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Protein

Multifunctional methyltransferase subunit TRM112-like protein

Gene

TRMT112

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species.1 Publication

GO - Molecular functioni

  • protein methyltransferase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-156581. Methylation.
R-HSA-6782315. tRNA modification in the nucleus and cytosol.
R-HSA-6790901. rRNA modification in the nucleus.
R-HSA-72764. Eukaryotic Translation Termination.

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional methyltransferase subunit TRM112-like protein
Alternative name(s):
tRNA methyltransferase 112 homolog
Gene namesi
Name:TRMT112
ORF Names:AD-001, HSPC152, HSPC170
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26940. TRMT112.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • nucleoplasm Source: Reactome
  • protein complex Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165543757.

Polymorphism and mutation databases

DMDMi47606219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 125125Multifunctional methyltransferase subunit TRM112-like proteinPRO_0000215797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei119 – 1191PhosphoserineCombined sources
Modified residuei125 – 1251PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UI30.
MaxQBiQ9UI30.
PaxDbiQ9UI30.
PeptideAtlasiQ9UI30.
PRIDEiQ9UI30.
TopDownProteomicsiQ9UI30-1. [Q9UI30-1]

PTM databases

iPTMnetiQ9UI30.
PhosphoSiteiQ9UI30.

Expressioni

Gene expression databases

BgeeiENSG00000173113.
ExpressionAtlasiQ9UI30. baseline and differential.
GenevisibleiQ9UI30. HS.

Organism-specific databases

HPAiHPA039901.
HPA040006.

Interactioni

Subunit structurei

Interacts with ALKBH8 and HEMK2/N6AMT1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ALKBH8Q96BT75EBI-373326,EBI-10825637

Protein-protein interaction databases

BioGridi119576. 38 interactions.
IntActiQ9UI30. 15 interactions.
MINTiMINT-3080552.
STRINGi9606.ENSP00000438349.

Structurei

3D structure databases

ProteinModelPortaliQ9UI30.
SMRiQ9UI30. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 119118TRM112Add
BLAST

Sequence similaritiesi

Belongs to the TRM112 family.Curated
Contains 1 TRM112 domain.Curated

Phylogenomic databases

eggNOGiKOG1088. Eukaryota.
ENOG4111NTJ. LUCA.
GeneTreeiENSGT00390000009268.
HOGENOMiHOG000181652.
HOVERGENiHBG056590.
InParanoidiQ9UI30.
KOiK15448.
OMAiAMVCPNC.
OrthoDBiEOG091G0W2D.
PhylomeDBiQ9UI30.
TreeFamiTF313256.

Family and domain databases

InterProiIPR005651. UPF0434/Trm112.
[Graphical view]
PfamiPF03966. Trm112p. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UI30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLLTHNLLS SHVRGVGSRG FPLRLQATEV RICPVEFNPN FVARMIPKVE
60 70 80 90 100
WSAFLEAADN LRLIQVPKGP VEGYEENEEF LRTMHHLLLE VEVIEGTLQC
110 120
PESGRMFPIS RGIPNMLLSE EETES
Length:125
Mass (Da):14,199
Last modified:May 1, 2000 - v1
Checksum:iA943569364D4FFEA
GO
Isoform 2 (identifier: Q9UI30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-65: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:120
Mass (Da):13,576
Checksum:i6CC084E35370CF66
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201E → G in AAH29482 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei61 – 655Missing in isoform 2. CuratedVSP_054748

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110774 mRNA. Translation: AAF14857.1.
AF229068 mRNA. Translation: AAF82266.1.
AF161501 mRNA. Translation: AAF29116.1.
AK312050 mRNA. Translation: BAG34986.1.
AP001453 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74251.1.
BC017172 mRNA. Translation: AAH17172.1.
BC029482 mRNA. Translation: AAH29482.1.
BC105294 mRNA. Translation: AAI05295.1.
CCDSiCCDS66113.1. [Q9UI30-2]
CCDS8068.1. [Q9UI30-1]
RefSeqiNP_001273011.1. NM_001286082.1. [Q9UI30-2]
NP_057488.1. NM_016404.2. [Q9UI30-1]
UniGeneiHs.333579.

