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Q9UID3

- VPS51_HUMAN

UniProt

Q9UID3 - VPS51_HUMAN

Protein

Vacuolar protein sorting-associated protein 51 homolog

Gene

VPS51

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. autophagy Source: UniProtKB
    2. lipid transport Source: UniProtKB-KW
    3. protein transport Source: UniProtKB-KW
    4. retrograde transport, endosome to Golgi Source: UniProtKB

    Keywords - Biological processi

    Lipid transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein sorting-associated protein 51 homolog
    Alternative name(s):
    Another new gene 2 protein
    Protein fat-free homolog
    Gene namesi
    Name:VPS51
    Synonyms:ANG2, C11orf2, C11orf3, FFR
    ORF Names:PP5382
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:1172. VPS51.

    Subcellular locationi

    Golgi apparatustrans-Golgi network 1 Publication

    GO - Cellular componenti

    1. GARP complex Source: UniProtKB
    2. Golgi apparatus Source: UniProtKB
    3. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25485.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 782781Vacuolar protein sorting-associated protein 51 homologPRO_0000089831Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei18 – 181Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UID3.
    PaxDbiQ9UID3.
    PRIDEiQ9UID3.

    PTM databases

    PhosphoSiteiQ9UID3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UID3.
    BgeeiQ9UID3.
    CleanExiHS_C11orf2.
    GenevestigatoriQ9UID3.

    Organism-specific databases

    HPAiHPA039650.

    Interactioni

    Subunit structurei

    Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Interacts with STX6.1 Publication

    Protein-protein interaction databases

    BioGridi107197. 11 interactions.
    DIPiDIP-60562N.
    IntActiQ9UID3. 7 interactions.
    MINTiMINT-3080728.
    STRINGi9606.ENSP00000279281.

    Structurei

    Secondary structure

    1
    782
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi34 – 418

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4J2CX-ray1.80B/D33-49[»]
    ProteinModelPortaliQ9UID3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili116 – 14732Sequence AnalysisAdd
    BLAST
    Coiled coili270 – 29223Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the VPS51 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG127717.
    HOGENOMiHOG000046877.
    HOVERGENiHBG107916.
    InParanoidiQ9UID3.
    OMAiPYFRGEF.
    OrthoDBiEOG7D59MX.
    PhylomeDBiQ9UID3.
    TreeFamiTF314825.

    Family and domain databases

    InterProiIPR016159. Cullin_repeat-like_dom.
    [Graphical view]
    SUPFAMiSSF74788. SSF74788. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UID3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAAAGPS PGSGPGDSPE GPEGEAPERR RKAHGMLKLY YGLSEGEAAG    50
    RPAGPDPLDP TDLNGAHFDP EVYLDKLRRE CPLAQLMDSE TDMVRQIRAL 100
    DSDMQTLVYE NYNKFISATD TIRKMKNDFR KMEDEMDRLA TNMAVITDFS 150
    ARISATLQDR HERITKLAGV HALLRKLQFL FELPSRLTKC VELGAYGQAV 200
    RYQGRAQAVL QQYQHLPSFR AIQDDCQVIT ARLAQQLRQR FREGGSGAPE 250
    QAECVELLLA LGEPAEELCE EFLAHARGRL EKELRNLEAE LGPSPPAPDV 300
    LEFTDHGGSG FVGGLCQVAA AYQELFAAQG PAGAEKLAAF ARQLGSRYFA 350
    LVERRLAQEQ GGGDNSLLVR ALDRFHRRLR APGALLAAAG LADAATEIVE 400
    RVARERLGHH LQGLRAAFLG CLTDVRQALA APRVAGKEGP GLAELLANVA 450
    SSILSHIKAS LAAVHLFTAK EVSFSNKPYF RGEFCSQGVR EGLIVGFVHS 500
    MCQTAQSFCD SPGEKGGATP PALLLLLSRL CLDYETATIS YILTLTDEQF 550
    LVQDQFPVTP VSTLCAEARE TARRLLTHYV KVQGLVISQM LRKSVETRDW 600
    LSTLEPRNVR AVMKRVVEDT TAIDVQVGLL YEEGVRKAQS SDSSKRTFSV 650
    YSSSRQQGRY APSYTPSAPM DTNLLSNIQK LFSERIDVFS PVEFNKVSVL 700
    TGIIKISLKT LLECVRLRTF GRFGLQQVQV DCHFLQLYLW RFVADEELVH 750
    LLLDEVVASA ALRCPDPVPM EPSVVEVICE RG 782
    Length:782
    Mass (Da):86,042
    Last modified:October 1, 2000 - v2
    Checksum:i0E858672E4C656DD
    GO
    Isoform 2 (identifier: Q9UID3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-124: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:658
    Mass (Da):72,655
    Checksum:iA887B9E4D045BAE6
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 124124Missing in isoform 2. 1 PublicationVSP_014700Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF024631 mRNA. Translation: AAF21627.2.
    AF289557 mRNA. Translation: AAL55741.1.
    AL833818 mRNA. Translation: CAD38681.2.
    AP003068 Genomic DNA. No translation available.
    BC006555 mRNA. Translation: AAH06555.2.
    BC007198 mRNA. Translation: AAH07198.1.
    BC009285 mRNA. Translation: AAH09285.2.
    BC010540 mRNA. Translation: AAH10540.1.
    BC017438 mRNA. Translation: AAH17438.1.
    CCDSiCCDS8093.1. [Q9UID3-1]
    RefSeqiNP_037397.2. NM_013265.3. [Q9UID3-1]
    UniGeneiHs.277517.
    Hs.732951.

