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Protein

SLAM family member 5

Gene

CD84

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity).By similarityCurated6 Publications

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • defense response Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc
  • innate immune response Source: UniProtKB-KW
  • leukocyte migration Source: Reactome
  • negative regulation of granulocyte macrophage colony-stimulating factor production Source: UniProtKB
  • negative regulation of interleukin-18 production Source: UniProtKB
  • negative regulation of mast cell activation Source: UniProtKB
  • negative regulation of mast cell degranulation Source: UniProtKB
  • regulation of store-operated calcium entry Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Cell adhesion, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
SLAM family member 5
Alternative name(s):
Cell surface antigen MAX.3
Hly9-beta
Leukocyte differentiation antigen CD84
Signaling lymphocytic activation molecule 5
CD_antigen: CD84
Gene namesi
Name:CD84
Synonyms:SLAMF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1704. CD84.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 225204ExtracellularSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Topological domaini247 – 34599CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi55 – 551T → A: Loss of dimerization. 1 Publication
Mutagenesisi62 – 621Y → A: No effect. 1 Publication
Mutagenesisi62 – 621Y → D: Loss of dimerization. 1 Publication
Mutagenesisi77 – 771T → A: Loss of dimerization. 1 Publication
Mutagenesisi78 – 781H → A: Loss of dimerization. 1 Publication
Mutagenesisi110 – 1101D → A: Loss of dimerization. 1 Publication
Mutagenesisi112 – 1121N → A: Loss of dimerization. 1 Publication
Mutagenesisi119 – 1191T → A: Loss of dimerization. 1 Publication
Mutagenesisi279 – 2791Y → F: Reduced tyrosine phosphorylation, reduced binding of SH2D1B and loss of binding of SH2D1A. 1 Publication
Mutagenesisi316 – 3161Y → F: Reduced tyrosine phosphorylation and reduced binding of SH2D1B. Loss of phosphorylation and loss of binding of SH2D1A and SH2D1B; when associated with F-279. 1 Publication

Organism-specific databases

PharmGKBiPA26242.

Polymorphism and mutation databases

BioMutaiCD84.
DMDMi74762772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 345324SLAM family member 5PRO_0000252029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence analysis
Disulfide bondi155 ↔ 193PROSITE-ProRule annotation
Modified residuei279 – 2791Phosphotyrosine1 Publication
Modified residuei296 – 2961Phosphotyrosine; by LYN2 Publications
Modified residuei316 – 3161Phosphotyrosine1 Publication1 Publication
Modified residuei341 – 3411Phosphotyrosine; by FES1 Publication

Post-translational modificationi

Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A is dependent of tyrosine phosphorylation of its cytoplasmic domain. Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation. Phosphorylated on tyrosine residues upon high affinity immunoglobulin epsilon receptor aggregation in mast cells.5 Publications
N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UIB8.
MaxQBiQ9UIB8.
PaxDbiQ9UIB8.
PeptideAtlasiQ9UIB8.
PRIDEiQ9UIB8.

PTM databases

iPTMnetiQ9UIB8.
PhosphoSiteiQ9UIB8.

Expressioni

Tissue specificityi

Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast cells.7 Publications

Developmental stagei

Expression is slightly increased in naive B-cells after the first dividion. By contrast, expression on memory B-cells decreased with each successive division.1 Publication

Gene expression databases

BgeeiENSG00000066294.
GenevisibleiQ9UIB8. HS.

Organism-specific databases

HPAiHPA070502.

Interactioni

Subunit structurei

Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/EAT-2. Interacts with tyrosine-protein phosphatases PTPN6/SHP-1 and PTPN11//SHP-2 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A. Interacts (via phosphorylated ITSM 1 and 2) with INPP5D/SHIP1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SH2D1BO147963EBI-6691679,EBI-3923013

Protein-protein interaction databases

BioGridi114359. 6 interactions.
DIPiDIP-60957N.
IntActiQ9UIB8. 3 interactions.
MINTiMINT-8013385.
STRINGi9606.ENSP00000312367.

