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Protein

Sodium/potassium/calcium exchanger 2

Gene

SLC24A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Potassium transport, Sensory transduction, Sodium transport, Symport, Transport, Vision

Keywords - Ligandi

Calcium, Potassium, Sodium

Enzyme and pathway databases

ReactomeiREACT_19320. Sodium/Calcium exchangers.

Protein family/group databases

TCDBi2.A.19.4.11. the ca(2+):cation antiporter (caca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 2
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 2
Retinal cone Na-Ca+K exchanger
Solute carrier family 24 member 2
Gene namesi
Name:SLC24A2
Synonyms:NCKX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:10976. SLC24A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Topological domaini60 – 13273ExtracellularSequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Topological domaini154 – 17825CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence AnalysisAdd
BLAST
Topological domaini200 – 2045ExtracellularSequence Analysis
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Topological domaini226 – 24318CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Topological domaini265 – 2651ExtracellularSequence Analysis
Transmembranei266 – 28621HelicalSequence AnalysisAdd
BLAST
Topological domaini287 – 497211CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei498 – 51821HelicalSequence AnalysisAdd
BLAST
Topological domaini519 – 53315ExtracellularSequence AnalysisAdd
BLAST
Transmembranei534 – 55421HelicalSequence AnalysisAdd
BLAST
Topological domaini555 – 56915CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei570 – 59021HelicalSequence AnalysisAdd
BLAST
Topological domaini591 – 60212ExtracellularSequence AnalysisAdd
BLAST
Transmembranei603 – 62321HelicalSequence AnalysisAdd
BLAST
Topological domaini624 – 6307CytoplasmicSequence Analysis
Transmembranei631 – 65121HelicalSequence AnalysisAdd
BLAST
Topological domaini652 – 66110ExtracellularSequence Analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi111 – 1111N → D: Loss of N-glycosylation. 1 Publication

Organism-specific databases

PharmGKBiPA35852.

Polymorphism and mutation databases

BioMutaiSLC24A2.
DMDMi17865516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 661661Sodium/potassium/calcium exchanger 2PRO_0000019367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi111 – 1111N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UI40.
PRIDEiQ9UI40.

PTM databases

PhosphoSiteiQ9UI40.

Expressioni

Gene expression databases

BgeeiQ9UI40.
CleanExiHS_SLC24A2.
GenevestigatoriQ9UI40.

Organism-specific databases

HPAiHPA057278.

Structurei

3D structure databases

ProteinModelPortaliQ9UI40.
SMRiQ9UI40. Positions 155-277, 471-576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati174 – 21441Alpha-1Add
BLAST
Repeati541 – 57232Alpha-2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0530.
GeneTreeiENSGT00760000119209.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ9UI40.
KOiK13750.
OMAiRIFWWEA.
OrthoDBiEOG776SP8.
PhylomeDBiQ9UI40.
TreeFamiTF318759.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030236. SLC24A2.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF33. PTHR10846:SF33. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UI40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLQQSTTIT SLEKWCLDES LSGCRRHYSV KKKLKLIRVL GLFMGLVAIS
60 70 80 90 100
TVSFSISAFS ETDTQSTGEA SVVSGPRVAQ GYHQRTLLDL NDKILDYTPQ
110 120 130 140 150
PPLSKEGESE NSTDHAQGDY PKDIFSLEER RKGAIILHVI GMIYMFIALA
160 170 180 190 200
IVCDEFFVPS LTVITEKLGI SDDVAGATFM AAGGSAPELF TSLIGVFIAH
210 220 230 240 250
SNVGIGTIVG SAVFNILFVI GMCALFSREI LNLTWWPLFR DVSFYIVDLI
260 270 280 290 300
MLIIFFLDNV IMWWESLLLL TAYFCYVVFM KFNVQVEKWV KQMINRNKVV
310 320 330 340 350
KVTAPEAQAK PSAARDKDEP TLPAKPRLQR GGSSASLHNS LMRNSIFQLM
360 370 380 390 400
IHTLDPLAEE LGSYGKLKYY DTMTEEGRFR EKASILHKIA KKKCHVDENE
410 420 430 440 450
RQNGAANHVE KIELPNSTST DVEMTPSSDA SEPVQNGNLS HNIEGAEAQT
460 470 480 490 500
ADEEEDQPLS LAWPSETRKQ VTFLIVFPIV FPLWITLPDV RKPSSRKFFP
510 520 530 540 550
ITFFGSITWI AVFSYLMVWW AHQVGETIGI SEEIMGLTIL AAGTSIPDLI
560 570 580 590 600
TSVIVARKGL GDMAVSSSVG SNIFDITVGL PLPWLLYTVI HRFQPVAVSS
610 620 630 640 650
NGLFCAIVLL FIMLLFVILS IALCKWRMNK ILGFIMFGLY FVFLVVSVLL
660
EDRILTCPVS I
Length:661
Mass (Da):73,664
Last modified:May 1, 2000 - v1
Checksum:iE6359C1F95C3AB3E
GO
Isoform 2 (identifier: Q9UI40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-376: Missing.

Show »
Length:644
Mass (Da):71,655
Checksum:i1DFB85DFA82A3F4B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei360 – 37617Missing in isoform 2. 2 PublicationsVSP_006164Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097366 mRNA. Translation: AAF21810.1.
AF177987 mRNA. Translation: AAF25811.1.
AL158077, AL133281, AL158206 Genomic DNA. Translation: CAH74108.1.
AL158206, AL133281, AL158077 Genomic DNA. Translation: CAH73020.1.
AL133281, AL158077, AL158206 Genomic DNA. Translation: CAH71736.1.
AL158077, AL133281, AL158206 Genomic DNA. Translation: CAH74109.1.
AL158206, AL133281, AL158077 Genomic DNA. Translation: CAH73021.1.
AL133281, AL158077, AL158206 Genomic DNA. Translation: CAH71737.1.
BC069622 mRNA. Translation: AAH69622.1.
BC143889 mRNA. Translation: AAI43890.1.
CCDSiCCDS55297.1. [Q9UI40-2]
CCDS6493.1. [Q9UI40-1]
RefSeqiNP_001180217.1. NM_001193288.2. [Q9UI40-2]
NP_065077.1. NM_020344.3. [Q9UI40-1]
XP_005251482.1. XM_005251425.1. [Q9UI40-1]
XP_005251483.1. XM_005251426.3. [Q9UI40-1]
XP_006716813.1. XM_006716750.2. [Q9UI40-2]
UniGeneiHs.283014.
Hs.590750.
Hs.738749.

Genome annotation databases

EnsembliENST00000286344; ENSP00000286344; ENSG00000155886. [Q9UI40-2]
ENST00000341998; ENSP00000344801; ENSG00000155886. [Q9UI40-1]
GeneIDi25769.
KEGGihsa:25769.
UCSCiuc003zoa.2. human. [Q9UI40-1]
uc003zob.2. human. [Q9UI40-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097366 mRNA. Translation: AAF21810.1.
AF177987 mRNA. Translation: AAF25811.1.
AL158077, AL133281, AL158206 Genomic DNA. Translation: CAH74108.1.
AL158206, AL133281, AL158077 Genomic DNA. Translation: CAH73020.1.
AL133281, AL158077, AL158206 Genomic DNA. Translation: CAH71736.1.
AL158077, AL133281, AL158206 Genomic DNA. Translation: CAH74109.1.
AL158206, AL133281, AL158077 Genomic DNA. Translation: CAH73021.1.
AL133281, AL158077, AL158206 Genomic DNA. Translation: CAH71737.1.
BC069622 mRNA. Translation: AAH69622.1.
BC143889 mRNA. Translation: AAI43890.1.
CCDSiCCDS55297.1. [Q9UI40-2]
CCDS6493.1. [Q9UI40-1]
RefSeqiNP_001180217.1. NM_001193288.2. [Q9UI40-2]
NP_065077.1. NM_020344.3. [Q9UI40-1]
XP_005251482.1. XM_005251425.1. [Q9UI40-1]
XP_005251483.1. XM_005251426.3. [Q9UI40-1]
XP_006716813.1. XM_006716750.2. [Q9UI40-2]
UniGeneiHs.283014.
Hs.590750.
Hs.738749.

3D structure databases

ProteinModelPortaliQ9UI40.
SMRiQ9UI40. Positions 155-277, 471-576.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.19.4.11. the ca(2+):cation antiporter (caca) family.

PTM databases

PhosphoSiteiQ9UI40.

Polymorphism and mutation databases

BioMutaiSLC24A2.
DMDMi17865516.

Proteomic databases

PaxDbiQ9UI40.
PRIDEiQ9UI40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286344; ENSP00000286344; ENSG00000155886. [Q9UI40-2]
ENST00000341998; ENSP00000344801; ENSG00000155886. [Q9UI40-1]
GeneIDi25769.
KEGGihsa:25769.
UCSCiuc003zoa.2. human. [Q9UI40-1]
uc003zob.2. human. [Q9UI40-2]

Organism-specific databases

CTDi25769.
GeneCardsiGC09M019507.
HGNCiHGNC:10976. SLC24A2.
HPAiHPA057278.
MIMi609838. gene.
neXtProtiNX_Q9UI40.
PharmGKBiPA35852.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0530.
GeneTreeiENSGT00760000119209.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ9UI40.
KOiK13750.
OMAiRIFWWEA.
OrthoDBiEOG776SP8.
PhylomeDBiQ9UI40.
TreeFamiTF318759.

Enzyme and pathway databases

ReactomeiREACT_19320. Sodium/Calcium exchangers.

Miscellaneous databases

ChiTaRSiSLC24A2. human.
GenomeRNAii25769.
NextBioi46893.
PROiQ9UI40.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UI40.
CleanExiHS_SLC24A2.
GenevestigatoriQ9UI40.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030236. SLC24A2.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF33. PTHR10846:SF33. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of the potassium-dependent sodium-calcium exchanger from human and chicken retinal cone photoreceptors."
    Prinsen C.F.M., Szerencsei R.T., Schnetkamp P.P.M.
    J. Neurosci. 20:1424-1434(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Retina.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  4. Cited for: TOPOLOGY, MUTAGENESIS OF ASN-111, GLYCOSYLATION AT ASN-111.

Entry informationi

Entry nameiNCKX2_HUMAN
AccessioniPrimary (citable) accession number: Q9UI40
Secondary accession number(s): B7ZLL8, Q9NTN5, Q9NZQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: May 1, 2000
Last modified: April 29, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.