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Q9UID3

- VPS51_HUMAN

UniProt

Q9UID3 - VPS51_HUMAN

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Protein

Vacuolar protein sorting-associated protein 51 homolog

Gene

VPS51

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN.1 Publication

GO - Biological processi

  1. autophagy Source: UniProtKB
  2. lipid transport Source: UniProtKB-KW
  3. protein transport Source: UniProtKB-KW
  4. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 51 homolog
Alternative name(s):
Another new gene 2 protein
Protein fat-free homolog
Gene namesi
Name:VPS51
Synonyms:ANG2, C11orf2, C11orf3, FFR
ORF Names:PP5382
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1172. VPS51.

Subcellular locationi

Golgi apparatustrans-Golgi network 1 Publication

GO - Cellular componenti

  1. GARP complex Source: UniProtKB
  2. Golgi apparatus Source: UniProtKB
  3. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25485.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 782781Vacuolar protein sorting-associated protein 51 homologPRO_0000089831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications
Modified residuei18 – 181Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9UID3.
PaxDbiQ9UID3.
PRIDEiQ9UID3.

PTM databases

PhosphoSiteiQ9UID3.

Expressioni

Gene expression databases

BgeeiQ9UID3.
CleanExiHS_C11orf2.
ExpressionAtlasiQ9UID3. baseline.
GenevestigatoriQ9UID3.

Organism-specific databases

HPAiHPA039650.

Interactioni

Subunit structurei

Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Interacts with STX6.1 Publication

Protein-protein interaction databases

BioGridi107197. 16 interactions.
DIPiDIP-60562N.
IntActiQ9UID3. 7 interactions.
MINTiMINT-3080728.
STRINGi9606.ENSP00000279281.

Structurei

Secondary structure

1
782
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi34 – 418Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4J2CX-ray1.80B/D33-49[»]
ProteinModelPortaliQ9UID3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili116 – 14732Sequence AnalysisAdd
BLAST
Coiled coili270 – 29223Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the VPS51 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG127717.
GeneTreeiENSGT00390000001738.
HOGENOMiHOG000046877.
HOVERGENiHBG107916.
InParanoidiQ9UID3.
OMAiPYFRGEF.
OrthoDBiEOG7D59MX.
PhylomeDBiQ9UID3.
TreeFamiTF314825.

Family and domain databases

InterProiIPR016159. Cullin_repeat-like_dom.
[Graphical view]
SUPFAMiSSF74788. SSF74788. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UID3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAAGPS PGSGPGDSPE GPEGEAPERR RKAHGMLKLY YGLSEGEAAG
60 70 80 90 100
RPAGPDPLDP TDLNGAHFDP EVYLDKLRRE CPLAQLMDSE TDMVRQIRAL
110 120 130 140 150
DSDMQTLVYE NYNKFISATD TIRKMKNDFR KMEDEMDRLA TNMAVITDFS
160 170 180 190 200
ARISATLQDR HERITKLAGV HALLRKLQFL FELPSRLTKC VELGAYGQAV
210 220 230 240 250
RYQGRAQAVL QQYQHLPSFR AIQDDCQVIT ARLAQQLRQR FREGGSGAPE
260 270 280 290 300
QAECVELLLA LGEPAEELCE EFLAHARGRL EKELRNLEAE LGPSPPAPDV
310 320 330 340 350
LEFTDHGGSG FVGGLCQVAA AYQELFAAQG PAGAEKLAAF ARQLGSRYFA
360 370 380 390 400
LVERRLAQEQ GGGDNSLLVR ALDRFHRRLR APGALLAAAG LADAATEIVE
410 420 430 440 450
RVARERLGHH LQGLRAAFLG CLTDVRQALA APRVAGKEGP GLAELLANVA
460 470 480 490 500
SSILSHIKAS LAAVHLFTAK EVSFSNKPYF RGEFCSQGVR EGLIVGFVHS
510 520 530 540 550
MCQTAQSFCD SPGEKGGATP PALLLLLSRL CLDYETATIS YILTLTDEQF
560 570 580 590 600
LVQDQFPVTP VSTLCAEARE TARRLLTHYV KVQGLVISQM LRKSVETRDW
610 620 630 640 650
LSTLEPRNVR AVMKRVVEDT TAIDVQVGLL YEEGVRKAQS SDSSKRTFSV
660 670 680 690 700
YSSSRQQGRY APSYTPSAPM DTNLLSNIQK LFSERIDVFS PVEFNKVSVL
710 720 730 740 750
TGIIKISLKT LLECVRLRTF GRFGLQQVQV DCHFLQLYLW RFVADEELVH
760 770 780
LLLDEVVASA ALRCPDPVPM EPSVVEVICE RG
Length:782
Mass (Da):86,042
Last modified:October 1, 2000 - v2
Checksum:i0E858672E4C656DD
GO
Isoform 2 (identifier: Q9UID3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.