Structurei

Secondary structure

1
345
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 326Combined sources
Beta strandi37 – 393Combined sources
Beta strandi49 – 6416Combined sources
Beta strandi68 – 703Combined sources
Beta strandi73 – 764Combined sources
Helixi79 – 813Combined sources
Beta strandi85 – 873Combined sources
Turni89 – 913Combined sources
Beta strandi94 – 963Combined sources
Helixi101 – 1033Combined sources
Beta strandi105 – 11511Combined sources
Beta strandi118 – 12912Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PKDX-ray2.04A/B/C/D/E/F22-131[»]
ProteinModelPortaliQ9UIB8.
SMRiQ9UIB8. Positions 23-131.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UIB8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 129104Ig-like V-typeAdd
BLAST
Domaini135 – 20773Ig-like C2-typeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi277 – 2826ITSM 1By similarity
Motifi314 – 3196ITSM 2By similarity

Domaini

The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).By similarity1 Publication

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVV0. Eukaryota.
ENOG410Z5M6. LUCA.
GeneTreeiENSGT00530000063114.
HOVERGENiHBG093961.
InParanoidiQ9UIB8.
KOiK06511.
OMAiWSPLGEE.
OrthoDBiEOG091G0KKU.
PhylomeDBiQ9UIB8.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UIB8-1) [UniParc]FASTAAdd to basket
Also known as: CD84a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQHHLWILL LCLQTWPEAA GKDSEIFTVN GILGESVTFP VNIQEPRQVK
60 70 80 90 100
IIAWTSKTSV AYVTPGDSET APVVTVTHRN YYERIHALGP NYNLVISDLR
110 120 130 140 150
MEDAGDYKAD INTQADPYTT TKRYNLQIYR RLGKPKITQS LMASVNSTCN
160 170 180 190 200
VTLTCSVEKE EKNVTYNWSP LGEEGNVLQI FQTPEDQELT YTCTAQNPVS
210 220 230 240 250
NNSDSISARQ LCADIAMGFR THHTGLLSVL AMFFLLVLIL SSVFLFRLFK
260 270 280 290 300
RRQGRIFPEG SCLNTFTKNP YAASKKTIYT YIMASRNTQP AESRIYDEIL
310 320 330 340
QSKVLPSKEE PVNTVYSEVQ FADKMGKAST QDSKPPGTSS YEIVI
Length:345
Mass (Da):38,782
Last modified:May 1, 2000 - v1
Checksum:iDA06BC5A682E62DE
GO
Isoform 2 (identifier: Q9UIB8-2) [UniParc]FASTAAdd to basket
Also known as: CD84b

The sequence of this isoform differs from the canonical sequence as follows:
     254-259: Missing.

Show »
Length:339
Mass (Da):38,082
Checksum:iE78D6D5CAC8D3604
GO
Isoform 3 (identifier: Q9UIB8-3) [UniParc]FASTAAdd to basket
Also known as: CD84c

The sequence of this isoform differs from the canonical sequence as follows:
     254-271: GRIFPEGSCLNTFTKNPY → D

Show »
Length:328
Mass (Da):36,871
Checksum:i6C9A89206A6D0344
GO
Isoform 4 (identifier: Q9UIB8-4) [UniParc]FASTAAdd to basket
Also known as: CD84e

The sequence of this isoform differs from the canonical sequence as follows:
     261-280: SCLNTFTKNPYAASKKTIYT → KMWKLTFSPPGTEAIYPRFS
     281-345: Missing.

Show »
Length:280
Mass (Da):31,651
Checksum:iA043E048E762A718
GO
Isoform 5 (identifier: Q9UIB8-5) [UniParc]FASTAAdd to basket
Also known as: CD84d

The sequence of this isoform differs from the canonical sequence as follows:
     255-272: RIFPEGSCLNTFTKNPYA → ASLQGRASEHSLFRSAVC
     273-345: Missing.

Show »
Length:272
Mass (Da):30,514
Checksum:i6A2E13AA4E22E13E
GO
Isoform 6 (identifier: Q9UIB8-6) [UniParc]FASTAAdd to basket
Also known as: CD84s

The sequence of this isoform differs from the canonical sequence as follows:
     214-241: DIAMGFRTHHTGLLSVLAMFFLLVLILS → GNQLCPSLLVSLRDHSEELQGLNVGHIL
     242-345: Missing.

