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Protein

Probable threonine protease PRSS50

Gene

PRSS50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in proteolysis through its threonine endopeptidase activity.1 Publication

Miscellaneous

DNA hypomethylation is accompanied by the expression of the gene in the testis.

Caution

Although related to peptidase S1 family, lacks the conserved active Ser residue in position 310 which is replaced by a Thr.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei153Charge relay systemPROSITE-ProRule annotation1
Active sitei206Charge relay systemPROSITE-ProRule annotation1
Active sitei310Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • threonine-type endopeptidase activity Source: UniProtKB

GO - Biological processi

  • proteolysis Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiS01.993

Names & Taxonomyi

Protein namesi
Recommended name:
Probable threonine protease PRSS50 (EC:3.4.25.-1 Publication)
Alternative name(s):
Cancer/testis antigen 20
Serine protease 50
Testis-specific protease-like protein 50
Gene namesi
Name:PRSS50
Synonyms:CT20, TSP50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000206549.12
HGNCiHGNC:17910 PRSS50
MIMi607950 gene
neXtProtiNX_Q9UI38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi310T → A: Loss of catalytic activity. 1 Publication1

Organism-specific databases

DisGeNETi29122
OpenTargetsiENSG00000206549
PharmGKBiPA165698443

Polymorphism and mutation databases

BioMutaiPRSS50
DMDMi37089988

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_000002849240 – 385Probable threonine protease PRSS50Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi138 ↔ 154PROSITE-ProRule annotation
Disulfide bondi240 ↔ 316PROSITE-ProRule annotation
Disulfide bondi273 ↔ 296PROSITE-ProRule annotation
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi306 ↔ 334PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UI38
PeptideAtlasiQ9UI38
PRIDEiQ9UI38
ProteomicsDBi84468

PTM databases

iPTMnetiQ9UI38
PhosphoSitePlusiQ9UI38

Expressioni

Tissue specificityi

Testis specific. Differentially expressed in some breast cancer tissues.

Gene expression databases

BgeeiENSG00000206549
ExpressionAtlasiQ9UI38 baseline and differential
GenevisibleiQ9UI38 HS

Organism-specific databases

HPAiHPA040768

Interactioni

Protein-protein interaction databases

BioGridi118887, 24 interactors
IntActiQ9UI38, 6 interactors
MINTiQ9UI38
STRINGi9606.ENSP00000326598

Structurei

3D structure databases

ProteinModelPortaliQ9UI38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 358Peptidase S1PROSITE-ProRule annotationAdd BLAST266

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00900000140944
HOGENOMiHOG000065742
HOVERGENiHBG068181
InParanoidiQ9UI38
OMAiMWPQFRT
OrthoDBiEOG091G0G74
PhylomeDBiQ9UI38
TreeFamiTF351676

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UI38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRWCQTVAR GQRPRTSAPS RAGALLLLLL LLRSAGCWGA GEAPGALSTA
60 70 80 90 100
DPADQSVQCV PKATCPSSRP RLLWQTPTTQ TLPSTTMETQ FPVSEGKVDP
110 120 130 140 150
YRSCGFSYEQ DPTLRDPEAV ARRWPWMVSV RANGTHICAG TIIASQWVLT
160 170 180 190 200
VAHCLIWRDV IYSVRVGSPW IDQMTQTASD VPVLQVIMHS RYRAQRFWSW
210 220 230 240 250
VGQANDIGLL KLKQELKYSN YVRPICLPGT DYVLKDHSRC TVTGWGLSKA
260 270 280 290 300
DGMWPQFRTI QEKEVIILNN KECDNFYHNF TKIPTLVQII KSQMMCAEDT
310 320 330 340 350
HREKFCYELT GEPLVCSMEG TWYLVGLVSW GAGCQKSEAP PIYLQVSSYQ
360 370 380
HWIWDCLNGQ ALALPAPSRT LLLALPLPLS LLAAL
Length:385
Mass (Da):43,088
Last modified:May 1, 2000 - v1
Checksum:iF5B39D6E12798AE5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05185975Q → P. Corresponds to variant dbSNP:rs34788938Ensembl.1
Natural variantiVAR_05186098V → I. Corresponds to variant dbSNP:rs35866901Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100707 mRNA Translation: AAF22500.1
BC033016 mRNA Translation: AAH33016.1
BC037775 mRNA Translation: AAH37775.1
CCDSiCCDS2745.1
RefSeqiNP_037402.1, NM_013270.4
UniGeneiHs.120365

Genome annotation databases

EnsembliENST00000315170; ENSP00000326598; ENSG00000283706
ENST00000460241; ENSP00000418875; ENSG00000206549
GeneIDi29122
KEGGihsa:29122
UCSCiuc003cqe.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTSP50_HUMAN
AccessioniPrimary (citable) accession number: Q9UI38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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