54,542
    Last modified:February 6, 2007 - v3
    Checksum:i40DBFE785051451D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261D → H in AAB62180. 1 PublicationCurated
    Sequence conflicti92 – 921C → V in AAB62180. 1 PublicationCurated
    Sequence conflicti201 – 2011R → C in AAB62180. 1 PublicationCurated
    Sequence conflicti214 – 2141R → H in AAB62180. 1 PublicationCurated
    Sequence conflicti220 – 2201G → R in AAB62180. 1 PublicationCurated
    Sequence conflicti265 – 2662FQ → LK in AAB62180. 1 PublicationCurated
    Sequence conflicti280 – 2801F → S in AAB62180. 1 PublicationCurated
    Sequence conflicti299 – 2991C → Y in AAB62180. 1 PublicationCurated
    Sequence conflicti308 – 3103YKS → SKC in AAB62180. 1 PublicationCurated
    Sequence conflicti383 – 3853QRV → PEG in AAB62180. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti310 – 3101S → C.
    Corresponds to variant rs1060877 [ dbSNP | Ensembl ].
    VAR_030534
    Natural varianti434 – 4341F → Y.
    Corresponds to variant rs6413542 [ dbSNP | Ensembl ].
    VAR_030535
    Natural varianti441 – 4411D → E.
    Corresponds to variant rs12753 [ dbSNP | Ensembl ].
    VAR_014827

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95044 mRNA. Translation: AAB62180.1.
    AC018725 Genomic DNA. Translation: AAF18685.1.
    AC067968 Genomic DNA. Translation: AAF66074.1.
    BC050340 mRNA. Translation: AAH50340.2.
    BC094708 mRNA. Translation: AAH94708.1.
    CCDSiCCDS33044.1.
    RefSeqiNP_006291.2. NM_006300.3.
    UniGeneiHs.193583.

    Genome annotation databases

    EnsembliENST00000429154; ENSP00000409318; ENSG00000159882.
    GeneIDi7773.
    KEGGihsa:7773.
    UCSCiuc002oyb.1. human.

    Polymorphism databases

    DMDMi125987869.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95044 mRNA. Translation: AAB62180.1 .
    AC018725 Genomic DNA. Translation: AAF18685.1 .
    AC067968 Genomic DNA. Translation: AAF66074.1 .
    BC050340 mRNA. Translation: AAH50340.2 .
    BC094708 mRNA. Translation: AAH94708.1 .
    CCDSi CCDS33044.1.
    RefSeqi NP_006291.2. NM_006300.3.
    UniGenei Hs.193583.

    3D structure databases

    ProteinModelPortali Q9UIE0.
    SMRi Q9UIE0. Positions 7-49, 134-463.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113556. 1 interaction.
    IntActi Q9UIE0. 2 interactions.

    PTM databases

    PhosphoSitei Q9UIE0.

    Polymorphism databases

    DMDMi 125987869.

    Proteomic databases

    PRIDEi Q9UIE0.

    Protocols and materials databases

    DNASUi 7773.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000429154 ; ENSP00000409318 ; ENSG00000159882 .
    GeneIDi 7773.
    KEGGi hsa:7773.
    UCSCi uc002oyb.1. human.

    Organism-specific databases

    CTDi 7773.
    GeneCardsi GC19P044507.
    HGNCi HGNC:13024. ZNF230.
    neXtProti NX_Q9UIE0.
    PharmGKBi PA37603.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9UIE0.
    KOi K09228.
    OMAi EAGPHED.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9UIE0.
    TreeFami TF341885.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 7773.
    NextBioi 30101.
    PROi Q9UIE0.

    Gene expression databases

    ArrayExpressi Q9UIE0.
    Bgeei Q9UIE0.
    CleanExi HS_ZNF230.
    Genevestigatori Q9UIE0.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel KRAB-containing zinc finger gene, FDZF2."
      Wu G., Yu L.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiZN230_HUMAN
    AccessioniPrimary (citable) accession number: Q9UIE0
    Secondary accession number(s): O15322
    , Q504X7, Q86W84, Q9P1U6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3