SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UI47

- CTNA3_HUMAN

UniProt

Q9UI47 - CTNA3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Catenin alpha-3

Gene
CTNNA3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in formation of stretch-resistant cell-cell adhesion complexes.1 Publication

GO - Molecular functioni

  1. cadherin binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. structural molecule activity Source: InterPro

GO - Biological processi

  1. single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin alpha-3
Alternative name(s):
Alpha T-catenin
Cadherin-associated protein
Gene namesi
Name:CTNNA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:2511. CTNNA3.

Subcellular locationi

Cytoplasmcytoskeleton Reviewed prediction
Note: Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2.1 Publication

GO - Cellular componenti

  1. actin cytoskeleton Source: InterPro
  2. cytoplasm Source: UniProtKB-KW
  3. fascia adherens Source: UniProtKB
  4. lamellipodium Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Arrhythmogenic right ventricular dysplasia, familial, 13 (ARVD13) [MIM:615616]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941V → D in ARVD13. 1 Publication
VAR_070998

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

MIMi615616. phenotype.
Orphaneti293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
PharmGKBiPA27010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 895895Catenin alpha-3PRO_0000064266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei637 – 6371Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9UI47.
PRIDEiQ9UI47.

PTM databases

PhosphoSiteiQ9UI47.

Expressioni

Tissue specificityi

Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle.1 Publication

Gene expression databases

ArrayExpressiQ9UI47.
BgeeiQ9UI47.
CleanExiHS_CTNNA3.
GenevestigatoriQ9UI47.

Organism-specific databases

HPAiHPA017977.

Interactioni

Subunit structurei

Interacts with CTNNB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
gagP045912EBI-3937546,EBI-6179727From a different organism.

Protein-protein interaction databases

BioGridi118885. 7 interactions.
IntActiQ9UI47. 2 interactions.
STRINGi9606.ENSP00000362849.

Structurei

3D structure databases

ProteinModelPortaliQ9UI47.
SMRiQ9UI47. Positions 19-867.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili74 – 11138 Reviewed predictionAdd
BLAST
Coiled coili325 – 37955 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG240050.
HOGENOMiHOG000280724.
HOVERGENiHBG000069.
InParanoidiQ9UI47.
KOiK05691.
OMAiAFKRQQD.
OrthoDBiEOG7HQN7B.
PhylomeDBiQ9UI47.
TreeFamiTF313686.

Family and domain databases

InterProiIPR001033. Alpha_catenin.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 1 hit.
PfamiPF01044. Vinculin. 2 hits.
[Graphical view]
PRINTSiPR00805. ALPHACATENIN.
SUPFAMiSSF47220. SSF47220. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q9UI47-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSAETPITLN IDPQDLQVQT FTVEKLLEPL IIQVTTLVNC PQNPSSRKKG    50
RSKRASVLLA SVEEATWNLL DKGEKIAQEA TVLKDELTAS LEEVRKESEA 100
LKVSAERFTD DPCFLPKREA VVQAARALLA AVTRLLILAD MIDVMCLLQH 150
VSAFQRTFES LKNVANKSDL QKTYQKLGKE LENLDYLAFK RQQDLKSPNQ 200
RDEIAGARAS LKENSPLLHS ICSACLEHSD VASLKASKDT VCEEIQNALN 250
VISNASQGIQ NMTTPPEPQA ATLGSALDEL ENLIVLNPLT VTEEEIRPSL 300
EKRLEAIISG AALLADSSCT RDLHRERIIA ECNAIRQALQ DLLSEYMNNA 350
GKKERSNTLN IALDNMCKKT RDLRRQLRKA IIDHVSDSFL DTTVPLLVLI 400
EAAKNGREKE IKEYAAIFHE HTSRLVEVAN LACSMSTNED GIKIVKIAAN 450
HLETLCPQII NAALALAARP KSQAVKNTME MYKRTWENHI HVLTEAVDDI 500
TSIDDFLAVS ESHILEDVNK CIIALRDQDA DNLDRAAGAI RGRAARVAHI 550
VTGEMDSYEP GAYTEGVMRN VNFLTSTVIP EFVTQVNVAL EALSKSSLNV 600
LDDNQFVDIS KKIYDTIHDI RCSVMMIRTP EELEDVSDLE EEHEVRSHTS 650
IQTEGKTDRA KMTQLPEAEK EKIAEQVADF KKVKSKLDAE IEIWDDTSND 700
IIVLAKNMCM IMMEMTDFTR GKGPLKHTTD VIYAAKMISE SGSRMDVLAR 750
QIANQCPDPS CKQDLLAYLE QIKFYSHQLK ICSQVKAEIQ NLGGELIMSA 800
LDSVTSLIQA AKNLMNAVVQ TVKMSYIAST KIIRIQSPAG PRHPVVMWRM 850
KAPAKKPLIK REKPEETCAA VRRGSAKKKI HPLQVMSEFR GRQIY 895
Length:895
Mass (Da):99,809
Last modified:October 25, 2005 - v2
Checksum:i269E6DFB4956BDFE
GO
Isoform 2 (identifier: Q9UI47-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     511-516: ESHILE → GMFLFF
     517-895: Missing.