Show »
Length:241
Mass (Da):26,902
Checksum:iF0121BC1609B6C52
GO
Isoform 7 (identifier: Q9UIB8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-130: WPEAAGKDSE...TKRYNLQIYR → C
     254-271: GRIFPEGSCLNTFTKNPY → D

Show »
Length:214
Mass (Da):24,025
Checksum:iF6E403CF77EB2D2A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti311 – 3111P → S in CAG46645 (Ref. 4) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 130115WPEAA…LQIYR → C in isoform 7. 2 PublicationsVSP_020848Add
BLAST
Alternative sequencei214 – 24128DIAMG…VLILS → GNQLCPSLLVSLRDHSEELQ GLNVGHIL in isoform 6. 1 PublicationVSP_020849Add
BLAST
Alternative sequencei242 – 345104Missing in isoform 6. 1 PublicationVSP_020850Add
BLAST
Alternative sequencei254 – 27118GRIFP…TKNPY → D in isoform 3 and isoform 7. 7 PublicationsVSP_020851Add
BLAST
Alternative sequencei254 – 2596Missing in isoform 2. 1 PublicationVSP_020852
Alternative sequencei255 – 27218RIFPE…KNPYA → ASLQGRASEHSLFRSAVC in isoform 5. 1 PublicationVSP_020853Add
BLAST
Alternative sequencei261 – 28020SCLNT…KTIYT → KMWKLTFSPPGTEAIYPRFS in isoform 4. 1 PublicationVSP_020854Add
BLAST
Alternative sequencei273 – 34573Missing in isoform 5. 1 PublicationVSP_020855Add
BLAST
Alternative sequencei281 – 34565Missing in isoform 4. 1 PublicationVSP_020856Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82988 mRNA. Translation: AAB84364.1.
AJ223324 mRNA. Translation: CAA11264.1.
AF054815 mRNA. Translation: AAF21721.1.
AF054816 mRNA. Translation: AAF21722.1.
AF054817 mRNA. Translation: AAF21723.1.
AF054818 mRNA. Translation: AAF21724.1.
AF081189 Genomic DNA. Translation: AAD13155.1.
AH008972 Genomic DNA. Translation: AAF21784.1.
AH008376 Genomic DNA. Translation: AAF06840.1.
U96627 mRNA. Translation: AAD04232.1.
Y12632 mRNA. Translation: CAA73181.1.
AK296290 mRNA. Translation: BAH12304.1.
AK313496 mRNA. Translation: BAG36278.1.
CR541847 mRNA. Translation: CAG46645.1.
CR933666 mRNA. Translation: CAI45963.1.
AL138930 Genomic DNA. Translation: CAI15158.1.
AL138930 Genomic DNA. Translation: CAI15159.1.
AL138930 Genomic DNA. Translation: CAI15160.1.
AL138930 Genomic DNA. Translation: CAI15161.1.
AL138930 Genomic DNA. Translation: CAI15162.1.
AL138930 Genomic DNA. Translation: CAI15163.1.
CH471121 Genomic DNA. Translation: EAW52707.1.
BC020063 mRNA. Translation: AAH20063.1.
CCDSiCCDS1206.1. [Q9UIB8-3]
CCDS53395.1. [Q9UIB8-7]
CCDS53396.1. [Q9UIB8-1]
CCDS53397.1. [Q9UIB8-5]
RefSeqiNP_001171808.1. NM_001184879.1. [Q9UIB8-1]
NP_001171810.1. NM_001184881.1. [Q9UIB8-5]
NP_001171811.1. NM_001184882.1. [Q9UIB8-7]
NP_003865.1. NM_003874.3. [Q9UIB8-3]
XP_011508396.1. XM_011510094.2. [Q9UIB8-2]
UniGeneiHs.398093.

