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Protein

Very putative protein from MEG3 locus

Gene

MEG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

  1. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. axon guidance Source: UniProtKB
  2. cell differentiation Source: UniProtKB
  3. gonadotropin secretion Source: UniProtKB
  4. hypomethylation of CpG island Source: UniProtKB
  5. negative regulation of angiogenesis Source: UniProtKB
  6. negative regulation of cell proliferation Source: UniProtKB
  7. negative regulation of DNA biosynthetic process Source: UniProtKB
  8. negative regulation of Notch signaling pathway Source: UniProtKB
  9. negative regulation of transcription, DNA-templated Source: UniProtKB
  10. negative regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
  11. positive regulation of embryonic development Source: UniProtKB
  12. positive regulation of skeletal muscle fiber development Source: UniProtKB
  13. positive regulation of transcription, DNA-templated Source: UniProtKB
  14. RNA folding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Very putative protein from MEG3 locus
Gene namesi
Name:MEG3
ORF Names:PRO0518
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:14575. MEG3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

Orphaneti96184. Maternal uniparental disomy of chromosome 14.
96334. Paternal uniparental disomy of chromosome 14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6868Very putative protein from MEG3 locusPRO_0000159092Add
BLAST

Proteomic databases

PRIDEiQ9UI56.

Expressioni

Gene expression databases

CleanExiHS_MEG3.
GenevestigatoriQ9UI56.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000404976.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000049553.
InParanoidiQ9UI56.

Sequencei

Sequence statusi: Complete.

Q9UI56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSRDTVNVK FTPRSFWGSR PKHTGGRSEM RAHVPQAPWA RQAPPVLPLW
60
TVVNDHPHEK PVSRPQNT
Length:68
Mass (Da):7,791
Last modified:May 1, 2000 - v1
Checksum:iDDC6B78EC2981B99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090934 mRNA. Translation: AAF24048.1.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090934 mRNA. Translation: AAF24048.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000404976.

Proteomic databases

PRIDEiQ9UI56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC14P101245.
HGNCiHGNC:14575. MEG3.
MIMi605636. gene.
neXtProtiNX_Q9UI56.
Orphaneti96184. Maternal uniparental disomy of chromosome 14.
96334. Paternal uniparental disomy of chromosome 14.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000049553.
InParanoidiQ9UI56.

Miscellaneous databases

ChiTaRSiMEG3. human.
NextBioi35542062.
SOURCEiSearch...

Gene expression databases

CleanExiHS_MEG3.
GenevestigatoriQ9UI56.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional prediction of the coding sequences of 50 new genes deduced by analysis of cDNA clones from human fetal liver."
    Yu Y., Zhang C., Luo L., Ouyang S., Zhang S., Li W., Wu J., Zhou S., Liu M., He F.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal liver.
  2. "Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q."
    Miyoshi N., Wagatsuma H., Wakana S., Shiroishi T., Nomura M., Aisaka K., Kohda T., Surani M.A., Kaneko-Ishino T., Ishino F.
    Genes Cells 5:211-220(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROBABLE FUNCTION AS A RNA.

Entry informationi

Entry nameiYYY4_HUMAN
AccessioniPrimary (citable) accession number: Q9UI56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Product of a dubious gene prediction. There is no evidence of expression of this protein. The MEG3 (Maternally Expressed) gene probably codes for an RNA.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.