Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UI56

- YYY4_HUMAN

UniProt

Q9UI56 - YYY4_HUMAN

Protein

Very putative protein from MEG3 locus

Gene

MEG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Protein uncertaini
  1. Functioni

    GO - Molecular functioni

    1. transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    1. axon guidance Source: UniProtKB
    2. cell differentiation Source: UniProtKB
    3. gonadotropin secretion Source: UniProtKB
    4. hypomethylation of CpG island Source: UniProtKB
    5. negative regulation of angiogenesis Source: UniProtKB
    6. negative regulation of cell proliferation Source: UniProtKB
    7. negative regulation of DNA biosynthetic process Source: UniProtKB
    8. negative regulation of Notch signaling pathway Source: UniProtKB
    9. negative regulation of transcription, DNA-templated Source: UniProtKB
    10. negative regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
    11. positive regulation of embryonic development Source: UniProtKB
    12. positive regulation of skeletal muscle fiber development Source: UniProtKB
    13. positive regulation of transcription, DNA-templated Source: UniProtKB
    14. RNA folding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Very putative protein from MEG3 locus
    Gene namesi
    Name:MEG3
    ORF Names:PRO0518
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:14575. MEG3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti96184. Maternal uniparental disomy of chromosome 14.
    96334. Paternal uniparental disomy of chromosome 14.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6868Very putative protein from MEG3 locusPRO_0000159092Add
    BLAST

    Proteomic databases

    PRIDEiQ9UI56.

    Expressioni

    Gene expression databases

    CleanExiHS_MEG3.
    GenevestigatoriQ9UI56.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000404976.

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000049553.

    Sequencei

    Sequence statusi: Complete.

    Q9UI56-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSRDTVNVK FTPRSFWGSR PKHTGGRSEM RAHVPQAPWA RQAPPVLPLW   50
    TVVNDHPHEK PVSRPQNT 68
    Length:68
    Mass (Da):7,791
    Last modified:May 1, 2000 - v1
    Checksum:iDDC6B78EC2981B99
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF090934 mRNA. Translation: AAF24048.1.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF090934 mRNA. Translation: AAF24048.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000404976.

    Proteomic databases

    PRIDEi Q9UI56.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC14P101245.
    HGNCi HGNC:14575. MEG3.
    MIMi 605636. gene.
    neXtProti NX_Q9UI56.
    Orphaneti 96184. Maternal uniparental disomy of chromosome 14.
    96334. Paternal uniparental disomy of chromosome 14.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000049553.

    Miscellaneous databases

    ChiTaRSi MEG3. human.
    NextBioi 35542062.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_MEG3.
    Genevestigatori Q9UI56.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Functional prediction of the coding sequences of 50 new genes deduced by analysis of cDNA clones from human fetal liver."
      Yu Y., Zhang C., Luo L., Ouyang S., Zhang S., Li W., Wu J., Zhou S., Liu M., He F.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal liver.
    2. "Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q."
      Miyoshi N., Wagatsuma H., Wakana S., Shiroishi T., Nomura M., Aisaka K., Kohda T., Surani M.A., Kaneko-Ishino T., Ishino F.
      Genes Cells 5:211-220(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROBABLE FUNCTION AS A RNA.

    Entry informationi

    Entry nameiYYY4_HUMAN
    AccessioniPrimary (citable) accession number: Q9UI56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Product of a dubious gene prediction. There is no evidence of expression of this protein. The MEG3 (Maternally Expressed) gene probably codes for an RNA.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3