    Genome annotation databases

    EnsembliENST00000279281; ENSP00000279281; ENSG00000149823. [Q9UID3-1]
    GeneIDi738.
    KEGGihsa:738.
    UCSCiuc001ocr.2. human. [Q9UID3-1]

    Polymorphism databases

    DMDMi71153003.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF024631 mRNA. Translation: AAF21627.2 .
    AF289557 mRNA. Translation: AAL55741.1 .
    AL833818 mRNA. Translation: CAD38681.2 .
    AP003068 Genomic DNA. No translation available.
    BC006555 mRNA. Translation: AAH06555.2 .
    BC007198 mRNA. Translation: AAH07198.1 .
    BC009285 mRNA. Translation: AAH09285.2 .
    BC010540 mRNA. Translation: AAH10540.1 .
    BC017438 mRNA. Translation: AAH17438.1 .
    CCDSi CCDS8093.1. [Q9UID3-1 ]
    RefSeqi NP_037397.2. NM_013265.3. [Q9UID3-1 ]
    UniGenei Hs.277517.
    Hs.732951.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4J2C X-ray 1.80 B/D 33-49 [» ]
    ProteinModelPortali Q9UID3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107197. 11 interactions.
    DIPi DIP-60562N.
    IntActi Q9UID3. 7 interactions.
    MINTi MINT-3080728.
    STRINGi 9606.ENSP00000279281.

    PTM databases

    PhosphoSitei Q9UID3.

    Polymorphism databases

    DMDMi 71153003.

    Proteomic databases

    MaxQBi Q9UID3.
    PaxDbi Q9UID3.
    PRIDEi Q9UID3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000279281 ; ENSP00000279281 ; ENSG00000149823 . [Q9UID3-1 ]
    GeneIDi 738.
    KEGGi hsa:738.
    UCSCi uc001ocr.2. human. [Q9UID3-1 ]

    Organism-specific databases

    CTDi 738.
    GeneCardsi GC11P064864.
    HGNCi HGNC:1172. VPS51.
    HPAi HPA039650.
    MIMi 615738. gene.
    neXtProti NX_Q9UID3.
    PharmGKBi PA25485.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG127717.
    HOGENOMi HOG000046877.
    HOVERGENi HBG107916.
    InParanoidi Q9UID3.
    OMAi PYFRGEF.
    OrthoDBi EOG7D59MX.
    PhylomeDBi Q9UID3.
    TreeFami TF314825.

    Miscellaneous databases

    ChiTaRSi C11orf2. human.
    GenomeRNAii 738.
    NextBioi 2996.
    PROi Q9UID3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UID3.
    Bgeei Q9UID3.
    CleanExi HS_C11orf2.
    Genevestigatori Q9UID3.

    Family and domain databases

    InterProi IPR016159. Cullin_repeat-like_dom.
    [Graphical view ]
    SUPFAMi SSF74788. SSF74788. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13."
      Lemmens I.H., Kas K., Merregaert J., Van de Ven W.J.M.
      Genomics 49:437-442(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Lemmens I.H., Kas K., Merregaert J., Van de Ven W.J.M.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix, Eye, Lung and Muscle.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 120-782 (ISOFORM 1).
      Tissue: Testis.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    9. "Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex."
      Perez-Victoria F.J., Schindler C., Magadan J.G., Mardones G.A., Delevoye C., Romao M., Raposo G., Bonifacino J.S.
      Mol. Biol. Cell 21:3386-3395(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH VPS52; VPS53; VPS54 AND STX6.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVPS51_HUMAN
    AccessioniPrimary (citable) accession number: Q9UID3
    Secondary accession number(s): Q6PJV5
    , Q7L8A6, Q8WZ35, Q96DF4, Q96GR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3