Note: No experimental confirmation available.

Show »
Length:516
Mass (Da):57,332
Checksum:iBC464A5D36E85839
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941V → D in ARVD13. 1 Publication
VAR_070998
Natural varianti535 – 5351R → C.
Corresponds to variant rs41274090 [ dbSNP | Ensembl ].
VAR_062093
Natural varianti596 – 5961S → N.
Corresponds to variant rs4548513 [ dbSNP | Ensembl ].
VAR_053369

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei511 – 5166ESHILE → GMFLFF in isoform 2. VSP_051852
Alternative sequencei517 – 895379Missing in isoform 2. VSP_051853Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601S → T1 Publication
Sequence conflicti160 – 1601S → T1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF091606 mRNA. Translation: AAF21801.1.
AF282692
, AF282679, AF282680, AF282681, AF282683, AF282685, AF282689, AF391793, AF282686, AF282688, AF282690, AF282691, AF391792, AF391794, AF282687, AF282682, AF282684 Genomic DNA. Translation: AAQ14328.1.
AL607022
, AC016819, AC018979, AC020642, AC022017, AC022401, AC026394, AL607023, AL731538, AL731549 Genomic DNA. Translation: CAI13390.1.
AL607023
, AC018979, AC020642, AC016819, AC022017, AC022401, AC026394, AL607022, AL731538, AL731549 Genomic DNA. Translation: CAI16316.1.
AL731538
, AC016819, AC018979, AC020642, AC022017, AC022401, AC026394, AL607022, AL607023, AL731549 Genomic DNA. Translation: CAH73988.1.
AL731549
, AC016819, AC018979, AC020642, AC022401, AL607022, AL731538, AL607023, AC026394, AC022017 Genomic DNA. Translation: CAH70164.1.
BC065819 mRNA. Translation: AAH65819.1.
CCDSiCCDS7269.1. [Q9UI47-1]
RefSeqiNP_001120856.1. NM_001127384.2. [Q9UI47-1]
NP_037398.2. NM_013266.3. [Q9UI47-1]
UniGeneiHs.21375.
Hs.660362.

Genome annotation databases

EnsembliENST00000373744; ENSP00000362849; ENSG00000183230. [Q9UI47-1]
ENST00000433211; ENSP00000389714; ENSG00000183230. [Q9UI47-1]
GeneIDi29119.
KEGGihsa:29119.
UCSCiuc001jmw.2. human. [Q9UI47-1]
uc001jmx.4. human. [Q9UI47-2]

