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Protein

rRNA methyltransferase 2, mitochondrial

Gene

MRM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.2 Publications

Catalytic activityi

S-adenosyl-L-methionine + uridine(1369) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine(1369) in 16S rRNA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei112S-adenosyl-L-methionine1 Publication1
Binding sitei154S-adenosyl-L-methionine1 Publication1
Active sitei194Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: BHF-UCL
  • rRNA 2'-O-methylation Source: Reactome
  • rRNA methylation Source: BHF-UCL
  • rRNA processing Source: BHF-UCL

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDAi2.1.1.166 2681
ReactomeiR-HSA-6793080 rRNA modification in the mitochondrion

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA methyltransferase 2, mitochondrial1 Publication (EC:2.1.1.-1 Publication)
Alternative name(s):
16S rRNA (uridine(1369)-2'-O)-methyltransferase1 Publication
16S rRNA [Um1369] 2'-O-methyltransferase1 Publication
Protein ftsJ homolog 21 Publication
Gene namesi
Name:MRM21 Publication
Synonyms:FJH11 Publication, FTSJ21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122687.17
HGNCiHGNC:16352 MRM2
MIMi606906 gene
neXtProtiNX_Q9UI43

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi29960
OpenTargetsiENSG00000122687
PharmGKBiPA28418

Polymorphism and mutation databases

BioMutaiFTSJ2
DMDMi9910866

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionSequence analysisAdd BLAST18
ChainiPRO_000015557619 – 246rRNA methyltransferase 2, mitochondrialAdd BLAST228

Proteomic databases

EPDiQ9UI43
PaxDbiQ9UI43
PeptideAtlasiQ9UI43
PRIDEiQ9UI43

PTM databases

iPTMnetiQ9UI43
PhosphoSitePlusiQ9UI43

Expressioni

Tissue specificityi

Widely expressed, with highest expression in muscle, placenta, and heart.1 Publication

Gene expression databases

BgeeiENSG00000122687
CleanExiHS_FTSJ2
ExpressionAtlasiQ9UI43 baseline and differential
GenevisibleiQ9UI43 HS

Organism-specific databases

HPAiHPA019826
HPA049622

Interactioni

Protein-protein interaction databases

BioGridi118996, 37 interactors
STRINGi9606.ENSP00000242257

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi56 – 67Combined sources12
Beta strandi75 – 79Combined sources5
Helixi85 – 93Combined sources9
Turni94 – 97Combined sources4
Beta strandi107 – 111Combined sources5
Beta strandi123 – 125Combined sources3
Helixi133 – 142Combined sources10
Helixi144 – 146Combined sources3
Beta strandi148 – 153Combined sources6
Helixi163 – 184Combined sources22
Beta strandi185 – 195Combined sources11
Helixi199 – 201Combined sources3
Helixi202 – 211Combined sources10
Beta strandi212 – 218Combined sources7
Beta strandi230 – 237Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NYUX-ray1.76A/B51-246[»]
ProteinModelPortaliQ9UI43
SMRiQ9UI43
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UI43

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 86S-adenosyl-L-methionine binding1 Publication4
Regioni129 – 130S-adenosyl-L-methionine binding1 Publication2

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4589 Eukaryota
COG0293 LUCA
GeneTreeiENSGT00730000111241
HOGENOMiHOG000162366
HOVERGENiHBG009202
InParanoidiQ9UI43
KOiK02427
OMAiHRQTDHL
OrthoDBiEOG091G0G8O
PhylomeDBiQ9UI43
TreeFamiTF316701

Family and domain databases

HAMAPiMF_01547 RNA_methyltr_E, 1 hit
InterProiView protein in InterPro
IPR015507 rRNA-MeTfrase_E
IPR002877 rRNA_MeTrfase_FtsJ_dom
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01728 FtsJ, 1 hit
PIRSFiPIRSF005461 23S_rRNA_mtase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UI43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGYLKLVCV SFQRQGFHTV GSRCKNRTGA EHLWLTRHLR DPFVKAAKVE
60 70 80 90 100
SYRCRSAFKL LEVNERHQIL RPGLRVLDCG AAPGAWSQVA VQKVNAAGTD
110 120 130 140 150
PSSPVGFVLG VDLLHIFPLE GATFLCPADV TDPRTSQRIL EVLPGRRADV
160 170 180 190 200
ILSDMAPNAT GFRDLDHDRL ISLCLTLLSV TPDILQPGGT FLCKTWAGSQ
210 220 230 240
SRRLQRRLTE EFQNVRIIKP EASRKESSEV YFLATQYHGR KGTVKQ
Length:246
Mass (Da):27,424
Last modified:May 1, 2000 - v1
Checksum:iDB7B9978695409D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73G → S in AAI14515 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093415 mRNA Translation: AAF22488.1
BC114514 mRNA Translation: AAI14515.1
CCDSiCCDS5328.1
RefSeqiNP_037525.1, NM_013393.1
UniGeneiHs.279877

Genome annotation databases

EnsembliENST00000242257; ENSP00000242257; ENSG00000122687
ENST00000440306; ENSP00000392343; ENSG00000122687
GeneIDi29960
KEGGihsa:29960

Similar proteinsi

Entry informationi

Entry nameiMRM2_HUMAN
AccessioniPrimary (citable) accession number: Q9UI43
Secondary accession number(s): Q24JR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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