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Q9UI47 (CTNA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Catenin alpha-3
Alternative name(s):
Alpha T-catenin
Cadherin-associated protein
Gene names
Name:CTNNA3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length895 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in formation of stretch-resistant cell-cell adhesion complexes. Ref.1

Subunit structure

Interacts with CTNNB1. Ref.1

Subcellular location

Cytoplasmcytoskeleton Potential. Note: Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. Ref.1

Tissue specificity

Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle. Ref.1

Sequence similarities

Belongs to the vinculin/alpha-catenin family.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell-cell adhesion

Inferred from physical interaction Ref.1. Source: UniProtKB

   Cellular_componentactin cytoskeleton

Inferred from electronic annotation. Source: InterPro

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

fascia adherens

Inferred from direct assay Ref.1. Source: UniProtKB

lamellipodium

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncadherin binding

Traceable author statement Ref.1. Source: UniProtKB

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

gagP045912EBI-3937546,EBI-6179727From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: Q9UI47-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UI47-2)

The sequence of this isoform differs from the canonical sequence as follows:
     511-516: ESHILE → GMFLFF
     517-895: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 895895Catenin alpha-3
PRO_0000064266

Regions

Coiled coil74 – 11138 Potential
Coiled coil325 – 37955 Potential

Amino acid modifications

Modified residue6371Phosphoserine Ref.5

Natural variations

Alternative sequence511 – 5166ESHILE → GMFLFF in isoform 2.
VSP_051852
Alternative sequence517 – 895379Missing in isoform 2.
VSP_051853
Natural variant5351R → C.
Corresponds to variant rs41274090 [ dbSNP | Ensembl ].
VAR_062093
Natural variant5961S → N.
Corresponds to variant rs4548513 [ dbSNP | Ensembl ].
VAR_053369

Experimental info

Sequence conflict1601S → T Ref.1
Sequence conflict1601S → T Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 25, 2005. Version 2.
Checksum: 269E6DFB4956BDFE

FASTA89599,809
        10         20         30         40         50         60 
MSAETPITLN IDPQDLQVQT FTVEKLLEPL IIQVTTLVNC PQNPSSRKKG RSKRASVLLA 

        70         80         90        100        110        120 
SVEEATWNLL DKGEKIAQEA TVLKDELTAS LEEVRKESEA LKVSAERFTD DPCFLPKREA 

       130        140        150        160        170        180 
VVQAARALLA AVTRLLILAD MIDVMCLLQH VSAFQRTFES LKNVANKSDL QKTYQKLGKE 

       190        200        210        220        230        240 
LENLDYLAFK RQQDLKSPNQ RDEIAGARAS LKENSPLLHS ICSACLEHSD VASLKASKDT 

       250        260        270        280        290        300 
VCEEIQNALN VISNASQGIQ NMTTPPEPQA ATLGSALDEL ENLIVLNPLT VTEEEIRPSL 

       310        320        330        340        350        360 
EKRLEAIISG AALLADSSCT RDLHRERIIA ECNAIRQALQ DLLSEYMNNA GKKERSNTLN 

       370        380        390        400        410        420 
IALDNMCKKT RDLRRQLRKA IIDHVSDSFL DTTVPLLVLI EAAKNGREKE IKEYAAIFHE 

       430        440        450        460        470        480 
HTSRLVEVAN LACSMSTNED GIKIVKIAAN HLETLCPQII NAALALAARP KSQAVKNTME 

       490        500        510        520        530        540 
MYKRTWENHI HVLTEAVDDI TSIDDFLAVS ESHILEDVNK CIIALRDQDA DNLDRAAGAI 

       550        560        570        580        590        600 
RGRAARVAHI VTGEMDSYEP GAYTEGVMRN VNFLTSTVIP EFVTQVNVAL EALSKSSLNV 

       610        620        630        640        650        660 
LDDNQFVDIS KKIYDTIHDI RCSVMMIRTP EELEDVSDLE EEHEVRSHTS IQTEGKTDRA 

       670        680        690        700        710        720 
KMTQLPEAEK EKIAEQVADF KKVKSKLDAE IEIWDDTSND IIVLAKNMCM IMMEMTDFTR 

       730        740        750        760        770        780 
GKGPLKHTTD VIYAAKMISE SGSRMDVLAR QIANQCPDPS CKQDLLAYLE QIKFYSHQLK 

       790        800        810        820        830        840 
ICSQVKAEIQ NLGGELIMSA LDSVTSLIQA AKNLMNAVVQ TVKMSYIAST KIIRIQSPAG 

       850        860        870        880        890 
PRHPVVMWRM KAPAKKPLIK REKPEETCAA VRRGSAKKKI HPLQVMSEFR GRQIY 

« Hide

Isoform 2 [UniParc].

