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Protein

Vacuolar protein sorting-associated protein 51 homolog

Gene

VPS51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).2 Publications

GO - Biological processi

  • autophagy Source: UniProtKB
  • endocytic recycling Source: UniProtKB
  • Golgi organization Source: GO_Central
  • Golgi vesicle transport Source: GO_Central
  • lipid transport Source: UniProtKB-KW
  • lysosomal transport Source: MGI
  • protein transport Source: UniProtKB-KW
  • retrograde transport, endosome to Golgi Source: UniProtKB

Keywordsi

Biological processLipid transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 51 homolog
Alternative name(s):
Another new gene 2 protein
Protein fat-free homolog
Gene namesi
Name:VPS51
Synonyms:ANG2, C11orf2, C11orf3, FFR
ORF Names:PP5382
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149823.7
HGNCiHGNC:1172 VPS51
MIMi615738 gene
neXtProtiNX_Q9UID3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi738
OpenTargetsiENSG00000149823
PharmGKBiPA25485

Polymorphism and mutation databases

DMDMi71153003

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000898312 – 782Vacuolar protein sorting-associated protein 51 homologAdd BLAST781

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei18PhosphoserineCombined sources1
Modified residuei44PhosphoserineBy similarity1
Modified residuei649PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UID3
PaxDbiQ9UID3
PeptideAtlasiQ9UID3
PRIDEiQ9UID3

PTM databases

iPTMnetiQ9UID3
PhosphoSitePlusiQ9UID3

Expressioni

Gene expression databases

BgeeiENSG00000149823
CleanExiHS_C11orf2
ExpressionAtlasiQ9UID3 baseline and differential
GenevisibleiQ9UID3 HS

Organism-specific databases

HPAiHPA039650
HPA061447

Interactioni

Subunit structurei

Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (PubMed:20685960). Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (PubMed:25799061). Interacts with STX6 (PubMed:20685960).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107197, 51 interactors
CORUMiQ9UID3
DIPiDIP-60562N
IntActiQ9UID3, 28 interactors
MINTiQ9UID3
STRINGi9606.ENSP00000279281

Structurei

Secondary structure

1782
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 41Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J2CX-ray1.80B/D33-49[»]
ProteinModelPortaliQ9UID3
SMRiQ9UID3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili116 – 147Sequence analysisAdd BLAST32
Coiled coili270 – 292Sequence analysisAdd BLAST23

Sequence similaritiesi

Belongs to the VPS51 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2346 Eukaryota
ENOG410XPIF LUCA
GeneTreeiENSGT00390000001738
HOGENOMiHOG000046877
HOVERGENiHBG107916
InParanoidiQ9UID3
KOiK20296
OMAiCEEFLAH
OrthoDBiEOG091G0321
PhylomeDBiQ9UID3
TreeFamiTF314825

Family and domain databases

InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR014812 Vps51
PANTHERiPTHR15954 PTHR15954, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UID3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAAGPS PGSGPGDSPE GPEGEAPERR RKAHGMLKLY YGLSEGEAAG
60 70 80 90 100
RPAGPDPLDP TDLNGAHFDP EVYLDKLRRE CPLAQLMDSE TDMVRQIRAL
110 120 130 140 150
DSDMQTLVYE NYNKFISATD TIRKMKNDFR KMEDEMDRLA TNMAVITDFS
160 170 180 190 200
ARISATLQDR HERITKLAGV HALLRKLQFL FELPSRLTKC VELGAYGQAV
210 220 230 240 250
RYQGRAQAVL QQYQHLPSFR AIQDDCQVIT ARLAQQLRQR FREGGSGAPE
260 270 280 290 300
QAECVELLLA LGEPAEELCE EFLAHARGRL EKELRNLEAE LGPSPPAPDV
310 320 330 340 350
LEFTDHGGSG FVGGLCQVAA AYQELFAAQG PAGAEKLAAF ARQLGSRYFA
360 370 380 390 400
LVERRLAQEQ GGGDNSLLVR ALDRFHRRLR APGALLAAAG LADAATEIVE
410 420 430 440 450
RVARERLGHH LQGLRAAFLG CLTDVRQALA APRVAGKEGP GLAELLANVA
460 470 480 490 500
SSILSHIKAS LAAVHLFTAK EVSFSNKPYF RGEFCSQGVR EGLIVGFVHS
510 520 530 540 550
MCQTAQSFCD SPGEKGGATP PALLLLLSRL CLDYETATIS YILTLTDEQF
560 570 580 590 600
LVQDQFPVTP VSTLCAEARE TARRLLTHYV KVQGLVISQM LRKSVETRDW
610 620 630 640 650
LSTLEPRNVR AVMKRVVEDT TAIDVQVGLL YEEGVRKAQS SDSSKRTFSV
660 670 680 690 700
YSSSRQQGRY APSYTPSAPM DTNLLSNIQK LFSERIDVFS PVEFNKVSVL
710 720 730 740 750
TGIIKISLKT LLECVRLRTF GRFGLQQVQV DCHFLQLYLW RFVADEELVH
760 770 780
LLLDEVVASA ALRCPDPVPM EPSVVEVICE RG
Length:782
Mass (Da):86,042
Last modified:October 1, 2000 - v2
Checksum:i0E858672E4C656DD
GO
Isoform 2 (identifier: Q9UID3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.

Note: No experimental confirmation available.
Show »
Length:658
Mass (Da):72,655
Checksum:iA887B9E4D045BAE6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0147001 – 124Missing in isoform 2. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024631 mRNA Translation: AAF21627.2
AF289557 mRNA Translation: AAL55741.1
AL833818 mRNA Translation: CAD38681.2
AP003068 Genomic DNA No translation available.
BC006555 mRNA Translation: AAH06555.2
BC007198 mRNA Translation: AAH07198.1
BC009285 mRNA Translation: AAH09285.2
BC010540 mRNA Translation: AAH10540.1
BC017438 mRNA Translation: AAH17438.1
CCDSiCCDS8093.1 [Q9UID3-1]
RefSeqiNP_037397.2, NM_013265.3 [Q9UID3-1]
UniGeneiHs.277517
Hs.732951

Genome annotation databases

EnsembliENST00000279281; ENSP00000279281; ENSG00000149823 [Q9UID3-1]
GeneIDi738
KEGGihsa:738
UCSCiuc001ocr.3 human [Q9UID3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVPS51_HUMAN
AccessioniPrimary (citable) accession number: Q9UID3
Secondary accession number(s): Q6PJV5
, Q7L8A6, Q8WZ35, Q96DF4, Q96GR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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