Genome annotation databases

EnsembliENST00000311224; ENSP00000312367; ENSG00000066294. [Q9UIB8-1]
ENST00000368048; ENSP00000357027; ENSG00000066294. [Q9UIB8-2]
ENST00000368051; ENSP00000357030; ENSG00000066294. [Q9UIB8-5]
ENST00000368054; ENSP00000357033; ENSG00000066294. [Q9UIB8-3]
ENST00000534968; ENSP00000442845; ENSG00000066294. [Q9UIB8-7]
GeneIDi8832.
KEGGihsa:8832.
UCSCiuc001fwf.5. human. [Q9UIB8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82988 mRNA. Translation: AAB84364.1.
AJ223324 mRNA. Translation: CAA11264.1.
AF054815 mRNA. Translation: AAF21721.1.
AF054816 mRNA. Translation: AAF21722.1.
AF054817 mRNA. Translation: AAF21723.1.
AF054818 mRNA. Translation: AAF21724.1.
AF081189 Genomic DNA. Translation: AAD13155.1.
AH008972 Genomic DNA. Translation: AAF21784.1.
AH008376 Genomic DNA. Translation: AAF06840.1.
U96627 mRNA. Translation: AAD04232.1.
Y12632 mRNA. Translation: CAA73181.1.
AK296290 mRNA. Translation: BAH12304.1.
AK313496 mRNA. Translation: BAG36278.1.
CR541847 mRNA. Translation: CAG46645.1.
CR933666 mRNA. Translation: CAI45963.1.
AL138930 Genomic DNA. Translation: CAI15158.1.
AL138930 Genomic DNA. Translation: CAI15159.1.
AL138930 Genomic DNA. Translation: CAI15160.1.
AL138930 Genomic DNA. Translation: CAI15161.1.
AL138930 Genomic DNA. Translation: CAI15162.1.
AL138930 Genomic DNA. Translation: CAI15163.1.
CH471121 Genomic DNA. Translation: EAW52707.1.
BC020063 mRNA. Translation: AAH20063.1.
CCDSiCCDS1206.1. [Q9UIB8-3]
CCDS53395.1. [Q9UIB8-7]
CCDS53396.1. [Q9UIB8-1]
CCDS53397.1. [Q9UIB8-5]
RefSeqiNP_001171808.1. NM_001184879.1. [Q9UIB8-1]
NP_001171810.1. NM_001184881.1. [Q9UIB8-5]
NP_001171811.1. NM_001184882.1. [Q9UIB8-7]
NP_003865.1. NM_003874.3. [Q9UIB8-3]
XP_011508396.1. XM_011510094.2. [Q9UIB8-2]
UniGeneiHs.398093.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PKDX-ray2.04A/B/C/D/E/F22-131[»]
ProteinModelPortaliQ9UIB8.
SMRiQ9UIB8. Positions 23-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114359. 6 interactions.
DIPiDIP-60957N.
IntActiQ9UIB8. 3 interactions.
MINTiMINT-8013385.
STRINGi9606.ENSP00000312367.

Protein family/group databases

MEROPSiI43.001.

PTM databases

iPTMnetiQ9UIB8.
PhosphoSiteiQ9UIB8.

Polymorphism and mutation databases

BioMutaiCD84.
DMDMi74762772.

Proteomic databases

EPDiQ9UIB8.
MaxQBiQ9UIB8.
PaxDbiQ9UIB8.
PeptideAtlasiQ9UIB8.
PRIDEiQ9UIB8.

Protocols and materials databases

DNASUi8832.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311224; ENSP00000312367; ENSG00000066294. [Q9UIB8-1]
ENST00000368048; ENSP00000357027; ENSG00000066294. [Q9UIB8-2]
ENST00000368051; ENSP00000357030; ENSG00000066294. [Q9UIB8-5]
ENST00000368054; ENSP00000357033; ENSG00000066294. [Q9UIB8-3]
ENST00000534968; ENSP00000442845; ENSG00000066294. [Q9UIB8-7]
GeneIDi8832.
KEGGihsa:8832.
UCSCiuc001fwf.5. human. [Q9UIB8-1]

Organism-specific databases

CTDi8832.
GeneCardsiCD84.
HGNCiHGNC:1704. CD84.
HPAiHPA070502.
MIMi604513. gene.
neXtProtiNX_Q9UIB8.
PharmGKBiPA26242.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVV0. Eukaryota.
ENOG410Z5M6. LUCA.
GeneTreeiENSGT00530000063114.
HOVERGENiHBG093961.
InParanoidiQ9UIB8.
KOiK06511.
OMAiWSPLGEE.
OrthoDBiEOG091G0KKU.
PhylomeDBiQ9UIB8.
TreeFamiTF334964.

Enzyme and pathway databases

ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

ChiTaRSiCD84. human.
EvolutionaryTraceiQ9UIB8.
GeneWikiiCD84.
GenomeRNAii8832.
PROiQ9UIB8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000066294.
GenevisibleiQ9UIB8. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLAF5_HUMAN
AccessioniPrimary (citable) accession number: Q9UIB8
Secondary accession number(s): B2R8T1
, B7Z3R8, O15430, O95266, O95660, Q5H9R1, Q6FHA8, Q8WLP1, Q8WWI8, Q9UF04, Q9UIB6, Q9UIB7, Q9UIT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.