Checksum: BC464A5D36E85839
Show »

FASTA51657,332

References

« Hide 'large scale' references
[1]"AlphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion."
Janssens B., Goossens S., Staes K., Gilbert B., van Hengel J., Colpaert C., Bruyneel E., Mareel M., van Roy F.
J. Cell Sci. 114:3177-3188(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Testis.
[2]"Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy."
Janssens B., Mohapatra B., Vatta M., Goossens S., Vanpoucke G., Kools P., Montoye T., van Hengel J., Bowles N.E., van Roy F., Towbin J.A.
Hum. Genet. 112:227-236(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: PNS.
[5]"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-637, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF091606 mRNA. Translation: AAF21801.1.
AF282692 expand/collapse EMBL AC list , AF282679, AF282680, AF282681, AF282683, AF282685, AF282689, AF391793, AF282686, AF282688, AF282690, AF282691, AF391792, AF391794, AF282687, AF282682, AF282684 Genomic DNA. Translation: AAQ14328.1.
AL607022 expand/collapse EMBL AC list , AC016819, AC018979, AC020642, AC022017, AC022401, AC026394, AL607023, AL731538, AL731549 Genomic DNA. Translation: CAI13390.1.
AL607023 expand/collapse EMBL AC list , AC018979, AC020642, AC016819, AC022017, AC022401, AC026394, AL607022, AL731538, AL731549 Genomic DNA. Translation: CAI16316.1.
AL731538 expand/collapse EMBL AC list , AC016819, AC018979, AC020642, AC022017, AC022401, AC026394, AL607022, AL607023, AL731549 Genomic DNA. Translation: CAH73988.1.
AL731549 expand/collapse EMBL AC list , AC016819, AC018979, AC020642, AC022401, AL607022, AL731538, AL607023, AC026394, AC022017 Genomic DNA. Translation: CAH70164.1.
BC065819 mRNA. Translation: AAH65819.1.
RefSeqNP_001120856.1. NM_001127384.1.
NP_037398.2. NM_013266.2.
UniGeneHs.660362.

3D structure databases

ProteinModelPortalQ9UI47.
SMRQ9UI47. Positions 19-867.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118885. 7 interactions.
IntActQ9UI47. 2 interactions.
STRING9606.ENSP00000362849.

PTM databases

PhosphoSiteQ9UI47.

Polymorphism databases

DMDM78099215.

Proteomic databases

PaxDbQ9UI47.
PRIDEQ9UI47.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373744; ENSP00000362849; ENSG00000183230. [Q9UI47-1]
ENST00000433211; ENSP00000389714; ENSG00000183230. [Q9UI47-1]
GeneID29119.
KEGGhsa:29119.
UCSCuc001jmw.2. human. [Q9UI47-1]
uc001jmx.4. human. [Q9UI47-2]

Organism-specific databases

CTD29119.
GeneCardsGC10M067679.
H-InvDBHIX0017706.
HGNCHGNC:2511. CTNNA3.
HPAHPA017977.
MIM607667. gene.
neXtProtNX_Q9UI47.
PharmGKBPA27010.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240050.
HOGENOMHOG000280724.
HOVERGENHBG000069.
InParanoidQ9UI47.
KOK05691.
OMAAFKRQQD.
OrthoDBEOG7HQN7B.
PhylomeDBQ9UI47.
TreeFamTF313686.

Gene expression databases

ArrayExpressQ9UI47.
BgeeQ9UI47.
CleanExHS_CTNNA3.
GenevestigatorQ9UI47.

Family and domain databases

InterProIPR001033. Alpha_catenin.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERPTHR18914. PTHR18914. 1 hit.
PfamPF01044. Vinculin. 2 hits.
[Graphical view]
PRINTSPR00805. ALPHACATENIN.
SUPFAMSSF47220. SSF47220. 4 hits.
ProtoNetSearch...

Other

ChiTaRSCTNNA3. human.
GenomeRNAi29119.
NextBio52211.
PROQ9UI47.
SOURCESearch...

Entry information

Entry nameCTNA3_HUMAN
AccessionPrimary (citable) accession number: Q9UI47
Secondary accession number(s): Q5VSR2, Q6P056
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: March 19, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM