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Protein

Sodium/potassium/calcium exchanger 2

Gene

SLC24A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Potassium transport, Sensory transduction, Sodium transport, Symport, Transport, Vision

Keywords - Ligandi

Calcium, Potassium, Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155886-MONOMER.
ReactomeiR-HSA-425561. Sodium/Calcium exchangers.

Protein family/group databases

TCDBi2.A.19.4.11. the ca(2+):cation antiporter (caca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 2
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 2
Retinal cone Na-Ca+K exchanger
Solute carrier family 24 member 2
Gene namesi
Name:SLC24A2
Synonyms:NCKX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:10976. SLC24A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 132ExtracellularSequence analysisAdd BLAST73
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 178CytoplasmicSequence analysisAdd BLAST25
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 204ExtracellularSequence analysis5
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 243CytoplasmicSequence analysisAdd BLAST18
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265ExtracellularSequence analysis1
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 497CytoplasmicSequence analysisAdd BLAST211
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21
Topological domaini519 – 533ExtracellularSequence analysisAdd BLAST15
Transmembranei534 – 554HelicalSequence analysisAdd BLAST21
Topological domaini555 – 569CytoplasmicSequence analysisAdd BLAST15
Transmembranei570 – 590HelicalSequence analysisAdd BLAST21
Topological domaini591 – 602ExtracellularSequence analysisAdd BLAST12
Transmembranei603 – 623HelicalSequence analysisAdd BLAST21
Topological domaini624 – 630CytoplasmicSequence analysis7
Transmembranei631 – 651HelicalSequence analysisAdd BLAST21
Topological domaini652 – 661ExtracellularSequence analysis10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi111N → D: Loss of N-glycosylation. 1 Publication1

Organism-specific databases

DisGeNETi25769.
OpenTargetsiENSG00000155886.
PharmGKBiPA35852.

Polymorphism and mutation databases

BioMutaiSLC24A2.
DMDMi17865516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000193671 – 661Sodium/potassium/calcium exchanger 2Add BLAST661

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi111N-linked (GlcNAc...)1 Publication1
Modified residuei336PhosphoserineBy similarity1
Modified residuei340PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UI40.
PeptideAtlasiQ9UI40.
PRIDEiQ9UI40.

PTM databases

iPTMnetiQ9UI40.
PhosphoSitePlusiQ9UI40.

Expressioni

Gene expression databases

BgeeiENSG00000155886.
CleanExiHS_SLC24A2.
GenevisibleiQ9UI40. HS.

Organism-specific databases

HPAiHPA057278.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344801.

Structurei

3D structure databases

ProteinModelPortaliQ9UI40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati174 – 214Alpha-1Add BLAST41
Repeati541 – 572Alpha-2Add BLAST32

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
GeneTreeiENSGT00760000119209.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ9UI40.
KOiK13750.
OMAiSSNTWCH.
OrthoDBiEOG091G0M5C.
PhylomeDBiQ9UI40.
TreeFamiTF318759.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UI40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLQQSTTIT SLEKWCLDES LSGCRRHYSV KKKLKLIRVL GLFMGLVAIS
60 70 80 90 100
TVSFSISAFS ETDTQSTGEA SVVSGPRVAQ GYHQRTLLDL NDKILDYTPQ
110 120 130 140 150
PPLSKEGESE NSTDHAQGDY PKDIFSLEER RKGAIILHVI GMIYMFIALA
160 170 180 190 200
IVCDEFFVPS LTVITEKLGI SDDVAGATFM AAGGSAPELF TSLIGVFIAH
210 220 230 240 250
SNVGIGTIVG SAVFNILFVI GMCALFSREI LNLTWWPLFR DVSFYIVDLI
260 270 280 290 300
MLIIFFLDNV IMWWESLLLL TAYFCYVVFM KFNVQVEKWV KQMINRNKVV
310 320 330 340 350
KVTAPEAQAK PSAARDKDEP TLPAKPRLQR GGSSASLHNS LMRNSIFQLM
360 370 380 390 400
IHTLDPLAEE LGSYGKLKYY DTMTEEGRFR EKASILHKIA KKKCHVDENE
410 420 430 440 450
RQNGAANHVE KIELPNSTST DVEMTPSSDA SEPVQNGNLS HNIEGAEAQT
460 470 480 490 500
ADEEEDQPLS LAWPSETRKQ VTFLIVFPIV FPLWITLPDV RKPSSRKFFP
510 520 530 540 550
ITFFGSITWI AVFSYLMVWW AHQVGETIGI SEEIMGLTIL AAGTSIPDLI
560 570 580 590 600
TSVIVARKGL GDMAVSSSVG SNIFDITVGL PLPWLLYTVI HRFQPVAVSS
610 620 630 640 650
NGLFCAIVLL FIMLLFVILS IALCKWRMNK ILGFIMFGLY FVFLVVSVLL
660
EDRILTCPVS I
Length:661
Mass (Da):73,664
Last modified:May 1, 2000 - v1
Checksum:iE6359C1F95C3AB3E
GO
Isoform 2 (identifier: Q9UI40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-376: Missing.