Note: No experimental confirmation available.

Show »
Length:658
Mass (Da):72,655
Checksum:iA887B9E4D045BAE6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 124124Missing in isoform 2. 1 PublicationVSP_014700Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024631 mRNA. Translation: AAF21627.2.
AF289557 mRNA. Translation: AAL55741.1.
AL833818 mRNA. Translation: CAD38681.2.
AP003068 Genomic DNA. No translation available.
BC006555 mRNA. Translation: AAH06555.2.
BC007198 mRNA. Translation: AAH07198.1.
BC009285 mRNA. Translation: AAH09285.2.
BC010540 mRNA. Translation: AAH10540.1.
BC017438 mRNA. Translation: AAH17438.1.
CCDSiCCDS8093.1. [Q9UID3-1]
RefSeqiNP_037397.2. NM_013265.3. [Q9UID3-1]
UniGeneiHs.277517.
Hs.732951.

Genome annotation databases

EnsembliENST00000279281; ENSP00000279281; ENSG00000149823. [Q9UID3-1]
GeneIDi738.
KEGGihsa:738.
UCSCiuc001ocr.2. human. [Q9UID3-1]

Polymorphism databases

DMDMi71153003.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024631 mRNA. Translation: AAF21627.2 .
AF289557 mRNA. Translation: AAL55741.1 .
AL833818 mRNA. Translation: CAD38681.2 .
AP003068 Genomic DNA. No translation available.
BC006555 mRNA. Translation: AAH06555.2 .
BC007198 mRNA. Translation: AAH07198.1 .
BC009285 mRNA. Translation: AAH09285.2 .
BC010540 mRNA. Translation: AAH10540.1 .
BC017438 mRNA. Translation: AAH17438.1 .
CCDSi CCDS8093.1. [Q9UID3-1 ]
RefSeqi NP_037397.2. NM_013265.3. [Q9UID3-1 ]
UniGenei Hs.277517.
Hs.732951.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4J2C X-ray 1.80 B/D 33-49 [» ]
ProteinModelPortali Q9UID3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107197. 16 interactions.
DIPi DIP-60562N.
IntActi Q9UID3. 7 interactions.
MINTi MINT-3080728.
STRINGi 9606.ENSP00000279281.

PTM databases

PhosphoSitei Q9UID3.

Polymorphism databases

DMDMi 71153003.

Proteomic databases

MaxQBi Q9UID3.
PaxDbi Q9UID3.
PRIDEi Q9UID3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000279281 ; ENSP00000279281 ; ENSG00000149823 . [Q9UID3-1 ]
GeneIDi 738.
KEGGi hsa:738.
UCSCi uc001ocr.2. human. [Q9UID3-1 ]

Organism-specific databases

CTDi 738.
GeneCardsi GC11P064864.
HGNCi HGNC:1172. VPS51.
HPAi HPA039650.
MIMi 615738. gene.
neXtProti NX_Q9UID3.
PharmGKBi PA25485.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG127717.
GeneTreei ENSGT00390000001738.
HOGENOMi HOG000046877.
HOVERGENi HBG107916.
InParanoidi Q9UID3.
OMAi PYFRGEF.
OrthoDBi EOG7D59MX.
PhylomeDBi Q9UID3.
TreeFami TF314825.

Miscellaneous databases

GenomeRNAii 738.
NextBioi 2996.
PROi Q9UID3.
SOURCEi Search...

Gene expression databases

Bgeei Q9UID3.
CleanExi HS_C11orf2.
ExpressionAtlasi Q9UID3. baseline.
Genevestigatori Q9UID3.

Family and domain databases

InterProi IPR016159. Cullin_repeat-like_dom.
[Graphical view ]
SUPFAMi SSF74788. SSF74788. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13."
    Lemmens I.H., Kas K., Merregaert J., Van de Ven W.J.M.
    Genomics 49:437-442(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Lemmens I.H., Kas K., Merregaert J., Van de Ven W.J.M.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix, Eye, Lung and Muscle.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 120-782 (ISOFORM 1).
    Tissue: Testis.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  9. "Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex."
    Perez-Victoria F.J., Schindler C., Magadan J.G., Mardones G.A., Delevoye C., Romao M., Raposo G., Bonifacino J.S.
    Mol. Biol. Cell 21:3386-3395(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH VPS52; VPS53; VPS54 AND STX6.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVPS51_HUMAN
AccessioniPrimary (citable) accession number: Q9UID3
Secondary accession number(s): Q6PJV5
, Q7L8A6, Q8WZ35, Q96DF4, Q96GR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3