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Q9UI56

- YYY4_HUMAN

UniProt

Q9UI56 - YYY4_HUMAN

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Protein
Very putative protein from MEG3 locus
Gene
MEG3, PRO0518
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Protein uncertaini

Functioni

GO - Molecular functioni

  1. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. RNA folding Source: UniProtKB
  2. axon guidance Source: UniProtKB
  3. cell differentiation Source: UniProtKB
  4. gonadotropin secretion Source: UniProtKB
  5. hypomethylation of CpG island Source: UniProtKB
  6. negative regulation of DNA biosynthetic process Source: UniProtKB
  7. negative regulation of Notch signaling pathway Source: UniProtKB
  8. negative regulation of angiogenesis Source: UniProtKB
  9. negative regulation of cell proliferation Source: UniProtKB
  10. negative regulation of transcription, DNA-templated Source: UniProtKB
  11. negative regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
  12. positive regulation of embryonic development Source: UniProtKB
  13. positive regulation of skeletal muscle fiber development Source: UniProtKB
  14. positive regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Very putative protein from MEG3 locus
Gene namesi
Name:MEG3
ORF Names:PRO0518
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:14575. MEG3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

Orphaneti96184. Maternal uniparental disomy of chromosome 14.
96334. Paternal uniparental disomy of chromosome 14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6868Very putative protein from MEG3 locus
PRO_0000159092Add
BLAST

Proteomic databases

PRIDEiQ9UI56.

Expressioni

Gene expression databases

CleanExiHS_MEG3.
GenevestigatoriQ9UI56.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000404976.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000049553.

Sequencei

Sequence statusi: Complete.

Q9UI56-1 [UniParc]FASTAAdd to Basket

« Hide

MQSRDTVNVK FTPRSFWGSR PKHTGGRSEM RAHVPQAPWA RQAPPVLPLW   50
TVVNDHPHEK PVSRPQNT 68
Length:68
Mass (Da):7,791
Last modified:May 1, 2000 - v1
Checksum:iDDC6B78EC2981B99
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090934 mRNA. Translation: AAF24048.1.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090934 mRNA. Translation: AAF24048.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000404976.

Proteomic databases

PRIDEi Q9UI56.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC14P101245.
HGNCi HGNC:14575. MEG3.
MIMi 605636. gene.
neXtProti NX_Q9UI56.
Orphaneti 96184. Maternal uniparental disomy of chromosome 14.
96334. Paternal uniparental disomy of chromosome 14.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000049553.

Miscellaneous databases

ChiTaRSi MEG3. human.
NextBioi 35542062.
SOURCEi Search...

Gene expression databases

CleanExi HS_MEG3.
Genevestigatori Q9UI56.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional prediction of the coding sequences of 50 new genes deduced by analysis of cDNA clones from human fetal liver."
    Yu Y., Zhang C., Luo L., Ouyang S., Zhang S., Li W., Wu J., Zhou S., Liu M., He F.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal liver.
  2. "Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q."
    Miyoshi N., Wagatsuma H., Wakana S., Shiroishi T., Nomura M., Aisaka K., Kohda T., Surani M.A., Kaneko-Ishino T., Ishino F.
    Genes Cells 5:211-220(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROBABLE FUNCTION AS A RNA.

Entry informationi

Entry nameiYYY4_HUMAN
AccessioniPrimary (citable) accession number: Q9UI56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Product of a dubious gene prediction. There is no evidence of expression of this protein. The MEG3 (Maternally Expressed) gene probably codes for an RNA.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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