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Protein

Cytohesin-4

Gene

CYTH4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei279Phosphatidylinositol 3,4,5-trisphosphateBy similarity1
Binding sitei290Phosphatidylinositol 3,4,5-trisphosphateBy similarity1
Binding sitei300Phosphatidylinositol 3,4,5-trisphosphateBy similarity1

GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: UniProtKB
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100055-MONOMER.
ReactomeiR-HSA-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytohesin-4
Alternative name(s):
PH, SEC7 and coiled-coil domain-containing protein 4
Gene namesi
Name:CYTH4
Synonyms:CYT4, PSCD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:9505. CYTH4.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • Golgi membrane Source: Reactome
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27128.
OpenTargetsiENSG00000100055.
PharmGKBiPA164718621.

Polymorphism and mutation databases

BioMutaiCYTH4.
DMDMi13124094.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202031 – 394Cytohesin-4Add BLAST394

Proteomic databases

MaxQBiQ9UIA0.
PaxDbiQ9UIA0.
PeptideAtlasiQ9UIA0.
PRIDEiQ9UIA0.

PTM databases

iPTMnetiQ9UIA0.
PhosphoSitePlusiQ9UIA0.

Expressioni

Tissue specificityi

Expressed predominantly in peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000100055.
CleanExiHS_CYTH4.
ExpressionAtlasiQ9UIA0. baseline and differential.
GenevisibleiQ9UIA0. HS.

Organism-specific databases

HPAiHPA071573.

Interactioni

Protein-protein interaction databases

BioGridi118019. 9 interactors.
IntActiQ9UIA0. 3 interactors.
STRINGi9606.ENSP00000248901.

Structurei

3D structure databases

ProteinModelPortaliQ9UIA0.
SMRiQ9UIA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 241SEC7PROSITE-ProRule annotationAdd BLAST188
Domaini259 – 375PHPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 275Phosphatidylinositol 3,4,5-trisphosphate bindingBy similarity8
Regioni386 – 394C-terminal autoinhibitory regionBy similarity9

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 65Sequence analysisAdd BLAST54

Domaini

Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.By similarity
Autoinhibited by its C-terminal basic region.By similarity

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SEC7 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0930. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOGENOMiHOG000253023.
HOVERGENiHBG002647.
InParanoidiQ9UIA0.
KOiK18441.
OMAiGERDPIN.
OrthoDBiEOG091G0RZS.
PhylomeDBiQ9UIA0.
TreeFamiTF352091.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UIA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLCHPEPAE LSSGETEELQ RIKWHRKQLL EDIQKLKDEI ADVFAQIDCF
60 70 80 90 100
ESAEESRMAQ KEKELCIGRK KFNMDPAKGI QYFIEHKLLT PDVQDIARFL
110 120 130 140 150
YKGEGLNKTA IGTYLGERDP INLQVLQAFV DCHEFANLNL VQALRQFLWS
160 170 180 190 200
FRLPGEAQKI DRMMEAFATR YCLCNPGVFQ STDTCYVLSF SIIMLNTSLH
210 220 230 240 250
NPNVRDRPPF ERFVSMNRGI NNGSDLPEDQ LRNLFDSIKS EPFSIPEDDG
260 270 280 290 300
NDLTHTFFNP DREGWLLKLG GRVKTWKRRW FILTDNCLYY FEFTTDKEPR
310 320 330 340 350
GIIPLENLSV QKVDDPKKPF CLELYNPSCR GQKIKACKTD GDGRVVEGKH
360 370 380 390
ESYRISATSA EERDQWIESI RASITRVPFY DLVSTRKKKI ASKQ
Length:394
Mass (Da):45,672
Last modified:May 1, 2000 - v1
Checksum:i0C9C8E8AD6890F34
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05192074M → V.Corresponds to variant rs16998061dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125349 mRNA. Translation: AAF28896.1.
AF075458 mRNA. Translation: AAF15389.1.
CR456551 mRNA. Translation: CAG30437.1.
Z94160 Genomic DNA. Translation: CAI22121.1.
BC041161 mRNA. Translation: AAH41161.1.
CCDSiCCDS13946.1.
RefSeqiNP_001304953.1. NM_001318024.1.
NP_037517.1. NM_013385.4.
UniGeneiHs.170944.

Genome annotation databases

EnsembliENST00000248901; ENSP00000248901; ENSG00000100055.
GeneIDi27128.
KEGGihsa:27128.
UCSCiuc003arf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125349 mRNA. Translation: AAF28896.1.
AF075458 mRNA. Translation: AAF15389.1.
CR456551 mRNA. Translation: CAG30437.1.
Z94160 Genomic DNA. Translation: CAI22121.1.
BC041161 mRNA. Translation: AAH41161.1.
CCDSiCCDS13946.1.
RefSeqiNP_001304953.1. NM_001318024.1.
NP_037517.1. NM_013385.4.
UniGeneiHs.170944.

3D structure databases

ProteinModelPortaliQ9UIA0.
SMRiQ9UIA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118019. 9 interactors.
IntActiQ9UIA0. 3 interactors.
STRINGi9606.ENSP00000248901.

PTM databases

iPTMnetiQ9UIA0.
PhosphoSitePlusiQ9UIA0.

Polymorphism and mutation databases

BioMutaiCYTH4.
DMDMi13124094.

Proteomic databases

MaxQBiQ9UIA0.
PaxDbiQ9UIA0.
PeptideAtlasiQ9UIA0.
PRIDEiQ9UIA0.

Protocols and materials databases

DNASUi27128.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248901; ENSP00000248901; ENSG00000100055.
GeneIDi27128.
KEGGihsa:27128.
UCSCiuc003arf.4. human.

Organism-specific databases

CTDi27128.
DisGeNETi27128.
GeneCardsiCYTH4.
HGNCiHGNC:9505. CYTH4.
HPAiHPA071573.
MIMi606514. gene.
neXtProtiNX_Q9UIA0.
OpenTargetsiENSG00000100055.
PharmGKBiPA164718621.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0930. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOGENOMiHOG000253023.
HOVERGENiHBG002647.
InParanoidiQ9UIA0.
KOiK18441.
OMAiGERDPIN.
OrthoDBiEOG091G0RZS.
PhylomeDBiQ9UIA0.
TreeFamiTF352091.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100055-MONOMER.
ReactomeiR-HSA-6811438. Intra-Golgi traffic.

Miscellaneous databases

GeneWikiiCYTH4.
GenomeRNAii27128.
PROiQ9UIA0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100055.
CleanExiHS_CYTH4.
ExpressionAtlasiQ9UIA0. baseline and differential.
GenevisibleiQ9UIA0. HS.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYH4_HUMAN
AccessioniPrimary (citable) accession number: Q9UIA0
Secondary accession number(s): Q5R3F9, Q9UGT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.