Show »
Length:644
Mass (Da):71,655
Checksum:i1DFB85DFA82A3F4B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006164360 – 376Missing in isoform 2. 2 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097366 mRNA. Translation: AAF21810.1.
AF177987 mRNA. Translation: AAF25811.1.
AL158077, AL133281, AL158206 Genomic DNA. Translation: CAH74108.1.
AL158206, AL133281, AL158077 Genomic DNA. Translation: CAH73020.1.
AL133281, AL158077, AL158206 Genomic DNA. Translation: CAH71736.1.
AL158077, AL133281, AL158206 Genomic DNA. Translation: CAH74109.1.
AL158206, AL133281, AL158077 Genomic DNA. Translation: CAH73021.1.
AL133281, AL158077, AL158206 Genomic DNA. Translation: CAH71737.1.
BC069622 mRNA. Translation: AAH69622.1.
BC143889 mRNA. Translation: AAI43890.1.
CCDSiCCDS55297.1. [Q9UI40-2]
CCDS6493.1. [Q9UI40-1]
RefSeqiNP_001180217.1. NM_001193288.2. [Q9UI40-2]
NP_065077.1. NM_020344.3. [Q9UI40-1]
XP_005251482.1. XM_005251425.2. [Q9UI40-1]
XP_005251483.1. XM_005251426.4. [Q9UI40-1]
XP_006716813.1. XM_006716750.3. [Q9UI40-2]
XP_016870081.1. XM_017014592.1. [Q9UI40-1]
XP_016870082.1. XM_017014593.1. [Q9UI40-2]
UniGeneiHs.283014.
Hs.590750.
Hs.738749.

Genome annotation databases

EnsembliENST00000286344; ENSP00000286344; ENSG00000155886. [Q9UI40-2]
ENST00000341998; ENSP00000344801; ENSG00000155886. [Q9UI40-1]
GeneIDi25769.
KEGGihsa:25769.
UCSCiuc003zoa.3. human. [Q9UI40-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097366 mRNA. Translation: AAF21810.1.
AF177987 mRNA. Translation: AAF25811.1.
AL158077, AL133281, AL158206 Genomic DNA. Translation: CAH74108.1.
AL158206, AL133281, AL158077 Genomic DNA. Translation: CAH73020.1.
AL133281, AL158077, AL158206 Genomic DNA. Translation: CAH71736.1.
AL158077, AL133281, AL158206 Genomic DNA. Translation: CAH74109.1.
AL158206, AL133281, AL158077 Genomic DNA. Translation: CAH73021.1.
AL133281, AL158077, AL158206 Genomic DNA. Translation: CAH71737.1.
BC069622 mRNA. Translation: AAH69622.1.
BC143889 mRNA. Translation: AAI43890.1.
CCDSiCCDS55297.1. [Q9UI40-2]
CCDS6493.1. [Q9UI40-1]
RefSeqiNP_001180217.1. NM_001193288.2. [Q9UI40-2]
NP_065077.1. NM_020344.3. [Q9UI40-1]
XP_005251482.1. XM_005251425.2. [Q9UI40-1]
XP_005251483.1. XM_005251426.4. [Q9UI40-1]
XP_006716813.1. XM_006716750.3. [Q9UI40-2]
XP_016870081.1. XM_017014592.1. [Q9UI40-1]
XP_016870082.1. XM_017014593.1. [Q9UI40-2]
UniGeneiHs.283014.
Hs.590750.
Hs.738749.

3D structure databases

ProteinModelPortaliQ9UI40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344801.

Protein family/group databases

TCDBi2.A.19.4.11. the ca(2+):cation antiporter (caca) family.

PTM databases

iPTMnetiQ9UI40.
PhosphoSitePlusiQ9UI40.

Polymorphism and mutation databases

BioMutaiSLC24A2.
DMDMi17865516.

Proteomic databases

PaxDbiQ9UI40.
PeptideAtlasiQ9UI40.
PRIDEiQ9UI40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286344; ENSP00000286344; ENSG00000155886. [Q9UI40-2]
ENST00000341998; ENSP00000344801; ENSG00000155886. [Q9UI40-1]
GeneIDi25769.
KEGGihsa:25769.
UCSCiuc003zoa.3. human. [Q9UI40-1]

Organism-specific databases

CTDi25769.
DisGeNETi25769.
GeneCardsiSLC24A2.
HGNCiHGNC:10976. SLC24A2.
HPAiHPA057278.
MIMi609838. gene.
neXtProtiNX_Q9UI40.
OpenTargetsiENSG00000155886.
PharmGKBiPA35852.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
GeneTreeiENSGT00760000119209.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ9UI40.
KOiK13750.
OMAiSSNTWCH.
OrthoDBiEOG091G0M5C.
PhylomeDBiQ9UI40.
TreeFamiTF318759.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155886-MONOMER.
ReactomeiR-HSA-425561. Sodium/Calcium exchangers.

Miscellaneous databases

ChiTaRSiSLC24A2. human.
GenomeRNAii25769.
PROiQ9UI40.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155886.
CleanExiHS_SLC24A2.
GenevisibleiQ9UI40. HS.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNCKX2_HUMAN
AccessioniPrimary (citable) accession number: Q9UI40
Secondary accession number(s): B7ZLL8, Q9NTN5, Q9NZQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.