Q9UI47 (CTNA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catenin alpha-3

Alternative name(s):
Alpha T-catenin
Cadherin-associated protein

Gene names

Name:

CTNNA3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	895 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in formation of stretch-resistant cell-cell adhesion complexes. Ref.1
Subunit structure	Interacts with CTNNB1. Ref.1
Subcellular location	Cytoplasm › cytoskeleton Potential. Note: Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. Ref.1
Tissue specificity	Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle. Ref.1
Sequence similarities	Belongs to the vinculin/alpha-catenin family.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell adhesion Inferred from physical interaction Ref.1. Source: UniProtKB
Cellular_component	actin cytoskeleton Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW fascia adherens Inferred from direct assay Ref.1. Source: UniProtKB lamellipodium Inferred from electronic annotation. Source: Compara
Molecular_function	cadherin binding Traceable author statement Ref.1. Source: UniProtKB structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
gag	P04591	2	EBI-3937546,EBI-6179727	From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 (identifier: Q9UI47-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UI47-2)

The sequence of this isoform differs from the canonical sequence as follows:
     511-516: ESHILE → GMFLFF
     517-895: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 895	895	Catenin alpha-3		PRO_0000064266
Regions
	Coiled coil	74 – 111	38	Potential
	Coiled coil	325 – 379	55	Potential
Amino acid modifications
	Modified residue	637	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	511 – 516	6	ESHILE → GMFLFF in isoform 2.		VSP_051852
	Alternative sequence	517 – 895	379	Missing in isoform 2.		VSP_051853
	Natural variant	535	1	R → C. Corresponds to variant rs41274090 [ dbSNP | Ensembl ].		VAR_062093
	Natural variant	596	1	S → N. Corresponds to variant rs4548513 [ dbSNP | Ensembl ].		VAR_053369
Experimental info
	Sequence conflict	160	1	S → T Ref.1
	Sequence conflict	160	1	S → T Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 25, 2005. Version 2. Checksum: 269E6DFB4956BDFE	FASTA	895	99,809
	10 20 30 40 50 60 MSAETPITLN IDPQDLQVQT FTVEKLLEPL IIQVTTLVNC PQNPSSRKKG RSKRASVLLA 70 80 90 100 110 120 SVEEATWNLL DKGEKIAQEA TVLKDELTAS LEEVRKESEA LKVSAERFTD DPCFLPKREA 130 140 150 160 170 180 VVQAARALLA AVTRLLILAD MIDVMCLLQH VSAFQRTFES LKNVANKSDL QKTYQKLGKE 190 200 210 220 230 240 LENLDYLAFK RQQDLKSPNQ RDEIAGARAS LKENSPLLHS ICSACLEHSD VASLKASKDT 250 260 270 280 290 300 VCEEIQNALN VISNASQGIQ NMTTPPEPQA ATLGSALDEL ENLIVLNPLT VTEEEIRPSL 310 320 330 340 350 360 EKRLEAIISG AALLADSSCT RDLHRERIIA ECNAIRQALQ DLLSEYMNNA GKKERSNTLN 370 380 390 400 410 420 IALDNMCKKT RDLRRQLRKA IIDHVSDSFL DTTVPLLVLI EAAKNGREKE IKEYAAIFHE 430 440 450 460 470 480 HTSRLVEVAN LACSMSTNED GIKIVKIAAN HLETLCPQII NAALALAARP KSQAVKNTME 490 500 510 520 530 540 MYKRTWENHI HVLTEAVDDI TSIDDFLAVS ESHILEDVNK CIIALRDQDA DNLDRAAGAI 550 560 570 580 590 600 RGRAARVAHI VTGEMDSYEP GAYTEGVMRN VNFLTSTVIP EFVTQVNVAL EALSKSSLNV 610 620 630 640 650 660 LDDNQFVDIS KKIYDTIHDI RCSVMMIRTP EELEDVSDLE EEHEVRSHTS IQTEGKTDRA 670 680 690 700 710 720 KMTQLPEAEK EKIAEQVADF KKVKSKLDAE IEIWDDTSND IIVLAKNMCM IMMEMTDFTR 730 740 750 760 770 780 GKGPLKHTTD VIYAAKMISE SGSRMDVLAR QIANQCPDPS CKQDLLAYLE QIKFYSHQLK 790 800 810 820 830 840 ICSQVKAEIQ NLGGELIMSA LDSVTSLIQA AKNLMNAVVQ TVKMSYIAST KIIRIQSPAG 850 860 870 880 890 PRHPVVMWRM KAPAKKPLIK REKPEETCAA VRRGSAKKKI HPLQVMSEFR GRQIY
	Isoform 2 [UniParc]. Checksum: BC464A5D36E85839	FASTA	516	57,332