Genome annotation databases

EnsembliENST00000308774; ENSP00000309433; ENSG00000173113. [Q9UI30-2]
ENST00000544844; ENSP00000438349; ENSG00000173113. [Q9UI30-1]
GeneIDi51504.
KEGGihsa:51504.
UCSCiuc001nzt.5. human. [Q9UI30-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110774 mRNA. Translation: AAF14857.1.
AF229068 mRNA. Translation: AAF82266.1.
AF161501 mRNA. Translation: AAF29116.1.
AK312050 mRNA. Translation: BAG34986.1.
AP001453 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74251.1.
BC017172 mRNA. Translation: AAH17172.1.
BC029482 mRNA. Translation: AAH29482.1.
BC105294 mRNA. Translation: AAI05295.1.
CCDSiCCDS66113.1. [Q9UI30-2]
CCDS8068.1. [Q9UI30-1]
RefSeqiNP_001273011.1. NM_001286082.1. [Q9UI30-2]
NP_057488.1. NM_016404.2. [Q9UI30-1]
UniGeneiHs.333579.

3D structure databases

ProteinModelPortaliQ9UI30.
SMRiQ9UI30. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119576. 38 interactions.
IntActiQ9UI30. 15 interactions.
MINTiMINT-3080552.
STRINGi9606.ENSP00000438349.

PTM databases

iPTMnetiQ9UI30.
PhosphoSiteiQ9UI30.

Polymorphism and mutation databases

DMDMi47606219.

Proteomic databases

EPDiQ9UI30.
MaxQBiQ9UI30.
PaxDbiQ9UI30.
PeptideAtlasiQ9UI30.
PRIDEiQ9UI30.
TopDownProteomicsiQ9UI30-1. [Q9UI30-1]

Protocols and materials databases

DNASUi51504.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308774; ENSP00000309433; ENSG00000173113. [Q9UI30-2]
ENST00000544844; ENSP00000438349; ENSG00000173113. [Q9UI30-1]
GeneIDi51504.
KEGGihsa:51504.
UCSCiuc001nzt.5. human. [Q9UI30-1]

Organism-specific databases

CTDi51504.
GeneCardsiTRMT112.
HGNCiHGNC:26940. TRMT112.
HPAiHPA039901.
HPA040006.
neXtProtiNX_Q9UI30.
PharmGKBiPA165543757.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1088. Eukaryota.
ENOG4111NTJ. LUCA.
GeneTreeiENSGT00390000009268.
HOGENOMiHOG000181652.
HOVERGENiHBG056590.
InParanoidiQ9UI30.
KOiK15448.
OMAiAMVCPNC.
OrthoDBiEOG091G0W2D.
PhylomeDBiQ9UI30.
TreeFamiTF313256.

Enzyme and pathway databases

ReactomeiR-HSA-156581. Methylation.
R-HSA-6782315. tRNA modification in the nucleus and cytosol.
R-HSA-6790901. rRNA modification in the nucleus.
R-HSA-72764. Eukaryotic Translation Termination.

Miscellaneous databases

GenomeRNAii51504.
PROiQ9UI30.

Gene expression databases

BgeeiENSG00000173113.
ExpressionAtlasiQ9UI30. baseline and differential.
GenevisibleiQ9UI30. HS.

Family and domain databases

InterProiIPR005651. UPF0434/Trm112.
[Graphical view]
PfamiPF03966. Trm112p. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTR112_HUMAN
AccessioniPrimary (citable) accession number: Q9UI30
Secondary accession number(s): B2R539
, J3KNG5, Q3MHC7, Q8N2Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.