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Reviewed, UniProtKB/Swiss-Prot Q9UI95 (MD2L2_HUMAN)

Last modified February 9, 2010. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Mitotic spindle assembly checkpoint protein MAD2B
Alternative name(s):
    Mitotic arrest deficient 2-like protein 2
      Short name=MAD2-like protein 2
    REV7 homolog
      Short name=hREV7
Gene names
Name: MAD2L2
Synonyms: MAD2B, REV7
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subunit structure

Binds REV1L By similarity. Interacts with REV3 and with ADAM9 (MDC9). Ref.1

Sequence similarities

Contains 1 HORMA domain.

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Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell division

Inferred from electronic annotation. Source: UniProtKB-KW

mitosis Ref.3

Non-traceable author statement. Source: ProtInc

mitotic cell cycle spindle assembly checkpoint Ref.3

Traceable author statement. Source: ProtInc

   Molecular functionprotein binding Ref.1

Inferred from physical interaction. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Mitotic spindle assembly checkpoint protein MAD2B
PRO_0000126119

Regions

Domain13 – 203191HORMA

Experimental info

Sequence conflict171D → A in AAD30290. Ref.3
Sequence conflict961E → D in AAF20267. Ref.2
Sequence conflict1991M → V in AAF20267. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q9UI95-1 [UniParc].

Last modified January 11, 2001. Version 2.
Checksum: 1DE6353EF7D650B9

FASTA21124,334
        10         20         30         40         50         60 
MTTLTRQDLN FGQVVADVLC EFLEVAVHLI LYVREVYPVG IFQKRKKYNV PVQMSCHPEL 

        70         80         90        100        110        120 
NQYIQDTLHC VKPLLEKNDV EKVVVVILDK EHRPVEKFVF EITQPPLLSI SSDSLLSHVE 

       130        140        150        160        170        180 
QLLRAFILKI SVCDAVLDHN PPGCTFTVLV HTREAATRNM EKIQVIKDFP WILADEQDVH 

       190        200        210 
MHDPRLIPLK TMTSDILKMQ LYVEERAHKG S

« Hide

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References

« Hide 'large scale' references
[1]"Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2-beta."
Nelson K.K., Schlondorff J., Blobel C.P.
Biochem. J. 343:673-680(1999) [PubMed: 10527948] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ADAM9.
[2]"Identification of a novel human homolog of the MAD2 protein that interacts with the h-warts protein."
Hirota T., Nakamura H., Tada K., Marumoto T., Saya H.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Characterization of MAD2B and other mitotic spindle checkpoint genes."
Cahill D.P., da Costa L.T., Carson-Walter E.B., Kinzler K.W., Vogelstein B., Lengauer C.
Genomics 58:181-187(1999) [PubMed: 10366450] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2."
Murakumo Y., Roth T., Ishii H., Rasio D., Numata S., Croce C.M., Fishel R.
J. Biol. Chem. 275:4391-4397(2000) [PubMed: 10660610] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]NIEHS SNPs program
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
+Additional computationally mapped references.

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Web resources

NIEHS-SNPs

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF072933 mRNA. Translation: AAD41647.1.
AF080398 mRNA. Translation: AAF20267.1.
AF139365 mRNA. Translation: AAD30290.1.
AF157482 mRNA. Translation: AAF34357.1.
DQ017900 Genomic DNA. Translation: AAY26393.1.
AL031731 Genomic DNA. Translation: CAI20218.1.
BC015244 mRNA. Translation: AAH15244.1.
IPIIPI00006109.
RefSeqNP_001120797.1.
NP_006332.3.
UniGeneHs.19400

3D structure databases

SMRQ9UI95. Positions 15-200.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9UI95. 9 interactions.
STRINGQ9UI95.

Proteomic databases

PRIDEQ9UI95.

Genome annotation databases

EnsemblENST00000235310; ENSP00000235310; ENSG00000116670; Homo sapiens. [Genome view]
ENST00000376667; ENSP00000365855; ENSG00000116670; Homo sapiens. [Genome view]
ENST00000376692; ENSP00000365882; ENSG00000116670; Homo sapiens. [Genome view]
GeneID10459.
KEGGhsa:10459.
UCSCuc001asp.1. human.

Organism-specific databases

CTD10459.
GeneCardsGC01M011668.
H-InvDBHIX0000127.
HGNCHGNC:6764. MAD2L2.
HPACAB008110.
MIM604094. gene.
PharmGKBPA398.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18060.
HOVERGENQ9UI95.
OrthoDBEOG9J9QJP.
PhylomeDBQ9UI95.

Enzyme and pathway databases

ReactomeREACT_216. DNA Repair.

Gene expression databases

ArrayExpressQ9UI95.
BgeeQ9UI95.
CleanExHS_MAD2L2.
GenevestigatorQ9UI95.
GermOnlineENSG00000116670. Homo sapiens.

Family and domain databases

InterProIPR003511. HORMA_DNA_bd.
[Graphical view]
PfamPF02301. HORMA. 1 hit.
[Graphical view]
PROSITEPS50815. HORMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio39659.
SOURCESearch...

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Entry information

Entry nameMD2L2_HUMAN
AccessionPrimary (citable) accession number: Q9UI95
Secondary accession number(s): Q5TGW7, Q9UNA7, Q9Y6I6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: February 9, 2010
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents