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Protein

Zinc finger protein 639

Gene

ZNF639

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds DNA and may function as a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri403 – 425C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 454C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri460 – 482C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein self-association Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • negative regulation by host of viral transcription Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation by host of viral transcription Source: UniProtKB
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • viral entry into host cell Source: UniProtKB

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 639
Alternative name(s):
Zinc finger protein ANC_2H01
Zinc finger protein ZASC1
Gene namesi
Name:ZNF639
Synonyms:ZASC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000121864.9.
HGNCiHGNC:30950. ZNF639.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51193.
OpenTargetsiENSG00000121864.
PharmGKBiPA134990796.

Polymorphism and mutation databases

BioMutaiZNF639.
DMDMi51316968.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476961 – 485Zinc finger protein 639Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1
Cross-linki76Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei88PhosphoserineCombined sources1
Cross-linki177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UID6.
MaxQBiQ9UID6.
PaxDbiQ9UID6.
PeptideAtlasiQ9UID6.
PRIDEiQ9UID6.

PTM databases

iPTMnetiQ9UID6.
PhosphoSitePlusiQ9UID6.

Expressioni

Gene expression databases

BgeeiENSG00000121864.
CleanExiHS_ZNF639.
ExpressionAtlasiQ9UID6. baseline and differential.
GenevisibleiQ9UID6. HS.

Organism-specific databases

HPAiHPA049023.
HPA052163.

Interactioni

Subunit structurei

Interacts with CTNNA2.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein self-association Source: UniProtKB

Protein-protein interaction databases

BioGridi119367. 11 interactors.
IntActiQ9UID6. 17 interactors.
MINTiMINT-2873018.
STRINGi9606.ENSP00000325634.

Structurei

3D structure databases

ProteinModelPortaliQ9UID6.
SMRiQ9UID6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni371 – 455Interaction with CTNNA21 PublicationAdd BLAST85

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri403 – 425C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 454C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri460 – 482C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063297.
HOGENOMiHOG000285973.
HOVERGENiHBG056718.
InParanoidiQ9UID6.
OMAiFPHVCDD.
OrthoDBiEOG091G05F4.
PhylomeDBiQ9UID6.
TreeFamiTF335557.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 9 hits.
SUPFAMiSSF57667. SSF57667. 4 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.

Sequencei

Sequence statusi: Complete.

Q9UID6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEYPKKRKR KTLHPSRYSD SSGISRIADG FNGIFSDHCY SVCSMRQPDL
60 70 80 90 100
KYFDNKDDDS DTETSNDLPK FADGIKARNR NQNYLVPSPV LRILDHTAFS
110 120 130 140 150
TEKSADIVIC DEECDSPESV NQQTQEESPI EVHTAEDVPI AVEVHAISED
160 170 180 190 200
YDIETENNSS ESLQDQTDEE PPAKLCKILD KSQALNVTAQ QKWPLLRANS
210 220 230 240 250
SGLYKCELCE FNSKYFSDLK QHMILKHKRT DSNVCRVCKE SFSTNMLLIE
260 270 280 290 300
HAKLHEEDPY ICKYCDYKTV IFENLSQHIA DTHFSDHLYW CEQCDVQFSS
310 320 330 340 350
SSELYLHFQE HSCDEQYLCQ FCEHETNDPE DLHSHVVNEH ACKLIELSDK
360 370 380 390 400
YNNGEHGQYS LLSKITFDKC KNFFVCQVCG FRSRLHTNVN RHVAIEHTKI
410 420 430 440 450
FPHVCDDCGK GFSSMLEYCK HLNSHLSEGI YLCQYCEYST GQIEDLKIHL
460 470 480
DFKHSADLPH KCSDCLMRFG NERELISHLP VHETT
Length:485
Mass (Da):56,054
Last modified:May 1, 2000 - v1
Checksum:iBDEB00B87BCC1C1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003924 mRNA. Translation: AAF21240.1.
AB097862 mRNA. Translation: BAC77610.1.
AC007823 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78413.1.
CH471052 Genomic DNA. Translation: EAW78414.1.
CH471052 Genomic DNA. Translation: EAW78415.1.
CH471052 Genomic DNA. Translation: EAW78416.1.
BC020500 mRNA. Translation: AAH20500.1.
BC026181 mRNA. Translation: AAH26181.1.
DQ323613 mRNA. Translation: ABD27860.1.
CCDSiCCDS3227.1.
RefSeqiNP_001290354.1. NM_001303425.1.
NP_001290355.1. NM_001303426.1.
NP_057415.1. NM_016331.2.
XP_016862039.1. XM_017006550.1.
XP_016862040.1. XM_017006551.1.
XP_016862041.1. XM_017006552.1.
XP_016862042.1. XM_017006553.1.
UniGeneiHs.632578.

Genome annotation databases

EnsembliENST00000326361; ENSP00000325634; ENSG00000121864.
ENST00000484866; ENSP00000418766; ENSG00000121864.
ENST00000496856; ENSP00000417740; ENSG00000121864.
ENST00000621687; ENSP00000477626; ENSG00000121864.
GeneIDi51193.
KEGGihsa:51193.
UCSCiuc003fjq.2. human.

Similar proteinsi

Entry informationi

Entry nameiZN639_HUMAN
AccessioniPrimary (citable) accession number: Q9UID6
Secondary accession number(s): A9X3Z9, D3DNR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families