	10 20 30 40 50 60 MSAETPITLN IDPQDLQVQT FTVEKLLEPL IIQVTTLVNC PQNPSSRKKG RSKRASVLLA 70 80 90 100 110 120 SVEEATWNLL DKGEKIAQEA TVLKDELTAS LEEVRKESEA LKVSAERFTD DPCFLPKREA 130 140 150 160 170 180 VVQAARALLA AVTRLLILAD MIDVMCLLQH VSAFQRTFES LKNVANKSDL QKTYQKLGKE 190 200 210 220 230 240 LENLDYLAFK RQQDLKSPNQ RDEIAGARAS LKENSPLLHS ICSACLEHSD VASLKASKDT 250 260 270 280 290 300 VCEEIQNALN VISNASQGIQ NMTTPPEPQA ATLGSALDEL ENLIVLNPLT VTEEEIRPSL 310 320 330 340 350 360 EKRLEAIISG AALLADSSCT RDLHRERIIA ECNAIRQALQ DLLSEYMNNA GKKERSNTLN 370 380 390 400 410 420 IALDNMCKKT RDLRRQLRKA IIDHVSDSFL DTTVPLLVLI EAAKNGREKE IKEYAAIFHE 430 440 450 460 470 480 HTSRLVEVAN LACSMSTNED GIKIVKIAAN HLETLCPQII NAALALAARP KSQAVKNTME 490 500 510 MYKRTWENHI HVLTEAVDDI TSIDDFLAVS GMFLFF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"AlphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion." Janssens B., Goossens S., Staes K., Gilbert B., van Hengel J., Colpaert C., Bruyneel E., Mareel M., van Roy F. J. Cell Sci. 114:3177-3188(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy." Janssens B., Mohapatra B., Vatta M., Goossens S., Vanpoucke G., Kools P., Montoye T., van Hengel J., Bowles N.E., van Roy F., Towbin J.A. Hum. Genet. 112:227-236(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: PNS.
[5]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-637, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF091606 mRNA. Translation: AAF21801.1. AF282692 , AF282679, AF282680, AF282681, AF282683, AF282685, AF282689, AF391793, AF282686, AF282688, AF282690, AF282691, AF391792, AF391794, AF282687, AF282682, AF282684 Genomic DNA. Translation: AAQ14328.1. AL607022 , AC016819, AC018979, AC020642, AC022017, AC022401, AC026394, AL607023, AL731538, AL731549 Genomic DNA. Translation: CAI13390.1. AL607023 , AC018979, AC020642, AC016819, AC022017, AC022401, AC026394, AL607022, AL731538, AL731549 Genomic DNA. Translation: CAI16316.1. AL731538 , AC016819, AC018979, AC020642, AC022017, AC022401, AC026394, AL607022, AL607023, AL731549 Genomic DNA. Translation: CAH73988.1. AL731549 , AC016819, AC018979, AC020642, AC022401, AL607022, AL731538, AL607023, AC026394, AC022017 Genomic DNA. Translation: CAH70164.1. BC065819 mRNA. Translation: AAH65819.1.
IPI	IPI00001712. IPI00654616.
RefSeq	NP_001120856.1. NM_001127384.1. NP_037398.2. NM_013266.2.
UniGene	Hs.660362.
3D structure databases
ProteinModelPortal	Q9UI47.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UI47. 2 interactions.
STRING	9606.ENSP00000362849.
PTM databases
PhosphoSite	Q9UI47.
Polymorphism databases
DMDM	78099215.
Proteomic databases
PaxDb	Q9UI47.
PRIDE	Q9UI47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373744; ENSP00000362849; ENSG00000183230. ENST00000433211; ENSP00000389714; ENSG00000183230.
GeneID	29119.
KEGG	hsa:29119.
UCSC	uc001jmw.2. human. uc001jmx.4. human.
Organism-specific databases
CTD	29119.
GeneCards	GC10M067679.
H-InvDB	HIX0017706.
HGNC	HGNC:2511. CTNNA3.
HPA	HPA017977.
MIM	607667. gene.
neXtProt	NX_Q9UI47.
PharmGKB	PA27010.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG240050.
HOGENOM	HOG000280724.
HOVERGEN	HBG000069.
InParanoid	Q9UI47.
KO	K05691.
OMA	SQGIQNM.
OrthoDB	EOG4P8FHC.
PhylomeDB	Q9UI47.
Gene expression databases
ArrayExpress	Q9UI47.
Bgee	Q9UI47.
CleanEx	HS_CTNNA3.
Genevestigator	Q9UI47.
GermOnline	ENSG00000183230. Homo sapiens.
Family and domain databases
InterPro	IPR001033. Alpha_catenin. IPR006077. Vinculin/catenin. [Graphical view]
Pfam	PF01044. Vinculin. 2 hits. [Graphical view]
PRINTS	PR00805. ALPHACATENIN.
SUPFAM	SSF47220. Vinculin/catenin. 4 hits.
PROSITE	PS00663. VINCULIN_1. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CTNNA3. human.
GenomeRNAi	29119.
NextBio	52211.
SOURCE	Search...

Entry information

Entry name

CTNA3_HUMAN

Accession

Primary (citable) accession number: Q9UI47
Secondary accession number(s): Q5VSR2, Q6P056

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	October 25, 2005
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.