Polymorphism databases

DMDMi78099215.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF091606 mRNA. Translation: AAF21801.1 .
AF282692
, AF282679 , AF282680 , AF282681 , AF282683 , AF282685 , AF282689 , AF391793 , AF282686 , AF282688 , AF282690 , AF282691 , AF391792 , AF391794 , AF282687 , AF282682 , AF282684 Genomic DNA. Translation: AAQ14328.1 .
AL607022
, AC016819 , AC018979 , AC020642 , AC022017 , AC022401 , AC026394 , AL607023 , AL731538 , AL731549 Genomic DNA. Translation: CAI13390.1 .
AL607023
, AC018979 , AC020642 , AC016819 , AC022017 , AC022401 , AC026394 , AL607022 , AL731538 , AL731549 Genomic DNA. Translation: CAI16316.1 .
AL731538
, AC016819 , AC018979 , AC020642 , AC022017 , AC022401 , AC026394 , AL607022 , AL607023 , AL731549 Genomic DNA. Translation: CAH73988.1 .
AL731549
, AC016819 , AC018979 , AC020642 , AC022401 , AL607022 , AL731538 , AL607023 , AC026394 , AC022017 Genomic DNA. Translation: CAH70164.1 .
BC065819 mRNA. Translation: AAH65819.1 .
CCDSi CCDS7269.1. [Q9UI47-1 ]
RefSeqi NP_001120856.1. NM_001127384.2. [Q9UI47-1 ]
NP_037398.2. NM_013266.3. [Q9UI47-1 ]
UniGenei Hs.21375.
Hs.660362.

3D structure databases

ProteinModelPortali Q9UI47.
SMRi Q9UI47. Positions 19-867.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118885. 7 interactions.
IntActi Q9UI47. 2 interactions.
STRINGi 9606.ENSP00000362849.

PTM databases

PhosphoSitei Q9UI47.

Polymorphism databases

DMDMi 78099215.

Proteomic databases

PaxDbi Q9UI47.
PRIDEi Q9UI47.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373744 ; ENSP00000362849 ; ENSG00000183230 . [Q9UI47-1 ]
ENST00000433211 ; ENSP00000389714 ; ENSG00000183230 . [Q9UI47-1 ]
GeneIDi 29119.
KEGGi hsa:29119.
UCSCi uc001jmw.2. human. [Q9UI47-1 ]
uc001jmx.4. human. [Q9UI47-2 ]

Organism-specific databases

CTDi 29119.
GeneCardsi GC10M067679.
H-InvDB HIX0017706.
HGNCi HGNC:2511. CTNNA3.
HPAi HPA017977.
MIMi 607667. gene.
615616. phenotype.
neXtProti NX_Q9UI47.
Orphaneti 293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
PharmGKBi PA27010.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240050.
HOGENOMi HOG000280724.
HOVERGENi HBG000069.
InParanoidi Q9UI47.
KOi K05691.
OMAi AFKRQQD.
OrthoDBi EOG7HQN7B.
PhylomeDBi Q9UI47.
TreeFami TF313686.

Miscellaneous databases

ChiTaRSi CTNNA3. human.
GenomeRNAii 29119.
NextBioi 52211.
PROi Q9UI47.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UI47.
Bgeei Q9UI47.
CleanExi HS_CTNNA3.
Genevestigatori Q9UI47.

Family and domain databases

InterProi IPR001033. Alpha_catenin.
IPR006077. Vinculin/catenin.
[Graphical view ]
PANTHERi PTHR18914. PTHR18914. 1 hit.
Pfami PF01044. Vinculin. 2 hits.
[Graphical view ]
PRINTSi PR00805. ALPHACATENIN.
SUPFAMi SSF47220. SSF47220. 4 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "AlphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion."
    Janssens B., Goossens S., Staes K., Gilbert B., van Hengel J., Colpaert C., Bruyneel E., Mareel M., van Roy F.
    J. Cell Sci. 114:3177-3188(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy."
    Janssens B., Mohapatra B., Vatta M., Goossens S., Vanpoucke G., Kools P., Montoye T., van Hengel J., Bowles N.E., van Roy F., Towbin J.A.
    Hum. Genet. 112:227-236(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: PNS.
  5. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-637, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: VARIANT ARVD13 ASP-94.

Entry informationi

Entry nameiCTNA3_HUMAN
AccessioniPrimary (citable) accession number: Q9UI47
Secondary accession number(s): Q5VSR2, Q6P056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi