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Q9UI56 (YYY4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Very putative protein from MEG3 locus
Gene names
Name:MEG3
ORF Names:PRO0518
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length68 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Caution

Product of a dubious gene prediction. There is no evidence of expression of this protein. The MEG3 (Maternally Expressed) gene probably codes for an RNA.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA folding

Inferred from direct assay PubMed 17569660PubMed 20032057. Source: UniProtKB

axon guidance

Inferred from sequence or structural similarity. Source: UniProtKB

cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

gonadotropin secretion

Inferred from mutant phenotype PubMed 18628527. Source: UniProtKB

hypomethylation of CpG island

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of DNA biosynthetic process

Inferred from direct assay PubMed 14602737PubMed 17569660PubMed 20032057. Source: UniProtKB

negative regulation of Notch signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of angiogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell proliferation

Inferred from direct assay PubMed 14602737PubMed 17569660PubMed 20032057PubMed 20179190. Source: UniProtKB

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 17569660. Source: UniProtKB

negative regulation of vascular endothelial growth factor receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of embryonic development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of skeletal muscle fiber development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 17569660PubMed 20032057PubMed 20179190. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 14602737PubMed 18628527. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 14602737. Source: UniProtKB

   Molecular_functiontranscription coactivator activity

Inferred from direct assay PubMed 17569660. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6868Very putative protein from MEG3 locus
PRO_0000159092

Sequences

Sequence LengthMass (Da)Tools
Q9UI56 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: DDC6B78EC2981B99

FASTA687,791
        10         20         30         40         50         60 
MQSRDTVNVK FTPRSFWGSR PKHTGGRSEM RAHVPQAPWA RQAPPVLPLW TVVNDHPHEK 


PVSRPQNT 

« Hide

References

« Hide 'large scale' references
[1]"Functional prediction of the coding sequences of 50 new genes deduced by analysis of cDNA clones from human fetal liver."
Yu Y., Zhang C., Luo L., Ouyang S., Zhang S., Li W., Wu J., Zhou S., Liu M., He F.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal liver.
[2]"Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q."
Miyoshi N., Wagatsuma H., Wakana S., Shiroishi T., Nomura M., Aisaka K., Kohda T., Surani M.A., Kaneko-Ishino T., Ishino F.
Genes Cells 5:211-220(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROBABLE FUNCTION AS A RNA.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF090934 mRNA. Translation: AAF24048.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000404976.

Proteomic databases

PRIDEQ9UI56.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC14P101245.
HGNCHGNC:14575. MEG3.
MIM605636. gene.
neXtProtNX_Q9UI56.
Orphanet96184. Maternal uniparental disomy of chromosome 14.
96334. Paternal uniparental disomy of chromosome 14.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000049553.

Gene expression databases

CleanExHS_MEG3.
GenevestigatorQ9UI56.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSMEG3. human.
NextBio35542062.
SOURCESearch...

Entry information

Entry nameYYY4_HUMAN
AccessionPrimary (citable) accession number: Q9UI56
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM